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Cardiovascular Drugs and Therapy
Erschienen in: Cardiovascular Drugs and Therapy 6/2023

16.02.2022 | Review Article

Depletion of microRNA-92a Enhances the Role of Sevoflurane Treatment in Reducing Myocardial Ischemia–Reperfusion Injury by Upregulating KLF4

verfasst von: Qianfu Wu, Haihui Wang, Fei He, Jiali Zheng, Hongjing Zhang, Chang Cheng, Panwei Hu, Rong Lu, Guoliang Yan

Erschienen in: Cardiovascular Drugs and Therapy | Ausgabe 6/2023

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Abstract

Objective

As some articles have highlighted the role of microRNA-92a (miR-92a) in myocardial ischemia–reperfusion injury (MI/RI), this article aimed to investigate the effect of miR-92a on Sevoflurane (Sevo)-treated MI/RI via regulation of Krüppel-like factor 4 (KLF4).

Methods

An MI/RI rat model was established by ligating the left anterior descending coronary artery. The cardiac function, pathological changes of myocardial tissues, inflammatory response, oxidative stress and cardiomyocyte apoptosis in MI/RI rats were determined. KLF4 and miR-92a expression was detected in the myocardial tissue of rats, and the target relationship between miR-92a and KLF4 was confirmed.

Results

Sevo treatment alleviated myocardial damage, inflammatory response, oxidative stress response, and cardiomyocyte apoptosis, and improved cardiac function in MI/RI rats. miR-92a increased and KLF4 decreased in the myocardial tissue of MI/RI rats. KLF4 was targeted by miR-92a. Downregulation of miR-92a or upregulation of KLF4 further enhanced the effect of Sevo treatment on MI/RI.

Conclusion

This study suggests that depletion of miR-92a promotes upregulation of KLF4 to improve cardiac function, reduce cardiomyocyte apoptosis and further enhance the role of Sevo treatment in alleviating MI/RI.
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Metadaten
Titel
Depletion of microRNA-92a Enhances the Role of Sevoflurane Treatment in Reducing Myocardial Ischemia–Reperfusion Injury by Upregulating KLF4
verfasst von
Qianfu Wu
Haihui Wang
Fei He
Jiali Zheng
Hongjing Zhang
Chang Cheng
Panwei Hu
Rong Lu
Guoliang Yan
Publikationsdatum
16.02.2022
Verlag
Springer US
Erschienen in
Cardiovascular Drugs and Therapy / Ausgabe 6/2023
Print ISSN: 0920-3206
Elektronische ISSN: 1573-7241
DOI
https://doi.org/10.1007/s10557-021-07303-x

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