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01.12.2012 | Original article

Radiation therapy for primary carcinoma of the eyelid: tumor control and visual function

verfasst von: M. Hata, MD, I. Koike, J. Maegawa, A. Kaneko, K. Odagiri, T. Kasuya, Y. Minagawa, H. Kaizu, Y. Mukai, T. Inoue

Erschienen in: Strahlentherapie und Onkologie | Ausgabe 12/2012

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Abstract

Background and purpose

Surgical excision remains the standard and most reliable curative treatment for eyelid carcinoma, but frequently causes functional and cosmetic impairment of the eyelid. We therefore investigated the efficacy and safety of radiation therapy in eyelid carcinoma.

Patients and methods

Twenty-three patients with primary carcinoma of the eyelid underwent radiation therapy. Sebaceous carcinoma was histologically confirmed in 16 patients, squamous cell carcinoma in 6, and basal cell carcinoma in 1. A total dose of 50–66.6 Gy (median, 60 Gy) was delivered to tumor sites in 18–37 fractions (median, 30 fractions).

Results

All but 3 of the 23 patients had survived at a median follow-up period of 49 months. The overall survival and local progression-free rates were 87% and 93% at 2 years, and 80% and 93% at 5 years, respectively. Although radiation-induced cataracts developed in 3 patients, visual acuity in the other patients was relatively well preserved. There were no other therapy-related toxicities of grade 3 or greater.

Conclusion

Radiation therapy is safe and effective for patients with primary carcinoma of the eyelid. It appears to contribute to prolonged survival as a result of good tumor control, and it also facilitates functional and cosmetic preservation of the eyelid.

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Titel: Radiation therapy for primary carcinoma of the eyelid: tumor control and visual function
verfasst von: M. Hata, MD
I. Koike
J. Maegawa
A. Kaneko
K. Odagiri
T. Kasuya
Y. Minagawa
H. Kaizu
Y. Mukai
T. Inoue
Publikationsdatum: 01.12.2012
Verlag: Springer-Verlag
Erschienen in: Strahlentherapie und Onkologie / Ausgabe 12/2012
Print ISSN: 0179-7158
Elektronische ISSN: 1439-099X
DOI: https://doi.org/10.1007/s00066-012-0145-9

Springer Medizin

Radiation therapy for primary carcinoma of the eyelid: tumor control and visual function