Skip to main content
Erschienen in: Current Diabetes Reports 9/2016

01.09.2016 | Treatment of Type 1 Diabetes (M Pietropaolo, Section Editor)

Management of Hypoglycemia in Children and Adolescents with Type 1 Diabetes Mellitus

verfasst von: Dayna E. McGill, Lynne L. Levitsky

Erschienen in: Current Diabetes Reports | Ausgabe 9/2016

Einloggen, um Zugang zu erhalten

Abstract

Hypoglycemia and fear of hypoglycemia limit appropriate glycemic control in many children and adolescents with type 1 diabetes. Traditional approaches to the prevention of hypoglycemia including patient education about modifiable risk factors for hypoglycemia (changes in insulin, diet, and exercise) and frequency of self glucose monitoring remain important for hypoglycemia prevention. Continuous glucose monitoring systems with or without a partial closed-loop control of insulin infusion have been very useful in the prevention of hypoglycemia. Oral carbohydrate and parenteral glucagon continue to be the mainstays of hypoglycemia treatment. In the future, we can look forward to regulatory approval of closed-loop insulin delivery and glucose monitoring systems to facilitate euglycemia, as well as glucagon administered by the intranasal route to treat hypoglycemia.
Literatur
1.
Zurück zum Zitat Karges B, Kapellen T, Wagner VM, Steigleder-Schweiger C, Karges W, Holl RW, et al. Glycated hemoglobin A1c as a risk factor for severe hypoglycemia in pediatric type 1 diabetes. Pediat Diabetes 2015. doi:10.1111/pedi.12348 Karges B, Kapellen T, Wagner VM, Steigleder-Schweiger C, Karges W, Holl RW, et al. Glycated hemoglobin A1c as a risk factor for severe hypoglycemia in pediatric type 1 diabetes. Pediat Diabetes 2015. doi:10.​1111/​pedi.​12348
2.
Zurück zum Zitat Barnard K, Thomas S, Royle P, Noyes K, Waugh N. Fear of hypoglycaemia in parents of young children with type 1 diabetes: a systematic review. BMC Pediatr. 2010;10:50.CrossRefPubMedPubMedCentral Barnard K, Thomas S, Royle P, Noyes K, Waugh N. Fear of hypoglycaemia in parents of young children with type 1 diabetes: a systematic review. BMC Pediatr. 2010;10:50.CrossRefPubMedPubMedCentral
3.
Zurück zum Zitat Johnson SR, Cooper MN, Davis EA, Jones TW. Hypoglycaemia, fear of hypoglycaemia and quality of life in children with Type 1 diabetes and their parents. Diabetic Med: J Br Diabetic Assoc. 2013;30:1126–31.CrossRef Johnson SR, Cooper MN, Davis EA, Jones TW. Hypoglycaemia, fear of hypoglycaemia and quality of life in children with Type 1 diabetes and their parents. Diabetic Med: J Br Diabetic Assoc. 2013;30:1126–31.CrossRef
4.
Zurück zum Zitat Freckleton E, Sharpe L, Mullan B. The relationship between maternal fear of hypoglycaemia and adherence in children with type-1 diabetes. Int J Behav Med. 2014;21:804–10.CrossRefPubMed Freckleton E, Sharpe L, Mullan B. The relationship between maternal fear of hypoglycaemia and adherence in children with type-1 diabetes. Int J Behav Med. 2014;21:804–10.CrossRefPubMed
5.
Zurück zum Zitat Arbelaez AM, Semenkovich K, Hershey T. Glycemic extremes in youth with T1DM: the structural and functional integrity of the developing brain. Pediatr Diabetes. 2013;14:541–53.CrossRefPubMed Arbelaez AM, Semenkovich K, Hershey T. Glycemic extremes in youth with T1DM: the structural and functional integrity of the developing brain. Pediatr Diabetes. 2013;14:541–53.CrossRefPubMed
6.
Zurück zum Zitat McNeilly AD, McCrimmon RJ. The Scylla and Charybdis of glucose control in childhood type 1 diabetes? Pediatr Diabetes. 2015;16:235–41.CrossRefPubMed McNeilly AD, McCrimmon RJ. The Scylla and Charybdis of glucose control in childhood type 1 diabetes? Pediatr Diabetes. 2015;16:235–41.CrossRefPubMed
7.
Zurück zum Zitat Cameron FJ. The impact of diabetes on brain function in childhood and adolescence. Pediatr Clin N Am. 2015;62:911–27.CrossRef Cameron FJ. The impact of diabetes on brain function in childhood and adolescence. Pediatr Clin N Am. 2015;62:911–27.CrossRef
8.
9.••
Zurück zum Zitat Mauras N, Mazaika P, Buckingham B, Weinzimer S, White NH, Tsalikian E, et al. Longitudinal assessment of neuroanatomical and cognitive differences in young children with type 1 diabetes: association with hyperglycemia. Diabetes. 2015;64:1770–9. This paper suggests that chronic hyperglycemia is much more likely to induce neuroanatomic structural changes and congitive loss than hypoglycemia.CrossRefPubMed Mauras N, Mazaika P, Buckingham B, Weinzimer S, White NH, Tsalikian E, et al. Longitudinal assessment of neuroanatomical and cognitive differences in young children with type 1 diabetes: association with hyperglycemia. Diabetes. 2015;64:1770–9. This paper suggests that chronic hyperglycemia is much more likely to induce neuroanatomic structural changes and congitive loss than hypoglycemia.CrossRefPubMed
10.
Zurück zum Zitat Marzelli MJ, Mazaika PK, Barnea-Goraly N, Hershey T, Tsalikian E, Tamborlane W, et al. Neuroanatomical correlates of dysglycemia in young children with type 1 diabetes. Diabetes. 2014;63:343–53.CrossRefPubMed Marzelli MJ, Mazaika PK, Barnea-Goraly N, Hershey T, Tsalikian E, Tamborlane W, et al. Neuroanatomical correlates of dysglycemia in young children with type 1 diabetes. Diabetes. 2014;63:343–53.CrossRefPubMed
11.
Zurück zum Zitat Barnea-Goraly N, Raman M, Mazaika P, Marzelli M, Hershey T, Weinzimer SA, et al. Alterations in white matter structure in young children with type 1 diabetes. Diabetes Care. 2014;37:332–40.CrossRefPubMedPubMedCentral Barnea-Goraly N, Raman M, Mazaika P, Marzelli M, Hershey T, Weinzimer SA, et al. Alterations in white matter structure in young children with type 1 diabetes. Diabetes Care. 2014;37:332–40.CrossRefPubMedPubMedCentral
12.
Zurück zum Zitat Hershey T, Perantie DC, Wu J, Weaver PM, Black KJ, White NH. Hippocampal volumes in youth with type 1 diabetes. Diabetes. 2010;59:236–41.CrossRefPubMed Hershey T, Perantie DC, Wu J, Weaver PM, Black KJ, White NH. Hippocampal volumes in youth with type 1 diabetes. Diabetes. 2010;59:236–41.CrossRefPubMed
13.
Zurück zum Zitat Perantie DC, Wu J, Koller JM, Lim A, Warren SL, Black KJ, et al. Regional brain volume differences associated with hyperglycemia and severe hypoglycemia in youth with type 1 diabetes. Diabetes Care. 2007;30:2331–7.CrossRefPubMed Perantie DC, Wu J, Koller JM, Lim A, Warren SL, Black KJ, et al. Regional brain volume differences associated with hyperglycemia and severe hypoglycemia in youth with type 1 diabetes. Diabetes Care. 2007;30:2331–7.CrossRefPubMed
14.•
Zurück zum Zitat Wilson DM, Calhoun PM, Maahs DM, Chase HP, Messer L, Buckingham BA, et al. Factors associated with nocturnal hypoglycemia in at-risk adolescents and young adults with type 1 diabetes. Diabetes Technol Ther. 2015;17:385–91. This paper examines the correlates of nocturnal hypoglycemia with exercise and other behaviors.CrossRefPubMedPubMedCentral Wilson DM, Calhoun PM, Maahs DM, Chase HP, Messer L, Buckingham BA, et al. Factors associated with nocturnal hypoglycemia in at-risk adolescents and young adults with type 1 diabetes. Diabetes Technol Ther. 2015;17:385–91. This paper examines the correlates of nocturnal hypoglycemia with exercise and other behaviors.CrossRefPubMedPubMedCentral
15.
Zurück zum Zitat Chiang JL, Kirkman MS, Laffel LM, Peters AL. Type 1 diabetes through the life span: a position statement of the American Diabetes Association. Diabetes Care. 2014;37:2034–54.CrossRefPubMed Chiang JL, Kirkman MS, Laffel LM, Peters AL. Type 1 diabetes through the life span: a position statement of the American Diabetes Association. Diabetes Care. 2014;37:2034–54.CrossRefPubMed
16.••
Zurück zum Zitat Seaquist ER, Anderson J, Childs B, Cryer P, Dagogo-Jack S, Fish L, et al. Hypoglycemia and diabetes: a report of a workgroup of the American Diabetes Association and the Endocrine Society. J Clin Endocrinol Metab. 2013;98:1845–59. This consensus review discusses the etiology and prevention of hypoglycemia in people with diabetes across the lifespan.CrossRefPubMed Seaquist ER, Anderson J, Childs B, Cryer P, Dagogo-Jack S, Fish L, et al. Hypoglycemia and diabetes: a report of a workgroup of the American Diabetes Association and the Endocrine Society. J Clin Endocrinol Metab. 2013;98:1845–59. This consensus review discusses the etiology and prevention of hypoglycemia in people with diabetes across the lifespan.CrossRefPubMed
17.
Zurück zum Zitat McMahon SK, Ferreira LD, Ratnam N, Davey RJ, Youngs LM, Davis EA, et al. Glucose requirements to maintain euglycemia after moderate-intensity afternoon exercise in adolescents with type 1 diabetes are increased in a biphasic manner. J Clin Endocrinol Metab. 2007;92:963–8.CrossRefPubMed McMahon SK, Ferreira LD, Ratnam N, Davey RJ, Youngs LM, Davis EA, et al. Glucose requirements to maintain euglycemia after moderate-intensity afternoon exercise in adolescents with type 1 diabetes are increased in a biphasic manner. J Clin Endocrinol Metab. 2007;92:963–8.CrossRefPubMed
18.
Zurück zum Zitat Tsalikian E, Mauras N, Beck RW, Tamborlane WV, Janz KF, Chase HP, et al. Impact of exercise on overnight glycemic control in children with type 1 diabetes mellitus. J Pediatr. 2005;147:528–34.CrossRefPubMed Tsalikian E, Mauras N, Beck RW, Tamborlane WV, Janz KF, Chase HP, et al. Impact of exercise on overnight glycemic control in children with type 1 diabetes mellitus. J Pediatr. 2005;147:528–34.CrossRefPubMed
19.••
Zurück zum Zitat Metcalf KM, Singhvi A, Tsalikian E, Tansey MJ, Zimmerman MB, Esliger DW, et al. Effects of moderate-to-vigorous intensity physical activity on overnight and next-day hypoglycemia in active adolescents with type 1 diabetes. Diabetes Care. 2014;37:1272–8. This study confirms the effects of the timing of exercise on glycemia for a day or more.CrossRefPubMedPubMedCentral Metcalf KM, Singhvi A, Tsalikian E, Tansey MJ, Zimmerman MB, Esliger DW, et al. Effects of moderate-to-vigorous intensity physical activity on overnight and next-day hypoglycemia in active adolescents with type 1 diabetes. Diabetes Care. 2014;37:1272–8. This study confirms the effects of the timing of exercise on glycemia for a day or more.CrossRefPubMedPubMedCentral
20.
Zurück zum Zitat Gomez AM, Gomez C, Aschner P, Veloza A, Munoz O, Rubio C, et al. Effects of performing morning versus afternoon exercise on glycemic control and hypoglycemia frequency in type 1 diabetes patients on sensor-augmented insulin pump therapy. J Diabetes Sci Technol. 2015;9:619–24.CrossRefPubMedPubMedCentral Gomez AM, Gomez C, Aschner P, Veloza A, Munoz O, Rubio C, et al. Effects of performing morning versus afternoon exercise on glycemic control and hypoglycemia frequency in type 1 diabetes patients on sensor-augmented insulin pump therapy. J Diabetes Sci Technol. 2015;9:619–24.CrossRefPubMedPubMedCentral
21.
Zurück zum Zitat Taplin CE, Cobry E, Messer L, McFann K, Chase HP, Fiallo-Scharer R. Preventing post-exercise nocturnal hypoglycemia in children with type 1 diabetes. J Pediatr. 2010;157:784–8. e1.CrossRefPubMedPubMedCentral Taplin CE, Cobry E, Messer L, McFann K, Chase HP, Fiallo-Scharer R. Preventing post-exercise nocturnal hypoglycemia in children with type 1 diabetes. J Pediatr. 2010;157:784–8. e1.CrossRefPubMedPubMedCentral
22.
Zurück zum Zitat Tsalikian E, Kollman C, Tamborlane WB, Beck RW, Fiallo-Scharer R, Fox L, et al. Prevention of hypoglycemia during exercise in children with type 1 diabetes by suspending basal insulin. Diabetes Care. 2006;29:2200–4.CrossRefPubMed Tsalikian E, Kollman C, Tamborlane WB, Beck RW, Fiallo-Scharer R, Fox L, et al. Prevention of hypoglycemia during exercise in children with type 1 diabetes by suspending basal insulin. Diabetes Care. 2006;29:2200–4.CrossRefPubMed
23.••
Zurück zum Zitat Robertson K, Riddell MC, Guinhouya BC, Adolfsson P, Hanas R, ISPAD Clinical Practice Consensus Guidelines. Exercise in children and adolescents with diabetes. Pediatr Diabetes. 2014;15 Suppl 20:203–23. This consensus guideline discusses how to prevent and treat hypoglycemia associated with exercise in children.CrossRefPubMed Robertson K, Riddell MC, Guinhouya BC, Adolfsson P, Hanas R, ISPAD Clinical Practice Consensus Guidelines. Exercise in children and adolescents with diabetes. Pediatr Diabetes. 2014;15 Suppl 20:203–23. This consensus guideline discusses how to prevent and treat hypoglycemia associated with exercise in children.CrossRefPubMed
24.
Zurück zum Zitat Kaufman FR, Devgan S. Use of uncooked cornstarch to avert nocturnal hypoglycemia in children and adolescents with type I diabetes. J Diabetes Complicat. 1996;10:84–7.CrossRefPubMed Kaufman FR, Devgan S. Use of uncooked cornstarch to avert nocturnal hypoglycemia in children and adolescents with type I diabetes. J Diabetes Complicat. 1996;10:84–7.CrossRefPubMed
25.
Zurück zum Zitat Kaufman FR, Halvorson M, Kaufman ND. Evaluation of a snack bar containing uncooked cornstarch in subjects with diabetes. Diabetes Res Clin Pract. 1997;35:27–33.CrossRefPubMed Kaufman FR, Halvorson M, Kaufman ND. Evaluation of a snack bar containing uncooked cornstarch in subjects with diabetes. Diabetes Res Clin Pract. 1997;35:27–33.CrossRefPubMed
26.
Zurück zum Zitat Kaufman FR, Halvorson M, Kaufman ND. A randomized, blinded trial of uncooked cornstarch to diminish nocturnal hypoglycemia at diabetes camp. Diabetes Res Clin Pract. 1995;30:205–9.CrossRefPubMed Kaufman FR, Halvorson M, Kaufman ND. A randomized, blinded trial of uncooked cornstarch to diminish nocturnal hypoglycemia at diabetes camp. Diabetes Res Clin Pract. 1995;30:205–9.CrossRefPubMed
27.
Zurück zum Zitat Detlofson I, Kroon M, Aman J. Oral bedtime cornstarch supplementation reduces the risk for nocturnal hypoglycaemia in young children with type 1 diabetes. Acta Paediatr. 1999;88:595–7.CrossRefPubMed Detlofson I, Kroon M, Aman J. Oral bedtime cornstarch supplementation reduces the risk for nocturnal hypoglycaemia in young children with type 1 diabetes. Acta Paediatr. 1999;88:595–7.CrossRefPubMed
28.
Zurück zum Zitat Moheet A, Mangia S, Kumar A, Tesfaye N, Eberly LE, Bai Y, et al. Naltrexone for treatment of impaired awareness of hypoglycemia in type 1 diabetes: a randomized clinical trial. J Diabetes Complicat. 2015;29:1277–82.CrossRefPubMed Moheet A, Mangia S, Kumar A, Tesfaye N, Eberly LE, Bai Y, et al. Naltrexone for treatment of impaired awareness of hypoglycemia in type 1 diabetes: a randomized clinical trial. J Diabetes Complicat. 2015;29:1277–82.CrossRefPubMed
29.
Zurück zum Zitat Tamborlane WV, Beck RW, Bode BW, Buckingham B, Chase HP, Clemons R, et al. Continuous glucose monitoring and intensive treatment of type 1 diabetes. N Engl J Med. 2008;359:1464–76.CrossRefPubMed Tamborlane WV, Beck RW, Bode BW, Buckingham B, Chase HP, Clemons R, et al. Continuous glucose monitoring and intensive treatment of type 1 diabetes. N Engl J Med. 2008;359:1464–76.CrossRefPubMed
30.
Zurück zum Zitat Beck RW, Hirsch IB, Laffel L, Tamborlane WV, Bode BW, Buckingham B, et al. The effect of continuous glucose monitoring in well-controlled type 1 diabetes. Diabetes Care. 2009;32:1378–83.CrossRefPubMed Beck RW, Hirsch IB, Laffel L, Tamborlane WV, Bode BW, Buckingham B, et al. The effect of continuous glucose monitoring in well-controlled type 1 diabetes. Diabetes Care. 2009;32:1378–83.CrossRefPubMed
31.
Zurück zum Zitat Bergenstal RM, Klonoff DC, Garg SK, Bode BW, Meredith M, Slover RH, et al. Threshold-based insulin-pump interruption for reduction of hypoglycemia. N Engl J Med. 2013;369:224–32.CrossRefPubMed Bergenstal RM, Klonoff DC, Garg SK, Bode BW, Meredith M, Slover RH, et al. Threshold-based insulin-pump interruption for reduction of hypoglycemia. N Engl J Med. 2013;369:224–32.CrossRefPubMed
32.
Zurück zum Zitat Ly TT, Nicholas JA, Retterath A, Lim EM, Davis EA, Jones TW. Effect of sensor-augmented insulin pump therapy and automated insulin suspension vs standard insulin pump therapy on hypoglycemia in patients with type 1 diabetes: a randomized clinical trial. JAMA. 2013;310:1240–7.CrossRefPubMed Ly TT, Nicholas JA, Retterath A, Lim EM, Davis EA, Jones TW. Effect of sensor-augmented insulin pump therapy and automated insulin suspension vs standard insulin pump therapy on hypoglycemia in patients with type 1 diabetes: a randomized clinical trial. JAMA. 2013;310:1240–7.CrossRefPubMed
33.•
Zurück zum Zitat Buckingham BA, Raghinaru D, Cameron F, Bequette BW, Chase HP, Maahs DM, et al. Predictive low-glucose insulin suspension reduces duration of nocturnal hypoglycemia in children without increasing ketosis. Diabetes Care. 2015;38:1197–204. Use of a partially closed loop insulin infusion and continuous glucose monitor reduces nocturnal hypoglycemia.CrossRefPubMedCentral Buckingham BA, Raghinaru D, Cameron F, Bequette BW, Chase HP, Maahs DM, et al. Predictive low-glucose insulin suspension reduces duration of nocturnal hypoglycemia in children without increasing ketosis. Diabetes Care. 2015;38:1197–204. Use of a partially closed loop insulin infusion and continuous glucose monitor reduces nocturnal hypoglycemia.CrossRefPubMedCentral
34.•
Zurück zum Zitat Russell SJ, Hillard MA, Balliro C, Magyar KL, Selagamsetty R, Sinha M, et al. Day and night glycaemic control with a bionic pancreas versus conventional insulin pump therapy in preadolescent children with type 1 diabetes: a randomised crossover trial. Lancet Diabetes Endocrinol 2016. Glycemic control is enhanced by bihormonal closed loop diabetes control in this study of a not regulatory-approved device. Russell SJ, Hillard MA, Balliro C, Magyar KL, Selagamsetty R, Sinha M, et al. Day and night glycaemic control with a bionic pancreas versus conventional insulin pump therapy in preadolescent children with type 1 diabetes: a randomised crossover trial. Lancet Diabetes Endocrinol 2016. Glycemic control is enhanced by bihormonal closed loop diabetes control in this study of a not regulatory-approved device.
35.
Zurück zum Zitat Zeigler C, Liberman A, Nimri R, Muller I, Klemencic S, Bratina N, et al. Reduced worries of hypoglycemia, high satisfaction, and increased perceived ease of use after experiencing four nights of MD-Logic artificial pancreas at home (DREAM4). J Diabetes Res. 2015;2015:590308. doi:10.1155/2015/590308. Zeigler C, Liberman A, Nimri R, Muller I, Klemencic S, Bratina N, et al. Reduced worries of hypoglycemia, high satisfaction, and increased perceived ease of use after experiencing four nights of MD-Logic artificial pancreas at home (DREAM4). J Diabetes Res. 2015;2015:590308. doi:10.​1155/​2015/​590308.
36.
Zurück zum Zitat Dehlinger K, Tarnowski K, House JL, Los E, Hanavan K, Bustamante B, et al. Can trained dogs detect a hypoglycemic scent in patients with type 1 diabetes? Diabetes Care. 2013;36:e98–9.CrossRefPubMedPubMedCentral Dehlinger K, Tarnowski K, House JL, Los E, Hanavan K, Bustamante B, et al. Can trained dogs detect a hypoglycemic scent in patients with type 1 diabetes? Diabetes Care. 2013;36:e98–9.CrossRefPubMedPubMedCentral
37.
Zurück zum Zitat Petry NM, Wagner JA, Rash CJ, Hood KK. Perceptions about professionally and non-professionally trained hypoglycemia detection dogs. Diabetes Res Clin Pract. 2015;109:389–96.CrossRefPubMedPubMedCentral Petry NM, Wagner JA, Rash CJ, Hood KK. Perceptions about professionally and non-professionally trained hypoglycemia detection dogs. Diabetes Res Clin Pract. 2015;109:389–96.CrossRefPubMedPubMedCentral
38.
Zurück zum Zitat Professional Practice Committee for the Standards of Medical Care in Diabetes-2016. Diabetes care 2016; 39 Suppl 1: S107-8. Professional Practice Committee for the Standards of Medical Care in Diabetes-2016. Diabetes care 2016; 39 Suppl 1: S107-8.
39.
Zurück zum Zitat Haymond MW, Schreiner B. Mini-dose glucagon rescue for hypoglycemia in children with type 1 diabetes. Diabetes Care. 2001;24:643–5.CrossRefPubMed Haymond MW, Schreiner B. Mini-dose glucagon rescue for hypoglycemia in children with type 1 diabetes. Diabetes Care. 2001;24:643–5.CrossRefPubMed
40.
Zurück zum Zitat Chung ST, Haymond MW. Minimizing morbidity of hypoglycemia in diabetes: a review of mini-dose glucagon. J Diabetes SciTechnol. 2015;9:44–51. Chung ST, Haymond MW. Minimizing morbidity of hypoglycemia in diabetes: a review of mini-dose glucagon. J Diabetes SciTechnol. 2015;9:44–51.
41.
Zurück zum Zitat Rickels MR, Ruedy KJ, Foster NC, Piche CA, Dulude H, Sherr JL, et al. Intranasal glucagon for treatment of insulin-induced hypoglycemia in adults with type 1 diabetes: a randomized crossover noninferiority study. Diabetes Care. 2016;39:264–70.PubMed Rickels MR, Ruedy KJ, Foster NC, Piche CA, Dulude H, Sherr JL, et al. Intranasal glucagon for treatment of insulin-induced hypoglycemia in adults with type 1 diabetes: a randomized crossover noninferiority study. Diabetes Care. 2016;39:264–70.PubMed
42.
Zurück zum Zitat Amiel SA, Tamborlane WV, Simonson DC, Sherwin RS. Defective glucose counterregulation after strict glycemic control of insulin-dependent diabetes mellitus. N Engl J Med. 1987;316:1376–83.CrossRefPubMed Amiel SA, Tamborlane WV, Simonson DC, Sherwin RS. Defective glucose counterregulation after strict glycemic control of insulin-dependent diabetes mellitus. N Engl J Med. 1987;316:1376–83.CrossRefPubMed
43.
Zurück zum Zitat Tsalikian E, Tamborlane W, Xing D, Becker DM, Mauras N, Fiallo-Scharer R, et al. Blunted counterregulatory hormone responses to hypoglycemia in young children and adolescents with well-controlled type 1 diabetes. Diabetes Care. 2009;32:1954–9.CrossRefPubMed Tsalikian E, Tamborlane W, Xing D, Becker DM, Mauras N, Fiallo-Scharer R, et al. Blunted counterregulatory hormone responses to hypoglycemia in young children and adolescents with well-controlled type 1 diabetes. Diabetes Care. 2009;32:1954–9.CrossRefPubMed
44.
Zurück zum Zitat Arbelaez AM, Xing D, Cryer PE, Kollman C, Beck RW, Sherr J, et al. Blunted glucagon but not epinephrine responses to hypoglycemia occurs in youth with less than 1 yr duration of type 1 diabetes mellitus. Pediatr Diabetes. 2014;15:127–34.CrossRefPubMed Arbelaez AM, Xing D, Cryer PE, Kollman C, Beck RW, Sherr J, et al. Blunted glucagon but not epinephrine responses to hypoglycemia occurs in youth with less than 1 yr duration of type 1 diabetes mellitus. Pediatr Diabetes. 2014;15:127–34.CrossRefPubMed
45.
Zurück zum Zitat Ly TT, Hewitt J, Davey RJ, Lim EM, Davis EA, Jones TW. Improving epinephrine responses in hypoglycemia unawareness with real-time continuous glucose monitoring in adolescents with type 1 diabetes. Diabetes Care. 2011;34:50–2.CrossRefPubMed Ly TT, Hewitt J, Davey RJ, Lim EM, Davis EA, Jones TW. Improving epinephrine responses in hypoglycemia unawareness with real-time continuous glucose monitoring in adolescents with type 1 diabetes. Diabetes Care. 2011;34:50–2.CrossRefPubMed
46.
Zurück zum Zitat Abid N, McGlone O, Cardwell C, McCallion W, Carson D. Clinical and metabolic effects of gluten free diet in children with type 1 diabetes and coeliac disease. Pediatr Diabetes. 2011;12:322–5.CrossRefPubMed Abid N, McGlone O, Cardwell C, McCallion W, Carson D. Clinical and metabolic effects of gluten free diet in children with type 1 diabetes and coeliac disease. Pediatr Diabetes. 2011;12:322–5.CrossRefPubMed
47.
Zurück zum Zitat Mohn A, Di Michele S, Di Luzio R, Tumini S, Chiarelli F. The effect of subclinical hypothyroidism on metabolic control in children and adolescents with Type 1 diabetes mellitus. Diabetic Med : J Br Diabetic Assoc. 2002;19:70–3.CrossRef Mohn A, Di Michele S, Di Luzio R, Tumini S, Chiarelli F. The effect of subclinical hypothyroidism on metabolic control in children and adolescents with Type 1 diabetes mellitus. Diabetic Med : J Br Diabetic Assoc. 2002;19:70–3.CrossRef
48.
Zurück zum Zitat Bougneres P, Boileau P, Aboumrad B. Secret insulin-injection syndrome among adolescents with type 1 diabetes. N Engl J Med. 2005;353:2516–7.CrossRefPubMed Bougneres P, Boileau P, Aboumrad B. Secret insulin-injection syndrome among adolescents with type 1 diabetes. N Engl J Med. 2005;353:2516–7.CrossRefPubMed
49.
Zurück zum Zitat Jain V, Satapathy AK, Yadav J. Surreptitious insulin overdosing in adolescents with type 1 diabetes. Indian Pediatr. 2015;52:701–3.CrossRefPubMed Jain V, Satapathy AK, Yadav J. Surreptitious insulin overdosing in adolescents with type 1 diabetes. Indian Pediatr. 2015;52:701–3.CrossRefPubMed
Metadaten
Titel
Management of Hypoglycemia in Children and Adolescents with Type 1 Diabetes Mellitus
verfasst von
Dayna E. McGill
Lynne L. Levitsky
Publikationsdatum
01.09.2016
Verlag
Springer US
Erschienen in
Current Diabetes Reports / Ausgabe 9/2016
Print ISSN: 1534-4827
Elektronische ISSN: 1539-0829
DOI
https://doi.org/10.1007/s11892-016-0771-1

Weitere Artikel der Ausgabe 9/2016

Current Diabetes Reports 9/2016 Zur Ausgabe

Health Care Delivery Systems and Implementation in Diabetes (EB Morton-Eggleston and ME McDonnell, Section Editors)

Effectiveness of Non-Primary Care-Based Smoking Cessation Interventions for Adults with Diabetes: A Systematic Literature Review

Psychosocial Aspects (S Jaser and KK Hood, Section Editors)

Physical Activity in Youth With Type 1 Diabetes: a Review

Obesity (J McCaffery, Section Editor)

Food Decision-Making: Effects of Weight Status and Age

Microvascular Complications—Neuropathy (R Pop-Busui, Section Editor)

Diabetes and Cognitive Impairment

Obesity (J McCaffery, Section Editor)

Food Insecurity and Diabetes in Developed Societies

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Echinokokkose medikamentös behandeln oder operieren?

06.05.2024 DCK 2024 Kongressbericht

Die Therapie von Echinokokkosen sollte immer in spezialisierten Zentren erfolgen. Eine symptomlose Echinokokkose kann – egal ob von Hunde- oder Fuchsbandwurm ausgelöst – konservativ erfolgen. Wenn eine Op. nötig ist, kann es sinnvoll sein, vorher Zysten zu leeren und zu desinfizieren. 

Umsetzung der POMGAT-Leitlinie läuft

03.05.2024 DCK 2024 Kongressbericht

Seit November 2023 gibt es evidenzbasierte Empfehlungen zum perioperativen Management bei gastrointestinalen Tumoren (POMGAT) auf S3-Niveau. Vieles wird schon entsprechend der Empfehlungen durchgeführt. Wo es im Alltag noch hapert, zeigt eine Umfrage in einem Klinikverbund.

Proximale Humerusfraktur: Auch 100-Jährige operieren?

01.05.2024 DCK 2024 Kongressbericht

Mit dem demographischen Wandel versorgt auch die Chirurgie immer mehr betagte Menschen. Von Entwicklungen wie Fast-Track können auch ältere Menschen profitieren und bei proximaler Humerusfraktur können selbst manche 100-Jährige noch sicher operiert werden.

Die „Zehn Gebote“ des Endokarditis-Managements

30.04.2024 Endokarditis Leitlinie kompakt

Worauf kommt es beim Management von Personen mit infektiöser Endokarditis an? Eine Kardiologin und ein Kardiologe fassen die zehn wichtigsten Punkte der neuen ESC-Leitlinie zusammen.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.