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18.03.2022 | Original Contribution

Plasma folate levels in relation to cognitive impairment: a community-based cohort of older adults in China

verfasst von: Xiao Chen, Jiaxi Yang, Hui Zhang, Yuhui Huang, Yaying Cao, Shiyu Yan, Geng Zong, Yan Zheng, Xiaofeng Wang, Changzheng Yuan

Erschienen in: European Journal of Nutrition | Ausgabe 5/2022

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Abstract

Purpose

Lower plasma level of folate has been associated with an increased risk of age-related cognitive impairment. However, studies that examined this relation have yielded mixed results. We aimed to examine the prospective association of plasma folate level with risk of cognitive impairment in a community-based prospective cohort of older adults in China.

Methods

This study included 615 participants (mean age: 76.3 years) without baseline cognitive impairment from the Rugao Longevity and Ageing Study (RuLAS). We used logistic regression to examine the prospective association between baseline plasma folate and risk of cognitive impairment in the next two years. Fasting blood samples were collected and assayed for plasma folate level at baseline. Cognitive impairment was defined as Hasegawa Dementia Scale (HDS) score ≤ 21.5 points.

Results

During two years’ follow-up, 20.7% of the participants developed cognitive impairment. After controlled for age, gender, and plasma homocysteine, a higher level of plasma folate was associated with lower odds of cognitive impairment. The corresponding odds ratio (OR) with 95% confidence interval was 0.41 (0.19–0.89) comparing participants at extreme quintiles of plasma folate (median level 17.2 vs. 6.3 nmol/L). The associations were similar after further adjustment for major demographic and lifestyle factors (OR = 0.42, 0.18–0.98). Moreover, the inverse association was particularly stronger among males (OR = 0.12, 0.03–0.52) but was non-significant among females.

Conclusion

Our findings support a potential beneficial role of higher plasma folate levels in cognitive function in older Chinese adults, particularly among males. Future studies with larger sample size and longer follow-up are warranted to confirm these findings and to identify the optimal plasma folate level for cognitive function.

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Titel: Plasma folate levels in relation to cognitive impairment: a community-based cohort of older adults in China
verfasst von: Xiao Chen
Jiaxi Yang
Hui Zhang
Yuhui Huang
Yaying Cao
Shiyu Yan
Geng Zong
Yan Zheng
Xiaofeng Wang
Changzheng Yuan
Publikationsdatum: 18.03.2022
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nutrition / Ausgabe 5/2022
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-022-02825-y

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Plasma folate levels in relation to cognitive impairment: a community-based cohort of older adults in China