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Head and Neck Pathology

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04.07.2018 | Case Report

Malignant Transformation of a Desmoplastic Ameloblastoma to Squamous Cell Carcinoma: A Case Report

verfasst von: Rehan Rais, Samir K. El-Mofty

Erschienen in: Head and Neck Pathology | Ausgabe 4/2019

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Abstract

Ameloblastomas are the most common odontogenic tumors, excluding odontomas. Several morphologic variants have been described including follicular, plexiform, acanthomatous, granular cell, basaloid and desmoplastic. Desmoplastic ameloblastoma differs from other conventional ameloblastomas microscopically, clinically, and radiographically. Ameloblastic carcinoma, the malignant counterpart of ameloblastoma is characterized by cytologic features of malignancy combined within the overall histologic features of conventional ameloblastoma. Malignant transformation of ameloblastoma to squamous cell carcinoma is a controversial subject. Here we report a case of a desmoplastic ameloblastoma with malignant transformation to squamous cell carcinoma in a 49 year old African American man. The patient underwent tumor resection and radiation therapy with no evidence of disease recurrence or progression 16 months post operatively. To our knowledge malignant transformation of a desmoplastic ameloblastoma to squamous cell carcinoma has not so far been reported. This observation may lend some support to the argument that desmoplastic ameloblastoma is phenotypically and biologically distinct entity.

El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ. WHO classification of head and neck tumours, 8. Lyon: International Agency for Research on Cancer; 2017; pp. 215–222.

Eversole LR, Leider AS, Hansen LS. Ameloblastomas with pronounced stromal desmoplasia. J Oral Maxillofac Surg. 1984;42:735–40.CrossRef

Waldron CA, El-Mofty SK. A histopathologic study of 116 ameloblastomas with special reference to the desmoplastic variant. Oral Surg Oral Med Oral Pathol. 1987;63:441–51.CrossRef

Barnes L, Eveson JW, Reichart P, Sidransky D. World Health Organization classification of tumours: pathology and genetics, head and neck tumours. Lyon: IARC Press; 2005.

Takata T, Miyauchi M, Ito H, Ogawa I, Kudo Y, Zhao M, Sato S, Takekoshi T, Nikai H, Tanimoto K. Clinical and histopathological analyses of desmoplastic ameloblastoma. Pathol Res Pract. 1999;195(10):669–75.CrossRef

Kishino M, Murakami S, Fukuda Y, Ishida T. Pathology of the desmoplastic ameloblastoma. J Oral Pathol Med. 2001;30(1):35–40.CrossRef

Sun ZJ, Wu YR, Cheng N, Zwahlen RA, Zhao YF. Desmoplastic ameloblastoma—a review. Oral Oncol. 2009;45(9):752–9. https://doi.org/10.1016/j.oraloncology.2009.01.016.CrossRefPubMedPubMedCentral

Li B, Long X, Wang S, Cheng Y, Chen X. Clinical and radiologic features of desmoplastic ameloblastoma. J Oral Maxillofac Surg. 2011;69(8):2173–85. https://doi.org/10.1016/j.joms.2010.09.015.CrossRefPubMed

González-García R, Sastre-Pérez J, Nam-Cha SH, Muñoz-Guerra MF, Rodríguez-Campo FJ, Naval-Gías L. Primary intraosseous carcinomas of the jaws arising within an odontogenic cyst, ameloblastoma, and de novo: report of new cases with reconstruction considerations. Oral Surg Oral Med Oral Pathol Oral Radiol Endodontol. 2007;103(2):e29–33.CrossRef

10.

Hamakawa H, Kayahara H, Sumida T, Tanioka H. Mandibular intraosseous carcinoma coexisting with ameloblastoma. J Oral Maxillofac Surg. 2000;58(4):430–3.CrossRef

11.

Sheikh S, Pallagatti S, Singla I, Kalucha A. Desmoplastic ameloblastoma: a case report. J Dent Res Dent Clin Dent Prospects. 2011;5(1):27–32.PubMedPubMedCentral

12.

Pillai RS, Ongole R, Ahsan A, Radhakrishnan RA, Pai KM. Recurrent desmoplastic ameloblastoma of the maxilla: a case report. J Can Dent Assoc. 2004;70(2):100–4.PubMed

13.

Neville BW. Oral and maxillofacial pathology. 15. St. Louis: Saunders; 2009. pp. 707–10.

14.

Chen Y-W, Li W-Y, Kao S-Y. Synchronous oral squamous cell carcinoma and ameloblastoma in a patient and using CK8 expression as an aid to differential diagnosis—case analysis. Taiwan J Oral Maxillofac Surg. 2008;19:170–8.

15.

Hijioka H, Nishihara K, Suzuki H, et al. Primary intraosseous squamous cell carcinoma arising from ameloblastoma of the mandible: a case report. J Oral Maxillofac Surg Med Pathol. 2015;27(5):693–7.CrossRef

16.

Ueta E, Yoneda K, Ohno A, Osaki T. Intraosseous carcinoma arising from mandibular ameloblastoma with progressive invasion and pulmonary metastasis. Int J Oral Maxillofac Surg. 1996;25(5):370–2.CrossRef

17.

Brown NA, Betz BL. Ameloblastoma. A review of recent molecular pathogenetic discoveries. Biomark Cancer. 2015;7(Suppl 2):19–24. https://doi.org/10.4137/BIC.S29329.CrossRefPubMedPubMedCentral

18.

Weber A, Langhanki L, Sommerer F, Markwarth A, Wittekind C, Tannapfel A. Mutations of the BRAF gene in squamous cell carcinoma of the head and neck. Oncogene 2003;22(30):4757–9.CrossRef

Titel: Malignant Transformation of a Desmoplastic Ameloblastoma to Squamous Cell Carcinoma: A Case Report
verfasst von: Rehan Rais
Samir K. El-Mofty
Publikationsdatum: 04.07.2018
Verlag: Springer US
Erschienen in: Head and Neck Pathology / Ausgabe 4/2019
Elektronische ISSN: 1936-0568
DOI: https://doi.org/10.1007/s12105-018-0946-y

Springer Medizin

Malignant Transformation of a Desmoplastic Ameloblastoma to Squamous Cell Carcinoma: A Case Report

Abstract

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Abstract

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