Erschienen in:
01.04.2003 | Editorial
Lipopolysaccharide preconditioning attenuates metabolic alteration induced by endotoxin shock: tissue-specific monitoring by microdialysis
verfasst von:
Jyrki J. Tenhunen
Erschienen in:
Intensive Care Medicine
|
Ausgabe 4/2003
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Excerpt
Murry and colleagues were the first to propose the term 'preconditioning' to describe the phenomenon where multiple brief ischemic episodes (5 min each) protect the heart from a subsequent sustained ischemic insult. Preconditioning of myocardium partly prevented ischemic injury and decreased the infarct area by 75% as compared to myocardial ischemia without preconditioning [
1]. Other, seemingly noxious stimuli—but nonetheless, inducers of protective cellular mechanisms—have been described since then. Such stressful events or interventions include injections of endotoxin (lipopolysaccharide, LPS) [
2] or endotoxin analogues [
3], heating of tissue [
4], and several chemical stimuli such as bradychinin, N-acetylcysteine, TNFα etc. …