Critical Care

Modeling sepsis using neural nets and biomarkers of organ dysfunction in patients, with links to animal models

J Schentag, D Parish, S Opal

Extracellular matrix turnover, angiogenesis and endothelial function in acute lung injury: relationship to pulmonary dysfunction and outcome

S Sayed, N Idriss, H Sayyed

Thalidomide modulates macrophage-mediated inflammatory innate immune response during Klebsiella pneumoniae B5055 infection in BALB/c mice

V Kumar, S Chhibber

Immunoglobulin therapy of abdominal sepsis in emergency surgery

O Butyrsky, V Starosek

Procalcitonin level as a marker of severe sepsis and septic shock patients who required polymyxin-B immobilized fiber with direct hemoperfusion

T Ikeda, K Ikeda, S Suda

Diagnostic accuracy of procalcitonin in proven and clinically suspected systemic infection

S Das, D Anand, S Ray, S Bhargava, A Manocha, M Kankra, LM Srivastava

Evaluation of a soluble CD14 subtype in patients with surgical sepsis

Y Fukui

Advance directives and end-of-life decision-making in the ICU: results from an observational study

CS Hartog, I Peschel, D Schwarzkopf, B Kabisch, A Günther, R Pfeifer, H Skupin, K Reinhart, N Riedemann

Protective effects of FCGR2A polymorphism in invasive pneumococcal diseases

A Bouglé, A Max, N Mongardon, D Grimaldi, F Pène, C Rousseau, JD Chiche, JP Bedos, E Vicaut, JP Mira

Examination of blood filtration membrane removal ability of HMGB1

H Imahase, Y Sakamoto, M Kusunose, H Koami, Y Nishimura, A Goto, T Yamashita, A Nakashima, T Iwamura, N Kutsukata

Decreased expression of HLA-DR antigen-associated invariant chain mRNA predicts mortality after septic shock

M-A Cazalis, L Cavé, J Demaret, V Barbalat, E Cerrato, A Lepape, A Pachot, G Monneret, F Venet

Kaiser Permanente Northern California sepsis mortality reduction initiative

B Crawford, M Skeath, A Whippy

Dynamics of lymphocyte subpopulations during Legionnaires' disease

CPC de Jager, EFA Gemen, J de Jongh-Leuvenink, IBB Walsh, RJF Laheij, T van der Poll, PC Wever

Receptor for advanced glycation endproducts controls deleterious lung inflammation in severe Pseudomonas aeruginosa pneumonia in immunosuppressed mice

C Ravinet-Trillou, F Soubrier, A Caron, S Llopart, M Fontanie, F Lantreibecq, PE Rouby, C Menet, L Leotard, C Serradeil-Le Gal

Low-tidal volume ventilation as compared with conventional tidal volume ventilation in patients of sepsis: a randomized controlled trial

A Waheed, S Bhat, V Nabi, S Gurcu, A Maqbool, S Patigaroo, N Mehfooz

Impact of daily auditing and weekly feedback on process of care and patient outcome in resuscitation of severe sepsis and septic shock

B Afessa, CB Bowron, RD Danielson, K Ramar

Candida score: a predictor of mortality in patients with candidemia

D Juneja, P Nasa, O Singh, Y Javeri, S Garg

Incidence and prognostic implications of acute kidney injury based on the RIFLE criteria at the time of admission to an Indian ICU

D Juneja, P Nasa, O Singh, Y Javeri, S Garg

Candiduria in ICUs: incidence, course and outcome

D Juneja, P Nasa, O Singh, Y Javeri, S Garg

Erythropoietin enhances the effects of transplanted mesenchymal stem cells in an experimental model of endotoxemia

A Sorokina, A Averyanov, F Zabozlaev, A Konoplyannikov, D Akulshin, O Kuzovlev

Abstract withdrawn

Abstract withdrawn

Development and validation of a bedside prediction score for nosocomial sepsis in the pediatric ICU: a prospective observational cohort study

LG Saptharishi, M Jayashree, S Singhi

Effects of statins on mitochondrial respiration and outcome during experimental sepsis

J Morel, I Hargreaves, B Bollen-Pinto, D Brealey, J Backman, A Dyson, M Singer

Abstract withdrawn

Effect of phenolic acids originating from microbes on mitochondria and neutrophils

NV Beloborodova, AY Olenin, NI Fedotcheva, V Shubina, VV Teplova

Immunological modulation of estrogen during sepsis

AM Stabile, ME Batalhão, EC Carnio

Use of Centre for Disease Control criteria to classify infections in critically ill patients: results from an interobserver agreement study

PMC Klein Klouwenberg, DSY Ong, LD Bos, FM de Beer, MA Huson, M Straat, LA van Vught, L Wieske, J Horn, MJ Schultz, T van der Poll, MJM Bonten, OL Cremer

Patients with sepsis exhibit mitochondrial biogenesis in peripheral blood immune cells

F Sjövall, S Morota, MJ Hansson, E Elmér

AMP-activated protein kinase preserves endothelial tight junctions in the coronary microcirculation during sepsis

D Castanares-Zapatero, C Bouleti, T Mathivet, B Gerber, C Oury, L Bertrand, JL Vanoverschelde, PF Laterre, S Horman, C Beauloye

Weibel-Palade body exocytosis as a therapeutic target to improve hemodynamics in Gram-positive sepsis

JY Lee, HM Linge, K Ochani, YZ Zhang, EJ Miller

Effectiveness of nebulized amphotericin B to eradicate Candida colonization from the lower respiratory tracts of ICU patients

DSY Ong, PMC Klein Klouwenberg, MJM Bonten, OL Cremer

Clinical and diagnostic significance of apoptosis in the development of neutropenia and bacterial complications in newborns with respiratory distress syndrome

M Puchtinskaya

Haemodynamic and renal effects of clonidine in an ovine model of severe sepsis and septic acute kidney injury

P Calzavacca, K Ishikawa, K Lu, R Bellomo, CN May

Regional perfusion and oxygenation of the kidney in an ovine model of severe sepsis with hypotension and kidney injury

P Calzavacca, K Ishikawa, K Lu, RG Evans, A Skene, R Bellomo, CN May

Abstract withdrawn

Simplified selective decontamination of the digestive tract reduces Gram-negative bloodstream infection and respiratory tract colonization in intensive care

Y Bar-Lavie, K Hussein, S Hadad, M Barzelay

Decreased incidence of SIRS and sepsis by acupuncture in severe multiple traumatic patients via facilitation of vagal activity

H Liang, J Qu

A study of Candida biofilms in intensive care patients

R Kaur, R Goyal, M Singh, P Bhalla, R Kumar

A limited set of molecular biomarkers may provide superior diagnostic outcomes to procalcitonin in sepsis

RB Brandon, M Thomas, RA Brandon, D Venter, J Presneill, J Lipman, J Morgan, B Venkatesh, J Sackier, A Sutherland

Monocytic and neutrophilic CD11b and CD64 in severe sepsis

J Jämsä, V Huotari, ER Savolainen, H Syrjälä, T Ala-Kokko

Clinical evaluation of the Magicplex Sepsis Real-time Test (Seegene) to detect Candida DNA in pediatric patients

J Serra, E Rosello, C Figueras, M Pujol, Y Peña, P Céspedes, JL Dapena, C Díaz-Heredia, MG Codina, A Andreu

Procalcitonin, IL-10 and sCD25 as diagnostic and prognostic markers in critically ill patients

A Focà, MC Liberto, L Rametti, A Giancotti, N Marascio, A Quirino, S Caroleo, A Renzulli, G Matera

Ninjurin 1 contributes to TLR-induced inflammation in endothelial cells

C Jennewein, K Zacharowski

Effect of Calotropis procera latex extracts on the hypothalamic TNFα and PGE2 levels in the rat model of yeast-induced pyrexia

B Guruprasad, P Chaudhary, VL Kumar

Regulation of sepsis-induced IFNγ upon natural killer cell or natural killer T cell depletion in vivo

E Christaki, E Diza, EJ Giamarellos-Bourboulis, N Papadopoulou, A Pistiki, D Droggiti, A Machova, M Georgitsi, D Lambrelli, G Karkavelas, A Iliadis, N Malisiovas, P Nikolaidis, SM Opal

Pattern recognition receptors as key players in adrenal gland dysfunction during sepsis

THN Tran, W Kanczkowski, V Hoesker, SR Bornstein, K Zacharowski

Effects of a TREM-like transcript-1 derived peptide during septic shock in pigs

S Gibot, A Boufenzer, Y Bouazza, F Groubatch, C Alauzet, D Barraud, PE Bollaert, P Leroy, N Tran, M Derive

Role of TREM-1 in endothelial dysfunction during experimental sepsis

A Boufenzer, N Sennoun, Y Bouazza, M Derive, PE Bollaert, S Gibot

LPS-induced Pellino3 degradation is mediated by p62-dependent autophagy

A Heeg, L Kuchler, LK Eifler, T Knape, H Heide, B Brüne, A von Knethen

Attenuated NOX2 expression impairs ROS production during the hypoinflammatory phase of sepsis

L Kuchler, V Morbitzer, A Heeg, LK Eifler, T Knape, B Brüne, A von Knethen

Kinetic characterization of selective peroxisome-proliferator-activated receptor gamma modulators in vitro

T Knape, LK Eifler, A Heeg, L Kuchler, B Brüne, MJ Parnham, A von Knethen

IL-6 and IFNγ play a role in fatal cases of 5N1 influenza in children

A Alam, H Jusuf, CB Kartasasmita, D Setiabudi, S Sudarwati, DA Wulandari, AU Suardi, DH Somasetia

Abstract withdrawn

Involvement of thrombopoietin in the development of organ injury in a mouse model of cecal ligation and puncture-induced sepsis

E Greco, A Cuccurullo, B Laface, D Gallo, O Bosco, P De Giuli, E Lupia, G Montrucchio

Cholecystokinin protects rats against Staphylococcus aureus-induced sepsis

RS Saia, FMC Zuelli, EC Cárnio

Polymyxin B-direct hemoperfusion therapy contributes to oxygen delivery in septic patients

A Yaguchi, M Yokota, T Goto, M Takeda, R Moroi, T Harada, M Namiki

Sepsis in neonates: experience in a tertiary-care hospital

I Guerrero-Lozano, A Alonso-Ojembarrena, F Galán-Sanchez, AM García-Tapia, P Marin-Casanova, P García-Martos, M Rodriguez-Iglesias

Is urinary kidney injury molecule-1 a good marker for acute kidney injury in septic shock?

J Göschl, L Sudhoff, M Koehler, W Rachinger, J Briegel, I Kaufmann

Necrotizing fasciitis: modern clinical view

O Chernyshev, M Shatil, L Akinchits, N Vedernykova, V Kotlov, M Semak, N Bubnova

Erysipelas: complement system and SIRS

O Chernyshev, A Petrov, A Shatil, N Serebryanaya, N Bubnova

Pancreatic stone protein: a new predictor of outcome in patients with peritonitis

R Gukasjan, D Raptis, HU Schulz, W Halangk, R Graf

Audit on patient outcome based on APACHE II scoring in the respiratory ICU of a south Indian university teaching hospital

H Mangu, M Anakapalli, A Samantaray

Internal jugular vein catheterization: a comparative study of apical and paracarotid approaches

H Mangu, A Samantaray

Citrate anticoagulation protocol to treat septic shock patients with liver dysfunction in CPFA extracorporeal therapy

F Ferrari, M Pozzato, T Casalicchio, S Mosca, MG Quattrone, R Cena, F Quarello, S Livigni

Manipulation of nitric oxide levels with a modified hydroxyethyl starch molecule

C Lupp, S Baasner, D Heckmann, C Ince, F Nocken, M Schimmel, M Westphal

Molecular diagnosis of severe bacterial sepsis in children

M Merisescu, M Luminos, G Jugulete, D Florea, A Streinu-Cercel

Insulin exerts anti-inflammatory effects through reduction of IKK/IκB/NF-κB pathway activation in septic rats

F Mittestainer, B de Melo Carvalho, K Lima Calisto, D Guadagnini, M Jose Abdalla Saad

Severe sepsis with multiple organ dysfunctions caused by Pseudomonas aeruginosa in an immunocompetent child

G Jugulete, M Luminos, A Visan, A Draganescu, M Merisescu, M Vasile, A Nica

Effects of sesamol against acute kidney injury in cecal-ligation-and-puncture-treated rats

S Chien, Y Li, M Liu

Noradrenergic neurons regulate the egress and trafficking of splenic monocytes and influence mortality during Gram-negative infection in mice

EJ Seeley, S Barry, M Matthay, PJ Wolters

Mannose-binding lectin deficiency and NOD2 mutations do not predispose to Staphylococcus aureus bloodstream infections but may influence outcome

M Osthoff, HM Au Yong, MM Dean, D Eisen

Homogeneity versus diversity: inhibition of plasma PAI-1 in murine sepsis proved lethal in homogeneous cohorts but not in all-inclusive populations

P Raeven, KM Weixelbaumer, S Drechsler, A Klotz, M Jafarmadar, A Khadem, H Redl, S Bahrami, PJ Declerck, MF Osuchowski

Effect of heparin during extracorporeal detoxification in the severity of thrombocytopenia in patients with severe sepsis

VV Kulabukhov, AG Chizhov, AN Kudryavtsev

Estimation of efficacy early selective LPS sorption in patients with septic shock

VV Kulabukhov, AN Kudryavtsev, AG Chizhov

Audit of the ward-based management of severe sepsis in a large teaching hospital

G Estebanez, M Cole

Neutrophil CD64 as a diagnostic marker of sepsis in neonates: impact on clinical care

P Kingma, E Hall, D Marmer

Pancreatic stone protein as a novel marker for neonatal sepsis

L Schlapbach, R Graf, A Woerner, M Nelle, M Stocker, M Fontana, U Zimmermann-Baer, D Glauser, E Giannoni, T Roger, C Mueller

A standardized protocol for the multiplex PCR technique Septifast® Roche for neonatal samples with suspected sepsis

F Ortiz Ibarra, J Reyna, P Treviño, L Fernandez, G Lara, E Valenzuela, Y Morales, A Limon, A Ceballos

Toll-like receptor 4 in phagocytosis of Escherichia coli by endotoxin-activated human neutrophils in whole blood

I Prokhorenko, S Zubova, D Kabanov, E Voloshina, S Grachev

CD24-mediated neutrophil death in inflammation: ex vivo study suggesting a potential role in sepsis

M Parlato, F Souza-Fonseca-Guimaraes, F Philippart, B Misset, M Adib-Conquy, JM Cavaillon

Resistant Escherichia coli strains circulating in a tertiary-care hospital in New Delhi, India

B Uppal, P Aggarwal, R Ghosh, AK Jha, S Krishna Prakash

5-Lipoxygenase contributes to PPARγ activation in macrophages in response to apoptotic cells

A von Knethen, L Eifler, L Kuchler, A Heeg, H Heide, I Wittig, T Maier, D Steinhilber, B Brüne

Natural killer cell status and tolerance in mouse and human bacterial sepsis

F Souza-Fonseca-Guimaraes, M Parlato, F Philippart, B Misset, JM Cavaillon, M Adib-Conquy

Raman spectroscopic investigation of the interaction of Enterococcus faecalis and vancomycin: towards a culture-independent antibiotic susceptibility test

U Neugebauer, C Assmann, U Schröder, A Ramoji, U Glaser, C Beleites, W Pfister, J Popp, M Bauer

Transthoracic echocardiographic assessment of IVC diameter variability to determine fluid responsiveness in children with septic shock: a pilot study

K Sasidaran, M Jaishree, S Singhi, R Manoj

Do we still accept central venous pressure measurements to assess preload responsiveness in children with septic shock? A single-center experience

K Sasidaran, M Jaishree, S Singhi

Emergence of carbapenem resistance in Gram-negative nosocomial bloodstream infections among critically ill children? A single-center experience

K Sasidaran, S Singhi, M Jaishree, A Bansal

Development of a point-of-care-testing system for procalcitonin

H Kim, ES Yoon, S Ho, SW Oh, EY Choi

Management of sepsis in Indian ICUs: Indian data from the MOSAICS study

J Divatia

Impact of interventions to reduce device-related infections in Indian cancer centre ICUs

S Myatra, JV Divatia

Early fluid therapy with splanchnic sympathetic blockage prevented microcirculation damage, gut bacterial overgrowth, bacterial translocation and mortality in sepsis

AMA Liberatore, EC Del-Massa, LR Gondim, ALB Yamamura, IHJ Koh

Abdominal organs' microcirculation dysfunction sequence in severe sepsis by SDF microscopy and histology

J Almeida-Filho, AMA Liberatore, RC Tedesco, EC Del-Massa, IHJ Koh

Role of the clarithromycin immune modulator activity on abdominal microhemodynamics and mortality in severe sepsis

FRE Jesus, CD Snak-Souza, FM Dulcini, EC Del-Massa, LR Gondim, AMA Liberatore, IHJ Koh

Preliminary results for the use of proteinase K to achieve release of LPS from the Alteco LPS Adsorber® after perfusion with LPS containing blood

E Hansen, L Pierre, S Blomqvist

PSP/reg and NT-proCNP to predict the occurrence of ICU-acquired sepsis in severe trauma patients: results of a pilot study

M Dupin, M Chanteperdrix, I Chaillol, A Pachot, F Venet, G Monneret, B Allaouchiche, A Gouel-Chéron

From positive blood culture to microbiological diagnosis in 4 hours by MALDI-TOF mass spectrometry bacterial identification and rapid antibiogram

S Barnini, V Brucculeri, P Morici, A Lupetti, M Campa

Relationship between plasma NGAL and serum creatinine is influenced by leucocytosis and neutrophilia in the critically ill

NJ Glassford, AG Schneider, G Eastwood, L Peck, H Young, S Xu, R Bellomo

Corticosteroid resistance in sepsis is influenced by microRNA-124-induced downregulation of glucocorticoid receptor-α

P Möhnle, C Ledderose, J Briegel, S Kreth

Glucocorticoids control systemic inflammatory response by regulation of energy metabolism and cytokine expression

A Kleyman, S Hübner, M Bauer, JP Tuckermann

Assessment of clinical deterioration and progressive organ failure in moderate-severity emergency department sepsis patients

R Arnold, L Glaspey, S Hollenberg, S Trzeciak

Increased endotoxin activity is associated with clinical deterioration in moderate-severity emergency department sepsis patients: a pilot study

R Arnold, C Schorr, S Trzeciak, RP Dellinger

Defining the impact of delayed antibiotic administration using a comprehensive electronic health record screen to identify sepsis

RC Arnold, SM Hollenberg

Effects on outcome of patients with severe sepsis and septic shock admitted to the ICU after implementation cooperative sepsis management protocol

R Champunot, N Kamsawang, D Thimsri, P Tuandoung, S Tansuphaswasdikul

Saving 500 Lives Campaign: another way to improve the mortality rate of patients with severe sepsis and septic shock

R Champunot, N Kamsawang, P Tuandoung, S Tansuphaswasdikul

Clinical utility of using C-reactive protein and procalcitonin as biomarkers for a novel neonatal sepsis diagnostic platform (ASCMicroPlat)

K McAllister, M Sheridan-Pereira, N O'Sullivan, R O'Kelly, D Mark, G Czilwik, C Martin, O Sheils, J O'Leary

GAPDH: is it a reliable housekeeper gene to use in sepsis research?

J Sarveswaran, NM Orsi, M Cummings, S Homer-Vanniasinkam, D Burke

Cytokine gene expression profiling identifies distinct patterns in severe sepsis

J Sarveswaran, NM Orsi, M Cummings, S Homer-Vanniasinkam, D Burke

Quantified temporal changes of heart rate variability when developing SIRS

N Matsumaru, K Shirai, Y Kawamura, Y Yokota, K Kumada, I Toyoda, S Ogura

Endothelial cell specific molecule 1 is today a relevant marker of respiratory failure in sepsis and polytrauma patients

P Lassalle, N De Freitas Caires, L Portier, A Palud, E Parmentier, J Pastre, C Shah, A Scherpereel, D Mathieu, M Delehedde

A microbiome approach to sepsis: development and case-study application of novel methods for detection and isolation of microbes from whole blood

M Faria Crowder, JM Conly, MG Surette

Antibacterial therapy in treatment of newborns with perinatal sepsis

G Khanes, S Bidnenko, O Liutko

Use of intravenous and intramuscular immunoglobulin in the practice of treatment for purulent and septic deaths in newborns

G Khanes, L Nazarchuk, I Maksakova, O Bakaieva

An overview of the sepsis situation in the Department of Infection Diseases, University Hospital Center, Tirana

E Puca, A Pilaca, P Pipero, J Gremi, P Luga, G Stroni, E Qyra, I Akshia, D Kraja, E Puca

Is visceral leishmaniasis a sepsis or not?

E Puca, P Pipero, P Pilaca, E Puca

Evaluation of procalcitonin in patients with sepsis in Albanian adults

E Puca, P Pipero, A Pilaca, G Huti, A Daka, E Qyra, G Stroni, D Kraja, E Puca

Role of the membrane receptor ALXR in polymicrobial sepsis

LC Resende Silva, ID Tavares, MM Teixeira, D Da Gloria De Souza