nach oben

Erschienen in:

06.11.2021 | Original Article

Beneficial effects of infrared light-emitting diode in corticosteroid-resistant asthma

verfasst von: Robson Alexandre Brochetti, Simone Klein, Paula Tatiane Alonso, Adriana Schapochnik, Amílcar Sabino Damazo, Michael R. Hamblin, Maria Fernanda de Souza Setubal Destro, Adriana Lino-dos-Santos-Franco

Erschienen in: Lasers in Medical Science | Ausgabe 3/2022

Einloggen, um Zugang zu erhalten

Abstract

Corticosteroid-resistant asthma (CRA) is a severe form of disease and clinically important, since patients do not respond to mainstay corticosteroid therapies. Thus, new therapies are needed. However, a big limiting factor in the understanding of CRA is the existence of different immunological and inflammatory phenotypes, a fact that makes it difficult to reproduce experimentally. Photobiomodulation (PBM) emerges as an alternative therapy based on earlier studies. This study aims to evaluate the effect of PBM using infrared light-emitting diode (ILED) on the development of corticosteroid-resistant asthma. Therefore, groups of rats were sensitized and challenged with ovalbumin plus Freund’s adjuvant for the induction of CRA, and treated or not with ILED directly in the respiratory tract on the skin (wavelength 810 nm; power 100 mW; density energy 5 J/cm; total energy 15 J; time 150 s). Our experimental model was capable to induce neutrophilic asthma. Besides that, the corticosteroid treatment did not reverse the lung cell migration as well as the levels of leukotriene B4, and interleukins 17 and 6. The treatment with ILED reduced the lung cell migration; myeloperoxidase activity; mast cell degranulation; and the levels of leukotriene B4, thromboxane B2, prostaglandin E2, tumoral necrosis factor alpha, and interleukins 17 and 6. Still, ILED increased the level of interleukin 10. In conclusion, we showed promisor effects of ILED when irradiated directly in the respiratory tract as adjuvant treatment of corticosteroid-resistant asthma.

Alonso P, Schapochnik A, Klein S et al (2021) Transcutaneous systemic photobiomodulation reduced lung inflammation in experimental model of asthma by altering the mast cell degranulation and interleukin 10 level. Lasers Med Sci. https://doi.org/10.1007/s10103-021-03359-1

Fischer R, Tomé D, Mcghee JR, Boyaka N (2007) Th1 and Th2 cells are required for both eosinophil-and neutrophil-associated airway inflammatory responses in mice. https://doi.org/10.1016/j.bbrc.2007.03.058

Foley SC, Hamid Q (2007) Images in allergy and immunology: neutrophils in asthma. J Allergy Clin Immunol 119:1282–1286. https://doi.org/10.1016/j.jaci.2007.02.006CrossRefPubMed

Leung DYM, Bloom JW (2003) Update on glucocorticoid action and resistance. J Allergy Clin Immunol 111:3–22CrossRef

Chan MTS, Leung DYM, Szefler SJ, Spahn JD (1998) Difficult-to-control asthma: clinical characteristics of steroid-insensitive asthma. J Allergy Clin Immunol 101:594–601. https://doi.org/10.1016/S0091-6749(98)70165-4CrossRefPubMed

Szefler SJ, Martin RJ, King TS et al (2002) Significant variability in response to inhaled corticosteroids for persistent asthma. J Allergy Clin Immunol 109:410–418. https://doi.org/10.1067/mai.2002.122635CrossRefPubMed

Monteseirín J (2009) Neutrophils and asthma. J Investig Allergol Clin Immunol 19:340–354PubMed

Schleimer R, Freeland H, Peters S et al (1989) An assessment of the effects of glucocorticoids on degranulation, chemotaxis, binding to vascular endothelium and formation of leukotriene B4 by purified human neutrophils. J Pharmacol Exp Ther 250:598–605PubMed

Sutton CE, Lalor SJ, Sweeney CM et al (2009) Interleukin-1 and IL-23 induce innate IL-17 production from γδ T cells, amplifying Th17 responses and autoimmunity. Immunity 31:331–341. https://doi.org/10.1016/j.immuni.2009.08.001CrossRefPubMed

10.

Murdoch JR, Lloyd CM Resolution of allergic airway inflammation and airway hyperreactivity is mediated by IL-17-producing gdT Cells. https://doi.org/10.1164/rccm.200911-1775OC

11.

Michel ML, Keller AC, Paget C et al (2007) Identification of an IL-17-producing NK1.1neg iNKT cell population involved in airway neutrophilia. J Exp Med 204:995–1001. https://doi.org/10.1084/jem.20061551CrossRefPubMedPubMedCentral

12.

Pichavant M, Goya S, Meyer EH et al (2008) Ozone exposure in a mouse model induces airway hyperreactivity that requires the presence of natural killer T cells and IL-17. J Exp Med 205:385–393. https://doi.org/10.1084/jem.20071507CrossRefPubMedPubMedCentral

13.

Siqueira VPC, Evangelista MIS, dos Santos A et al (2017) Light-emitting diode treatment ameliorates allergic lung inflammation in experimental model of asthma induced by ovalbumin. J Biophotonics 10:1683–1693. https://doi.org/10.1002/jbio.201600247CrossRefPubMed

14.

Rigonato-Oliveira NC, De Brito AA, Vitoretti LB et al (2019) Effect of low-level laser therapy (LLLT) in pulmonary inflammation in asthma induced by house dust mite (HDM): dosimetry study. Int J Inflam 2019. https://doi.org/10.1155/2019/3945496

15.

Carvalho JL, Britto A, de Oliveira APL et al (2017) Beneficial effect of low-level laser therapy in acute lung injury after i-I/R is dependent on the secretion of IL-10 and independent of the TLR/MyD88 signaling. Lasers Med Sci 32:305–315. https://doi.org/10.1007/s10103-016-2115-4CrossRefPubMed

16.

Tsai S-R, Hamblin MR (2017) Biological effects and medical applications of infrared radiation HHS Public Access. J Photochem Photobiol B 170:197–207. https://doi.org/10.1016/j.jphotobiol.2017.04.014CrossRefPubMedPubMedCentral

17.

Hamblin MR (2017) Mechanisms and applications of the anti-inflammatory effects of photobiomodulation. AIMS Biophys 4:337–361. https://doi.org/10.3934/biophy.2017.3.337CrossRefPubMedPubMedCentral

18.

de Lima WT, Sirois P, Jancar S (1992) Immune-complex alveolitis in the rat: evidence for platelet activating factor and leukotrienes as mediators of the vascular lesions. Eur J Pharmacol 213:63–70. https://doi.org/10.1016/0014-2999(92)90233-TCrossRefPubMed

19.

Maiellaro M, Correa-Costa M, Vitoretti LB et al (2014) Exposure to low doses of formaldehyde during pregnancy suppresses the development of allergic lung inflammation in offspring. Toxicol Appl Pharmacol 278:266–274. https://doi.org/10.1016/j.taap.2014.05.003CrossRefPubMed

20.

Lee JU, Park JS, Jun JA et al (2021) Inhibitory effect of paquinimod on a murine model of neutrophilic asthma induced by ovalbumin with complete Freund’s adjuvant. Can Respir J 2021. https://doi.org/10.1155/2021/8896108

21.

Dejager L, Dendoncker K, Eggermont M et al (2015) Neutralizing TNFα restores glucocorticoid sensitivity in a mouse model of neutrophilic airway inflammation. Mucosal Immunol 8:1212–1225. https://doi.org/10.1038/mi.2015.12CrossRefPubMed

22.

da Silva JGF, dos Santos SS, de Almeida P et al (2020) Effect of systemic photobiomodulation in the course of acute lung injury in rats. Lasers Med Sci. https://doi.org/10.1007/s10103-020-03119-7CrossRefPubMed

23.

Brochetti RA, Leal MP, Rodrigues R et al (2017) Photobiomodulation therapy improves both inflammatory and fibrotic parameters in experimental model of lung fibrosis in mice. Lasers Med Sci 32:1825–1834. https://doi.org/10.1007/s10103-017-2281-zCrossRefPubMed

24.

Schapochnik A, da Silva MR, Leal MP et al (2018) Vitamin D treatment abrogates the inflammatory response in paraquat-induced lung fibrosis. Toxicol Appl Pharmacol 355:60–67. https://doi.org/10.1016/j.taap.2018.06.020CrossRefPubMed

25.

Fekrazad R, Asefi S, Pourhajibagher M et al (2021) Photobiomodulation and antiviral photodynamic therapy in COVID-19 management. In: Adv Exp Med Biol. pp 517–547

26.

Nejatifard M, Asefi S, Jamali R et al (2021) Probable positive effects of the photobiomodulation as an adjunctive treatment in COVID-19: a systematic review. Cytokine 137:155312. https://doi.org/10.1016/j.cyto.2020.155312CrossRefPubMed

27.

Fahy JV (2009) Eosinophilic and neutrophilic inflammation in asthma insights from clinical studies. Proc Am Thorac Soc 6:256–259. https://doi.org/10.1513/pats.200808-087RMCrossRefPubMed

28.

Bousquet J, Chanez P, Lacoste JY et al (1990) Eosinophilic inflammation in asthma. N Engl J Med 323:1033–1039. https://doi.org/10.1056/NEJM199010113231505CrossRefPubMed

29.

Wang M, Gao P, Wu X et al (2016) Impaired anti-inflammatory action of glucocorticoid in neutrophil from patients with steroid-resistant asthma. Respir Res 17:1–9. https://doi.org/10.1186/s12931-016-0462-0CrossRef

30.

Chanez P, Humbert M Asthma: still a promising future? https://doi.org/10.1183/09059180.00009614

31.

Kudo M, Ishigatsubo Y, Aoki I, Nakazawa M (2013) Pathology of asthma. https://doi.org/10.3389/fmicb.2013.00263

32.

Haworth O, Levy BD (2007) Endogenous lipid mediators in the resolution of airway inflammation. Eur Respir J 30:980–992. https://doi.org/10.1183/09031936.00005807CrossRefPubMedPubMedCentral

33.

Meshram D, Bhardwaj K, Rathod C et al (2020) The role of leukotrienes inhibitors in the management of chronic inflammatory diseases. Recent Pat Inflamm Allergy Drug Discov 14:15–31. https://doi.org/10.2174/1872213X14666200130095040CrossRefPubMed

34.

Kytikova O, Novgorodtseva T, Denisenko Y et al (2019) Pro-resolving lipid mediators in the pathophysiology of asthma. Medicina 55:1–12. https://doi.org/10.3390/medicina55060284CrossRef

35.

Lipworth B, Chan R, Kuo C (2020) Systemic IL-6 and severe asthma. Am J Respir Crit Care Med 202:1324–1325. https://doi.org/10.1164/rccm.202006-2354LECrossRefPubMedPubMedCentral

Titel: Beneficial effects of infrared light-emitting diode in corticosteroid-resistant asthma
verfasst von: Robson Alexandre Brochetti
Simone Klein
Paula Tatiane Alonso
Adriana Schapochnik
Amílcar Sabino Damazo
Michael R. Hamblin
Maria Fernanda de Souza Setubal Destro
Adriana Lino-dos-Santos-Franco
Publikationsdatum: 06.11.2021
Verlag: Springer London
Erschienen in: Lasers in Medical Science / Ausgabe 3/2022
Print ISSN: 0268-8921
Elektronische ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-021-03457-0

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 3/2022

Photobiomodulation therapy preconditioning modifies nitric oxide pathway and oxidative stress in human-induced pluripotent stem cell-derived ventricular cardiomyocytes treated with doxorubicin

Excimer laser atherectomy combined with drug-coated balloon versus drug-eluting balloon angioplasty for the treatment of infrapopliteal arterial revascularization in ischemic diabetic foot: 24-month outcomes

The effectiveness and safety of low-level laser therapy on breast cancer–related lymphedema: An overview and update of systematic reviews

Impact of preconditioned diabetic stem cells and photobiomodulation on quantity and degranulation of mast cells in a delayed healing wound simulation in type one diabetic rats

Impact of small diameter and low level of emission laser coronary atherectomy in patients with acute myocardial infarction

The effect of photodynamic therapy by gold nanoparticles on Streptococcus mutans and biofilm formation: an in vitro study