Background
Methods
Patients and definitions
Etiological diagnosis
Data collection
Statistical analysis
Results
Demography
Variables | Data |
---|---|
Demography data | |
Mean age (years) | 36.0(23.0,53.0) |
Male (%) | 135(64.6%) |
Hospitalization data | |
Onset time (days) | 4.0(2.0,7.0) |
Hospitalized days | 17.0(9.5,30.5) |
Admission to ICU (days) | 6.0(3.0,13.0) |
Days of critical condition (days) | 9.0(4.0,18.8) |
Number of rescuing | 0.0(0.0,1.0) |
Days of advanced care (days) | 6.0(3.0,12.0) |
Days of primary care (days) | 12.0(6.0,22.5) |
Clinical data | |
Cerebrospinal fluid pressure ≥ 180mmH2O | 109(52.4%) |
Cerebrospinal fluid pressure ≥ 400mmH2O | 32(15.4%) |
White blood cell abnormality in CSF | 137(65.9%) |
Total protein abnormality in CSF | 137(65.6%) |
Abnormal imaging | 78(38.6%) |
Abnormal electroencephalogram | 65(32.8%) |
Complications | 118(56.5%) |
Causative agent | |
Viral | 147(70.3%) |
Bacterial | 36(17.2%) |
Fungal | 10(4.8%) |
Tubercular | 16(7.7%) |
Investigations
Predictors of mortality
Factors | Survivors(n = 187) | Death(n = 22) | Z/χ2 | p-value |
---|---|---|---|---|
Mean age (years) | 36.0(23.0,53.0) | 37.5(23.3,54.3) | -0.3 | 0.747 |
Male (%) | 120(64.2%) | 15(68.2%) | 0.1 | 0.710 |
Onset time (days) | 4.0(2.0,7.0) | 4.0(1.8,7.5) | -0.4 | 0.657 |
Hospitalized days | 19.0(10.0,32.0) | 9.0(2.8,18.3) | -3.3 | 0.001* |
Admission to ICU (days) | 6.0(3.0,12.0) | 7.0(2.5,15.5) | -0.5 | 0.588 |
Days of critical condition | 10.0(5.0,20.3) | 5.0(2.0,15.3) | -2.1 | 0.038* |
Number of rescuing | 0.0(0.0,0.0) | 1.5(0.8,3.0) | -5.2 | <0.001* |
Days of advanced care | 6.0(3.0,12.0) | 7.5(2.8,7.5) | -0.7 | 0.507 |
Days of primary care | 13.0(7.0,24.0) | 1.0(1.0,7.0) | -3.1 | 0.002* |
CSFP | ||||
CSFP ≥ 180mmH2O | 89(47.8%) | 20(90.9%) | 14.6 | <0.001* |
CSFP ≥ 400mmH2O | 25(13.4%) | 7(31.8%) | 5.1 | 0.024* |
White blood cell abnormality in CSF | 124(66.3%) | 13(61.9%) | 0.2 | 0.686 |
Total protein abnormality in CSF | 123(65.8%) | 14(63.6%) | 0.0 | 0.842 |
Abnormal imaging | 63(34.8%) | 14(70.0%) | 9.4 | 0.002* |
Abnormal electroencephalogram | 52(29.2%) | 13(65.0%) | 10.4 | 0.001* |
Complication | 96(51.3%) | 22(100.0%) | 19.0 | < 0.001* |
Causative agent | ||||
Viral | 135(72.2%) | 12(54.5%) | 5.4 | 0.145 |
Bacterial | 31(16.6%) | 5(22.7%) | ||
Fungal | 7(3.7%) | 3(13.6%) | ||
Tubercular | 14(7.5%) | 2(9.1%) |
Predictors of outcome among survivors
Factors | mRS<3(n = 122) | 3 ≤ mRS<6(n = 65) | Z/χ2 | p value |
---|---|---|---|---|
Mean age (years) | 33.0(22.0,50.0) | 42.0(23.0,56.5) | -2.0 | 0.041* |
Male (%) | 80(65.6%) | 40(61.5%) | 0.3 | 0.584 |
Onset time (days) | 3.5(2.0,7.0) | 4.0(2.0,8.5) | -1.3 | 0.183 |
Hospitalized days | 18.0(11.0,29) | 19.0(8.5,48.0) | -0.4 | 0.706 |
Admission to ICU (days) | 6.0(3.0,11.0) | 6.0(2.0,18.5) | -0.9 | 0.386 |
Days of critical condition | 8.0(4.0,14.0) | 16.0(5.0,30.5) | -2.6 | 0.010* |
Number of rescuing | 0.0(0.0,0.0) | 0.0(0.0,2.5) | -3.9 | <0.001* |
Days of advanced care | 5.0(3.0,9.0) | 8.0(3.0,20.0) | -2.0 | 0.044* |
Days of primary care | 14.0(7.0,21.5) | 12.0(6.0,30.5) | -0.3 | 0.771 |
CSFP | ||||
CSFP ≥ 180mmH2O | 54(44.3%) | 35(54.7%) | 1.8 | 0.175 |
CSFP ≥ 400mmH2O | 14(11.5%) | 11(17.2%) | 1.2 | 0.278 |
White blood cell in CSF>10/uL | 80(65.6%) | 44(67.7%) | 0.1 | 0.770 |
White blood cell in CSF>500/uL | 20(16.4%) | 5(7.7%) | 2.8 | 0.096 |
Total protein in CSF>0.4 g/L | 81(66.4%) | 42(64.6%) | 0.1 | 0.807 |
Total protein in CSF>1 g/L | 31(25.4%) | 23(35.4%) | 2.1 | 0.152 |
Abnormal imaging | 34(28.6%) | 29(46.8%) | 6.0 | 0.015* |
Abnormal electroencephalogram | 35(29.9%) | 17(27.9%) | 0.1 | 0.776 |
Complication | 57(46.7%) | 39(60.0%) | 3.0 | 0.084 |
Causative agent | ||||
Viral | 94(77.0%) | 41(63.1%) | 15.0 | 0.002* |
Bacterial | 22(18.0%) | 9(13.8%) | ||
Fungal | 3(2.5%) | 4(6.2%) | ||
Tubercular | 3(2.5%) | 11(16.9%) |