Background
Methods
Patients and controls
Coronary angiography
Biochemical investigations
Statistics
Results
Baseline clinical characteristics and biochemical measurements
Variable | Control group (n = 83) | CAD group (n = 241) | P value |
---|---|---|---|
Men (%) | 38(45.8) | 165(68.5) | <0.0001 |
Age (yrs) | 62 ± 10 | 66 ± 10 | 0.001 |
Cigarette smoking (%) | 11(13.3) | 68(28.2) | 0.007 |
Hypertension (%) | 52(62.7) | 175(72.6) | NS |
Blood pressure | |||
Systolic (mmHg) | 138 ± 21 | 137 ± 20 | NS |
Diastolic (mmHg) | 81 ± 10 | 79 ± 11 | NS |
Hyperlipidemia (%) | 47(56.6) | 137(56.8) | NS |
Cholesterol | |||
Total cholesterol (mmol/L) | 4.77 ± 1.27 | 4.70 ± 1.15 | NS |
HDL-cholesterol (mmol/L) | 1.19 ± 0.30 | 1.13 ± 0.41 | NS |
LDL-cholesterol (mmol/L) | 2.80 ± 0.89 | 2.73 ± 0.90 | NS |
Triglycerides(mmol/L) | 2.23 ± 1.79 | 2.01 ± 1.19 | NS |
Lipoprotein-a (g/L) | 0.19 ± 0.11 | 0.25 ± 0.19 | 0.025 |
Apo-A (g/L) | 1.29 ± 0.19 | 1.24 ± 0.22 | NS |
Apo-B (g/L) | 0.94 ± 0.26 | 0.94 ± 0.25 | NS |
Glucose (mmol/L) | 7.03 ± 1.88 | 7.28 ± 2.72 | NS |
Blood urea nitrogen (mmol/L) | 5.49 ± 1.60 | 6.05 ± 2.29 | 0.043 |
Creatinine (μmol/L) | 74.67 ± 16.31 | 92.59 ± 29.22 | <0.0001 |
Uric acid (μmol/L) | 307.9 ± 76.03 | 314.19 ± 83.07 | NS |
Glycated albumin (%) | 19.37 ± 4.29 | 21.21 ± 5.24 | 0.001 |
Hs-CRP (mg/L) | 7.37 ± 8.71 | 25.77 ± 30.35 | <0.0001 |
Logistic regression model
Variable | Odds Ratio | 95% Confidence interval | P Value |
---|---|---|---|
Men | 3.573 | 1.64–7.81 | 0.001 |
Age ≥ 65 Yrs | 2.267 | 1.12–4.57 | 0.022 |
Cigarette smoking | 1.026 | 0.4–2.63 | 0.958 |
Hypertension | 1.158 | 0.57–2.36 | 0.686 |
Hyperlipidemia | 1.252 | 0.59–2.64 | 0.556 |
Total cholesterol | 1.139 | 0.53–2.44 | 0.737 |
HDL-cholesterol | 0.871 | 0.57–1.34 | 0.568 |
LDL-cholesterol | 0.937 | 0.38–2.29 | 0.887 |
Triglycerides | 1.017 | 0.71–1.46 | 0.927 |
Lipoprotein-a ≥ 0.22 g/L | 2.057 | 1.03–4.09 | 0.04 |
Blood urea nitrogen | 0.955 | 0.80–1.15 | 0.624 |
Creatinine ≥ 100 (μmol/L) | 8.109 | 2.06–31.9 | 0.003 |
Uric acid | 1 | 1.00–1.01 | 0.849 |
Glycated albumin ≥ 20% | 3.54 | 1.74–7.20 | <0.001 |
Hs-CRP ≥ 10 mg/L | 2.648 | 1.32–5.30 | 0.006 |
Variable | B | Odds ratio | 95% CI | P value |
---|---|---|---|---|
Constant | -1.5 | 0.223 | <0.0001 | |
Men | 1.265 | 3.542 | 1.818–6.689 | <0.0001 |
Age ≥ 65 Yrs | 0.812 | 2.253 | 1.161–4.372 | 0.016 |
Glycated albumin ≥ 20% | 1.24 | 3.456 | 1.777–6.720 | <0.0001 |
Hs-CRP ≥ 10 (mg/L) | 0.953 | 2.593 | 1.313–5.119 | 0.006 |
Lp (a) ≥ 0.22 g/L | 0.902 | 2.464 | 1.249–4.858 | 0.009 |
Creatinine ≥ 100 umol/L | 1.918 | 6.805 | 1.956–23.673 | 0.003 |
Receiver-operating characteristic curves
Variable | Area under curve (95% CI) | P value | Cut-off point | Sensitivity | Specificity |
---|---|---|---|---|---|
Glycated albumin | 0.654(0.579–0.730) | <0.0001 | 18.7% | 67.9% | 60% |
Hs-CRP | 0.721(0.658–0.785) | <0.0001 | 5.2 mg/L | 72.2% | 60% |
Regression model | 0.824(0.768–0.879) | <0.0001 | 0.648 | 82.3% | 68.6% |