Erschienen in:
19.09.2023 | Research Letter
Safety and efficacy of omalizumab for antihistamine-resistant chronic urticaria in children: a case series and literature review
verfasst von:
Wei-Fang Zhu, Chen Wang, Jian-Jun Qiao, Lan-Juan Li
Erschienen in:
World Journal of Pediatrics
|
Ausgabe 3/2024
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Excerpt
Chronic urticaria (CU) is a common skin disease characterized by the occurrence of wheals, with or without angioedema, lasting more than 6 weeks. The prevalence of CU is about 0.7% [
1], but higher in children, with an incidence of 1.38% [
1]. The occurrence of severe pruritus and unpredictable wheals may severely impact patients’ quality of life, cause psychological problems, including sleep disorders and depression, and lead to economic burden due to limitation on daily life and work [
2,
3]. A standard-dose, second-generation H
1-antihistamine (sgAHs) is the first-line therapy for patients with CU [
4]. However, more than one-third of CU patients are insufficiently responsive to H
1-antihistamines, even with a dosage four times the standard dose (second line; off-label) [
4,
5]. Therefore, add-on treatment should be considered. …