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Current Diabetes Reports
Erschienen in: Current Diabetes Reports 11/2014

01.11.2014 | Genetics (AP Morris, Section Editor)

Insights into the Genetic Susceptibility to Type 2 Diabetes from Genome-Wide Association Studies of Glycaemic Traits

verfasst von: Letizia Marullo, Julia S. El-Sayed Moustafa, Inga Prokopenko

Erschienen in: Current Diabetes Reports | Ausgabe 11/2014

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Abstract

Over the past 8 years, the genetics of complex traits have benefited from an unprecedented advancement in the identification of common variant loci for diseases such as type 2 diabetes (T2D). The ability to undertake genome-wide association studies in large population-based samples for quantitative glycaemic traits has permitted us to explore the hypothesis that models arising from studies in non-diabetic individuals may reflect mechanisms involved in the pathogenesis of diabetes. Amongst 88 T2D risk and 72 glycaemic trait loci, only 29 are shared and show disproportionate magnitudes of phenotypic effects. Important mechanistic insights have been gained regarding the physiological role of T2D loci in disease predisposition through the elucidation of their contribution to glycaemic trait variability. Further investigation is warranted to define causal variants within these loci, including functional characterisation of associated variants, to dissect their role in disease mechanisms and to enable clinical translation.
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Metadaten
Titel
Insights into the Genetic Susceptibility to Type 2 Diabetes from Genome-Wide Association Studies of Glycaemic Traits
verfasst von
Letizia Marullo
Julia S. El-Sayed Moustafa
Inga Prokopenko
Publikationsdatum
01.11.2014
Verlag
Springer US
Erschienen in
Current Diabetes Reports / Ausgabe 11/2014
Print ISSN: 1534-4827
Elektronische ISSN: 1539-0829
DOI
https://doi.org/10.1007/s11892-014-0551-8

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Fine Mapping of Type 2 Diabetes Susceptibility Loci

Psychosocial Aspects (KK Hood, Section Editor)

Assessing Premorbid Cognitive Ability in Adults With Type 2 Diabetes Mellitus—a Review With Implications for Future Intervention Studies

Pathogenesis of Type 1 Diabetes (A Pugliese, Section Editor)

Role of B Lymphocytes in the Pathogenesis of Type 1 Diabetes

Diabetes Epidemiology (NM Maruthur, Section Editor)

Beyond HbA1c and Glucose: the Role of Nontraditional Glycemic Markers in Diabetes Diagnosis, Prognosis, and Management

Transplantation (A Pileggi, Section Editor)

Type 2 Diabetes: Is Pancreas Transplantation an Option?

Microvascular Complications—Neuropathy (D Ziegler, Section Editor)

Microvascular Dysfunction in the Context of Diabetic Neuropathy

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