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Journal of Cancer Research and Clinical Oncology

Erschienen in:

01.07.2014 | Original Article – Cancer Research

Overexpression of epithelial cell adhesion molecule protein is associated with favorable prognosis in an unselected cohort of ovarian cancer patients

verfasst von: Marco Johannes Battista, Cristina Cotarelo, Sina Jakobi, Joscha Steetskamp, Georgios Makris, Isabel Sicking, Veronika Weyer, Marcus Schmidt

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 7/2014

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Abstract

Purpose

The aim of this study was to evaluate the prognostic influence of epithelial cell adhesion molecule (EpCAM) in an unselected cohort of ovarian cancer (OC) patients.

Methods

Expression of EpCAM was determined by immunohistochemistry in an unselected cohort of 117 patients with OC. Univariable and multivariable Cox regression analyses adjusted for age, tumor stage, histological grading, histological subtype, postoperative tumor burden and completeness of chemotherapy were performed in order to determine the prognostic influence of EpCAM. The Kaplan–Meier method is used to estimate survival rates.

Results

Univariable Cox regression analysis showed that overexpression of EpCAM is associated with favorable prognosis in terms of progression-free survival (PFS) (p = 0.011) and disease-specific survival (DSS) (p = 0.003). In multivariable Cox regression analysis, overexpression of EpCAM retains its significance independent of established prognostic factors for longer PFS [hazard ratios (HR) 0.408, 95 % confidence interval (CI) 0.197–0.846, p = 0.003] but not for PFS (HR 0.666, 95 % CI 0.366–1.212, p = 0.183). Kaplan–Meier plots demonstrate an influence on 5-year PFS rates (0 vs. 27.6 %, p = 0.048) and DSS rates (11.8 vs. 54.0 %, p = 0.018).

Conclusions

These findings support the hypothesis that the expression of EpCAM is associated with favorable prognosis in OC.

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Titel: Overexpression of epithelial cell adhesion molecule protein is associated with favorable prognosis in an unselected cohort of ovarian cancer patients
verfasst von: Marco Johannes Battista
Cristina Cotarelo
Sina Jakobi
Joscha Steetskamp
Georgios Makris
Isabel Sicking
Veronika Weyer
Marcus Schmidt
Publikationsdatum: 01.07.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Cancer Research and Clinical Oncology / Ausgabe 7/2014
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-014-1672-9

Springer Medizin

Overexpression of epithelial cell adhesion molecule protein is associated with favorable prognosis in an unselected cohort of ovarian cancer patients