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Current Cardiology Reports

Erschienen in:

14.08.2023 | Ischemic Heart Disease (D Mukherjee, Section Editor)

Sodium Homeostasis and Hypertension

verfasst von: KoKo Aung, Sarah Ream-Winnick, Mariela Lane, Idris Akinlusi, Ted Shi, Thwe Htay

Erschienen in: Current Cardiology Reports | Ausgabe 10/2023

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Abstract

Purpose of Review

This review aims to summarize and discuss the relationship between sodium homeostasis and hypertension, including emerging concepts of factors outside cardiovascular and renal systems influencing sodium homeostasis and hypertension.

Recent Findings

Recent studies support the dose–response association between higher sodium and lower potassium intakes and a higher cardiovascular risk in addition to the dose–response relationship between sodium restriction and blood pressure lowering. The growing body of evidence suggests the role of genetic determinants, immune system, and gut microbiota in sodium homeostasis and hypertension.

Summary

Although higher sodium and lower potassium intakes increase cardiovascular risk, salt restriction is beneficial only to a certain limit. The immune system contributes to hypertension through pro-inflammatory effects. Sodium can affect the gut microbiome and induce pro-inflammatory and immune responses that contribute to salt-sensitive hypertension.

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Titel: Sodium Homeostasis and Hypertension
verfasst von: KoKo Aung
Sarah Ream-Winnick
Mariela Lane
Idris Akinlusi
Ted Shi
Thwe Htay
Publikationsdatum: 14.08.2023
Verlag: Springer US
Erschienen in: Current Cardiology Reports / Ausgabe 10/2023
Print ISSN: 1523-3782
Elektronische ISSN: 1534-3170
DOI: https://doi.org/10.1007/s11886-023-01931-5

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