Ausgabe 1/2020
Inhalt (45 Artikel)
δ-secretase in neurodegenerative diseases: mechanisms, regulators and therapeutic opportunities
Zhentao Zhang, Ye Tian, Keqiang Ye
Replacing what’s lost: a new era of stem cell therapy for Parkinson’s disease
Yong Fan, Winanto, Shi-Yan Ng
Correction to: Detecting neurodegenerative pathology in multiple sclerosis before irreversible brain tissue loss sets in
Jeroen Van Schependom, Kaat Guldolf, Marie Béatrice D’hooghe, Guy Nagels, Miguel D’haeseleer
Deep brain stimulation for Tourette’s syndrome
Wenying Xu, Chencheng Zhang, Wissam Deeb, Bhavana Patel, Yiwen Wu, Valerie Voon, Michael S. Okun, Bomin Sun
Effect of the micro-environment on α-synuclein conversion and implication in seeded conversion assays
Niccolo Candelise, Matthias Schmitz, Katrin Thüne, Maria Cramm, Alberto Rabano, Saima Zafar, Erik Stoops, Hugo Vanderstichele, Anna Villar-Pique, Franc Llorens, Inga Zerr
Reprogrammed astrocytes display higher neurogenic competence, migration ability and cell death resistance than reprogrammed fibroblasts
Xiaohuan Xia, Chunhong Li, Yi Wang, Xiaobei Deng, Yizhao Ma, Lu Ding, Jialin Zheng
Insights into the pathogenesis of multiple system atrophy: focus on glial cytoplasmic inclusions
Seiji Kaji, Takakuni Maki, Tomoyuki Ishimoto, Hodaka Yamakado, Ryosuke Takahashi
Race modifies default mode connectivity in Alzheimer’s disease
Maria B. Misiura, J. Christina Howell, Junjie Wu, Deqiang Qiu, Monica W. Parker, Jessica A. Turner, William T. Hu
Effectiveness and safety of opicapone in Parkinson’s disease patients with motor fluctuations: the OPTIPARK open-label study
Heinz Reichmann, Andrew Lees, José-Francisco Rocha, Diogo Magalhães, Patrício Soares-da-Silva, Csaba Antal Zolnai, Claudius Bartels, Andreas Barth, Kriemhild Barth, Stephan Behrens, Arnfin Bergmann, Ralf Bodenschatz, Rommy Born, Moriz Brandt, Sebastian Brock, Bernd Brockmeier, Christof Brücke, Norbert Brüggemann, Bernhard Bühler, Uwe Bungard, Lukas Cepek, Ilona Csoti, Max Deist, Carl Detlev Reimers, Ulrich Dölle, Sylke Domke, Imanuel Dzialowski, Georg Ebersbach, Heike Eggert, Karla Eggert, Reinhard Ehret, Jana Engel, Urban Fietzek, Anke Friedrich, Michael Fritzinger, Florin Gandor, Klaus Gehring, Stephan Gierer, Stephanie Gierer, Vasil Gjaurov, Doreen Gruber, Özkan Günes, Thomas Haas, Kirsten Hahn, Anna Eszter Haraszti, Rolf Hartmann, Bernhard Haslinger, Eva Heiss, Heinz P. Herbst, Frank Hoffmann, Werner E. Hofmann, Günter Höglinger, Wolfgang Jost, Anna-Maria Kavcic, Christoph Kellinghaus, Bertold Klemperer, Fabian Klostermann, Thomas Knoll, Natalia Koleva-Alazeh, Jiri Koschel, Diana Waltraud Kraft-Safavi, Almut Kronenberger, Andrea Kühn, Andreas Kupsch, Thomas Lehnhoff, Peter Laumen, Paul Lingor, Karla Lippmann, Michael Lorrain, Fabian Maass, Siegfried Muhlack, Thomas Müller, Michael Nagel, Stephan Neudecker, Katja Odin, Christian Oehlwein, Hakan Orbasli, Wolfram von Pannwitz, Heidi Pape, Robert Pfister, Tino Prell, Reinhard Puzich, Daniela Rau, Rene Reese, Gerd Reifschneider, Gernot Reimann, Stefani Ries, Christoph Rieth, Charlotte Rewitzer, Ali Safavi, Alexander B. Schmied, Johannes Schwarz, Wolfgang Schwarz, Joachim Springub, Inga Suttrup Claus, Vera Tadic, Klaus Tiel-Wilck, Lars Tönges, Jens Tröger, Christoph Schrey, Alexander Schulze, Sven Thonke, Tobias Wächter, Achim S. Wannenmacher, Tobias Warnecke, Bettina Wieder, Martin Wimmer, Christian Winkler, Otto Witte, Dirk Woitalla, Samis Zella, Uwe Ziebold, Jane Alty, Reem Amin, Michaela Boca, Stephen Butterworth, Camille Carroll, Gavin Charlesworth, K. Ray Chaudhuri, Rajkumar Chinnadurai, Jemima Collins, Jeremy Stephen Cosgrove, Samantha Cravey, Dinesh Damodaran, Nikolay Dimitrov, Rory Durcan, Simon Ellis, Adbdul Elmarimi, Jonathan Evans, James Fisher, Donald Grosset, Stuart Jamieson, Christopher Kobylecki, Sze Hway Lim, Veronica Lyell, Biju Mohamed, Sophie Molloy, Nicola Pavese, Dominic Paviour, Madeleine Purchas, Khalid Rashed, Christopher Rickards, Tabish Saifee, Gillian Sare, Christine Schofield, Naveen Setty, Jagdish Sharma, Ray Sheridan, Siew Lee Shu, Monty Silverdale, Rani Sophia, Sarah Statton, Malcolm Steiger, Christopher Thomas, Richard Walker, Tai Yen Foung
A different vision of translational research in biomarker discovery: a pilot study on circulatory mitochondrial proteins as Parkinson’s disease potential biomarkers
Sandra I. Anjo, Patrícia Valério dos Santos, Luiza Rosado, Graça Baltazar, Inês Baldeiras, Diana Pires, Andreia Gomes, Cristina Januário, Miguel Castelo-Branco, Mário Grãos, Bruno Manadas
Current understanding of metal ions in the pathogenesis of Alzheimer’s disease
Lu Wang, Ya-Ling Yin, Xin-Zi Liu, Peng Shen, Yan-Ge Zheng, Xin-Rui Lan, Cheng-Biao Lu, Jian-Zhi Wang
Freezing of gait in Parkinson’s disease: pathophysiology, risk factors and treatments
Chao Gao, Jun Liu, Yuyan Tan, Shengdi Chen
Human iPSCs derived astrocytes rescue rotenone-induced mitochondrial dysfunction and dopaminergic neurodegeneration in vitro by donating functional mitochondria
Xiao-Yu Cheng, Sangita Biswas, Juan Li, Cheng-Jie Mao, Olga Chechneva, Jing Chen, Kai Li, Jiao Li, Jin-Ru Zhang, Chun-Feng Liu, Wen-Bin Deng
Correction to: Effectiveness and safety of opicapone in Parkinson’s disease patients with motor fluctuations: the OPTIPARK open-label study
Heinz Reichmann, Andrew Lees, José-Francisco Rocha, Diogo Magalhães, Patrício Soares-da-Silva
CSF total and oligomeric α-Synuclein along with TNF-α as risk biomarkers for Parkinson’s disease: a study in LRRK2 mutation carriers
Nour K. Majbour, Jan O. Aasly, Eldbjørg Hustad, Mercy A. Thomas, Nishant N. Vaikath, Naser Elkum, Wilma D. J. van de Berg, Takahiko Tokuda, Brit Mollenhauer, Henk W. Berendse, Omar M. A. El-Agnaf
Peripheral clearance of brain-derived Aβ in Alzheimer's disease: pathophysiology and therapeutic perspectives
Yuan Cheng, Ding-Yuan Tian, Yan-Jiang Wang
The emerging roles of vacuolar-type ATPase-dependent Lysosomal acidification in neurodegenerative diseases
Qiaoyun Song, Bo Meng, Haidong Xu, Zixu Mao
Paroxetine ameliorates prodromal emotional dysfunction and late-onset memory deficit in Alzheimer’s disease mice
Peng-Hui Ai, Si Chen, Xian-Dong Liu, Xiao-Na Zhu, Yuan-Bo Pan, Dong-Fu Feng, Shengdi Chen, Nan-Jie Xu, Suya Sun
Mitochondria as a target for neuroprotection: role of methylene blue and photobiomodulation
Luodan Yang, Hannah Youngblood, Chongyun Wu, Quanguang Zhang
Transplantation of bone marrow mesenchymal stem cells improves cognitive deficits and alleviates neuropathology in animal models of Alzheimer’s disease: a meta-analytic review on potential mechanisms
Chuan Qin, Yalan Lu, Kewei Wang, Lin Bai, Guiying Shi, Yiying Huang, Yongning Li
The compensatory phenomenon of the functional connectome related to pathological biomarkers in individuals with subjective cognitive decline
Haifeng Chen, Xiaoning Sheng, Caimei Luo, Ruomeng Qin, Qing Ye, Hui Zhao, Yun Xu, Feng Bai
The human olfactory system in two proteinopathies: Alzheimer’s and Parkinson’s diseases
Isabel Ubeda-Bañon, Daniel Saiz-Sanchez, Alicia Flores-Cuadrado, Ernesto Rioja-Corroto, Melania Gonzalez-Rodriguez, Sandra Villar-Conde, Veronica Astillero-Lopez, Juan Pablo Cabello-de la Rosa, Maria Jose Gallardo-Alcañiz, Julia Vaamonde-Gamo, Fernanda Relea-Calatayud, Lucia Gonzalez-Lopez, Alicia Mohedano-Moriano, Alberto Rabano, Alino Martinez-Marcos
Downregulated miR-18b-5p triggers apoptosis by inhibition of calcium signaling and neuronal cell differentiation in transgenic SOD1 (G93A) mice and SOD1 (G17S and G86S) ALS patients
Ki Yoon Kim, Yu Ri Kim, Kyung Won Choi, Mijung Lee, Somyung Lee, Wooseok Im, Je-Young Shin, Jin Young Kim, Yoon Ho Hong, Manho Kim, Jong-Il Kim, Jung-Joon Sung
Correction: GM604 regulates developmental neurogenesis pathways and the expression of genes associated with amyotrophic lateral sclerosis
William R. Swindell, Krzysztof Bojanowski, Mark S. Kindy, Raymond M. W. Chau, Dorothy Ko
Nucleo–cytoplasmic transport defects and protein aggregates in neurodegeneration
Giacomo Bitetto, Alessio Di Fonzo
Upregulation of RIN3 induces endosomal dysfunction in Alzheimer’s disease
Ruinan Shen, Xiaobei Zhao, Lu He, Yongbo Ding, Wei Xu, Suzhen Lin, Savannah Fang, Wanlin Yang, Kijung Sung, Brian Spencer, Robert A. Rissman, Ming Lei, Jianqing Ding, Chengbiao Wu
Altered levels of CSF proteins in patients with FTD, presymptomatic mutation carriers and non-carriers
Julia Remnestål, Linn Öijerstedt, Abbe Ullgren, Jennie Olofsson, Sofia Bergström, Kim Kultima, Martin Ingelsson, Lena Kilander, Mathias Uhlén, Anna Månberg, Caroline Graff, Peter Nilsson
Potential use of corneal confocal microscopy in the diagnosis of Parkinson’s disease associated neuropathy
Ning-Ning Che, Hong-Qi Yang
Early morning off in patients with Parkinson’s disease: a Chinese nationwide study and a 7-question screening scale
Chao Han, Wei Mao, Jing An, Lifei Jiao, Piu Chan
Increased prediction value of biomarker combinations for the conversion of mild cognitive impairment to Alzheimer’s dementia
Aonan Zhao, Yuanyuan Li, Yi Yan, Yinghui Qiu, Binyin Li, Wei Xu, Ying Wang, Jun Liu, Yulei Deng
GCH1 variants contribute to the risk and earlier age-at-onset of Parkinson’s disease: a two-cohort case-control study
Hong-xu Pan, Yu-wen Zhao, Jun-pu Mei, Zheng-huan Fang, Yige Wang, Xun Zhou, Yang-jie Zhou, Rui Zhang, Kai-lin Zhang, Li Jiang, Qian Zeng, Yan He, Zheng Wang, Zhen-hua Liu, Qian Xu, Qi-ying Sun, Yang Yang, Ya-cen Hu, Ya-se Chen, Juan Du, Li-fang Lei, Hai-nan Zhang, Chun-yu Wang, Xin-xiang Yan, Lu Shen, Hong Jiang, Jie-qiong Tan, Jin-chen Li, Bei-sha Tang, Ji-feng Guo
Inflammation-induced PINCH expression leads to actin depolymerization and mitochondrial mislocalization in neurons
Kalimuthusamy Natarajaseenivasan, Santhanam Shanmughapriya, Prema Velusamy, Matthew Sayre, Alvaro Garcia, Nestor Mas Gomez, Dianne Langford
Does wild-type Cu/Zn-superoxide dismutase have pathogenic roles in amyotrophic lateral sclerosis?
Yoshiaki Furukawa, Eiichi Tokuda
The relationships of vitamin D, vitamin D receptor gene polymorphisms, and vitamin D supplementation with Parkinson’s disease
Lingling Lv, Xuling Tan, Xinke Peng, Rongrong Bai, Qile Xiao, Ting Zou, Jieqiong Tan, Hainan Zhang, Chunyu Wang
Exploring the regulatory roles of circular RNAs in Alzheimer’s disease
Yuan Zhang, Yanfang Zhao, Ying Liu, Man Wang, Wanpeng Yu, Lei Zhang
Integrated lipidomics and proteomics network analysis highlights lipid and immunity pathways associated with Alzheimer’s disease
Jin Xu, Giulia Bankov, Min Kim, Asger Wretlind, Jodie Lord, Rebecca Green, Angela Hodges, Abdul Hye, Dag Aarsland, Latha Velayudhan, Richard J. B. Dobson, Petroula Proitsi, Cristina Legido-Quigley
SPECT imaging of distribution and retention of a brain-penetrating bispecific amyloid-β antibody in a mouse model of Alzheimer’s disease
Tobias Gustavsson, Stina Syvänen, Paul O’Callaghan, Dag Sehlin
Targeting α-synuclein by PD03 AFFITOPE® and Anle138b rescues neurodegenerative pathology in a model of multiple system atrophy: clinical relevance
Miguel Lemos, Serena Venezia, Violetta Refolo, Antonio Heras-Garvin, Sabine Schmidhuber, Armin Giese, Andrei Leonov, Sergey Ryazanov, Christian Griesinger, Gergana Galabova, Guenther Staffler, Gregor Karl Wenning, Nadia Stefanova
Precision medicine in Parkinson’s disease patients with LRRK2 and GBA risk variants – Let’s get even more personal
Christian U. von Linstow, Ziv Gan-Or, Patrik Brundin
Maintaining the balance of TDP-43, mitochondria, and autophagy: a promising therapeutic strategy for neurodegenerative diseases
Chunhui Huang, Sen Yan, Zaijun Zhang
Cerebrospinal fluid α-synuclein predicts neurodegeneration and clinical progression in non-demented elders
Jie-Qiong Li, Yan-Lin Bi, Xue-Ning Shen, Hui-Fu Wang, Wei Xu, Chen-Chen Tan, Qiang Dong, Yan-Jiang Wang, Lan Tan, Jin-Tai Yu
Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes
Hyuk Sung Kwon, Seong-Ho Koh
Parkinson’s disease and translational research
Elisabeth Dinter, Theodora Saridaki, Leonie Diederichs, Heinz Reichmann, Björn H. Falkenburger
Targeting neuroplasticity in patients with neurodegenerative diseases using brain stimulation techniques
Ti-Fei Yuan, Wei-Guang Li, Chencheng Zhang, Hongjiang Wei, Suya Sun, Nan-Jie Xu, Jun Liu, Tian-Le Xu
Correction to: Surfen and oxalyl surfen decrease tau hyperphosphorylation and mitigate neuron deficits in vivo in a zebrafish model of tauopathy
Seyedeh Maryam Alavi Naini, Constantin Yanicostas, Rahma Hassan-Abdi, Sébastien Blondeel, Mohamed Bennis, Ryan J. Weiss, Yitzhak Tor, Jeffrey D. Esko, Nadia Soussi-Yanicostas