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Erschienen in: Intensive Care Medicine 4/2003

01.04.2003 | Editorial

Lipopolysaccharide preconditioning attenuates metabolic alteration induced by endotoxin shock: tissue-specific monitoring by microdialysis

verfasst von: Jyrki J. Tenhunen

Erschienen in: Intensive Care Medicine | Ausgabe 4/2003

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Excerpt

Murry and colleagues were the first to propose the term 'preconditioning' to describe the phenomenon where multiple brief ischemic episodes (5 min each) protect the heart from a subsequent sustained ischemic insult. Preconditioning of myocardium partly prevented ischemic injury and decreased the infarct area by 75% as compared to myocardial ischemia without preconditioning [1]. Other, seemingly noxious stimuli—but nonetheless, inducers of protective cellular mechanisms—have been described since then. Such stressful events or interventions include injections of endotoxin (lipopolysaccharide, LPS) [2] or endotoxin analogues [3], heating of tissue [4], and several chemical stimuli such as bradychinin, N-acetylcysteine, TNFα etc. …
Literatur
1.
Zurück zum Zitat Murry CE, Jennings RB, Reimer KA (1986) Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation 74:1124–1136PubMed Murry CE, Jennings RB, Reimer KA (1986) Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation 74:1124–1136PubMed
2.
Zurück zum Zitat Brown JM, Grosso MA, Terada LS, Whitman GJ, Banerjee A, White CW, Harken AH, Repine JE (1989) Endotoxin pretreatment increases endogenous myocardial catalase activity and decreases ischemia-reperfusion injury of isolated rat hearts. Proc Natl Acad Sci USA 86:2516–2520PubMed Brown JM, Grosso MA, Terada LS, Whitman GJ, Banerjee A, White CW, Harken AH, Repine JE (1989) Endotoxin pretreatment increases endogenous myocardial catalase activity and decreases ischemia-reperfusion injury of isolated rat hearts. Proc Natl Acad Sci USA 86:2516–2520PubMed
3.
Zurück zum Zitat Yoshida K, Maaieh MM, Shipley JB, Doloresco M, Bernardo NL, Qian YZ, Elliott GT, Kukreja RC (1996) Monophosphoryl lipid A induces pharmacologic 'preconditioning' in rabbit hearts without concomitant expression of 70-kDa heat shock protein. Mol Cell Biochem 156:1–8PubMed Yoshida K, Maaieh MM, Shipley JB, Doloresco M, Bernardo NL, Qian YZ, Elliott GT, Kukreja RC (1996) Monophosphoryl lipid A induces pharmacologic 'preconditioning' in rabbit hearts without concomitant expression of 70-kDa heat shock protein. Mol Cell Biochem 156:1–8PubMed
4.
Zurück zum Zitat Uchinami H, Yamamoto Y, Kume M, Yonezawa K, Ishikawa Y, Taura K, Nakajima A, Hata K, Yamaoka Y (2002) Effect of heat shock preconditioning on NF-kappaB/I-kappaB pathway during I/R injury of the rat liver. Am J Physiol Gastrointest Liver Physiol 282: G962–971PubMed Uchinami H, Yamamoto Y, Kume M, Yonezawa K, Ishikawa Y, Taura K, Nakajima A, Hata K, Yamaoka Y (2002) Effect of heat shock preconditioning on NF-kappaB/I-kappaB pathway during I/R injury of the rat liver. Am J Physiol Gastrointest Liver Physiol 282: G962–971PubMed
5.
Zurück zum Zitat Liu J, Ginis I, Spatz M, Hallenbeck JM (2000) Hypoxic preconditioning protects cultured neurons against hypoxic stress via TNF-alpha and ceramide. Am J Physiol Cell Physiol 278: C144–153PubMed Liu J, Ginis I, Spatz M, Hallenbeck JM (2000) Hypoxic preconditioning protects cultured neurons against hypoxic stress via TNF-alpha and ceramide. Am J Physiol Cell Physiol 278: C144–153PubMed
6.
Zurück zum Zitat Zimmermann C, Ginis I, Furuya K, Klimanis D, Ruetzler C, Spatz M, Hallenbeck JM (2001) Lipopolysaccharide-induced ischemic tolerance is associated with increased levels of ceramide in brain and in plasma. Brain Res 895:59–65CrossRefPubMed Zimmermann C, Ginis I, Furuya K, Klimanis D, Ruetzler C, Spatz M, Hallenbeck JM (2001) Lipopolysaccharide-induced ischemic tolerance is associated with increased levels of ceramide in brain and in plasma. Brain Res 895:59–65CrossRefPubMed
7.
Zurück zum Zitat Puisieux F, Deplanque D, Pu Q, Souil E, Bastide M, Bordet R (2000) Differential role of nitric oxide pathway and heat shock protein in preconditioning and lipopolysaccharide-induced brain ischemic tolerance. Eur J Pharmacol 389:71–78CrossRefPubMed Puisieux F, Deplanque D, Pu Q, Souil E, Bastide M, Bordet R (2000) Differential role of nitric oxide pathway and heat shock protein in preconditioning and lipopolysaccharide-induced brain ischemic tolerance. Eur J Pharmacol 389:71–78CrossRefPubMed
8.
Zurück zum Zitat Meng X, Brown JM, Ao L, Nordeen SK, Franklin W, Harken AH, Banerjee A (1996) Endotoxin induces cardiac HSP70 and resistance to endotoxemic myocardial depression in rats. Am J Physiol 271:C1316–1324PubMed Meng X, Brown JM, Ao L, Nordeen SK, Franklin W, Harken AH, Banerjee A (1996) Endotoxin induces cardiac HSP70 and resistance to endotoxemic myocardial depression in rats. Am J Physiol 271:C1316–1324PubMed
9.
Zurück zum Zitat Hausenloy DJ, Maddock HL, Baxter GF, Yellon DM (2002) Inhibiting mitochondrial permeability transition pore opening: a new paradigm for myocardial preconditioning? Cardiovasc Res 55:534–543CrossRefPubMed Hausenloy DJ, Maddock HL, Baxter GF, Yellon DM (2002) Inhibiting mitochondrial permeability transition pore opening: a new paradigm for myocardial preconditioning? Cardiovasc Res 55:534–543CrossRefPubMed
10.
Zurück zum Zitat Klaus S, Heringlake M, Block K, Nolde J, Staubach K, Bahlmann L (2003) Metabolic changes detected by microdialysis during endotoxin shock and after endotoxin preconditioning. Intensive Care Med (this issue) Klaus S, Heringlake M, Block K, Nolde J, Staubach K, Bahlmann L (2003) Metabolic changes detected by microdialysis during endotoxin shock and after endotoxin preconditioning. Intensive Care Med (this issue)
11.
Zurück zum Zitat Filkins JP, Cornell RP (1974) Depression of hepatic gluconeogenesis and the hypoglycemia of endotoxin shock. Am J Physiol 227:778–781PubMed Filkins JP, Cornell RP (1974) Depression of hepatic gluconeogenesis and the hypoglycemia of endotoxin shock. Am J Physiol 227:778–781PubMed
12.
Zurück zum Zitat Santak B, Radermacher P, Adler J, Iber T, Rieger KM, Wachter U, Vogt J, Georgieff M, Trager K (1998) Effect of increased cardiac output on liver blood flow, oxygen exchange and metabolic rate during long-term endotoxin-induced shock in pigs. Br J Pharmacol 124:1689–1697PubMed Santak B, Radermacher P, Adler J, Iber T, Rieger KM, Wachter U, Vogt J, Georgieff M, Trager K (1998) Effect of increased cardiac output on liver blood flow, oxygen exchange and metabolic rate during long-term endotoxin-induced shock in pigs. Br J Pharmacol 124:1689–1697PubMed
13.
Zurück zum Zitat Leclercq P, Filippi C, Sibille B, Hamant S, Keriel C, Leverve XM (1997) Inhibition of glycerol metabolism in hepatocytes isolated from endotoxic rats. Biochem J 325:519–525PubMed Leclercq P, Filippi C, Sibille B, Hamant S, Keriel C, Leverve XM (1997) Inhibition of glycerol metabolism in hepatocytes isolated from endotoxic rats. Biochem J 325:519–525PubMed
14.
Zurück zum Zitat Green A, Dobias SB, Walters DJ, Brasier AR (1994) Tumor necrosis factor increases the rate of lipolysis in primary cultures of adipocytes without altering levels of hormone-sensitive lipase. Endocrinology 13:2581–2588 Green A, Dobias SB, Walters DJ, Brasier AR (1994) Tumor necrosis factor increases the rate of lipolysis in primary cultures of adipocytes without altering levels of hormone-sensitive lipase. Endocrinology 13:2581–2588
15.
Zurück zum Zitat Ungerstedt U, Pycock C (1974) Functional correlates of dopamine neurotransmission. Bull Schweiz Akad Med Wiss 30:44–55PubMed Ungerstedt U, Pycock C (1974) Functional correlates of dopamine neurotransmission. Bull Schweiz Akad Med Wiss 30:44–55PubMed
16.
Zurück zum Zitat Bundgaard H, Kjeldsen K, Suarez Krabbe K, Van Hall G, Simonsen L, Qvist J, Muff Hansen C, Moller K, Fonsmark L, Lav Madsen P, Klarlund Pedersen B (2003) Endotoxemia stimulates skeletal muscle Na+-K+-ATPase and raises blood lactate under aerobic conditions in humans. Am J Physiol Heart Circ Physiol 284:H1028–H1034PubMed Bundgaard H, Kjeldsen K, Suarez Krabbe K, Van Hall G, Simonsen L, Qvist J, Muff Hansen C, Moller K, Fonsmark L, Lav Madsen P, Klarlund Pedersen B (2003) Endotoxemia stimulates skeletal muscle Na+-K+-ATPase and raises blood lactate under aerobic conditions in humans. Am J Physiol Heart Circ Physiol 284:H1028–H1034PubMed
17.
Zurück zum Zitat Tenhunen JJ, Jakob SM, Ruokonen E, Takala J (2002) Jejunal luminal microdialysate lactate in cardiac tamponade – effect of low systemic blood flow on gut mucosa. Intensive Care Med 28:953–962PubMed Tenhunen JJ, Jakob SM, Ruokonen E, Takala J (2002) Jejunal luminal microdialysate lactate in cardiac tamponade – effect of low systemic blood flow on gut mucosa. Intensive Care Med 28:953–962PubMed
18.
Zurück zum Zitat Muller M (2002) Science, medicine, and the future: microdialysis. BMJ 324:588–591PubMed Muller M (2002) Science, medicine, and the future: microdialysis. BMJ 324:588–591PubMed
19.
Zurück zum Zitat Jacobson I, Sandberg M, Hamberger A (1985) Mass transfer in brain dialysis devices - a new method for the estimation of extracellular amino acids concentration. J Neurosci Methods 15:263–268PubMed Jacobson I, Sandberg M, Hamberger A (1985) Mass transfer in brain dialysis devices - a new method for the estimation of extracellular amino acids concentration. J Neurosci Methods 15:263–268PubMed
20.
Zurück zum Zitat Lönnroth P, Jansson PA, Smith U (1987) A microdialysis method allowing characterization of intercellular water space in humans. Am J Physiol 253: E228–231PubMed Lönnroth P, Jansson PA, Smith U (1987) A microdialysis method allowing characterization of intercellular water space in humans. Am J Physiol 253: E228–231PubMed
Metadaten
Titel
Lipopolysaccharide preconditioning attenuates metabolic alteration induced by endotoxin shock: tissue-specific monitoring by microdialysis
verfasst von
Jyrki J. Tenhunen
Publikationsdatum
01.04.2003
Verlag
Springer-Verlag
Erschienen in
Intensive Care Medicine / Ausgabe 4/2003
Print ISSN: 0342-4642
Elektronische ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-003-1692-4

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