Annals of Hematology OnlineFirst articles

Open Access 25.04.2024 | Research

Hematocrit control and thrombotic risk in patients with polycythemia vera treated with ruxolitinib in clinical practice

Polycythemia vera (PV) is a myeloproliferative neoplasm characterized by unregulated red blood cell production resulting in elevated hemoglobin and/or hematocrit levels. Patients often have symptoms such as fatigue, pruritus, and painful …

verfasst von:: Aleksander Chojecki, Danielle Boselli, Allison Dortilus, Issam Hamadeh, Stephanie Begley, Tommy Chen, Rupali Bose, Nikolai Podoltsev, Amer M. Zeidan, Nicole Baranda Balmaceda, Abdulraheem Yacoub, Jing Ai, Thomas Gregory Knight, Brittany Knick Ragon, Nilay Arvind Shah, Srinivasa Reddy Sanikommu, James Symanowski, Ruben Mesa, Michael Richard Grunwald

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25.04.2024 | Review

Dermatologic manifestations of hematologic disorders

Distinguishing key morphologic features and understanding the pathophysiology of common cutaneous manifestations of hematologic disorders is essential to ensure prompt and appropriate treatment. In fact, classic cutaneous signs may provide the …

verfasst von:: Hannah L. King, Genevieve B. Benedetti, Jesse J. Keller, Thomas G. DeLoughery, Joseph J. Shatzel, Kylee L. Martens

25.04.2024 | Correspondence

Enhancing end-of-life care: ethical considerations and the role of social work in geriatric bone marrow biopsy decisions

verfasst von:: Shijie Guo, Guang Yang

25.04.2024 | Original Article

Systemic inflammatory autoimmune disease before allogeneic hematopoietic stem cell transplantation is a risk factor for death in patients with myelodysplastic syndrome or chronic myelomonocytic leukemia

Myelodysplastic syndrome (MDS) is well known to be complicated by systemic inflammatory autoimmune disease (SIADs). However, it remains unclear how the prognosis after allogenic hematopoietic stem cell transplantation (allo-HSCT) in patients with …

verfasst von:: Kumiyo Tazoe, Naonori Harada, Yosuke Makuuchi, Masatomo Kuno, Teruhito Takakuwa, Hiroshi Okamura, Asao Hirose, Mika Nakamae, Mitsutaka Nishimoto, Yasuhiro Nakashima, Hideo Koh, Masayuki Hino, Hirohisa Nakamae

25.04.2024 | Research

Daratumumab and venetoclax combined with CAGE for late R/R T-ALL/LBL patients: Single-arm, open-label, phase I study

The prognosis of patients diagnosed with relapsed or refractory (R/R) T-lymphoblastic leukemia/lymphoma (T-ALL/LBL) has consistently been unsatisfactory, with limited treatment options. As reports, the CAG regimen can serve as a salvage treatment …

verfasst von:: Hui Shi, Fan Yang, Miaomiao Cao, Teng Xu, Peihao Zheng, Yuelu Guo, Guoai Su, Shaomei Feng, Ruiting Li, Rui Liu, Haidi Liu, Lixia Ma, Xiaoyan Ke, Kai Hu

24.04.2024 | Original Article

Cytogenetic and epidemiological profile of chronic myeloid leukemia in Morocco

Chronic myeloid leukemia (CML) is a neoplastic disease of genetic origin resulting from clonal proliferation of hematopoietic stem cells (HSCs). The reciprocal translocation t(9;22)(q34;q11) is the main chromosomal abnormality involved in this …

verfasst von:: Sara Benchikh, Soro Somda Georgina Charlène, Amale Bousfiha, Lunda Razoki, Jamila Aboulfaraj, Latifa Zarouf, Adil El Hamouchi, Abderrahim Malki, Sanaa Nassereddine

24.04.2024 | Research

Unrelated umbilical cord blood transplantation with low-dose anti-thymocyte globulin for children with severe aplastic anemia: A case series

Aplastic anemia (AA) is a rare and life-threatening disorder characterized by the presence of hypocellular bone marrow resulting in progressive pancytopenia (low reticulocyte, granulocyte, and platelet count) without dysplasia or bone marrow …

verfasst von:: Mengze Hu, Junhui Li, Rong Liu, Zhaoxia Zhang, Shunqiao Feng, Dixiao Zhong, Ruihong Tang, Litian Xuan

23.04.2024 | Correspondence

Letter to Editor: Treatment with the apoptosis inhibitor asunercept reduces clone sizes in patients with lower risk myelodysplastic neoplasms

verfasst von:: Syeda Dua e Zehra Zaidi, Syeda Mahrukh Fatima Zaidi, Burhanuddin Sohail Rangwala

23.04.2024 | Correspondence

Triple a score (AAA: age, absolute neutrophil count and absolute lymphocyte count) and its prognostic utility in patients with overt fibrotic and prefibrotic myelofibrosis

verfasst von:: Marko Lucijanic, Ivan Krecak, Davor Galusic, Hrvoje Holik, Vlatka Perisa, Martina Moric Peric, Ivan Zekanovic, Josipa Budimir, Danijela Lekovic, Rajko Kusec

Open Access 23.04.2024 | Research

Association of JAK2V617F allele burden and clinical correlates in polycythemia vera: a systematic review and meta-analysis

Janus kinase 2 (JAK2) V617F mutation is present in most patients with polycythemia vera (PV). One persistently puzzling aspect unresolved is the association between JAK2V617F allele burden (also known as variant allele frequency) and the relevant …

verfasst von:: Chih-Cheng Chen, Justin L. Chen, Alex Jia-Hong Lin, Lennex Hsueh-Lin Yu, Hsin-An Hou

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23.04.2024 | Review

SARS-CoV-2 infection-induced immune thrombocytopenia: a systematic review of current reports

Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by a low platelet count with increased risk of bleeding, and viral infection may trigger ITP. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection-induced ITP …

verfasst von:: Ryohei Ono, Izumi Kitagawa

22.04.2024 | Research

Multi-center study of COVID-19 infection in elderly patients with lymphoma: on behalf of Jiangsu Cooperative Lymphoma Group (JCLG)

Elderly patients with lymphoproliferative diseases (LPD) are vulnerable to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Here, we retrospectively described the clinical features and outcomes of the first time infection of …

verfasst von:: Huayuan Zhu, Xiao Lu, Xiaoping Zhang, Haiying Hua, Jie Zhang, Yuqing Miao, Weiying Gu, Min Xu, Xuzhang Lu, Bingzong Li, Chunling Wang, Haiwen Ni, Jun Qian, Jinning Shi, Maozhong Xu, Guangqi Wu, Yunping Zhang, Qiudan Shen, Zhi Wang, Jianfeng Zhu, Zhen Cheng, Wanchuan Zhuang, Guoqiang Lin, Yongjun Hu, Qiurong Shan, Yifei Chen, Hongchun Qiu, Jianyong Li, Wenyu Shi

22.04.2024 | Original Article

Mendelian randomization of circulating proteome identifies IFN-γ as a druggable target in aplastic anemia

Aplastic anemia (AA) is a kind of bone marrow failure (BMF) characterized by pancytopenia with a hypoplasia/aplasia bone marrow [ 1 ]. Patients with AA present with infections due to neutropenia, bleeding due to thrombocytopenia, and/or fatigue due …

verfasst von:: Shanshan Qin, Yingxin Jiang, Yang Ou, Yanxia Zhan, Lili Ji, Pengcheng Xu, Xia Shao, Hao Chen, Tong Chen, Yunfeng Cheng

22.04.2024 | Research

Bortezomib elevates intracellular free Fe2+ by enhancing NCOA4-mediated ferritinophagy and synergizes with RSL-3 to inhibit multiple myeloma cells

Iron contributes to tumor initiation and progression; however, excessive intracellular free Fe2+ can be toxic to cancer cells. Our findings confirmed that multiple myeloma (MM) cells exhibited elevated intracellular iron levels and increased …

verfasst von:: Yanyan Zhang, Fen He, Wei Hu, Jingqi Sun, Hongyan Zhao, Yuzhi Cheng, Zhanyou Tang, Jiarui He, Xiangyuan Wang, Tairan Liu, Cong Luo, Zhongwei Lu, Mei Xiang, Yiting Liao, Yihao Wang, Junjun Li, Jiliang Xia

20.04.2024 | Original Article

Expert consensus on the management of infusion-related reactions (IRRs) in patients with sickle cell disease (SCD) receiving crizanlizumab: a RAND/UCLA modified Delphi panel

Crizanlizumab, a monoclonal antibody against P-selectin, has been shown to reduce vaso-occlusive crises (VOCs) compared to placebo in patients ≥ 16 years with sickle cell disease (SCD). However, there have been rare reports of patients …

verfasst von:: Julie Kanter, Kenneth I. Ataga, Neha Bhasin, Stephanie Guarino, Abdullah Kutlar, Sophie Lanzkron, Deepa Manwani, Patrick McGann, Sean R. Stowell, Venée N. Tubman, Irina Yermilov, Cynthia Campos, Michael S. Broder

19.04.2024 | Case Report

Diagnosing aceruloplasminemia: navigating through red herrings

A 58-year-old female was found to have hyperferritinemia (Serum ferritin:1683 ng/mL) during work-up for mild normocytic anemia. Transferrin saturation(TSAT) was low-normal. Magnetic resonance imaging (MRI) abdomen showed evidence of hepatic iron …

verfasst von:: Zeni Kharel, Himal Kharel, Pradyumna D. Phatak

19.04.2024 | Research

Psychological and physical side effects during G-CSF mobilization in related donors of allo-HCT

The psychological side effects of granulocyte colony-stimulating factor mobilization in related donors of allogeneic hematopoietic cell transplantation (allo-HCT) and impacts of psychological/physical side effects on harvest outcomes remain …

verfasst von:: Lingxia Cai, Diange Jin, Jianbo Lai, Lin Li, Yi Luo, Jimin Shi, Xiaoyu Lai, Lizhen Liu, Yanmin Zhao, Jian Yu, Yunfei Qiu, Kaixia Song, Fangquan Yu, Qinna Guo, Aiyun Jin, He Huang, Shuyi Ding, Yishan Ye

Open Access 18.04.2024 | Research

COVID-19 severity in patients with chronic lymphocytic leukemia treated with venetoclax: a single-center observational cohort study

Patients with chronic lymphocytic leukemia (CLL) are at high risk of developing severe COVID-19. The present study was undertaken to elucidate COVID-19 related morbidity and mortality in CLL patients treated with venetoclax. We present a …

verfasst von:: Sophie Thau, Christian Bjørn Poulsen, Christian Brieghel, Morten Kranker Larsen, Lothar Wiese, Xiaohui Chen Nielsen, Lars Møller Pedersen

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18.04.2024 | Research

Pharmacogenetic guided versus standard warfarin dosing for routine clinical care with its pharmacoeconomic impact: a randomized controlled clinical trial

Warfarin still plays a role in the era of novel direct oral anticoagulants [ 1 ]. The possible reasons could be lower cost, wide availability, long clinical experience, and preferential use in prosthetic heart valve patients, children, and those …

verfasst von:: Aishwarya Anand, Naveen C Hegde, Pulkit Chhabra, Jai Purohit, Rupesh Kumar, Ankur Gupta, Deepesh P Lad, Ritin Mohindra, Saurabh Mehrotra, Rajesh Vijayvergiya, Basant Kumar, Vishal Sharma, Pankaj Malhotra, Jasmina Ahluwalia, Reena Das, Amol N Patil, Nusrat Shafiq, Samir Malhotra

18.04.2024 | Research

Immune reconstitution after single-unit umbilical cord blood transplantation using anti-thymoglobulin and myeloablative conditioning in adults with hematological malignancies

This study aimed to investigate the kinetics of immune recovery following umbilical cord blood transplantation (UCBT) in adults who received a myeloablative conditioning (MAC) regimen and antithymocyte globulin (ATG). While the immune recovery …

verfasst von:: Lourdes Cordón, Pedro Chorão, Beatriz Martín-Herreros, Juan Montoro, Aitana Balaguer, Manuel Guerreiro, Marta Villalba, Ana Facal, Pedro Asensi, Pilar Solves, Inés Gómez, Marta Santiago, Brais Lamas, Ana Bataller, Pablo Granados, Amparo Sempere, Guillermo F. Sanz, Miguel A. Sanz, Jaime Sanz

Springer Medizin