Background
Methods
Data collection
Clinical symptoms and laboratory examinations
Statistical analysis
Results
Demographic characteristics of patients with COVID-19
Variables | All patients (n = 187) | Non-severe group (n = 43) | Severe group (n = 144) | p value |
---|---|---|---|---|
Age (years) | 61.53 ± 1.675 | 57.67 ± 2.275 | 62.55 ± 1.098 | 0.0404 |
Gender | ||||
Male | 111 (59.36) | 28 (65.12) | 83 (57.64) | 0.4795 |
Female | 76 (40.64) | 15 (34.88) | 61 (42.36) | |
Symptoms | ||||
Fever | 169 (90.37) | 42 (97.67) | 127 (88.19) | 0.0784 |
Cough | 154 (82.35) | 42 (97.67) | 112 (77.78) | 0.0012 |
Expectoration | 101 (54.01) | 37 (86.05) | 64 (44.44) | < 0.0001 |
Chest distress | 77 (41.18) | 13 (30.23) | 64 (44.44) | 0.1134 |
Myalgia | 37 (19.79) | 16 (37.21) | 21 (14.58) | 0.0020 |
Fatigue | 50 (26.74) | 18 (41.86) | 32 (22.22) | 0.0175 |
Diarrhea | 48 (25.67) | 9 (20.93) | 39 (27.08) | 0.5510 |
Nausea | 18 (9.63) | 6 (13.95) | 12 (8.33) | 0.3746 |
Time interval (days) | ||||
On admission | 2 (0–4) | 2 (0–3) | 2 (1–4) | 0.7675 |
Discharge | 24 (14–39) | 20 (14–26) | 29 (22–39) | 0.0113 |
Underlying diseases | ||||
Hypertension | 89 (47.59) | 18 (41.86) | 71 (49.31) | 0.4868 |
Diabetes | 33 (17.65) | 5 (11.63) | 28 (19.44) | 0.3611 |
Cardiovascular disease | 21 (11.23) | 6 (13.95) | 15 (10.42) | 0.5825 |
Chronic lung disease | 12 (6.42) | 2 (4.65) | 10 (6.94) | 0.7365 |
Chronic hepatic disease | 3 (1.60) | 1 (2.33) | 2 (1.39) | 0.5456 |
Chronic kidney disease | 3 (1.60) | 1 (2.33) | 2 (1.39) | 0.5456 |
Past history | ||||
Smoking | 8 (4.28) | 1 (2.33) | 7 (4.86) | 0.6842 |
Drinking | 5 (2.67) | 2 (4.65) | 3 (2.08) | 0.3245 |
Laboratory markers
Variables | All patients (n = 187) | Non-severe group (n = 43) | Severe group (n = 144) | p value |
---|---|---|---|---|
WBC count (× 109) | 8.62 ± 0.40 | 5.59 ± 0.27 | 9.50 ± 0.51 | 0.001 |
Neutrophils (× 109) | 6.45 ± 0.37 | 3.47 ± 0.22 | 7.32 ± 0.52 | < 0.001 |
Lymphocyte (× 109) | 1.55 ± 0.18 | 2.43 ± 0.11 | 1.30 ± 0.24 | 0.157 |
Hemoglobin (g/L) | 118 ± 2.45 | 123 ± 2.91 | 117 ± 1.99 | 0.096 |
Platelet (× 109) | 180 ± 10.9 | 240 ± 12.6 | 163 ± 9.23 | < 0.001 |
C-reaction protein (mg/L) | 66.4 ± 8.48 | 22.4 ± 9.86 | 73.6 ± 7.14 | 0.021 |
Procalcitonin (ng/mL) | 1.45 ± 0.84 | 1.40 ± 1.22 | 1.46 ± 0.54 | 0.961 |
Interleukin-6 (pg/mL) | 66.02 ± 3.82 | 6.62 ± 3.15 | 78.52 ± 4.49 | 0.031 |
Interleukin-8 (pg/mL) | 37.84 ± 4.50 | 8.96 ± 2.85 | 43.98 ± 6.12 | 0.007 |
Interleukin-10 (pg/mL) | 12.2 ± 2.13 | 5.8 ± 1.56 | 13.5 ± 2.70 | 0.056 |
Tumor necrosis factor-a (pg/mL) | 13.0 ± 1.72 | 8.3 ± 1.33 | 13.9 ± 1.93 | 0.148 |
Logistic regression analysis for the severe COVID-19
Variables | Univariate analysis p value | OR (odd ratio) | Multivariate analysis p value | OR (odd ratio) |
---|---|---|---|---|
Age | 0.0404 | 1.031 | 0.793 | 0.994 |
WBC count | 0.001 | 1.220 | 0.890 | 1.009 |
Neutrophils | < 0.001 | 1.325 | 0.027 | 1.541 |
Lymphocyte | 0.157 | 0.940 | 0.123 | 0.992 |
Hemoglobin | 0.096 | 0.987 | 0.766 | 0.996 |
Platelet | < 0.001 | 0.993 | 0.004 | 0.890 |
C-reaction protein | 0.021 | 1.014 | 0.791 | 0.998 |
Interleukin-6 | 0.031 | 1.040 | 0.846 | 1.006 |
Interleukin-8 | 0.007 | 1.105 | 0.153 | 1.180 |
Interleukin-10 | 0.056 | 1.210 | 0.090 | 0.741 |
Tumor necrosis factor-a | 0.148 | 1.059 | 0.723 | 1.062 |
ROC curves for predicting the severe COVID-19
Variables | AUROC | Std. error | p value | Asymptotic 95% confidence interval | |
---|---|---|---|---|---|
Lower bound | Upper bound | ||||
WBC | 0.618 | 0.057 | 0.169 | 0.506 | 0.729 |
Neutrophils | 0.681 | 0.056 | 0.034 | 0.572 | 0.790 |
Lymphocyte | 0.761 | 0.052 | 0.002 | 0.138 | 0.341 |
Hemoglobin | 0.408 | 0.079 | 0.281 | 0.252 | 0.563 |
Platelet | 0.764 | 0.055 | 0.002 | 0.129 | 0.344 |
C-reaction protein | 0.722 | 0.071 | 0.010 | 0.584 | 0.860 |
Procalcitonin | 0.697 | 0.072 | 0.022 | 0.555 | 0.838 |
Interleukin-6 | 0.706 | 0.061 | 0.016 | 0.587 | 0.825 |
Interleukin-8 | 0.828 | 0.052 | < 0.001 | 0.725 | 0.930 |
Interleukin-10 | 0.689 | 0.069 | 0.027 | 0.553 | 0.825 |
Tumor necrosis factor-a | 0.704 | 0.069 | 0.017 | 0.569 | 0.839 |
Neutrophils + platelet | 0.821 | 0.032 | < 0.001 | 0.758 | 0.883 |