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European Journal of Nutrition

Erschienen in:

06.11.2021 | Original Contribution

Magnesium intake is inversely associated with risk of non-alcoholic fatty liver disease among American adults

verfasst von: Liping Lu, Cheng Chen, Yuexia Li, Wenzhi Guo, Shuijun Zhang, John Brockman, James M. Shikany, Ka Kahe

Erschienen in: European Journal of Nutrition | Ausgabe 3/2022

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Abstract

Purpose

Human data are limited linking magnesium (Mg) intake to the risk of non-alcoholic fatty liver disease (NAFLD). We aimed to examine the association between Mg intake and the risk of NAFLD among young adults in the US with a 25-year follow-up.

Methods

This study included 2685 participants from the Coronary Artery Risk Development in Young Adult (CARDIA) study. Diet and dietary supplements were assessed at baseline (1985–1986) and exam years 7 and 20 using an interview-based dietary history. NAFLD, defined as liver attenuation ≤ 51 Hounsfield Units excluding secondary causes of liver fat accumulation, was identified by non-contrast-computed tomography scanning at exam year 25. Multivariable-adjusted logistic regression model was used to examine the associations between cumulative average total intake of Mg (dietary plus supplemental) and NAFLD odds.

Results

A total of 629 NAFLD cases were documented. After adjustment for potential confounders, an inverse association between total Mg intake and NAFLD odds was observed. Compared to participants in the lowest quintile of total Mg intake, the odds of NAFLD was 55% lower among individuals in the highest quintile [multivariable-adjusted odds ratio (OR) = 0.45, 95% confidence interval (CI) (0.23, 0.85), p for trend = 0.03]. Consistently, whole-grain consumption, a major dietary source of Mg, was inversely associated with NAFLD odds (p for trend = 0.02).

Conclusions

This study suggests that higher cumulative intake of Mg throughout adulthood is associated with lower odds of NAFLD in midlife. Future studies are needed to establish a possible causal relationship.

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Titel: Magnesium intake is inversely associated with risk of non-alcoholic fatty liver disease among American adults
verfasst von: Liping Lu
Cheng Chen
Yuexia Li
Wenzhi Guo
Shuijun Zhang
John Brockman
James M. Shikany
Ka Kahe
Publikationsdatum: 06.11.2021
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nutrition / Ausgabe 3/2022
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-021-02732-8

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Magnesium intake is inversely associated with risk of non-alcoholic fatty liver disease among American adults