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Current Diabetes Reports
Erschienen in: Current Diabetes Reports 12/2015

01.12.2015 | Microvascular Complications—Nephropathy (T Isakova, Section Editor)

Therapies on the Horizon for Diabetic Kidney Disease

verfasst von: Sadaf S. Khan, Susan E. Quaggin

Erschienen in: Current Diabetes Reports | Ausgabe 12/2015

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Abstract

Diabetic nephropathy is rapidly becoming the major cause of end-stage renal disease and cardiovascular mortality worldwide. Standard of care therapies include strict glycemic control and blockade of the renin-angiotensin-aldosterone axis. While these treatments slow progression of diabetic nephropathy, they do not arrest or reverse it. Newer therapies targeting multiple molecular pathways involved in renal inflammation, fibrosis, and oxidative stress have shown promise in animal models. Subsequently, many of these agents have been investigated in clinical human trials with mixed results. In this review, we will discuss recent findings of novel agents used in the treatment of diabetic nephropathy.
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Metadaten
Titel
Therapies on the Horizon for Diabetic Kidney Disease
verfasst von
Sadaf S. Khan
Susan E. Quaggin
Publikationsdatum
01.12.2015
Verlag
Springer US
Erschienen in
Current Diabetes Reports / Ausgabe 12/2015
Print ISSN: 1534-4827
Elektronische ISSN: 1539-0829
DOI
https://doi.org/10.1007/s11892-015-0685-3

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