Background
Methods
Data sources and searches
Inclusion criteria
Exclusion criteria
Data extraction and quality assessment
Statistical analysis
Results
Basic characteristics and quality assessment
References | Country | No. of Patients (RF/Control) | Treatment Gender (M/F) | Control Gender (M/F) | Mean age (years) (RF/Control) | Kellgren-Lawrence grade | BMI (RF/Control) | Disease courses (years) (RF/Control) | Treatment pain score baseline | Control pain score baseline |
---|---|---|---|---|---|---|---|---|---|---|
[21] | Korea | 17/18 | 2/15 | 3/15 | 67.9/66.5 | NA | 26.2/26.5 | 6.3/7.4 | 7.82 (1.38) | 7.72 (0.75) |
[22] | China | 17/19 | NA | NA | NA | 1–3 | NA | NA | 7.26 (1.34) | 7.19 (1.57) |
[23] | Iran | 24/26 | 11/13 | 10/16 | 57.0/60.6 | 3–4 | NA | NA | 7.08 (1.41) | 7.11 (1.03) |
[24] | China | 31/31 | NA | NA | NA | NA | NA | NA | 7.25 (1.33) | 7.21 (1.58) |
[25] | China | 27/27 | 7/20 | 9/18 | 62.2/62.4 | 2–4 | NA | 5.01/4.96 | 7.12 (1.08) | 7.14 (1.03) |
[35] | China | 12/12 | 5/7 | 3/9 | 51.7/54.0 | 1–3 | NA | NA | 8.25 (0.62) | 8.16 (0.72) |
[26] | Turkey | 37/36 | 7/30 | 9/25 | 64.0/64.0 | 2–3 | 23.5/22.9 | 5/5 | NA | NA |
[27] | China | 45/47 | 17/28 | 20/27 | 66.1/65.9 | NA | 24.5/24.9 | 8.2/8.2 | 6.53 (1.10) | 6.38 (1.03) |
[28] | China | 49/47 | 12/37 | 11/36 | 56.5/61.5 | 3–4 | NA | 3.04/2.96 | 7.3 (1.2) | 7.3 (1.4) |
[29] | Egypt | 30/30 | 9/21 | 12/18 | 62.0/56.9 | 2–4 | 32.0/30.2 | 7.6/5.7 | 7.07 (0.2) | 7.07 (0.2) |
[30] | America | 76/75 | 26/50 | 26/49 | 63.0/66.0 | 3–4 | 30.6/30.4 | 10.7/8.6 | 7.3 (1.2) | 7.2 (1.0) |
[31] | UK | 15/15 | 6/9 | 6/9 | 63.0/63.0 | 2–4 | 31.0/31.0 | 5.6/4.3 | 6.3 (1.2) | 5.8 (1.2) |
[32] | America | 89/88 | 37/52 | 34/54 | 63.3/63.1 | 2–3 | 32.2/30.5 | 7.5/8.8 | NA | NA |
[33] | China | 26/27 | 10/16 | 12/15 | 59.5/60.9 | 3–4 | 24.6/25.8 | 2.7/2.9 | 6.46 (1.14) | 6.37 (0.93) |
[34] | Italy | 8/8 | 2/6 | 3/5 | 70.4/70.9 | NA | 29.5/29.6 | 9.6/10.4 | 8.25 (0.70) | 8.0 (1.19) |
References | Intervention | Control | Treatment target | Intervention parameters | Diagnostic nerve block | Scoring methods | Adverse effects | Follow-up time (weeks) |
---|---|---|---|---|---|---|---|---|
[21] | RFA | Shame-RFA | GN | 70 °C, 90 s | Yes | VAS, GPE, OKS | None reported | 1, 4,12 |
[22] | RFA | Intra-articular injection of sodium hyaluronate | GN | 70 °C, 120 s | No | VAS | None reported | 1, 4, 12 |
[23] | PRF | Intra-articular injection of dextrose | IA | 42 °C, 15 min | No | VAS | None reported | 1, 4,12 |
[24] | RFA | Intra-articular injection of sodium hyaluronate | GN | 70 °C, 120 s | No | VAS, OKS | None reported | 1, 4,12 |
[25] | RFA | Intra-articular injection of platelet-rich plasma and sodium hyaluronate | IA | 70 °C, 120 s | No | VAS | NA | 1, 12 |
[35] | PRF | Intra-articular injection of lidocaine and betamethasone | IA | 42 °C, 120 s | Yes | VAS, WOMAC | None reported | 1, 4, 12, 24 |
[26] | RFA | Intra-articular injection of bupivacaine, morphine, and betamethasone | GN | 80 °C, 90 s | No | WOMAC | NA | 4, 12 |
[27] | PRF | Oral celecoxib | IA | 42 °C, 120 s | No | VAS, WOMAC | NA | 4, 24 |
[28] | RFA | Intra-articular injection of sodium hyaluronate | GN | 60, 70, and 80˚C, 90 s | No | VAS | NA | 1, 12, 24 |
[29] | RFA | Oral paracetamol and NAIDS | GN | 80 °C, 270 s | No | VAS, WOMAC | None reported | 1, 12, 24 |
[30] | CRF | Intra-articular steroid | GN | 60 °C, 150 s | Yes | NRS, OKS | 34/30 | 4, 12, 24 |
[31] | CRMRF | Shame-CRMRF | IA | 15 min | No | VAS | None reported | 1, 4,12 |
[32] | CRF | Intra-articular injection of sodium hyaluronate | IA | 60 °C, 150 s | Yes | GPE, WOMAC | 18/9 | 4, 12, 24 |
[33] | RF thermocoagulation | Intra-articular steroid | GN | 70 °C, 120 s | No | GPE | None reported | 1, 4, 12, 24 |
[34] | PRF | Shame-PRF | IA | 42 °C, 120 s | Yes | NRS, OKS | None reported | 1, 4, 12, 24 |
Pain score
OKS/WOMAC scores
GPE scale
Adverse effects
Subgroup analysis
Outcomes | No. of trials | WMD (95% CI) | Z-value | P | Heterogeneity | |
---|---|---|---|---|---|---|
I2(%) | P | |||||
RF mode | ||||||
RFA | 6 | − 1.76 [− 2.30, − 1.22] | 6.39 | < 0.001 | 86 | < 0.001 |
Others | 4 | − 1.61 [− 2.32, − 0.89] | 4.39 | < 0.001 | 40 | 0.17 |
Location | ||||||
Asia | 8 | − 1.63 [− 2.07, − 1.20] | 7.31 | < 0.001 | 80 | < 0.001 |
Others | 2 | − 2.45 [− 3.46, − 1.43] | 4.73 | < 0.001 | 0 | 0.50 |
Site of radiofrequency | ||||||
Genicular nerve | 5 | − 1.64 [− 2.19, − 1.09] | 5.83 | < 0.001 | 84 | < 0.001 |
Intra-articular | 5 | − 1.83 [− 2.48, − 1.17] | 5.47 | < 0.001 | 56 | 0.06 |
Diagnosed nerve block | ||||||
Yes | 2 | − 1.11 [− 2.40, − 0.17] | 1.70 | 0.09 | 43 | 0.19 |
No | 8 | − 1.81 [− 2.27, − 1.35] | 7.71 | < 0.001 | 82 | < 0.001 |
Sex ratio (female/male) | ||||||
< 2 | 5 | − 1.51 [− 2.27, − 0.75] | 3.91 | < 0.001 | 65 | 0.06 |
≥ 2 | 5 | − 1.59 [− 2.15, − 1.02] | 5.50 | < 0.001 | 62 | 0.03 |
BMI | ||||||
< 30 | 2 | − 1.80 [− 3.29, − 0.31] | 2.37 | 0.02 | 82 | 0.02 |
≥ 30 | 2 | − 1.11 [− 2.40, 0.17] | 1.70 | 0.09 | 43 | 0.19 |