The signs and symptoms of COVID-19 present at illness onset vary from mild or nonspecific symptoms to severe respiratory distress, and non-respiratory symptoms have also been reported [
6]. Common neurological manifestations reported for COVID-19 are acute stroke, impaired consciousness, and muscle injury. Patients with severe cases and older patients are more susceptible to these complications [
4]. In light of the lack of sufficient data on COVID-19, a review of past experience with neurological aspects of previous forms of coronavirus was carried out. Although the data are sparse, rare cases of acute disseminated encephalomyelitis (ADEM)-like demyelination, encephalitis, and brainstem encephalitis have been reported for Middle East respiratory syndrome (MERS), severe acute respiratory syndrome (SARS), and other types [
7‐
10]. One report described a case of encephalopathy in a 72-year-old man with underlying neurological disease who was infected with COVID-19 [
4]. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) invades the brain by various routes, such as binding to the ACE2 receptor on neurons and endothelial cells, through the olfactory system and spread across the cribriform plate, and by crossing the blood–brain barrier via infected leukocyte migration by a Trojan horse mechanism. Encephalopathy is reported in older patients and patients with severe or critical disease [
11‐
13]. Our patient was middle-aged, without any previous medical history, and with normal brain imaging and non-severe infection. Due to the relatively rapid resolution of neurological symptoms and no pathological findings in the imaging, further studies were not performed. The etiology of encephalopathy or possible encephalitis in COVID-19 or other coronaviruses remains poorly understood, and could be due to misdirected host immune responses [
14]. Neurological manifestations of COVID-19 derive from both direct invasion and indirect effects due to hyperinflammation and encephalopathy [
15]. As the number of patients with COVID-19 increases worldwide, clinicians should be watchful for patients presenting with bizarre behavior or altered mental status. Possible spread from the respiratory tract to the central nervous system must be considered, and cerebrospinal fluid analysis for virus detection is recommended in similar cases to determine whether a direct viral infection is responsible for the clinical presentations or immune system response.