Background
Methods
Experimental Diabetic Model
Surgical Protocol
Blood Pressure and Left Ventricular Pressure Recording
Experimental Protocol
Data Analysis
Statistical Analysis
Results
Weight and Blood Glucose
Weight | Blood Glucose | ||||
---|---|---|---|---|---|
1
st
day
|
3
rd
day
|
15
th
day
|
3
rd
day
|
15
th
day
| |
Control
| 323 ± 10 | 344 ± 8 | 446 ± 9‡ | 107 ± 3 | 109 ± 3 |
STZ
| 348 ± 13 | 330 ± 15 | 296 ± 6†§ | 453 ± 18* | 444 ± 17§ |
STZ + Insulin
| 303 ± 15 | 335 ± 3 | 416 ± 11‡ | 464 ± 35* | 101 ± 3 |
Hemodynamic and Cardiac Function Parameters
MAP | HR | +dP/dtmax | -dP/dtmax | |
---|---|---|---|---|
Control
| 103 ± 3 | 359 ± 5 | 12676 ± 723 | -8207 ± 339 |
STZ
| 91 ± 3* | 312 ± 7* | 9512 ± 437* | -5763 ± 422* |
STZ + Insulin
| 105 ± 4 | 357 ± 11 | 13943 ± 863 | -8985 ± 315 |