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01.08.2015 | Original Communication

Magnetization transfer ratio in lesions rather than normal-appearing brain relates to disability in patients with multiple sclerosis

verfasst von: Michael Amann, Athina Papadopoulou, Michaela Andelova, Stefano Magon, Nicole Mueller-Lenke, Yvonne Naegelin, Christoph Stippich, Ernst Wilhelm Radue, Oliver Bieri, Ludwig Kappos, Till Sprenger

Erschienen in: Journal of Neurology | Ausgabe 8/2015

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Abstract

Magnetization transfer ratio (MTR) is a semi-quantitative measure that seems to correlate with the degree of myelin loss and generally tissue destruction in multiple sclerosis (MS). Our objective was to comprehensively assess the MTR of lesions and normal appearing (NA) tissue separately in the white matter (WM), the cortex, the thalamus and the basal ganglia (BG) and determine their relative contribution to disability. In this cross-sectional study 71 patients were included (59 with relapsing–remitting MS, 12 with secondary progressive MS). We used a three-dimensional MTR sequence with high spatial resolution, based on balanced steady-state free precession. Mean MTR was calculated for lesions and NA tissue separately for each tissue type. Lesional MTR was lower than normal-appearing MTR in WM, cortex and thalamus. In the regression analysis, MTR of cortical lesions (β = −0.23, p = 0.05) and MTR of WML (β = −0.21, p = 0.08) were related by trend to the expanded disability status scale. MTR of WML significantly predicted the paced auditory serial-addition test (β = 0.35, p = 0.004). MTR of normal-appearing tissue did not relate to any outcome. Our results suggest that MTR of lesions in the white matter and cortex rather than of normal-appearing tissue relates to disability in patients with MS.

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Titel: Magnetization transfer ratio in lesions rather than normal-appearing brain relates to disability in patients with multiple sclerosis
verfasst von: Michael Amann
Athina Papadopoulou
Michaela Andelova
Stefano Magon
Nicole Mueller-Lenke
Yvonne Naegelin
Christoph Stippich
Ernst Wilhelm Radue
Oliver Bieri
Ludwig Kappos
Till Sprenger
Publikationsdatum: 01.08.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Neurology / Ausgabe 8/2015
Print ISSN: 0340-5354
Elektronische ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-015-7793-5

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