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22.02.2021 | Original Contribution

Vitamin B₁₂ may play a preventive role in esophageal precancerous lesions: a case–control study based on markers in blood and 3-day duplicate diet samples

verfasst von: Da Pan, Shaokang Wang, Ming Su, Guiju Sun, Xiaopan Zhu, Mahsa Ghahvechi Chaeipeima, Ziqi Guo, Niannian Wang, Ziyu Zhang, Mengjing Cui

Erschienen in: European Journal of Nutrition | Ausgabe 6/2021

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Abstract

Purpose

It is hypothesized that vitamin B₁₂ may prevent tumor initiation during the early stage of carcinogenesis such as esophageal precancerous lesions (EPL), whereas an excessive level may promote tumor progression during the later stages of carcinogenesis. This study aimed to determine the role of vitamin B₁₂ in EPL by detecting vitamin B₁₂-related markers in both blood and diet.

Methods

This case–control study based on 3-day duplicated diet samples was conducted in a high-risk area of Huai'an, China. A 100 EPL cases and 100 healthy controls matched by gender, age (± 2 years) and villages were included. Dietary intake of vitamin B₁₂ and cobalt, plasma cobalt level, the serum levels of vitamin B₁₂ and transcobalamin II (TC II) were quantitatively analyzed.

Results

Dietary vitamin B₁₂ intake (p for trend = 0.384) and plasma cobalt level (p for trend = 0.253) were not associated with EPL risk, but high dietary cobalt intake (p for trend = 0.034), increased serum levels of vitamin B₁₂ (p for trend = 0.036) and TC II (p for trend < 0.001) were significantly associated with the reduced EPL risk. However, the significant negative association between dietary cobalt intake, plasma cobalt level or serum vitamin B₁₂ level and EPL was only found in female or male subjects.

Conclusion

Excellent transport capability of bio-active vitamin B₁₂ in vivo and adequate levels of vitamin B₁₂ and cobalt may play preventive roles in EPL. Additionally, the association between vitamin B₁₂, cobalt and the risk of EPL may vary in different genders.

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Titel: Vitamin B12 may play a preventive role in esophageal precancerous lesions: a case–control study based on markers in blood and 3-day duplicate diet samples
verfasst von: Da Pan
Shaokang Wang
Ming Su
Guiju Sun
Xiaopan Zhu
Mahsa Ghahvechi Chaeipeima
Ziqi Guo
Niannian Wang
Ziyu Zhang
Mengjing Cui
Publikationsdatum: 22.02.2021
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nutrition / Ausgabe 6/2021
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-021-02516-0

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Vitamin B₁₂ may play a preventive role in esophageal precancerous lesions: a case–control study based on markers in blood and 3-day duplicate diet samples