22.04.2024 | Letter to the Editor
Rubella virus-associated cutaneous granulomatous disease in an immunocompetent woman
verfasst von:
Vega-López TL, Carballido-Vázquez AM, González-Jiménez I, García-Gamero MJ, Delgado-Mucientes CM, González-López A, Martínez-García G, Rojo-Rello S, Manchado-López P, Mateos-Mayo A
Erschienen in:
European Journal of Clinical Microbiology & Infectious Diseases
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Excerpt
Cutaneous granulomatous diseases encompass the clinical spectrum of type-IV hypersensitivity reactions, leading to granuloma formation. Histologically, granulomas represent a chronic inflammatory response characterized by focal aggregates of epithelioid histiocytes, multinucleated giant cells, and mononuclear leukocytes. Although their etiology frequently remains unclear, granulomas normally develop in response to chronic infection [
1]. Interestingly, the term “rubella virus (RuV) granulomas” has recently been introduced to describe granulomas in which vaccine-derived or wild-type RuV (wt-RuV) has been identified in tissue biopsy [
2]. …