Journal of Nephrology OnlineFirst articles

04.05.2024 | Review

The mechanisms of ferroptosis in the pathogenesis of kidney diseases

The pathological features of acute and chronic kidney diseases are closely associated with cell death in glomeruli and tubules. Ferroptosis is a form of programmed cell death characterized by iron overload-induced oxidative stress. Ferroptosis has …

verfasst von:: Jia Liu, Jianheng Chen, Jie Lv, Yuhang Gong, Jie Song

02.05.2024 | Original Article

Clinical and histopathological characteristics of acute kidney injury in a cohort of brain death donors with procurement biopsies

Acute kidney injury (AKI) can occur in nearly 50% of patients admitted to the intensive care unit (ICU), and has been associated with a wide range of adverse events [ 1 ]. Therefore, it is not surprising that mortality is higher for many years …

verfasst von:: Florian G. Scurt, Angela Ernst, Alexandra Korda, Carl-Ludwig Fischer-Fröhlich, Anke Schwarz, Jan U. Becker, Christos Chatzikyrkou

Open Access 02.05.2024 | Lessons for the Clinical Nephrologist

Vitamin E-coated membrane reversed itchy rash during hemodialysis

A 73-year-old woman on chronic hemodialysis (HD) presented a relapsing itchy rash during her HD sessions (Fig. 1 ). She had been diagnosed with chronic kidney disease (CKD) 7 years earlier, in 2014, presumably due to oxalate nephropathy in enteric …

verfasst von:: Fulvia Zappulo, Miriam Di Nunzio, Gabriele Donati, Anna Scrivo, Anna Laura Croci Chiocchini, Gaetano La Manna

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Open Access 30.04.2024 | Systematic Reviews

The current use of proteomics and metabolomics in glomerulonephritis: a systematic literature review

Kidney disease is increasingly becoming a significant worldwide health burden [ 1 ]. The global all-age chronic kidney disease (CKD) mortality increased by 41.5% between 1990 and 2019 [ 2 , 3 ]. There is a growing, unified acknowledgement of an …

verfasst von:: Elin Davies, Andrew Chetwynd, Garry McDowell, Anirudh Rao, Louise Oni

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29.04.2024 | Original Article

Effect of pre-transplantation use of angiotensin-converting enzyme inhibitor or angiotensin receptor blocker in kidney transplant recipients—propensity score-matched analysis

Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers (ACEi/ARBs) are commonly used anti-hypertensive drugs. Recent hypertension guidelines recommend dual combination therapy including ACEi/ARBs as an initial form of …

verfasst von:: Jaeyun Lee, Chan-Young Jung, Hyosang Kim, Hwa Jung Kim, Youngmin Ko, Hyunwook Kwon, Sung Shin, Young Hoon Kim, Su-Kil Park, Chung Hee Baek

Open Access 24.04.2024 | Original Article

Physical activity, exercise habits and health-related quality of life in maintenance hemodialysis patients: a multicenter cross-sectional study

Patients undergoing maintenance hemodialysis experience a range of symptom clusters and economic burdens, resulting in a lower health-related quality of life (HRQOL) compared to their healthy counterparts [ 1 ]. Physical activity refers to any body …

verfasst von:: Huagang Hu, Pui Hing Chau, Edmond Pui Hang Choi

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24.04.2024 | Commentary

Role of the left atrial appendage closure in preventing thromboembolism in atrial fibrillation: what is the importance for chronic kidney disease patients?

verfasst von:: Simonetta Genovesi, Stefano Bianchi, Carlo Basile

23.04.2024 | Commentary

Ultrasound is mightier than bioimpedance spectrometry but not ad lib

verfasst von:: Ahmad J. Abdulsalam, Murat Kara, Levent Özçakar

20.04.2024 | Lessons for the Clinical Nephrologist

Kidney disease in acute intermittent porphyria: histological features and therapeutic perspectives

Patient 1, a 33-year-old woman, was referred to our Unit in November 2018. The patient suffered from recurrent abdominal pain starting from menarche. The crises were not regularly connected with menstrual cycles. During the acute crises, this pain …

verfasst von:: Claudio Carmine Guida, Angela Maria Pellegrino, Aurora Del Mar Perez Ys, Filippo Aucella, CSS Porphiria Study Group

Open Access 18.04.2024 | Original Article

The association of socioeconomic status on kidney transplant access and outcomes: a nationwide cohort study in Taiwan

Taiwan has the highest incidence of end-stage kidney disease (ESKD) worldwide. The prevalence of ESKD reached 3546 per million people by 2021 [ 1 ]. Furthermore, at least 20% of Taiwan’s population consists of elderly people, making it an …

verfasst von:: Tung-Ling Chung, Nai-Ching Chen, Chun-Hao Yin, Ching-Chih Lee, Chien-Liang Chen

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17.04.2024 | Original Article

Body fat predicts urinary tract infection in kidney transplant recipients: a prospective cohort study

More than one billion people worldwide are obese. Obesity leads to multiple complications and results in over 2.8 million deaths yearly [ 1 , 2 ].

verfasst von:: Thaysa Sobral Antonelli, Milena dos Santos Mantovani, Nyara Coelho de Carvalho, Thomáz Eduardo Archangelo, Marcos Ferreira Minicucci, Sebastião Pires Ferreira Filho, Ricardo de Souza Cavalcante, Luis Gustavo Modelli de Andrade, Nara Aline Costa, Paulo Roberto Kawano, Gabriel Berg de Almeida, Silvia Justina Papini, Ricardo Augusto Monteiro de Barros Almeida

17.04.2024 | Case Report

ALECT2 amyloidosis with concurrent IgG4-related interstitial nephritis, membranous nephropathy and diabetic kidney disease: a case report and literature review

Leukocyte chemotactic factor-2 amyloidosis (ALECT2) is a recently described subtype of amyloidosis. IgG4-related disease is a rare fibroinflammatory condition characterized by dense interstitial lymphoplasmacytic infiltrates and fibrosis.

verfasst von:: Muhammad Shaheen, Anchit Bharat, Allon N. Friedman, Shunhua Guo

17.04.2024 | Original Article

Low skeletal muscle mass index is independently associated with low bone mineral density in kidney transplant recipients: a retrospective observational cohort study

Osteoporosis and osteopenia are more frequent in kidney transplant recipients than in healthy individuals. Bone mineral density in kidney transplant recipients decreases by 4 − 10% during the first 6 months after transplantation [ 1 ], followed by …

verfasst von:: Morikuni Nishihira, Yutaka Matsuoka, Mayuko Hori, Makoto Tsujita, Kaoru Yasuda, Satoshi Ashimine, Kohei Ishiyama, Kazuharu Uchida, Kunio Morozumi, Takaaki Kobayashi

16.04.2024 | Points of View

Uremic toxins and the brain in chronic kidney disease

Chronic kidney disease (CKD) patients have an increased risk for cognitive impairment compared to the general population. The risk is much higher in CKD patients who progress to end-stage kidney disease (ESKD) and require hemodialysis or …

verfasst von:: Maurizio Bossola, Barbara Picconi

09.04.2024 | Original Article

Hemodynamics in nutcracker syndrome: implications for diagnosis

Nutcracker syndrome is a relatively rare disorder, most often caused by the compression of the left renal vein between the abdominal aorta and superior mesenteric artery [ 1 ]. Renal Doppler ultrasonography is often the initial option for the …

verfasst von:: Hui Tang, Xianchao Yu, Qun Chen, Yuexing Zhu, Shikun Zhang, Lu Tang, Yinghong Zhao, Gang Hua, Jinqiu Hu

Open Access 09.04.2024 | Original Article

Improving outcomes in atherosclerotic renovascular disease: importance of clinical presentation and multi-disciplinary review

Atherosclerosis is the leading cause of renal artery stenosis. The epidemiology of atherosclerotic renovascular disease varies depending on the cohort studied and the screening tool used. The prevalence amongst the overall US Medicare population …

verfasst von:: Áine M. de Bhailis, Edward Lake, Constantina Chrysochou, Darren Green, Rajkumar Chinnadurai, Philip A. Kalra

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Open Access 09.04.2024 | Original Article

Association of kidney function with physical performance: the Maastricht study

Impaired physical function represents a rising public health concern in the aging population, as it is associated with increased rates of morbidity and mortality [ 1 ]. Loss of muscle strength and the development of sarcopenia have been linked to …

verfasst von:: Ioannis Bellos, Smaragdi Marinaki, Pagona Lagiou, Ioannis N. Boletis, Annemarie Koster, Marleen M. J. van Greevenbroek, Simone J. P. M. Eussen, Hans H. C. M. Savelberg, Anke Wesselius, Vassiliki Benetou

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02.04.2024 | Nephrology Zebra

Acute kidney injury and bilateral renal enlargement: a sonography matter

A 60-year-old male was hospitalized for acute kidney injury (AKI) after 2 weeks of lower abdominal pain and fatigue, though without flank pain. His medical history was unremarkable; two weeks earlier he began taking omeprazole 20 mg once daily for …

verfasst von:: Matteo Righini, Benedetta Fabbrizio, Giovanna Cenacchi, Andrea Buscaroli

Open Access 02.04.2024 | Original Article

A real-world exploration into clinical outcomes of direct oral anticoagulant therapy in people with chronic kidney disease: a large hospital-based study

Direct Oral Anticoagulants (DOACs) are the first-line anticoagulation therapy prescribed for venous thromboembolism and atrial fibrillation patients with normal kidney function or moderately severe chronic kidney disease (CKD) [ 1 ]. The volume of …

verfasst von:: Ezekwesiri Michael Nwanosike, Hamid A. Merchant, Wendy Sunter, Muhammad Ayub Ansari, Barbara R. Conway, Syed Shahzad Hasan

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28.03.2024 | Original Article

Effect of a single small volume fluid bolus with balanced or un-balanced fluids on chloride and acid–base status: a prospective randomized pilot study (the FLURES-trial)

As recently as a decade ago, saline was the first-choice resuscitation fluid in critically ill patients [ 1 , 2 ]. As more data became available demonstrating the possible harmful effects of saline, its use diminished and balanced solutions …

verfasst von:: M. Raes, J. A. Kellum, R. Colman, S. Wallaert, M. Crivits, F. Viaene, M. Hemeryck, D. Benoit, J. Poelaert, E. Hoste

Springer Medizin