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Erschienen in:
01.02.2008 | ORIGINAL CONTRIBUTION
Methylmalonic acid values in healthy Dutch children
Erschienen in: European Journal of Nutrition | Ausgabe 1/2008
Einloggen, um Zugang zu erhaltenAbstract
Background
Plasma methylmalonic acid (MMA) is a specific marker for functional cobalamin deficiency. This deficiency can give rise to non-specific but serious symptoms in childhood such as developmental delay, convulsions and failure to thrive and may even lead to irreversible neurological damage.
Aim of the study
To analyse plasma MMA concentrations in Dutch children and to evaluate possible factors influencing its concentration.
Methods
A number of 186 Dutch children aged 0–19 years were analysed cross-sectionally. Blood was collected to measure MMA, total homocysteine (tHcy), cobalamin (Cbl) and serum creatinine concentrations. In addition, information about medical history, age and sex was recorded.
Results
The geometric mean (GM) plasma MMA concentration was 0.17 µmol/l (95% CI 0.07–0.42) and the GM tHcy was 6.6 µmol/l (95% CI 3.1–13.9). There is a slight positive correlation between plasma MMA and age in children >1 year (r = 0.211, P < 0.05). Plasma MMA concentrations were significantly higher in children with low Cbl concentrations. No significant difference in MMA, Cbl, tHcy or creatinine concentrations between sexes could be observed. Regression analysis showed that Cbl was the strongest determinant of plasma MMA (regression coefficient −0.414, P < 0.05). The association between MMA and Cbl is stronger at increasing age (P for trend 0.045).
Conclusions
Plasma Cbl is the main determinant of MMA in this group of Dutch children. The strength of the association increased with increasing age.