Methods
This is a retrospective nonrandomised study in which data of patients with congenital ptosis with fair to good levator muscle function who underwent levator muscle surgery by the authors between 2019 and 2022 were retrieved from the hospital records at ophthalmology department at Cairo university hospital.
Data of the preoperative assessment, intraoperative and postoperative data together with recorded photographs and videos were reviewed. Patients with any medical illness, ocular inflammation, trauma, contact lens wearing were excluded. All photos of the included patients were routinely taken by the authors in primary gaze position using a digital camera with flashlight to show the corneal light reflex, in downgaze and during eye closure.
Data included:
(1)
General ophthalmological assessment (best corrected visual acuity when feasible, pupil, extraocular motility, anterior and posterior segment examination).
(2)
Ptosis assessment (marginal reflex distance 1 (MRD1), crease height, levator muscle function, Bell’s phenomena, lid position in downward gaze to detect lid lag).
All patients with congenital ophthalmological defects were examined by a geneticist to exclude other congenital anomalies.
A crease incision was done through the skin and the orbicularis muscle. The orbital septum was opened layer by layer slightly higher than the superior tarsal border to avoid accidental injury to the levator aponeurosis till bulging of the pre-aponeurotic fat that was retracted to identify the aponeurosis. Once the muscle was identified at its insertion, levator resection was accomplished according to the Beard’s tables as well as the intraoperative assessment based on Berke’s formula and the surgeon’s experience to reach the desired intraoperative palpebral fissure height.
Cases where the aponeurosis was missing at its anatomical insertion were marked as congenital ptosis with aponeurotic maldevelopment and documented with Intraoperative photographs. Further upward dissection was done till the aponeurosis edge was detected and the distance between it and the tarsus was measured using a calliper. The identified aponeurosis was advanced and reattached to the anterior surface of the upper third of the tarsus using double armed prolene 5/0 suture. Lid height and contour were checked. Skin incision was closed using polyglycolic 6/0 suture with incorporating bites of the aponeurosis. All patients received combined topical antibiotic steroid ointment and intensive lubricants.
The data of the first postoperative day and week included the degree of lid oedema, lagophthalmos and corneal condition. The final MRD1, lid contour and crease height were detected at one month.
Ethics approval: This study adhered to international ethical standards and tenets of the Declaration of Helsinki.
This study was approved by the Ethics Review Committee of Cairo University, Faculty of Medicine with ID approval N-98–2023.
Consent to participate: Patient’s privacy was respected throughout the study. Participants’ parents were informed about the study, and a written informed consent about using their photos was obtained.
Intraoperative data
The mean dehiscence distance was 13.44 ± 4.89 mm. Twenty-five eyes out of the twenty-seven met the diagnostic criteria (92.6%) showing total absence of the levator aponeurosis edge at the area above the tarsus. Hence, upon dissecting the preseptal orbicularis muscle and the orbital septum, a bare conjunctival surface was directly found revealing the underlying corneal hue and the blood vessels of the peripheral arcade on the surface of the Muller muscle (confirming the absence of the aponeurotic attachment) (Figs.
1 and
2). Opening of the orbital septum where it covers the distal edge of the preaponeurotic fat resulted in its bulging with the appearance of the “paused edge” of the levator muscle which seemed to fuse with the septum at this point (Fig.
2 and Online Resources 1, 2). However, in two eyes (7.4%), the edge of the aponeurosis was found dehisced just above the superior tarsal border and distal to the fat pad i.e. (achieved septal penetration). Those two eyes had crease height of 6 mm. In the 3 cases with fair Levator function and preoperative lid lag, the retrieved levator muscle was tight and cutting fibrous bands and septal attachments was required to achieve proper mobilization.
The degree of dehiscence was directly correlated to the preoperative crease level (r value 0.25) and inversely related to MRD (r value −0.36). However, this correlation was statistically insignificant (p -value 0.21, 0.066 respectively).
The mean postoperative MRD1 was 4.22 ± 0.75 mm while crease height was 7.07 ± 1.41 mm. Both showed statistically significant change compared to the preoperative values (p value < 0.0001). Two eyes (7.4%) showed under-correction that required surgical exploration revealing suture migration; hence the aponeurosis was reattached.
Based on the reviewed records, 5 patients ( 6 eyes) had been examined after one year of surgical intervention ( for other ophthalmological causes) and were found to have stable surgical outcome.
Discussion
Aponeurotic defects in senile ptosis are a well-established entity that was first described by Quickert in 1970. It was first described in congenital ptosis by Anderson and Gordy in 1979 who reported criteria like levator disinsertion with good levator function, high lid crease and absence of lid lag. Those criteria are different from those of true congenital ptosis which is mainly due to muscle dysgenesis with a variable degree of levator dysfunction, weak lid crease, downgaze lid lag [
5].
They also attributed some of the unsatisfactory results with standard procedures and correct amount of surgery to missing such aponeurotic defects [
4]. This entity, however, is less reported in literature [
2].
In the current study, criteria of congenital aponeurotic defect were found in 27 eyes out of the reviewed 287 (9.4%). This percentage is higher than that reported primarily by Anderson and Gordy 7% (3 eyes out of 46) [
4] and by Martin and Rogers 7.4% (12 out of 162 cases) [
2]. The latter authors operated on 14 eyes (12 cases) and the 162 cases were not clearly specified if they were bilateral cases other than the ones they had operated upon in their series. They also included one case of traumatic aponeurotic defect.
Although the amount of ptosis in this study was like both reports (2–5 mm), we believe that the higher percentage could be attributed to larger sample size because of increased awareness of such entity with including wider range of muscle function (4–15 mm). All cases in the above-mentioned reports had good levator function; (8 and 15 mm) in Martin and Rogers’ [
2] and (7–10 mm) in Anderson and Gordy’s [
4].
The first few cases included in this series were discovered intraoperatively and hence attracted the authors’ attention to such entity. On data reviewing, it was found that there are certain preoperative clues that would be suggestive. These clues included the lid crease position, absence of lid lag on down gaze (except for those found with fair function and intraoperative dense septal adhesions) and the visibility of bluish corneal hue through the thin lid skin.
Absence of lid lag on down gaze was noted in 88.9% of cases with even more drooping compared to the sound side in unilateral cases (14 eyes, 70.4%). Anderson and Gordy described it as a sure sign of congenital aponeurotic defect [
4]. We agree on its significance yet, we suggest that its absence does not negate the presence of aponeurotic defect. The lower lid position on the down gaze is suggestive of absent muscle dysgenesis which is present in most congenital myogenic ptosis cases.
The levator function was found to be anywhere from good to fair. This series included three eyes with fair levator function and evident preoperative lid lag, they were scheduled for maximum levator resection as was adopted by the authors. Intraoperatively, all the previously mentioned aponeurotic maldevelopment features were found however, with significant abnormal dense septal fibrous bands especially at the site of the medial and the lateral horns with a totally healthy muscle once freed from the adhesions. These fibrotic changes were found reproducibly in those three cases. All these factors could contribute to the lid lag and probably the cause of the fair function. This hypothesis was raised by some authors in previous reports [
6‐
9]. Some mentioned that the aponeurosis fibrotic changes found in ptotic eyes with poor preoperative levator function could inversely affect its stretching capability and aggravate the limitation of eyelid excursion [
10]. Surprisingly simple aponeurotic attachment after complete mobilization of the muscle from its fibrous prison achieved the desired lid position.
The lid skin crease was usually present yet at a higher position compared to the sound side or the expected position in bilateral cases. Twenty-five eyes (92.6%) had a crease at 8 mm or higher compared to 2 eyes (7.3%) with normally positioned crease yet showed an aponeurotic defect intraoperatively aponeurosis was found about 3 mm above the superior tarsal border with a higher septal attachment denoting arrested septal development yet with aponeurosis penetration unlike the rest of cases.
Collins reported that this could happen in the presence of malunion rather than disinsertion [
11]. Martin and Rogers also reported that there is always a skin fold/ crease either in its normal position which they attributed to malunion or high which they attributed to disinsertion [
2]. In the current study, the three cases with fair levator function had a hardly developed high crease but there was always a high accentuated skin fold on attempted up gaze signifying the upward traction on the paused distal end of the aponeurosis during muscle contraction.
Visibility of the corneal hue through the lid skin is highly suggestive of possible aponeurotic defect and was detected in 18.5% of cases, all had fair complexion which is not common in our community.
Intraoperatively, a sure sign of aponeurotic defect was identifying Muller conjunctival complex with vascular arcade after opening of the orbital septum. As the dissection was carried out meticulously layer by layer [
3] and the septum was opened at a higher level than the upper tarsal border, the accidental aponeurosis severance was excluded, and the aponeurosis could only be identified once the preaponeurotic fat was retracted before dissection was carried down to expose the tarsus.
Embryologically, Levator muscle arises from different cell types that migrate to their destination to acquire full maturation [
12‐
14]. Recent literature shows that neural crest cells component of the lid mesenchyme gives rise to levator aponeurosis, orbital septum, and Muller’s muscle while mesodermal component gives rise to striated muscle fibers [
15,
16].
The levator muscle starts to arise within the orbit as early as the 6
thweek of embryogenesis. It then acquires its final differentiation at the 10
thweek, and it finally reaches the adult position above the superior rectus at the week thirteen [
11].
On the other hand, the aponeurosis starts to appear during the 12
thweek close to the primitive orbital septum, The muscle and the septum come to join below the developing central fat pad around week 20 and reach their final insertion together by week 24 [
17].
We presume that any interruption of the downward growth of the septum and aponeurosis between week 12 and week 24 could give rise to this paused development of levator aponeurosis. It also seems that neural crest cell migration defect may have an important role in the pathogenesis of aponeurosis maldevelopment [
9].
The dehiscence distance was inversely proportional to MRD 1. This correlation was statistically insignificant (p value: 0.21). This goes with the observation that the degree of ptosis does not necessarily signify the presence of the aponeurotic defect. However, it logically explains the presence of the ptosis due to the inability of the muscle to conduct its action to the tarsus and could barely accentuate the skin fold proximal to the crease on attempted upward gaze due to muscle contraction. This suggests searching for the aponeurosis at a higher level as far as the orbital margin in suspected cases. The amount of dehiscence was also directly related to the crease height yet was statistically insignificant. The absence of properly developed aponeurosis would explain the higher and multiple creases, meanwhile it explains the presence of ptosis; something like aponeurotic ptosis in elderly.
Several techniques and modifications for aponeurosis repair have been reported. Levator muscle advancement and resection are the most popular external techniques used. If total disinsertion is discovered intraoperatively, levator aponeurosis reattachment to the tarsal plate is performed however, if the aponeurosis is stretched and thin but still attached, a resection or advancement may be completed [
18,
19].
Internal repair techniques; conjunctival mullerectomy was originally described for patients with mild to moderate ptosis, good levator function, and a positive response to 2.5–5% phenylephrine testing [
20].
Simple aponeurosis advancement to the tarsus was done in all cases of our series with no further need for muscle resection, however additional release of the fibrous adhesions was done in the 3 cases with fair levator function for better aponeurosis mobilization.
The desired amount of correction was guided by the gapping method [
21,
22]. Even the two re-operated eyes improved by further aponeurotic re-suturing without any muscle shortening.
Simple aponeurosis reinsertion was also done by Martin and Rogers who reported achieving cosmetically good results in (7 out of 12 patients) and reintervention for 5 cases, not emphasizing if these were 7 patients or eyes especially that they had mentioned that they operated on 14 eyes [
2].
Despite being an underreported condition, yet a retrospective study with limited number of cases is considered a limitation to truly validate its incidence. A prospective study with a long follow up period is recommended. A future multidisciplinary Collaboration with a geneticist, an embryologist and a developmental biologist is required for a better comprehensive understanding of this developmental anomaly.
Longer scheduled follow-up visits are also recommended in future studies to assess the long-term effect of aponeurotic advancement.
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