Suspicion of upper genital infection is a frequent clinical situation in gynecological emergencies and in primary care consultations. Pyosalpinx and tubo-ovarian abscess are almost always complications of pelvic inflammatory disease and are sexually transmitted infections in several cases. Pyosalpinx is defined as purulent intratubal collections, which may occur
de novo or by ascending infection of a hydrosalpinx. Therefore, pyosalpinx and tubo-ovarian abscess are usually observed in young women; they are rarely found in older women [
3]. In the literature, 194 cases of pyosalpinx or tubo-ovarian abscess in postmenopausal woman have been reported [
3,
4]. Pyosalpinx may present with very few specific symptoms or remain silent [
5]. Less than 50% of women with pyosalpinx present with fever and chills [
5,
6]. Other symptoms include nausea, vaginal discharge, and abnormal vaginal bleeding [
5,
6]. Functional urinary signs are reported in 15–30% of upper genital infections [
7]. On physical examination, patients may show tenderness over the adnexal region with or without guarding or rebound. The absence of specific symptoms and conclusive signs during the physical examination may delay a proper diagnosis [
5]. In the majority of cases, salpingitis results from a sexually transmitted ascending infection [
2]. In sexually inactive females, biological factors may play a role in the development of infection, including decreased level of protective antibodies, relative larger zone of cervical ectopy, greater permeability of cervical mucus, and alteration of vagina flora [
2]. The initial imaging modality of choice for the diagnosis of pyosalpinx is transvaginal ultrasound, because it is cost-effective and allows detailed visualization of pelvic structures. Ultrasound can show a dilated serpentine/tubular structure in the pelvis. Low-level echoes due to the higher protein content of the debris within the tube distinguish a pyosalpinx from a hydrosalpinx. Abdominopelvic computed tomography with contrast injection is often performed in an emergency setting. Typically, the pyosalpinx forms an elongated pseudocystic image, latero-uterine and then curving backwards from the uterus towards the cul-de-sac of Douglas, marked by one or more flexion folds. The wall and folds appear thick and echogenic. The 3D mode allows a more precise analysis of the shape and partitions. Under the probe, particularly vaginally, the mass is fixed and painful. Magnetic resonance imaging is a very useful method to examine and diagnose gynecological organs in elderly as well as young women. Magnetic resonance imaging images in the pelvis show a markedly dilated fallopian tube posterior to the ovary, edema surrounding the fallopian tube, and a thickened and enhanced tube wall with active inflammation. The early diagnosis of this pathology is hampered by its rarity and overlapping of symptoms with other causes of the acute abdomen, such as acute appendicitis, cystitis, gastroenteritis, pyelonephritis, and peritonitis [
1,
2]. As a therapy for pyosalpinx, it is recommended that antibiotics therapy is started as soon as possible for patients [
4,
8]. Pyosalpinx requires prompt diagnosis, admission, intravenous antibiotics, and possibly aspiration or surgery [
5,
9]. Treatment of pyosalpinx varies from conservative management with intravenous antibiotics to laparoscopic aspiration, image-guided aspiration or drainage, laparoscopic salpingostomy, or salpingectomy [
5,
10]. In more than 75% of patients, antibiotics alone may be sufficient for treating pyosalpinx [
11]. In case of a collection > 3–4 cm, drainage should be performed because the failure rate is higher in the absence of drainage as is the risk of serious complications [
12].