Skip to main content
Erschienen in: hautnah dermatologie 5/2014

18.09.2014 | Rosazea | Fortbildung

Aktuelle, alternative und künftige Wege zur erfolgreichen Behandlung

Therapie der Rosazea

verfasst von: Dr. med. Katharina Belge, Martin Schaller

Erschienen in: hautnah dermatologie | Ausgabe 5/2014

Einloggen, um Zugang zu erhalten

Zusammenfassung

Die Rosazea ist gekennzeichnet durch meist zentrofaziale Erytheme, Teleangiektasien, Pusteln sowie eine diffuse Bindegewebs- und Talgdrüsenhyperplasie. Eine rechtzeitige Diagnosestellung und adäquate Therapieeinleitung ist nicht zuletzt aufgrund des hohen psychischen Leidensdruckes betroffener Patienten essenziell. Sie finden hier eine Übersicht über die neuesten Therapieformen bzw. einen Ausblick auf alternative und künftige Therapiemöglichkeiten.
Literatur
1.
Zurück zum Zitat Akamatsu H, Asada M, Komura J, Asada Y, Niwa Y. Effect of doxycycline on the generation of reactive oxygen species: a possible mechanism of action of acne therapy with doxycycline. Acta Derm Venereol. 1992;72:178–9PubMed Akamatsu H, Asada M, Komura J, Asada Y, Niwa Y. Effect of doxycycline on the generation of reactive oxygen species: a possible mechanism of action of acne therapy with doxycycline. Acta Derm Venereol. 1992;72:178–9PubMed
2.
Zurück zum Zitat Akhyani M, Ehsani AH, Ghiasi M, Jafari AK (2008) Comparison of efficacy of azithromycin vs. doxycycline in the treatment of rosacea: a randomized open clinical trial. Int J Dermatol. 47:284–8PubMedCrossRef Akhyani M, Ehsani AH, Ghiasi M, Jafari AK (2008) Comparison of efficacy of azithromycin vs. doxycycline in the treatment of rosacea: a randomized open clinical trial. Int J Dermatol. 47:284–8PubMedCrossRef
3.
Zurück zum Zitat Allen KJ, Davis CL, Billings SD, Mousdicas N. Recalcitrant papulopustular rosacea in an immunocompetent patient responding to combination therapy with oral ivermectin and topical permethrin. Cutis. 2007 Aug;80:149–51PubMed Allen KJ, Davis CL, Billings SD, Mousdicas N. Recalcitrant papulopustular rosacea in an immunocompetent patient responding to combination therapy with oral ivermectin and topical permethrin. Cutis. 2007 Aug;80:149–51PubMed
4.
Zurück zum Zitat Altinyazar HC, Koca R, Tekin NS, Esturk E. Adapalene vs. metronidazole gel for the treatment of rosacea. Int J Dermatol 2005; 44:252–5PubMedCrossRef Altinyazar HC, Koca R, Tekin NS, Esturk E. Adapalene vs. metronidazole gel for the treatment of rosacea. Int J Dermatol 2005; 44:252–5PubMedCrossRef
5.
Zurück zum Zitat Alvarez-Elcoro S, Enzler MJ (1999) The macrolides: erythromycin, clarithromycin, and azithromycin. Mayo Clin Proc 74(6):613–34PubMedCrossRef Alvarez-Elcoro S, Enzler MJ (1999) The macrolides: erythromycin, clarithromycin, and azithromycin. Mayo Clin Proc 74(6):613–34PubMedCrossRef
6.
Zurück zum Zitat Antille C, Saurat J-H, Lübbe J. Induction of rosaceiform dermatitis during treatment of facial inflammatory dermatoses with tacrolimus ointment. Arch Dermatol 2004; 140:457–60PubMedCrossRef Antille C, Saurat J-H, Lübbe J. Induction of rosaceiform dermatitis during treatment of facial inflammatory dermatoses with tacrolimus ointment. Arch Dermatol 2004; 140:457–60PubMedCrossRef
7.
Zurück zum Zitat Bakar O, Demircay Z, Toker E, Cakir S (2009) Ocular signs, symptoms and tear function tests of papulopustular rosacea patients receiving azithromycin. J Eur Acad Dermatol Venerol 23:544–9CrossRef Bakar O, Demircay Z, Toker E, Cakir S (2009) Ocular signs, symptoms and tear function tests of papulopustular rosacea patients receiving azithromycin. J Eur Acad Dermatol Venerol 23:544–9CrossRef
8.
Zurück zum Zitat Bhat YJ, Manzoor S, Qayoom S. Steroid-induced rosacea: a clinical study of 200 patients. Ind J of Dermatol. 2011; 56: 30–2CrossRef Bhat YJ, Manzoor S, Qayoom S. Steroid-induced rosacea: a clinical study of 200 patients. Ind J of Dermatol. 2011; 56: 30–2CrossRef
9.
Zurück zum Zitat Borelli C, Korting HC. Nichtmedikamentöses Management der Rosazea. Hautarzt. 2011;62:828–33PubMedCrossRef Borelli C, Korting HC. Nichtmedikamentöses Management der Rosazea. Hautarzt. 2011;62:828–33PubMedCrossRef
10.
Zurück zum Zitat Bormann G, Gaber G, Fischer M, Marsch WC (2001) Dapsone in rosacea fulminans. J Eur Acad Dermatol Venerol 15(5):465–7CrossRef Bormann G, Gaber G, Fischer M, Marsch WC (2001) Dapsone in rosacea fulminans. J Eur Acad Dermatol Venerol 15(5):465–7CrossRef
11.
Zurück zum Zitat Bostanci O, Borelli C, Schaller M. Treatment of extrafacial rosacea with low-dose isotretinoin. Act Dermatol Venereol 2010;90: 409–10CrossRef Bostanci O, Borelli C, Schaller M. Treatment of extrafacial rosacea with low-dose isotretinoin. Act Dermatol Venereol 2010;90: 409–10CrossRef
12.
Zurück zum Zitat Chosidow O, Cribier B. Elacpidemiology of rosacea: updated data. Ann Dermatol Venereol 2011;138 Suppl 3:179–83CrossRef Chosidow O, Cribier B. Elacpidemiology of rosacea: updated data. Ann Dermatol Venereol 2011;138 Suppl 3:179–83CrossRef
13.
Zurück zum Zitat Chu CY. The use of 1% pimecrolimus cream for the treatment of steroid-induced rosacea. Br J Dermatol 2005;152: 396–9PubMedCrossRef Chu CY. The use of 1% pimecrolimus cream for the treatment of steroid-induced rosacea. Br J Dermatol 2005;152: 396–9PubMedCrossRef
14.
Zurück zum Zitat Ci X, Li H, Yu Q, Zhang X, Yu L, Chen N, Song Y, Deng X. Avermectin exerts anti-inflammatory effect by downregulating the nuclear transcription factor kappa-B and mitogen-activated protein kinase activation pathway. Fundam Clin Pharmacol. 2009 Aug;23:449–55PubMedCrossRef Ci X, Li H, Yu Q, Zhang X, Yu L, Chen N, Song Y, Deng X. Avermectin exerts anti-inflammatory effect by downregulating the nuclear transcription factor kappa-B and mitogen-activated protein kinase activation pathway. Fundam Clin Pharmacol. 2009 Aug;23:449–55PubMedCrossRef
15.
Zurück zum Zitat Coda AB, Hata T, Miller J, Audish D, Kotol P, Two A, Shafiq F, Yamasaki K, Harper JC, Del Rosso JQ, Gallo RL. Cathelicidin, kallikrein 5, and serine protease activity is inhibited during treatment of rosacea with azelaic acid 15% gel. J Am Acad Dermatol. 2013 Oct;69:570–7PubMedCrossRefPubMedCentral Coda AB, Hata T, Miller J, Audish D, Kotol P, Two A, Shafiq F, Yamasaki K, Harper JC, Del Rosso JQ, Gallo RL. Cathelicidin, kallikrein 5, and serine protease activity is inhibited during treatment of rosacea with azelaic acid 15% gel. J Am Acad Dermatol. 2013 Oct;69:570–7PubMedCrossRefPubMedCentral
16.
Zurück zum Zitat Crawford GH, Pelle MT, James WD. Rosacea: I. Etiology, pathogenesis, and subtype classification. J Am Acad Dermatol. 2004;51:327–41PubMedCrossRef Crawford GH, Pelle MT, James WD. Rosacea: I. Etiology, pathogenesis, and subtype classification. J Am Acad Dermatol. 2004;51:327–41PubMedCrossRef
17.
Zurück zum Zitat Currie BJ, McCarthy JS. Permethrin and ivermectin for scabies. N Engl J Med. 2010 Feb 25;362:717–25PubMedCrossRef Currie BJ, McCarthy JS. Permethrin and ivermectin for scabies. N Engl J Med. 2010 Feb 25;362:717–25PubMedCrossRef
18.
Zurück zum Zitat Del Rosso JQ. Advances in Understanding and Managing Rosacea: Part 1. Connecting the Dots Between Pathophysiological Mechanisms and Common Clinical Features of Rosacea with Emphasis on Vascular Changes and Facial Erythema. J ClinAesthetDermatol. 2012; 5:16–25 Del Rosso JQ. Advances in Understanding and Managing Rosacea: Part 1. Connecting the Dots Between Pathophysiological Mechanisms and Common Clinical Features of Rosacea with Emphasis on Vascular Changes and Facial Erythema. J ClinAesthetDermatol. 2012; 5:16–25
19.
Zurück zum Zitat Del Rosso JQ, Webster GF, Jackson M, Rendon M, Rich P, Torok H, Bradshaw M. Two randomized phase III clinical trials evaluating anti-inflammatory dose doxycycline (40-mg doxycycline, USP capsules) administered once daily for treatment of rosacea. J Am Acad Dermatol. 2007 May;56:791–802PubMedCrossRef Del Rosso JQ, Webster GF, Jackson M, Rendon M, Rich P, Torok H, Bradshaw M. Two randomized phase III clinical trials evaluating anti-inflammatory dose doxycycline (40-mg doxycycline, USP capsules) administered once daily for treatment of rosacea. J Am Acad Dermatol. 2007 May;56:791–802PubMedCrossRef
20.
Zurück zum Zitat Del Rosso JQ, Schlessinger J, Werschler P. Comparison of anti-inflammatory dose doxycycline versus doxycycline 100 mg in the treatment of rosacea. J Drugs Dermatol. 2008 Jun;7:573–6PubMed Del Rosso JQ, Schlessinger J, Werschler P. Comparison of anti-inflammatory dose doxycycline versus doxycycline 100 mg in the treatment of rosacea. J Drugs Dermatol. 2008 Jun;7:573–6PubMed
21.
Zurück zum Zitat Doan S, Gabison E, Chiambaretta F, Touati M, Cochereau I. Efficacy of azithromycin 1.5% eye drops in childhood ocular rosacea with phlyctenular blepharokeratoconjunctivitis. J Ophthalmic Inflamm Infect. 2013 Feb 22;3:38PubMedCrossRefPubMedCentral Doan S, Gabison E, Chiambaretta F, Touati M, Cochereau I. Efficacy of azithromycin 1.5% eye drops in childhood ocular rosacea with phlyctenular blepharokeratoconjunctivitis. J Ophthalmic Inflamm Infect. 2013 Feb 22;3:38PubMedCrossRefPubMedCentral
22.
Zurück zum Zitat Fowler J, Jarratt M, Moore A, Meadows K, Pollack A, Steinhoff M, Liu Y, Leoni M; Brimonidine Phase II Study Group. Once-daily topical brimonidine tartrate gel 0o5% is a novel treatment for moderate to severe facial erythema of rosacea: results of two multicentre, randomized and vehicle-controlled studies. Br J Dermatol. 2012;166:633–41PubMedCrossRefPubMedCentral Fowler J, Jarratt M, Moore A, Meadows K, Pollack A, Steinhoff M, Liu Y, Leoni M; Brimonidine Phase II Study Group. Once-daily topical brimonidine tartrate gel 0o5% is a novel treatment for moderate to severe facial erythema of rosacea: results of two multicentre, randomized and vehicle-controlled studies. Br J Dermatol. 2012;166:633–41PubMedCrossRefPubMedCentral
23.
Zurück zum Zitat Fowler J Jr, Jackson M, Moore A, Jarratt M, Jones T, Meadows K, Steinhoff M, Rudisill D, Leoni M. Efficacy and safety of once-daily topical brimonidine tartrate gel 0.5% for the treatment of moderate to severe facial erythema of rosacea: results of two randomized, double-blind, and vehicle-controlled pivotal studies. J Drugs Dermatol. 2013 Jun 1;12:650–6PubMed Fowler J Jr, Jackson M, Moore A, Jarratt M, Jones T, Meadows K, Steinhoff M, Rudisill D, Leoni M. Efficacy and safety of once-daily topical brimonidine tartrate gel 0.5% for the treatment of moderate to severe facial erythema of rosacea: results of two randomized, double-blind, and vehicle-controlled pivotal studies. J Drugs Dermatol. 2013 Jun 1;12:650–6PubMed
24.
Zurück zum Zitat Forstinger C, Kittler H, Binder M. Treatment of rosacea-like demodicidosis with oral ivermectin and topical permethrin cream. J Am Acad Dermatol. 1999 Nov;41(5 Pt 1):775–7PubMedCrossRef Forstinger C, Kittler H, Binder M. Treatment of rosacea-like demodicidosis with oral ivermectin and topical permethrin cream. J Am Acad Dermatol. 1999 Nov;41(5 Pt 1):775–7PubMedCrossRef
25.
Zurück zum Zitat Forton F, Seys B, Marchal JL, Song AM. Demodex folliculorum and topical treatment: acaricidal action evaluated by standardized skin surface biopsy. Br J Dermatol. 1998 Mar;138:461–6PubMedCrossRef Forton F, Seys B, Marchal JL, Song AM. Demodex folliculorum and topical treatment: acaricidal action evaluated by standardized skin surface biopsy. Br J Dermatol. 1998 Mar;138:461–6PubMedCrossRef
26.
Zurück zum Zitat Gauwerky K, Klövekorn W, Korting HC, Lehmann P, Meigel EM, Reinel D, Ruzicka T, Schaller M, Schöfer H, Tietze J. Rosacea. J Dtsch Dermatol Ges. 2009;7:996–1003PubMed Gauwerky K, Klövekorn W, Korting HC, Lehmann P, Meigel EM, Reinel D, Ruzicka T, Schaller M, Schöfer H, Tietze J. Rosacea. J Dtsch Dermatol Ges. 2009;7:996–1003PubMed
27.
Zurück zum Zitat Goldman D. Tacrolimus ointment for the treatment of steroid-induced rosacea: A preliminary report. J Am Acad Dermatol 2001;44: 995–8PubMedCrossRef Goldman D. Tacrolimus ointment for the treatment of steroid-induced rosacea: A preliminary report. J Am Acad Dermatol 2001;44: 995–8PubMedCrossRef
28.
Zurück zum Zitat Gollnick H, Blume-Peytavi U, Szabó EL, Meyer KG, Hauptmann P, Popp G, Sebastian M, Zwingers T, Willers C, von der Weth R. Systemic isotretinoin in the treatment of rosacea - doxycycline- and placebo-controlled, randomized clinical study. J Dtsch Dermatol Ges. 2010;8:505–15PubMed Gollnick H, Blume-Peytavi U, Szabó EL, Meyer KG, Hauptmann P, Popp G, Sebastian M, Zwingers T, Willers C, von der Weth R. Systemic isotretinoin in the treatment of rosacea - doxycycline- and placebo-controlled, randomized clinical study. J Dtsch Dermatol Ges. 2010;8:505–15PubMed
29.
Zurück zum Zitat Helm TN, Schechter J. Biopsy may help identify early pyoderma faciale (rosacea fulminans). Cutis. 2006 Apr;77:225–7PubMed Helm TN, Schechter J. Biopsy may help identify early pyoderma faciale (rosacea fulminans). Cutis. 2006 Apr;77:225–7PubMed
30.
Zurück zum Zitat Hsu CC, Lee JY. Pronounced facial flushing and persistent erythema of rosacea effectively treated by carvedilol, a nonselective β-adrenergic blocker. J Am Acad Dermatol. 2012 Sep;67:491–3PubMedCrossRef Hsu CC, Lee JY. Pronounced facial flushing and persistent erythema of rosacea effectively treated by carvedilol, a nonselective β-adrenergic blocker. J Am Acad Dermatol. 2012 Sep;67:491–3PubMedCrossRef
31.
Zurück zum Zitat Hoyt JC, Ballering J, Numanami H, Hayden JM, Robbins RA. Doxycycline modulates nitric oxide production in murine lung epithelial cells. J Immunol. 2006 Jan 1;176:567–72PubMedCrossRef Hoyt JC, Ballering J, Numanami H, Hayden JM, Robbins RA. Doxycycline modulates nitric oxide production in murine lung epithelial cells. J Immunol. 2006 Jan 1;176:567–72PubMedCrossRef
32.
Zurück zum Zitat Jansen T, Plewig G, Kligman AM. Diagnosis and treatment of rosacea fulminans. Dermatology. 1994;188:251–4PubMedCrossRef Jansen T, Plewig G, Kligman AM. Diagnosis and treatment of rosacea fulminans. Dermatology. 1994;188:251–4PubMedCrossRef
33.
Zurück zum Zitat Jarrett R, Gonsalves R, Anstey AV. Differing obstetric outcomes of rosacea fulminans in pregnancy: report of three cases with review of pathogenesis and management. Clin Exp Dermatol. 2010 Dec;35:888–91PubMedCrossRef Jarrett R, Gonsalves R, Anstey AV. Differing obstetric outcomes of rosacea fulminans in pregnancy: report of three cases with review of pathogenesis and management. Clin Exp Dermatol. 2010 Dec;35:888–91PubMedCrossRef
34.
Zurück zum Zitat Karabulut AA, IzolSerel B, Eksioglu HM. A randomized, single-blind, placebo-controlled, split-face study with pimecrolimus cream 1% for papulopustular rosacea. J Eur Acad Dermatol Venereol. 2008;22:729–34 34a Kim JH, Oh YS, Choi EH. Oral azithromycin for treatment of intractable rosacea. J Korean Med Sci. 2011;26:694–6PubMedCrossRef Karabulut AA, IzolSerel B, Eksioglu HM. A randomized, single-blind, placebo-controlled, split-face study with pimecrolimus cream 1% for papulopustular rosacea. J Eur Acad Dermatol Venereol. 2008;22:729–34 34a Kim JH, Oh YS, Choi EH. Oral azithromycin for treatment of intractable rosacea. J Korean Med Sci. 2011;26:694–6PubMedCrossRef
35.
Zurück zum Zitat Krause MH, Torricelli R, Kundig T, Trueb RM, Hafner J. [Dapsone in granulomatous Krause MH, Torricelli R, Kundig T, Trueb RM, Hafner J. [Dapsone in granulomatous
36.
37.
Zurück zum Zitat Lacey N, Delaney S, Kavanagh K, Powell FC. Mite-related bacterial antigens stimulate inflammatory cells in rosacea. Br J Dermatol. 2007;157:474–81PubMedCrossRef Lacey N, Delaney S, Kavanagh K, Powell FC. Mite-related bacterial antigens stimulate inflammatory cells in rosacea. Br J Dermatol. 2007;157:474–81PubMedCrossRef
38.
Zurück zum Zitat Lacouture ME, Anadkat MJ, Bensadoun RJ, Bryce J, Chan A, Epstein JB, Eaby-Sandy B, Murphy BA; MASCC Skin Toxicity Study Group. Clinical practice guidelines for the prevention and treatment of EGFR inhibitor-associated dermatologic toxicities. Support Care Cancer. 2011 Aug;19:1079–95PubMedCrossRefPubMedCentral Lacouture ME, Anadkat MJ, Bensadoun RJ, Bryce J, Chan A, Epstein JB, Eaby-Sandy B, Murphy BA; MASCC Skin Toxicity Study Group. Clinical practice guidelines for the prevention and treatment of EGFR inhibitor-associated dermatologic toxicities. Support Care Cancer. 2011 Aug;19:1079–95PubMedCrossRefPubMedCentral
39.
Zurück zum Zitat Lacouture ME, Schadendorf D, Chu CY, Uttenreuther-Fischer M, Stammberger U, O'Brien D, Hauschild A. Dermatologic adverse events associated with afatinib: an oral ErbB family blocker. Expert Rev Anticancer Ther. 2013 Jun;13:721–8PubMedCrossRef Lacouture ME, Schadendorf D, Chu CY, Uttenreuther-Fischer M, Stammberger U, O'Brien D, Hauschild A. Dermatologic adverse events associated with afatinib: an oral ErbB family blocker. Expert Rev Anticancer Ther. 2013 Jun;13:721–8PubMedCrossRef
40.
Zurück zum Zitat Layton A, Thiboutot D. Emerging therapies in rosacea. J Am Acad Dermatol. 2013 Dec;69:57–65CrossRef Layton A, Thiboutot D. Emerging therapies in rosacea. J Am Acad Dermatol. 2013 Dec;69:57–65CrossRef
42.
Zurück zum Zitat Melnik B, Jansen T. Akne und Rosazea. In: Plewig G, Landthaler M, Burgdorf W et al. (Hrsg): Dermatologie und Venerologie. 6. Auflage. Berlin: Springer Verlag, 2012;197–1229 Melnik B, Jansen T. Akne und Rosazea. In: Plewig G, Landthaler M, Burgdorf W et al. (Hrsg): Dermatologie und Venerologie. 6. Auflage. Berlin: Springer Verlag, 2012;197–1229
43.
Zurück zum Zitat Moore A, Kempers S, Murakawa G, Weiss J, Tauscher A, Swinyer L, Liu H, Leoni M. Long-term safety and efficacy of once-daily topical brimonidine tartrate gel 0.5% for the treatment of moderate to severe facial erythema of rosacea: results of a 1-year open-label study. J Drugs Dermatol. 2014 Jan;13:56–61PubMed Moore A, Kempers S, Murakawa G, Weiss J, Tauscher A, Swinyer L, Liu H, Leoni M. Long-term safety and efficacy of once-daily topical brimonidine tartrate gel 0.5% for the treatment of moderate to severe facial erythema of rosacea: results of a 1-year open-label study. J Drugs Dermatol. 2014 Jan;13:56–61PubMed
44.
Zurück zum Zitat Park H, Del Rosso JQ (2011) Use of oral isotretinoin in the management of rosacea. J Clin Aesthet Dermatol 4:54–61PubMedPubMedCentral Park H, Del Rosso JQ (2011) Use of oral isotretinoin in the management of rosacea. J Clin Aesthet Dermatol 4:54–61PubMedPubMedCentral
45.
Zurück zum Zitat Parodi A, Paolino S, Greco A, Drago F, Mansi C, Rebora A, Parodi A, Savarino V. Small intestinal bacterial overgrowth in rosacea: clinical effectiveness of its eradication. Clin Gastroenterol Hepatol. 2008 Jul;6:759–64PubMedCrossRef Parodi A, Paolino S, Greco A, Drago F, Mansi C, Rebora A, Parodi A, Savarino V. Small intestinal bacterial overgrowth in rosacea: clinical effectiveness of its eradication. Clin Gastroenterol Hepatol. 2008 Jul;6:759–64PubMedCrossRef
46.
Zurück zum Zitat Patterson CR, Wilkinson JD, Lewis FM. Rosacea fulminans confined to the nose. J Eur Acad Dermatol Venereol. 2009 Sep;23:1101–2PubMedCrossRef Patterson CR, Wilkinson JD, Lewis FM. Rosacea fulminans confined to the nose. J Eur Acad Dermatol Venereol. 2009 Sep;23:1101–2PubMedCrossRef
47.
Zurück zum Zitat Pfeffer I, Borelli C, Zierhut M, Schaller M. Treatment of ocular rosacea with 40 mg doxycycline in a slow release form. J Dtsch Dermatol Ges. 2011;9:904–7PubMed Pfeffer I, Borelli C, Zierhut M, Schaller M. Treatment of ocular rosacea with 40 mg doxycycline in a slow release form. J Dtsch Dermatol Ges. 2011;9:904–7PubMed
48.
Zurück zum Zitat Quarterman MJ, Johnson DW, Abele DC, Lesher JL Jr, Hull DS, Davis LS. Ocular rosacea. Signs, symptoms, and tear studies before and after treatment with doxycycline. Arch Dermatol. 1997 Jan;133:49–54PubMedCrossRef Quarterman MJ, Johnson DW, Abele DC, Lesher JL Jr, Hull DS, Davis LS. Ocular rosacea. Signs, symptoms, and tear studies before and after treatment with doxycycline. Arch Dermatol. 1997 Jan;133:49–54PubMedCrossRef
49.
Zurück zum Zitat Reinholz M, Tietze JK, Kilian K, Schaller M, Schöfer H, Lehmann P, Zierhut M, Klövekorn W, Ruzicka T, Schauber J. Rosacea - S1 guideline. J Dtsch Dermatol Ges. 2013 Aug;11:768–80; 768–79PubMed Reinholz M, Tietze JK, Kilian K, Schaller M, Schöfer H, Lehmann P, Zierhut M, Klövekorn W, Ruzicka T, Schauber J. Rosacea - S1 guideline. J Dtsch Dermatol Ges. 2013 Aug;11:768–80; 768–79PubMed
50.
Zurück zum Zitat Ribeiro LB, Ramos-e-Silva M. Rosacea fulminans. Cutis. 2013 Jul;92:29–32PubMed Ribeiro LB, Ramos-e-Silva M. Rosacea fulminans. Cutis. 2013 Jul;92:29–32PubMed
51.
Zurück zum Zitat Rote Liste, August 2013, Frankfurt/Main Rote Liste, August 2013, Frankfurt/Main
52.
Zurück zum Zitat Routt ET, Levitt JO. Rebound erythema and burning sensation from a new topical brimonidine tartrate gel 0.33%. J Am Acad Dermatol. 2014 Feb;70:e37–8PubMedCrossRef Routt ET, Levitt JO. Rebound erythema and burning sensation from a new topical brimonidine tartrate gel 0.33%. J Am Acad Dermatol. 2014 Feb;70:e37–8PubMedCrossRef
53.
Zurück zum Zitat Salem DA, El-Shazly A, Nabih N, El-Bayoumy Y, Saleh S. Evaluation of the efficacy of oral ivermectin in comparison with ivermectin-metronidazole combined therapy in the treatment of ocular and skin lesions of Demodex folliculorum. Int J Infect Dis. 2013 May;17:e343-7 Salem DA, El-Shazly A, Nabih N, El-Bayoumy Y, Saleh S. Evaluation of the efficacy of oral ivermectin in comparison with ivermectin-metronidazole combined therapy in the treatment of ocular and skin lesions of Demodex folliculorum. Int J Infect Dis. 2013 May;17:e343-7
54.
Zurück zum Zitat Sapadin AN, Fleischmajer R. Tetracyclines: Nonantibiotic properties and their clinical implications. J Am Acad Dermatol 2006; 54:258–65PubMedCrossRef Sapadin AN, Fleischmajer R. Tetracyclines: Nonantibiotic properties and their clinical implications. J Am Acad Dermatol 2006; 54:258–65PubMedCrossRef
55.
Zurück zum Zitat Sattler EC, Maier T, Hoffmann VS, Hegyi J, Ruzicka T, Berking C. Non-invasive in vivo detection and quantification of Demodex mites by confocal laser scanning microscopy.Br J Dermatol. 2012 Jun 20. [Epub ahead of print] Sattler EC, Maier T, Hoffmann VS, Hegyi J, Ruzicka T, Berking C. Non-invasive in vivo detection and quantification of Demodex mites by confocal laser scanning microscopy.Br J Dermatol. 2012 Jun 20. [Epub ahead of print]
56.
Zurück zum Zitat Schaller M, Sander CA, Plewig G. Demodex abscesses: clinical and therapeutic challenges. J Am AcadDermatol. 2003;49:272–4CrossRef Schaller M, Sander CA, Plewig G. Demodex abscesses: clinical and therapeutic challenges. J Am AcadDermatol. 2003;49:272–4CrossRef
57.
Zurück zum Zitat Sobottka A, Lehmann P (2009) Rosazea 2009. Neue Erkenntnisse zur Pathophysiologie, klinische Manifestationsformen und Therapiestrategien. Hautarzt 60: 999–1009PubMedCrossRef Sobottka A, Lehmann P (2009) Rosazea 2009. Neue Erkenntnisse zur Pathophysiologie, klinische Manifestationsformen und Therapiestrategien. Hautarzt 60: 999–1009PubMedCrossRef
58.
Zurück zum Zitat Stein L, Kircik L, Fowler J, Tan J, Draelos Z, Fleischer A, Appell M, Steinhoff M, Lynde C, Liu H, Jacovella J. Efficacy and safety of ivermectin 1% cream in treatment of papulopustular rosacea: results of two randomized, double-blind, vehicle-controlled pivotal studies. J Drugs Dermatol. 2014 Mar;13:316–23PubMed Stein L, Kircik L, Fowler J, Tan J, Draelos Z, Fleischer A, Appell M, Steinhoff M, Lynde C, Liu H, Jacovella J. Efficacy and safety of ivermectin 1% cream in treatment of papulopustular rosacea: results of two randomized, double-blind, vehicle-controlled pivotal studies. J Drugs Dermatol. 2014 Mar;13:316–23PubMed
59.
Zurück zum Zitat Tirnaksiz F, Kayiş A, Çelebi N, Adişen E, Erel A. Preparation and evaluation of topical microemulsion system containing metronidazole for remission in rosacea. Chem Pharm Bull (Tokyo). 2012;60:583–92 Tirnaksiz F, Kayiş A, Çelebi N, Adişen E, Erel A. Preparation and evaluation of topical microemulsion system containing metronidazole for remission in rosacea. Chem Pharm Bull (Tokyo). 2012;60:583–92
60.
Zurück zum Zitat Webster G, Schaller M. Ocular rosacea: a dermatologic perspective. J Am Acad Dermatol. 2013 Dec;69(6 Suppl 1):sobot42–3CrossRef Webster G, Schaller M. Ocular rosacea: a dermatologic perspective. J Am Acad Dermatol. 2013 Dec;69(6 Suppl 1):sobot42–3CrossRef
61.
Zurück zum Zitat Weinstock LB, Steinhoff M. Rosacea and small intestinal bacterial overgrowth: prevalence and response to rifaximin. J Am Acad Dermatol. 2013 May;68:875–6PubMedCrossRef Weinstock LB, Steinhoff M. Rosacea and small intestinal bacterial overgrowth: prevalence and response to rifaximin. J Am Acad Dermatol. 2013 May;68:875–6PubMedCrossRef
62.
Zurück zum Zitat Wilkin J, Dahl M, Detmar M, Drake L, Liang MH, Odom R, Powell F; National Rosacea Society Expert Committee. Standard grading system for rosacea: report of the National Rosacea Society Expert Committee on the classification and staging of rosacea. J Am Acad Dermatol. 2004 Jun;50:907–12PubMedCrossRef Wilkin J, Dahl M, Detmar M, Drake L, Liang MH, Odom R, Powell F; National Rosacea Society Expert Committee. Standard grading system for rosacea: report of the National Rosacea Society Expert Committee on the classification and staging of rosacea. J Am Acad Dermatol. 2004 Jun;50:907–12PubMedCrossRef
63.
Zurück zum Zitat Yamasaki K, Di Nardo A, Bardan A, Murakami M, Ohtake T, Coda A, Dorschner RA, Bonnart C, Descargues P, Hovnanian A, Morhenn VB, Gallo RL. Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea. Nat Med. 2007;13:975–80PubMedCrossRef Yamasaki K, Di Nardo A, Bardan A, Murakami M, Ohtake T, Coda A, Dorschner RA, Bonnart C, Descargues P, Hovnanian A, Morhenn VB, Gallo RL. Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea. Nat Med. 2007;13:975–80PubMedCrossRef
Metadaten
Titel
Aktuelle, alternative und künftige Wege zur erfolgreichen Behandlung
Therapie der Rosazea
verfasst von
Dr. med. Katharina Belge
Martin Schaller
Publikationsdatum
18.09.2014
Verlag
Urban & Vogel
Schlagwort
Rosazea
Erschienen in
hautnah dermatologie / Ausgabe 5/2014
Print ISSN: 0938-0221
Elektronische ISSN: 2196-6451
DOI
https://doi.org/10.1007/s15012-014-1885-2

Weitere Artikel der Ausgabe 5/2014

hautnah dermatologie 5/2014 Zur Ausgabe

Passend zum Thema

ANZEIGE

Die entscheidende Rolle des Mikrobioms bei atopischer Dermatitis

Bei atopischer Dermatitis besteht eine direkte Korrelation des Schweregrad der Erkrankung und einer verminderten Diversität des Mikrobioms. Studiendaten zeigen, dass durch eine Behandlung mit Emollienzien plus, die Besiedelung mit Staphylokokken reduziert und das Mikrobiom stabilisiert werden kann.

ANZEIGE

Welche Bedeutung hat das Mikrobiom bei Wundheilung und AD?

Warum hat das Mikrobiom der Haut in den letzten Jahren in der Wissenschaft an enormer Bedeutung gewonnen? Welche Möglichkeiten ergeben sich dadurch für die Behandlung bei Hautkrankheiten wie atopischer Dermatitis und der Wundheilung? Dies erläutert Prof. Thomas Luger im Interview.

ANZEIGE

Neueste Erkenntnisse zum Hautmikrobiom: vier Experten im Gespräch

Content Hub

Die Experten Prof. Luger (Münster), Prof. Zuberbier (Berlin), Prof. Thaçi (Lübeck) und PD Dr. Jansen (Essen) erörtern im von La Roche Posay unterstützen Expertenworkshop die Bedeutung des Mikrobioms für verschiedene Hautkrankheiten wie atopische Dermatitis, Akne oder Rosazea.

La Roche Posay