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Literatur
Zurück zum Zitat Albiges L, Powles T, Staehler M et al (2019 Aug) Updated European Association of Urology Guidelines on Renal Cell Carcinoma: Immune Checkpoint Inhibition Is the New Backbone in First-line Treatment of Metastatic Clear-cell Renal Cell Carcinoma. Eur Urol. 76(2):151–156 Albiges L, Powles T, Staehler M et al (2019 Aug) Updated European Association of Urology Guidelines on Renal Cell Carcinoma: Immune Checkpoint Inhibition Is the New Backbone in First-line Treatment of Metastatic Clear-cell Renal Cell Carcinoma. Eur Urol. 76(2):151–156
Zurück zum Zitat Ahrens M, Scheich S, Hartmann A, Bergmann L (2019) IAG-N Interdisciplinary Working Group Kidney Cancer of the German Cancer Society. Oncol Res Treat. 42(3):128–135CrossRef Ahrens M, Scheich S, Hartmann A, Bergmann L (2019) IAG-N Interdisciplinary Working Group Kidney Cancer of the German Cancer Society. Oncol Res Treat. 42(3):128–135CrossRef
Zurück zum Zitat Watanabe K, Sugiyama T, Otsuka A, Miyake H. Complete response to combination therapy with nivolumab and ipilimumab for metastatic collecting duct carcinoma of the kidney. Int Cancer Conf J. 2019 Sep 28;9(1):32–35. eCollection 2020 Jan. Watanabe K, Sugiyama T, Otsuka A, Miyake H. Complete response to combination therapy with nivolumab and ipilimumab for metastatic collecting duct carcinoma of the kidney. Int Cancer Conf J. 2019 Sep 28;9(1):32–35. eCollection 2020 Jan.
Zurück zum Zitat Rosenberg SA et al (1993) Prospective randomized trial of high-dose interleukin-2 alone or in conjunction with lymphokine-activated killer cells for the treatment of patients with advanced cancer. J Natl Cancer Inst 85:622CrossRef Rosenberg SA et al (1993) Prospective randomized trial of high-dose interleukin-2 alone or in conjunction with lymphokine-activated killer cells for the treatment of patients with advanced cancer. J Natl Cancer Inst 85:622CrossRef
Zurück zum Zitat Fyfe G et al (1995) Results of treatment of 255 patients with metastatic renal cell carcinoma who received high-dose recombinant interleukin-2 therapy. J Clin Oncol 13:688CrossRef Fyfe G et al (1995) Results of treatment of 255 patients with metastatic renal cell carcinoma who received high-dose recombinant interleukin-2 therapy. J Clin Oncol 13:688CrossRef
Zurück zum Zitat McDermott DF et al (2005) Randomized phase III trial of high-dose interleukin-2 versus subcutaneous interleukin-2 and interferon in patients with metastatic renal cell carcinoma. J Clin Oncol 23:133CrossRef McDermott DF et al (2005) Randomized phase III trial of high-dose interleukin-2 versus subcutaneous interleukin-2 and interferon in patients with metastatic renal cell carcinoma. J Clin Oncol 23:133CrossRef
Zurück zum Zitat Yang JC, Childs RJ (10. Dezember 2006) Immunotherapy for renal cell cancer. Clin Oncol. 24(35):5576–5583 Yang JC, Childs RJ (10. Dezember 2006) Immunotherapy for renal cell cancer. Clin Oncol. 24(35):5576–5583
Zurück zum Zitat Yang JC1, Abad J, Sherry R. Treatment of oligometastases after successful immunotherapy. Semin Radiat Oncol. 2006 Apr;16(2):131–5 Yang JC1, Abad J, Sherry R. Treatment of oligometastases after successful immunotherapy. Semin Radiat Oncol. 2006 Apr;16(2):131–5
Zurück zum Zitat Bracarda S, Bellmunt J, Melichar B et al (2011 Jan) Overall survival in patients with metastatic renal cell carcinoma initially treated with bevacizumab plus interferon-α2a and subsequent therapy with tyrosine kinase inhibitors: a retrospective analysis of the phase III AVOREN trial. BJU Int. 107(2):214–219 Bracarda S, Bellmunt J, Melichar B et al (2011 Jan) Overall survival in patients with metastatic renal cell carcinoma initially treated with bevacizumab plus interferon-α2a and subsequent therapy with tyrosine kinase inhibitors: a retrospective analysis of the phase III AVOREN trial. BJU Int. 107(2):214–219
Zurück zum Zitat Escudier B et al (2010) Phase III trial of bevacizumab plus interferon alfa-2a in patients with metastatic renal cell carcinoma (AVOREN): final analysis of overall survival. J Clin Oncol 28:2144CrossRef Escudier B et al (2010) Phase III trial of bevacizumab plus interferon alfa-2a in patients with metastatic renal cell carcinoma (AVOREN): final analysis of overall survival. J Clin Oncol 28:2144CrossRef
Zurück zum Zitat Motzer RJ et al (2015a) Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma. N Engl J Med 373:1803CrossRef Motzer RJ et al (2015a) Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma. N Engl J Med 373:1803CrossRef
Zurück zum Zitat Motzer RJ et al (2018) Nivolumab plus Ipilimumab versus Sunitinib in Advanced Renal-Cell Carcinoma. N Engl J Med 378:1277CrossRef Motzer RJ et al (2018) Nivolumab plus Ipilimumab versus Sunitinib in Advanced Renal-Cell Carcinoma. N Engl J Med 378:1277CrossRef
Zurück zum Zitat Escudier B et al (2007) Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med 356:125CrossRef Escudier B et al (2007) Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med 356:125CrossRef
Zurück zum Zitat Bellmunt J et al (2009) The medical treatment of metastatic renal cell cancer in the elderly: position paper of a SIOG Taskforce. Crit Rev Oncol Hematol 69:64CrossRef Bellmunt J et al (2009) The medical treatment of metastatic renal cell cancer in the elderly: position paper of a SIOG Taskforce. Crit Rev Oncol Hematol 69:64CrossRef
Zurück zum Zitat Motzer RJ et al (2009) Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma. J Clin Oncol 27:3584CrossRef Motzer RJ et al (2009) Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma. J Clin Oncol 27:3584CrossRef
Zurück zum Zitat Motzer RJ et al (2012) Randomized phase II trial of sunitinib on an intermittent versus continuous dosing schedule as first-line therapy for advanced renal cell carcinoma. J Clin Oncol 30:1371CrossRef Motzer RJ et al (2012) Randomized phase II trial of sunitinib on an intermittent versus continuous dosing schedule as first-line therapy for advanced renal cell carcinoma. J Clin Oncol 30:1371CrossRef
Zurück zum Zitat Bracarda S et al (2016) Sunitinib administered on 2/1 schedule in patients with metastatic renal cell carcinoma: the RAINBOW analysis. Ann Oncol 27:366CrossRef Bracarda S et al (2016) Sunitinib administered on 2/1 schedule in patients with metastatic renal cell carcinoma: the RAINBOW analysis. Ann Oncol 27:366CrossRef
Zurück zum Zitat Dror Michaelson M., et al. Phase III AXIS trial of axitinib versus sorafenib in metastatic renal cell carcinoma: Updated results among cytokine-treated patients. J Clin Oncol 2012. J Clin Oncol 30, 2012 (suppl; abstr 4546) Dror Michaelson M., et al. Phase III AXIS trial of axitinib versus sorafenib in metastatic renal cell carcinoma: Updated results among cytokine-treated patients. J Clin Oncol 2012. J Clin Oncol 30, 2012 (suppl; abstr 4546)
Zurück zum Zitat Motzer, R.J., et al. Axitinib versus sorafenib as second-line treatment for advanced renal cell carcinoma: overall survival analysis and updated results from a randomised phase 3 trial. Lancet Oncol, 2013. 14 Motzer, R.J., et al. Axitinib versus sorafenib as second-line treatment for advanced renal cell carcinoma: overall survival analysis and updated results from a randomised phase 3 trial. Lancet Oncol, 2013. 14
Zurück zum Zitat Hutson TE et al (2013) Axitinib versus sorafenib as first-line therapy in patients with metastatic renal-cell carcinoma: a randomised open-label phase 3 trial. Lancet Oncol 14:1287CrossRef Hutson TE et al (2013) Axitinib versus sorafenib as first-line therapy in patients with metastatic renal-cell carcinoma: a randomised open-label phase 3 trial. Lancet Oncol 14:1287CrossRef
Zurück zum Zitat Sternberg CN et al (2010) Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III trial. J Clin Oncol 28:1061CrossRef Sternberg CN et al (2010) Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III trial. J Clin Oncol 28:1061CrossRef
Zurück zum Zitat Motzer RJ et al (2013) Pazopanib versus sunitinib in metastatic renal-cell carcinoma. N Engl J Med 369:722CrossRef Motzer RJ et al (2013) Pazopanib versus sunitinib in metastatic renal-cell carcinoma. N Engl J Med 369:722CrossRef
Zurück zum Zitat Larkin JM et al (2006) Kinase inhibitors in the treatment of renal cell carcinoma. Crit Rev Oncol Hematol 60:216CrossRef Larkin JM et al (2006) Kinase inhibitors in the treatment of renal cell carcinoma. Crit Rev Oncol Hematol 60:216CrossRef
Zurück zum Zitat Motzer RJ et al (2008) Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial. Lancet 372:449CrossRef Motzer RJ et al (2008) Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial. Lancet 372:449CrossRef
Zurück zum Zitat Choueiri TK et al (2015) Cabozantinib versus Everolimus in Advanced Renal-Cell Carcinoma. N Engl J Med 373:1814CrossRef Choueiri TK et al (2015) Cabozantinib versus Everolimus in Advanced Renal-Cell Carcinoma. N Engl J Med 373:1814CrossRef
Zurück zum Zitat Choueiri TK et al (2017) Cabozantinib Versus Sunitinib As Initial Targeted Therapy for Patients With Metastatic Renal Cell Carcinoma of Poor or Intermediate Risk: The Alliance A031203 CABOSUN Trial. J Clin Oncol 35:591CrossRef Choueiri TK et al (2017) Cabozantinib Versus Sunitinib As Initial Targeted Therapy for Patients With Metastatic Renal Cell Carcinoma of Poor or Intermediate Risk: The Alliance A031203 CABOSUN Trial. J Clin Oncol 35:591CrossRef
Zurück zum Zitat Motzer RJ et al (2015) Lenvatinib, everolimus, and the combination in patients with metastatic renal cell carcinoma: a randomised, phase 2, open-label, multicentre trial. Lancet Oncol 16:1473CrossRef Motzer RJ et al (2015) Lenvatinib, everolimus, and the combination in patients with metastatic renal cell carcinoma: a randomised, phase 2, open-label, multicentre trial. Lancet Oncol 16:1473CrossRef
Zurück zum Zitat Motzer RJ et al (2013) Tivozanib versus sorafenib as initial targeted therapy for patients with metastatic renal cell carcinoma: results from a phase III trial. J Clin Oncol 31:3791CrossRef Motzer RJ et al (2013) Tivozanib versus sorafenib as initial targeted therapy for patients with metastatic renal cell carcinoma: results from a phase III trial. J Clin Oncol 31:3791CrossRef
Zurück zum Zitat Molina AM et al (2018) Efficacy of tivozanib treatment after sorafenib in patients with advanced renal cell carcinoma: crossover of a phase 3 study. Eur J Cancer 94:87CrossRef Molina AM et al (2018) Efficacy of tivozanib treatment after sorafenib in patients with advanced renal cell carcinoma: crossover of a phase 3 study. Eur J Cancer 94:87CrossRef
Zurück zum Zitat Rini BI et al (2011) Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial. Lancet 378: 1931 Rini BI et al (2011) Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial. Lancet 378: 1931
Metadaten
Titel
Systemtherapie beim metastasierten Nierenzellkarzinom
verfasst von
Sabine D. Brookman-May
Copyright-Jahr
2021
Verlag
Springer Berlin Heidelberg
DOI
https://doi.org/10.1007/978-3-662-61492-1_22

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