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19.03.2024 | Original Paper

Does cannabis use substitute for opioids? A preliminary exploratory survey in opioid maintenance patients

verfasst von: Nina Kim Bekier, Ulrich Frischknecht, Katharina Eidenmueller, Franz Grimm, Patrick Bach, Manuel Stenger, Falk Kiefer, Derik Hermann

Erschienen in: European Archives of Psychiatry and Clinical Neuroscience

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Abstract

Various studies showed that people with substance use disorder use cannabis to reduce withdrawal or dose of their main drug. Using a questionnaire about their cannabis use, 118 participants in an opioid maintenance treatment (OMT) in Germany were examined regarding this strategy. 60% reported to use cannabis. Of those, 72% were using cannabis in the suggested way. Cannabis was used to substitute for, e.g., heroin (44.8%) and benzodiazepines (16.4%). We also asked for an estimation of how good cannabis was able to substitute for several substances (in German school grades (1 till 6)); heroin average grade: 2.6 ± 1.49. Besides that we asked about the idea of cannabis as “self-medication”, e.g., to reduce pain (47%) and about negative consequences from cannabis use. Our results suggest to consider the use of cannabis by patients in OMT rather as a harm reduction strategy to reduce the intake of more dangerous drugs.
Literatur
1.
Zurück zum Zitat Abrams DI, Couey P, Shade SB, Kelly M, Benowitz NL (2010) Cannabinoid-opioid interaction in chronic pain. Clin Pharmacol Ther 90(6):844–841CrossRef Abrams DI, Couey P, Shade SB, Kelly M, Benowitz NL (2010) Cannabinoid-opioid interaction in chronic pain. Clin Pharmacol Ther 90(6):844–841CrossRef
2.
Zurück zum Zitat Aharonovich E, Garawi F, Bisaga A, Brooks D, Raby WN, Rubin E, Australian Institute of Health and Welfare (2002) 2001 national drug strategy household survey: first results. Curr Psychiatry Rep 61 Aharonovich E, Garawi F, Bisaga A, Brooks D, Raby WN, Rubin E, Australian Institute of Health and Welfare (2002) 2001 national drug strategy household survey: first results. Curr Psychiatry Rep 61
3.
Zurück zum Zitat Bachhuber MA, Saloner B, Cunningham CO, Barry CL (2014) Medical cannabis laws and opioid analgesic overdose mortality in the United States, 1999–2010. JAMA Intern Med 174(10):1668–1673CrossRefPubMedPubMedCentral Bachhuber MA, Saloner B, Cunningham CO, Barry CL (2014) Medical cannabis laws and opioid analgesic overdose mortality in the United States, 1999–2010. JAMA Intern Med 174(10):1668–1673CrossRefPubMedPubMedCentral
4.
Zurück zum Zitat Betäubungsmittel-Verschreibungsverordnung vom 20. Januar 1998 (BGBl. I S. 74, 80), die zuletzt durch Artikel 2 der Verordnung vom 18. Mai 2021 (BGBl. I S. 1096) geändert worden ist, §5 Betäubungsmittel-Verschreibungsverordnung vom 20. Januar 1998 (BGBl. I S. 74, 80), die zuletzt durch Artikel 2 der Verordnung vom 18. Mai 2021 (BGBl. I S. 1096) geändert worden ist, §5
5.
Zurück zum Zitat Bushlin I, Rozenfeld R, Devi LA (2010) Cannabnoid-opioid interactions during neuropathic pain and analgesia. Curr Opin Pharmacol 10(1):80–86CrossRefPubMed Bushlin I, Rozenfeld R, Devi LA (2010) Cannabnoid-opioid interactions during neuropathic pain and analgesia. Curr Opin Pharmacol 10(1):80–86CrossRefPubMed
7.
Zurück zum Zitat Darke F (2007) National drug strategy. Dept. of Health and Aged Care, Canberra Darke F (2007) National drug strategy. Dept. of Health and Aged Care, Canberra
8.
Zurück zum Zitat Darke S, Duflou J, Kaye S (2007) Comparative toxicology of fatal heroin overdose cases and morphine positive homicide victims. Addiction 102(11):1793–1797 (Epub 2007 Sep 3)CrossRefPubMed Darke S, Duflou J, Kaye S (2007) Comparative toxicology of fatal heroin overdose cases and morphine positive homicide victims. Addiction 102(11):1793–1797 (Epub 2007 Sep 3)CrossRefPubMed
10.
11.
Zurück zum Zitat Fergusson DM, Boden JM, Horwood LJ (2006) Cannabis use and other illicit drug use: testing the cannabis gateway hypothesis. Addiction 101(4):556–569CrossRefPubMed Fergusson DM, Boden JM, Horwood LJ (2006) Cannabis use and other illicit drug use: testing the cannabis gateway hypothesis. Addiction 101(4):556–569CrossRefPubMed
12.
Zurück zum Zitat Heidebrecht F, MacLeod MB, Dawkins L (2018) Predictors of heroin abstinence in opiate substitution therapy in heroin-omly users and dualusers of heroin and crack. Addict Behav 77:210–216CrossRefPubMed Heidebrecht F, MacLeod MB, Dawkins L (2018) Predictors of heroin abstinence in opiate substitution therapy in heroin-omly users and dualusers of heroin and crack. Addict Behav 77:210–216CrossRefPubMed
13.
Zurück zum Zitat Hursh SR, Galuska CM, Winger G, Woods JH (2005) The economics of drug abuse: a quantitative assassment of drug demand. Mol Interv 5(1):20–28CrossRefPubMed Hursh SR, Galuska CM, Winger G, Woods JH (2005) The economics of drug abuse: a quantitative assassment of drug demand. Mol Interv 5(1):20–28CrossRefPubMed
15.
Zurück zum Zitat Li JX, Koek W, France CP (2012) Interactions between Δ (9)-tetrahydrocannabinol and heroin: self-administration in rhesus monkeys. Behav Pharmacol 23(8):754–761CrossRefPubMedCentral Li JX, Koek W, France CP (2012) Interactions between Δ (9)-tetrahydrocannabinol and heroin: self-administration in rhesus monkeys. Behav Pharmacol 23(8):754–761CrossRefPubMedCentral
16.
Zurück zum Zitat Lichtman AH, Sheikh SM, Loh HH, Martin BR (2001) Opioid and cannabinoid modulation of precipitated withdrawal in delta (9)-tetrahydrocannabinol and morphine-dependent mice. J Pharmacol Exp Ther 298(3):1007–1014PubMed Lichtman AH, Sheikh SM, Loh HH, Martin BR (2001) Opioid and cannabinoid modulation of precipitated withdrawal in delta (9)-tetrahydrocannabinol and morphine-dependent mice. J Pharmacol Exp Ther 298(3):1007–1014PubMed
17.
Zurück zum Zitat Lucas P, Reiman A, Earleywine M, McGowan SK, Oleson M, Coward MP, Thomas B (2013) Cannabis as a substitute for alcohol and other drugs: a dispensery-based survey of substitution effect in Canadian medical cannabis patients. Addiction Res Theory 21(5):435–442CrossRef Lucas P, Reiman A, Earleywine M, McGowan SK, Oleson M, Coward MP, Thomas B (2013) Cannabis as a substitute for alcohol and other drugs: a dispensery-based survey of substitution effect in Canadian medical cannabis patients. Addiction Res Theory 21(5):435–442CrossRef
18.
Zurück zum Zitat Lucas P, Walsh Z, Crosby K, Callaway R, Belle-Isle L, Kay R, Capler R, Holtzman S (2016) Substituting cannabis for prescription drugs, alcohol and other substances among medical cannabis patients: the impact of contextual factors. Drug and Alcohol Rev 35(3):326–333CrossRef Lucas P, Walsh Z, Crosby K, Callaway R, Belle-Isle L, Kay R, Capler R, Holtzman S (2016) Substituting cannabis for prescription drugs, alcohol and other substances among medical cannabis patients: the impact of contextual factors. Drug and Alcohol Rev 35(3):326–333CrossRef
21.
Zurück zum Zitat Maguire DR, Yang W, France CP (2013) Interactions between µ-opioid receptor agonists and cannabinoid receptor agonists in rhesus monkeys: antinociception, drug discrimination and drug self-administration. J Pharmacol Exp Ther 345(3):354–362CrossRefPubMedPubMedCentral Maguire DR, Yang W, France CP (2013) Interactions between µ-opioid receptor agonists and cannabinoid receptor agonists in rhesus monkeys: antinociception, drug discrimination and drug self-administration. J Pharmacol Exp Ther 345(3):354–362CrossRefPubMedPubMedCentral
22.
Zurück zum Zitat Maguire DR, Yang W, France CP (2016) Interactions of daily delta-9-tetrahydrocannabinol treatment on heroin self-administration in rhesus monkeys. Behav Pharmacol 27(2–3 Spec Issue):249–257CrossRefPubMedPubMedCentral Maguire DR, Yang W, France CP (2016) Interactions of daily delta-9-tetrahydrocannabinol treatment on heroin self-administration in rhesus monkeys. Behav Pharmacol 27(2–3 Spec Issue):249–257CrossRefPubMedPubMedCentral
23.
24.
Zurück zum Zitat Mokdad AH, Ballestros K, Echko M, Glenn S, Olsen HE, Mullany E, Lee A, Khan AR, Ahmadi R, Ferrari AJ, Kasaeian A, Werdecker A, Carter A, Zipkin B, Sartorius B, Serdar B, Sykes BL, Troeger C, Fitzmaurice C, Rehm CD, Santomauro D, Kim D, Colombara D, Schwebel DC, Tsoi D, Kolte D, Nsoesie E, Nichols E, Oren E, Charlson FJ, Patton CG, Roth GA, Hosgood HD, Whitford HA, Kyu H, Erskine HE, Huang H, Martopullo I, Singh JA, Nachega JB, Sanabria JR, Abbas K, Ong K, Tabb K, Krohn KJ, Cornaby L, Degenhardt L, Moses M, Farvid M, Griswold M, Criqui M, Bell M, Nguyen M, Wallin M, Mirarefin M, Qorbani M, Younis M, Fullman N, Liu P, Briant P, Fona P, Havmollet R, Leung R, Kimokoti R, Bazargan-Hejazi S, Hay SI, Yadgir S, Birjyukov S, Vollset SE, Alam T, Frank T, Farid T, Miller T, Vos T, Bärnihausen T, Gebrehlwot TT, Yano Y, Al-Aly Z, Mehari A, Handal A, Kandel A, Anderson B, Biroscak B, Mozaffarian D, Dorsey ER, Ding EL, Park EK, Wagner G, Hu G, Chen H, Sunshine JE, Khubchandani J, Leasher J, Leung J, Salomon JE, Unutzer J, Cahil L, Cooper L, Horino M, Brauer M, Breitborde N, Hotez P, Topor-Madry R, Soneji S, Stranges S, James S, Amrock S, Jayaraman S, Patel T, Akinyemiju T, Skirbekk V, Kinfu Y, Bhutta JB, Murray CJL (2018) The state of US health, 1999–2016: burden of diseases, injuries and risk factors among Us states. JAMA 319(14):1444–1472. https://doi.org/10.1001/jama.2018.0158. (Published online 2018 Apr 10)CrossRefPubMedPubMedCentral Mokdad AH, Ballestros K, Echko M, Glenn S, Olsen HE, Mullany E, Lee A, Khan AR, Ahmadi R, Ferrari AJ, Kasaeian A, Werdecker A, Carter A, Zipkin B, Sartorius B, Serdar B, Sykes BL, Troeger C, Fitzmaurice C, Rehm CD, Santomauro D, Kim D, Colombara D, Schwebel DC, Tsoi D, Kolte D, Nsoesie E, Nichols E, Oren E, Charlson FJ, Patton CG, Roth GA, Hosgood HD, Whitford HA, Kyu H, Erskine HE, Huang H, Martopullo I, Singh JA, Nachega JB, Sanabria JR, Abbas K, Ong K, Tabb K, Krohn KJ, Cornaby L, Degenhardt L, Moses M, Farvid M, Griswold M, Criqui M, Bell M, Nguyen M, Wallin M, Mirarefin M, Qorbani M, Younis M, Fullman N, Liu P, Briant P, Fona P, Havmollet R, Leung R, Kimokoti R, Bazargan-Hejazi S, Hay SI, Yadgir S, Birjyukov S, Vollset SE, Alam T, Frank T, Farid T, Miller T, Vos T, Bärnihausen T, Gebrehlwot TT, Yano Y, Al-Aly Z, Mehari A, Handal A, Kandel A, Anderson B, Biroscak B, Mozaffarian D, Dorsey ER, Ding EL, Park EK, Wagner G, Hu G, Chen H, Sunshine JE, Khubchandani J, Leasher J, Leung J, Salomon JE, Unutzer J, Cahil L, Cooper L, Horino M, Brauer M, Breitborde N, Hotez P, Topor-Madry R, Soneji S, Stranges S, James S, Amrock S, Jayaraman S, Patel T, Akinyemiju T, Skirbekk V, Kinfu Y, Bhutta JB, Murray CJL (2018) The state of US health, 1999–2016: burden of diseases, injuries and risk factors among Us states. JAMA 319(14):1444–1472. https://​doi.​org/​10.​1001/​jama.​2018.​0158. (Published online 2018 Apr 10)CrossRefPubMedPubMedCentral
25.
Zurück zum Zitat Morel LJ, Giros B, Daugé V (2009) Adolescent exposure to chronic delt-9-tetrahydrocannabinol blocks opiate dependence in maternally deprived rats. Neuropsychopharmacology 34(11):2469–2476CrossRefPubMed Morel LJ, Giros B, Daugé V (2009) Adolescent exposure to chronic delt-9-tetrahydrocannabinol blocks opiate dependence in maternally deprived rats. Neuropsychopharmacology 34(11):2469–2476CrossRefPubMed
27.
Zurück zum Zitat Navarro M, Carrera MR, Fratta W, Valverde O, Cossu G, Fattore L, Chowen JA, Gomez R, del Arco I, Villanua MA, Maldonado R, Koob GF, de Fonseca FR (2001) functional interaction between opioid and cannabinoid receptors in drug self-administration. J Neurosci. 21(14):5344–5350CrossRefPubMedPubMedCentral Navarro M, Carrera MR, Fratta W, Valverde O, Cossu G, Fattore L, Chowen JA, Gomez R, del Arco I, Villanua MA, Maldonado R, Koob GF, de Fonseca FR (2001) functional interaction between opioid and cannabinoid receptors in drug self-administration. J Neurosci. 21(14):5344–5350CrossRefPubMedPubMedCentral
28.
Zurück zum Zitat Navarro M, Chowen J, Carrera MRA, del Arco I, Villanúa MA, Martin Y, Roberts AJ, Koob GF, de Fonseca FR (1998) CB1 cannabinoid receptor antagonist-induced opiate withdrawal in morphine-dependent rats. NeuroReport 9(15):3397–3402CrossRefPubMed Navarro M, Chowen J, Carrera MRA, del Arco I, Villanúa MA, Martin Y, Roberts AJ, Koob GF, de Fonseca FR (1998) CB1 cannabinoid receptor antagonist-induced opiate withdrawal in morphine-dependent rats. NeuroReport 9(15):3397–3402CrossRefPubMed
29.
Zurück zum Zitat Reiman A (2009) Cannabis as a substitute for alcohol and other drugs. Harm Reduct J 2009(6):35CrossRef Reiman A (2009) Cannabis as a substitute for alcohol and other drugs. Harm Reduct J 2009(6):35CrossRef
30.
Zurück zum Zitat Salio C, Fischer J, Franzoni MF, Mackie K, Taneko T, Conrath M (2001) CB-1 Cannabinid and µ-opioid receptor co-localization on postsynaptic target in the rat dorsal horn. NeuroReport 12(17):3689–3692CrossRefPubMed Salio C, Fischer J, Franzoni MF, Mackie K, Taneko T, Conrath M (2001) CB-1 Cannabinid and µ-opioid receptor co-localization on postsynaptic target in the rat dorsal horn. NeuroReport 12(17):3689–3692CrossRefPubMed
31.
Zurück zum Zitat Scavone JL, Sterling RC, Van Bockstale EJ (2013) Cannabinoid and opiod interactions: implications for opiate dependence and withdrawal. Neuroscience 248(17):637–654CrossRefPubMed Scavone JL, Sterling RC, Van Bockstale EJ (2013) Cannabinoid and opiod interactions: implications for opiate dependence and withdrawal. Neuroscience 248(17):637–654CrossRefPubMed
33.
Zurück zum Zitat Skopp G, Strohbeck-Kuehner P, Mann K, Hermann D (2007) Deposition of cannabinoids in hair after long-term use of cannabis. Forensic Sci Int 170(1):46–50CrossRefPubMed Skopp G, Strohbeck-Kuehner P, Mann K, Hermann D (2007) Deposition of cannabinoids in hair after long-term use of cannabis. Forensic Sci Int 170(1):46–50CrossRefPubMed
36.
Zurück zum Zitat Viganò D, Rubino T, Parolaro D (2005) Molecular and cellular basis of cannabinoid and opioid interactions. Pharmacol Bichem Behav 81(2):360–368CrossRef Viganò D, Rubino T, Parolaro D (2005) Molecular and cellular basis of cannabinoid and opioid interactions. Pharmacol Bichem Behav 81(2):360–368CrossRef
39.
Zurück zum Zitat Yamaguchi T, Hagiwara T, Tanaka H, Sugiura S, Waku K, Shoyama Y, Watanabe S, Yamamoto T (2001) Endogenous cannabinoid, 2-arachidonoylglygerol, attenuaes naloxone-precipitated withdrawal signs in morphine-dependent mice. Brain Res 909(1–2):121–126CrossRefPubMed Yamaguchi T, Hagiwara T, Tanaka H, Sugiura S, Waku K, Shoyama Y, Watanabe S, Yamamoto T (2001) Endogenous cannabinoid, 2-arachidonoylglygerol, attenuaes naloxone-precipitated withdrawal signs in morphine-dependent mice. Brain Res 909(1–2):121–126CrossRefPubMed
Metadaten
Titel
Does cannabis use substitute for opioids? A preliminary exploratory survey in opioid maintenance patients
verfasst von
Nina Kim Bekier
Ulrich Frischknecht
Katharina Eidenmueller
Franz Grimm
Patrick Bach
Manuel Stenger
Falk Kiefer
Derik Hermann
Publikationsdatum
19.03.2024
Verlag
Springer Berlin Heidelberg
Erschienen in
European Archives of Psychiatry and Clinical Neuroscience
Print ISSN: 0940-1334
Elektronische ISSN: 1433-8491
DOI
https://doi.org/10.1007/s00406-023-01718-3

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