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04.05.2024 | Review

The mechanisms of ferroptosis in the pathogenesis of kidney diseases

verfasst von: Jia Liu, Jianheng Chen, Jie Lv, Yuhang Gong, Jie Song

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Abstract

The pathological features of acute and chronic kidney diseases are closely associated with cell death in glomeruli and tubules. Ferroptosis is a form of programmed cell death characterized by iron overload-induced oxidative stress. Ferroptosis has recently gained increasing attention as a pathogenic mechanism of kidney damage. Specifically, the ferroptosis signaling pathway has been found to be involved in the pathological process of acute and chronic kidney injury, potentially contributing to the development of both acute and chronic kidney diseases. This paper aims to elucidate the underlying mechanisms of ferroptosis and its role in the pathogenesis of kidney disease, highlighting its significance and proposing novel directions for its treatment.

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Titel: The mechanisms of ferroptosis in the pathogenesis of kidney diseases
verfasst von: Jia Liu
Jianheng Chen
Jie Lv
Yuhang Gong
Jie Song
Publikationsdatum: 04.05.2024
Verlag: Springer International Publishing
Erschienen in: Journal of Nephrology
Print ISSN: 1121-8428
Elektronische ISSN: 1724-6059
DOI: https://doi.org/10.1007/s40620-024-01927-6

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The mechanisms of ferroptosis in the pathogenesis of kidney diseases

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Ist Fasten vor Koronarinterventionen wirklich nötig?

Typ-2-Diabetes: Ernährungsunsicherheit vervierfacht Risiko für schwere Hypoglykämien

Mehr Brustkrebs, aber weniger andere gynäkologische Tumoren mit Levonorgestrel-IUS

GLP-1-Agonist Semaglutid wirkt kardio- und nephroprotektiv

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