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27.04.2024 | Diagnostic Neuroradiology

Expression of regional brain amyloid-β deposition with [18F]Flutemetamol in Centiloid scale -a multi-site study

verfasst von: Yi-Wen Bao, Zuo-Jun Wang, Li-Li Guo, Gen-Ji Bai, Yun Feng, Guo-Dong Zhao

Erschienen in: Neuroradiology

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Abstract

Purpose

The Centiloid project helps calibrate the quantitative amyloid-β (Aβ) load into a unified Centiloid (CL) scale that allows data comparison across multi-site. How the smaller regional amyloid converted into CL has not been attempted. We first aimed to express regional Aβ deposition in CL using [18F]Flutemetamol and evaluate regional Aβ deposition in CL with that in standardized uptake value ratio (SUVr). Second, we aimed to determine the presence or absence of focal Aβ deposition by measuring regional CL in equivocal cases showing negative global CL.

Methods

Following the Centiloid project pipeline, Level-1 replication, Level-2 calibration, and quality control were completed to generate corresponding Centiloid conversion equations to convert SUVr into Centiloid at regional levels. In equivocal cases, the regional CL was compared with visual inspection to evaluate regional Aβ positivity.

Results

14 out of 16 regional conversions from [18F]Flutemetamol SUVr to Centiloid successfully passed the quality control, showing good reliability and relative variance, especially precuneus/posterior cingulate and prefrontal regions with good stability for Centiloid scaling. The absence of focal Aβ deposition could be detected by measuring regional CL, showing a high agreement rate with visual inspection. The regional Aβ positivity in the bilateral anterior cingulate cortex was most prevalent in equivocal cases.

Conclusion

The expression of regional brain Aβ deposition in CL with [18F]Flutemetamol has been attempted in this study. Equivocal cases had focal Aβ deposition that can be detected by measuring regional CL.
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Metadaten
Titel
Expression of regional brain amyloid-β deposition with [18F]Flutemetamol in Centiloid scale -a multi-site study
verfasst von
Yi-Wen Bao
Zuo-Jun Wang
Li-Li Guo
Gen-Ji Bai
Yun Feng
Guo-Dong Zhao
Publikationsdatum
27.04.2024
Verlag
Springer Berlin Heidelberg
Erschienen in
Neuroradiology
Print ISSN: 0028-3940
Elektronische ISSN: 1432-1920
DOI
https://doi.org/10.1007/s00234-024-03364-5

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