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Current Allergy and Asthma Reports

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31.08.2022 | Immune Deficiency and Dysregulation (C Kuo, Section Editor)

Is Icatibant Safe for the Treatment of Hereditary Angioedema During Pregnancy?

verfasst von: Daniel Victor Šimac, Tea Štimac, Srđan Novak

Erschienen in: Current Allergy and Asthma Reports | Ausgabe 10/2022

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Abstract

Purpose of Review

Hereditary angioedema (HAE) is a disorder affecting bradykinin regulation presenting as recurrent cutaneous or mucosal swelling. Treatment options include plasma-derived or human-recombinant C1-inhibitor, icatibant, or ecallantide. Due to the lack of knowledge and experience on the topic, the treatment of choice in pregnancy is plasma-derived C1-inhibitor, and reporting any new experience is recommended. This review presents current guidelines for HAE treatment with a focus on pregnancy and reviews all experience with icatibant use during pregnancy.

Recent Findings

Our experience of treating a pregnant nC1-INH HAE patient with icatibant is presented, with no adverse effects or abnormalities, to add to the growing knowledge of icatibant use during pregnancy.

Summary

Considering the limited number of attacks that our patient usually experiences, which continued at more or less the same frequency during pregnancy, we feel icatibant to be a safe choice for on-demand HAE treatment during pregnancy for such cases.

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Farkas H, Kojalmi KV, Veszeli N, Toth F, Varga L. First report of icatibant treatment in a pregnant patient with hereditary angioedema. J. Obstet. Gynaecol. Res. [Internet]. 2016;42(8):1026–8. Available from: https://obgyn.onlinelibrary.wiley.com/doi/abs/10.1111/jog.13003. [Accessed 27 Jan 2020].

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Boufleur K, Delcaro L, Cordeiro DL, Botelho Palhas PB, Fernandes de Melo Sousa J, Mendonca T, et al. Successful and safe use of icatibant for life-threatening angioedema attack during pregnancy in a patient with hereditary angioedema type 1. J Allergy Clin Immunol. [Internet]. 2014;133(2):AB36. Available from: https://www.jacionline.org/article/S0091-6749(13)02057-5/fulltext. [Accessed 02 Feb 2020].

13.

Hakl R, Kuklinek P, Krcmova I, Kralickova P, Freiberger T, Janku P, et al. Treatment of hereditary angioedema attacks with icatibant and recombinant C1 inhibitor during pregnancy. J Clin Immunol. [Internet]. 2018;38(7):810–815. Available from: https://link.springer.com/article/10.1007%2Fs10875-018-0553-4 . [Accessed 27 Jan 2020].

Titel: Is Icatibant Safe for the Treatment of Hereditary Angioedema During Pregnancy?
verfasst von: Daniel Victor Šimac
Tea Štimac
Srđan Novak
Publikationsdatum: 31.08.2022
Verlag: Springer US
Erschienen in: Current Allergy and Asthma Reports / Ausgabe 10/2022
Print ISSN: 1529-7322
Elektronische ISSN: 1534-6315
DOI: https://doi.org/10.1007/s11882-022-01040-3

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Springer Medizin

Is Icatibant Safe for the Treatment of Hereditary Angioedema During Pregnancy?

Abstract

Purpose of Review

Recent Findings

Summary

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Intrakapsuläre Tonsillektomie gewinnt an Boden

Bilateraler Hörsturz hat eine schlechte Prognose

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Springer Medizin

Abstract

Purpose of Review

Recent Findings

Summary

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Neu im Fachgebiet HNO

HNO-Op. auch mit über 90?

Intrakapsuläre Tonsillektomie gewinnt an Boden

Bilateraler Hörsturz hat eine schlechte Prognose

„Nur wer sich gut aufgehoben fühlt, kann auch für Patientensicherheit sorgen“

Update HNO