Background
Methods
Design
Animals and Ethics
Animal Preparation
Invasive accesses and measurements
Embolus formation
Blood gases
Statistics
Results
RV afterload
RV function
Clot burden correlation
Variable | Group | Slope | 95%CI | p-value vs. 0 | r2 |
---|---|---|---|---|---|
Hemodynamics | |||||
HR, bpm | PE | 2.55 | 0.59–4.51 | 0.01 | 0.08 |
Sham | 0.78 | -1.69-3.25 | 0.52 | 0.002 | |
mPAP, mmHg | PE | 3.46 | 2.88–4.04 | < 0.0001 | 0.61 |
Sham | 0.04 | -0.11-0.19 | 0.57 | 0.01 | |
PVR, dynes | PE | 83.9 | 46.6-121.1 | < 0.0001 | 0.25 |
Sham | -6.1 | -21.0-8.8 | 0.41 | 0.02 | |
RV function | |||||
RV end-systolic pressure, mmHg | PE | 3.34 | 2.56–4.13 | < 0.0001 | 0.51 |
Sham | -0.31 | -0.90-0.26 | 0.30 | 0.009 | |
RV end-diastolic volume, mL | PE | 6.62 | 1.19–12.06 | 0.02 | 0.05 |
Sham | 1.81 | − 0.147 − 5.10 | 0.27 | 0.03 | |
RV arterial elastance, mmHg/mL | PE | 0.067 | -0.007-0.15 | 0.07 | 0.08 |
Sham | -0.014 | -0.044-0.016 | 0.34 | 0.03 | |
RV ejection fraction, % | PE | -2.96 | -4.32- -1.60 | 0.0001 | 0.24 |
Sham | 1.08 | -0.86-3.03 | 0.26 | 0.02 | |
Ventilatory function | |||||
PaO2, kPa | PE | -1.41 | -1.87- -0.95 | < 0.0001 | 0.27 |
Sham | -0.36 | -0,51- -0.18 | 0.0002 | 0.16 | |
PaCO2, kPa | PE | 0.33 | 0.25–0.41 | < 0.0001 | 0.46 |
Sham | 0.10 | 0.07–0.13 | < 0.0001 | 0.29 | |
EtCO2, kPa | PE | -0.07 | -0.12- -0.03 | 0.004 | 0.10 |
Sham | 0.002 | -0.038-0.042 | 0.91 | 0.0004 |