Ausgabe 1/2021
Inhalt (201 Artikel)
Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer’s disease
Akira Sobue, Okiru Komine, Yuichiro Hara, Fumito Endo, Hiroyuki Mizoguchi, Seiji Watanabe, Shigeo Murayama, Takashi Saito, Takaomi C. Saido, Naruhiko Sahara, Makoto Higuchi, Tomoo Ogi, Koji Yamanaka
A roadmap of brain recovery in a mouse model of concussion: insights from neuroimaging
Xuan Vinh To, Fatima A. Nasrallah
Frequent SLC35A2 brain mosaicism in mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE)
Thomas Bonduelle, Till Hartlieb, Sara Baldassari, Nam Suk Sim, Se Hoon Kim, Hoon-Chul Kang, Katja Kobow, Roland Coras, Mathilde Chipaux, Georg Dorfmüller, Homa Adle-Biassette, Eleonora Aronica, Jeong Ho Lee, Ingmar Blumcke, Stéphanie Baulac
Individual responsiveness of macrophage migration inhibitory factor predicts long-term cognitive impairment after bacterial meningitis
Anne T. Kloek, Mercedes Valls Seron, Ben Schmand, Michael W. T. Tanck, Arie van der Ende, Matthijs C. Brouwer, Diederik van de Beek
Type 2 diabetes mellitus-associated transcriptome alterations in cortical neurones and associated neurovascular unit cells in the ageing brain
Joanna J. Bury, Annabelle Chambers, Paul R. Heath, Paul G. Ince, Pamela J. Shaw, Fiona E. Matthews, Carol Brayne, Julie E. Simpson, Stephen B. Wharton
The AppNL-G-F mouse retina is a site for preclinical Alzheimer’s disease diagnosis and research
Marjan Vandenabeele, Lien Veys, Sophie Lemmens, Xavier Hadoux, Géraldine Gelders, Luca Masin, Lutgarde Serneels, Jan Theunis, Takashi Saito, Takaomi C. Saido, Murali Jayapala, Patrick De Boever, Bart De Strooper, Ingeborg Stalmans, Peter van Wijngaarden, Lieve Moons, Lies De Groef
The administration of antisense oligonucleotide golodirsen reduces pathological regeneration in patients with Duchenne muscular dystrophy
Dominic Scaglioni, Francesco Catapano, Matthew Ellis, Silvia Torelli, Darren Chambers, Lucy Feng, Matthew Beck, Caroline Sewry, Mauro Monforte, Shawn Harriman, Erica Koenig, Jyoti Malhotra, Linda Popplewell, Michela Guglieri, Volker Straub, Eugenio Mercuri, Laurent Servais, Rahul Phadke, Jennifer Morgan, Francesco Muntoni
Sporadic multiple meningiomas harbor distinct driver mutations
Tareq A. Juratli, Insa Prilop, Felix C. Saalfeld, Sylvia Herold, Matthias Meinhardt, Carina Wenzel, Silke Zeugner, Daniela E. Aust, Fred G. Barker 2nd, Daniel P. Cahill, Priscilla K. Brastianos, Sandro Santagata, Gabriele Schackert, Thomas Pinzer
Dysfunction in nonsense-mediated decay, protein homeostasis, mitochondrial function, and brain connectivity in ALS-FUS mice with cognitive deficits
Wan Yun Ho, Ira Agrawal, Sheue-Houy Tyan, Emma Sanford, Wei-Tang Chang, Kenneth Lim, Jolynn Ong, Bernice Siu Yan Tan, Aung Aung Kywe Moe, Regina Yu, Peiyan Wong, Greg Tucker-Kellogg, Edward Koo, Kai-Hsiang Chuang, Shuo-Chien Ling
Amyloid β and tau pathology in brains of aged pinniped species (sea lion, seal, and walrus)
Yuta Takaichi, James K. Chambers, Kei Takahashi, Yoshiyuki Soeda, Riki Koike, Etsuko Katsumata, Chiaki Kita, Fuko Matsuda, Makoto Haritani, Akihiko Takashima, Hiroyuki Nakayama, Kazuyuki Uchida
Human cutaneous neurofibroma matrisome revealed by single-cell RNA sequencing
Jean-Philippe Brosseau, Adwait A. Sathe, Yong Wang, Toan Nguyen, Donald A. Glass II, Chao Xing, Lu Q. Le
Loss of cholinergic innervation differentially affects eNOS-mediated blood flow, drainage of Aβ and cerebral amyloid angiopathy in the cortex and hippocampus of adult mice
Shereen Nizari, Jack A. Wells, Roxana O. Carare, Ignacio A. Romero, Cheryl A. Hawkes
14-3-3 mitigates alpha-synuclein aggregation and toxicity in the in vivo preformed fibril model
Rachel Underwood, Mary Gannon, Aneesh Pathak, Navya Kapa, Sidhanth Chandra, Alyssa Klop, Talene A. Yacoubian
A pilot radiogenomic study of DIPG reveals distinct subgroups with unique clinical trajectories and therapeutic targets
Xiaoting Zhu, Margot A. Lazow, Austin Schafer, Allison Bartlett, Shiva Senthil Kumar, Deepak Kumar Mishra, Phillip Dexheimer, Mariko DeWire, Christine Fuller, James L. Leach, Maryam Fouladi, Rachid Drissi
Spreading of TDP-43 pathology via pyramidal tract induces ALS-like phenotypes in TDP-43 transgenic mice
Xuebing Ding, Zhi Xiang, Chi Qin, Yongkang Chen, Haiyan Tian, Lin Meng, Danhao Xia, Han Liu, Jia Song, Jun Fu, Mingming Ma, Xuejing Wang
Glioma cells require one-carbon metabolism to survive glutamine starvation
Kazuhiro Tanaka, Takashi Sasayama, Hiroaki Nagashima, Yasuhiro Irino, Masatomo Takahashi, Yoshihiro Izumi, Takiko Uno, Naoko Satoh, Akane Kitta, Katsusuke Kyotani, Yuichi Fujita, Mitsuru Hashiguchi, Tomoaki Nakai, Masaaki Kohta, Yoichi Uozumi, Masakazu Shinohara, Kohkichi Hosoda, Takeshi Bamba, Eiji Kohmura
Prion-induced photoreceptor degeneration begins with misfolded prion protein accumulation in cones at two distinct sites: cilia and ribbon synapses
James F. Striebel, Brent Race, Jacqueline M. Leung, Cindi Schwartz, Bruce Chesebro
Tau-proximity ligation assay reveals extensive previously undetected pathology prior to neurofibrillary tangles in preclinical Alzheimer’s disease
Nora Bengoa-Vergniory, Elisavet Velentza-Almpani, Ana Maria Silva, Connor Scott, Mariana Vargas-Caballero, Magdalena Sastre, Richard Wade-Martins, Javier Alegre-Abarrategui
Neuroligin-1 in brain and CSF of neurodegenerative disorders: investigation for synaptic biomarkers
Elena Camporesi, Tammaryn Lashley, Johan Gobom, Juan Lantero-Rodriguez, Oskar Hansson, Henrik Zetterberg, Kaj Blennow, Bruno Becker
Molecular analysis of pediatric CNS-PNET revealed nosologic heterogeneity and potent diagnostic markers for CNS neuroblastoma with FOXR2-activation
Andrey Korshunov, Konstantin Okonechnikov, Felix Schmitt-Hoffner, Marina Ryzhova, Felix Sahm, Damian Stichel, Daniel Schrimpf, David E. Reuss, Philipp Sievers, Abigail Kora Suwala, Ella Kumirova, Olga Zheludkova, Andrey Golanov, David T. W. Jones, Stefan M. Pfister, Marcel Kool, Andreas von Deimling
Protein disulfide isomerase ERp57 protects early muscle denervation in experimental ALS
Pablo Rozas, Cristina Pinto, Francisca Martínez Traub, Rodrigo Díaz, Viviana Pérez, Daniela Becerra, Patricia Ojeda, Jorge Ojeda, Madison T. Wright, Jessica Mella, Lars Plate, Juan Pablo Henríquez, Claudio Hetz, Danilo B. Medinas
Non-cell autonomous astrocyte-mediated neuronal toxicity in prion diseases
Rajesh Kushwaha, Anshuman Sinha, Natallia Makarava, Kara Molesworth, Ilia V. Baskakov
A novel recessive mutation affecting DNAJB6a causes myofibrillar myopathy
Fang-Yuan Qian, Yu-Dong Guo, Juan Zu, Jin-Hua Zhang, Yi-Ming Zheng, Idriss Ali Abdoulaye, Zhao-Hui Pan, Chun-Ming Xie, Han-Chao Gao, Zhi-Jun Zhang
Three-dimensional vascular microenvironment landscape in human glioblastoma
George P. Cribaro, Elena Saavedra-López, Leire Romarate, Izaskun Mitxitorena, Laura R. Díaz, Paola V. Casanova, Meritxell Roig-Martínez, José M. Gallego, Ana Perez-Vallés, Carlos Barcia
Contribution of rare homozygous and compound heterozygous VPS13C missense mutations to dementia with Lewy bodies and Parkinson’s disease
Stefanie Smolders, Stéphanie Philtjens, David Crosiers, Anne Sieben, Elisabeth Hens, Bavo Heeman, Sara Van Mossevelde, Philippe Pals, Bob Asselbergh, Roberto Dos Santos Dias, Yannick Vermeiren, Rik Vandenberghe, Sebastiaan Engelborghs, Peter Paul De Deyn, Jean-Jacques Martin, Patrick Cras, Wim Annaert, Christine Van Broeckhoven, Chris van der Linden, Emke Maréchal, Rik Vandenberghe, Bruno Bergmans
Nucleolar stress in C9orf72 and sporadic ALS spinal motor neurons precedes TDP-43 mislocalization
Olubankole Aladesuyi Arogundade, Sandra Nguyen, Ringo Leung, Danielle Wainio, Maria Rodriguez, John Ravits
Iron loading is a prominent feature of activated microglia in Alzheimer’s disease patients
Boyd Kenkhuis, Antonios Somarakis, Lorraine de Haan, Oleh Dzyubachyk, Marieke E. IJsselsteijn, Noel F. C. C. de Miranda, Boudewijn P. F. Lelieveldt, Jouke Dijkstra, Willeke M. C. van Roon-Mom, Thomas Höllt, Louise van der Weerd
Alzheimer’s disease brain contains tau fractions with differential prion-like activities
Longfei Li, Ruirui Shi, Jianlan Gu, Yunn Chyn Tung, Yan Zhou, Dingwei Zhou, Ruozhen Wu, Dandan Chu, Nana Jin, Kevin Deng, Jiawei Xu, Cheng-Xin Gong, Khalid Iqbal, Fei Liu
Differentiated glioblastoma cells accelerate tumor progression by shaping the tumor microenvironment via CCN1-mediated macrophage infiltration
Atsuhito Uneda, Kazuhiko Kurozumi, Atsushi Fujimura, Kentaro Fujii, Joji Ishida, Yosuke Shimazu, Yoshihiro Otani, Yusuke Tomita, Yasuhiko Hattori, Yuji Matsumoto, Nobushige Tsuboi, Keigo Makino, Shuichiro Hirano, Atsunori Kamiya, Isao Date
Frontotemporal lobar degeneration proteinopathies have disparate microscopic patterns of white and grey matter pathology
Lucia A. A. Giannini, Claire Peterson, Daniel Ohm, Sharon X. Xie, Corey T. McMillan, Katya Raskovsky, Lauren Massimo, EunRah Suh, Vivianna M. Van Deerlin, David A. Wolk, John Q. Trojanowski, Edward B. Lee, Murray Grossman, David J. Irwin
Trans-synaptic spreading of alpha-synuclein pathology through sensory afferents leads to sensory nerve degeneration and neuropathic pain
Nelson Ferreira, Nádia Pereira Gonçalves, Asad Jan, Nanna Møller Jensen, Amelia van der Laan, Simin Mohseni, Christian Bjerggaard Vægter, Poul Henning Jensen
COllaborative Neuropathology NEtwork Characterizing ouTcomes of TBI (CONNECT-TBI)
Douglas H. Smith, Jean-Pierre Dollé, Kamar E. Ameen-Ali, Abigail Bretzin, Etty Cortes, John F. Crary, Kristen Dams-O’Connor, Ramon Diaz-Arrastia, Brian L. Edlow, Rebecca Folkerth, Lili-Naz Hazrati, Sidney R. Hinds, Diego Iacono, Victoria E. Johnson, C. Dirk Keene, Julia Kofler, Gabor G. Kovacs, Edward B. Lee, Geoffrey Manley, David Meaney, Thomas Montine, David O. Okonkwo, Daniel P. Perl, John Q. Trojanowski, Douglas J. Wiebe, Kristine Yaffe, Thomas McCabe, William Stewart
Laterality and region-specific tau phosphorylation correlate with PTSD-related behavioral traits in rats exposed to repetitive low-level blast
Georgina Perez Garcia, Rita De Gasperi, Miguel A. Gama Sosa, Gissel M. Perez, Alena Otero-Pagan, Dylan Pryor, Rania Abutarboush, Usmah Kawoos, Patrick R. Hof, Dara L. Dickstein, David G. Cook, Sam Gandy, Stephen T. Ahlers, Gregory A. Elder
Neuronal hibernation following hippocampal demyelination
Selva Baltan, Safdar S. Jawaid, Anthony M. Chomyk, Grahame J. Kidd, Jacqueline Chen, Harsha D. Battapady, Ricky Chan, Ranjan Dutta, Bruce D. Trapp
The number of methylated CpG sites within the MGMT promoter region linearly correlates with outcome in glioblastoma receiving alkylating agents
Sebastian Siller, Michael Lauseker, Philipp Karschnia, Maximilian Niyazi, Sabina Eigenbrod, Armin Giese, Joerg-Christian Tonn
C11orf95-RELA fusion drives aberrant gene expression through the unique epigenetic regulation for ependymoma formation
Tatsuya Ozawa, Syuzo Kaneko, Frank Szulzewsky, Zhiwei Qiao, Mutsumi Takadera, Yoshitaka Narita, Tadashi Kondo, Eric C. Holland, Ryuji Hamamoto, Koichi Ichimura
Reduced erythrocytic CHCHD2 mRNA is associated with brain pathology of Parkinson’s disease
Xiaodan Liu, Qilong Wang, Ying Yang, Tessandra Stewart, Min Shi, David Soltys, Genliang Liu, Eric Thorland, Eugene M. Cilento, Yiran Hou, Zongran Liu, Tao Feng, Jing Zhang
Systemic delivery of a specific antibody targeting the pathological N-terminal truncated tau peptide reduces retinal degeneration in a mouse model of Alzheimer’s Disease
Valentina Latina, Giacomo Giacovazzo, Federica Cordella, Bijorn Omar Balzamino, Alessandra Micera, Monica Varano, Cristina Marchetti, Francesca Malerba, Rita Florio, Bruno Bruni Ercole, Federico La Regina, Anna Atlante, Roberto Coccurello, Silvia Di Angelantonio, Pietro Calissano, Giuseppina Amadoro
Prolonged activation of cytomegalovirus early gene e1-promoter exclusively in neurons during infection of the developing cerebrum
Isao Kosugi, Yoshifumi Arai, Satoshi Baba, Hideya Kawasaki, Toshihide Iwashita, Yoshihiro Tsutsui
Gut microbial dysbiosis after traumatic brain injury modulates the immune response and impairs neurogenesis
Marta Celorrio, Miguel A. Abellanas, James Rhodes, Victoria Goodwin, Jennie Moritz, Sangeetha Vadivelu, Leran Wang, Rachel Rodgers, Sophia Xiao, Ilakkia Anabayan, Camryn Payne, Alexandra M. Perry, Megan T. Baldridge, Maria S. Aymerich, Ashley Steed, Stuart H. Friess
Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue
Lauren V. C. Miller, Aamir S. Mukadam, Claire S. Durrant, Marina J. Vaysburd, Taxiarchis Katsinelos, Benjamin J. Tuck, Sophie Sanford, Olivia Sheppard, Claire Knox, Shi Cheng, Leo C. James, Michael P. Coleman, William A. McEwan
Tau antibody isotype induces differential effects following passive immunisation of tau transgenic mice
Rinie Bajracharya, David Brici, Liviu-Gabriel Bodea, Phillip W. Janowicz, Jürgen Götz, Rebecca M. Nisbet
Expression of an alternatively spliced variant of SORL1 in neuronal dendrites is decreased in patients with Alzheimer’s disease
Giulia Monti, Mads Kjolby, Anne Mette G. Jensen, Mariet Allen, Juliane Reiche, Peter L. Møller, Raquel Comaposada-Baró, Bartlomiej E. Zolkowski, Cármen Vieira, Margarita Melnikova Jørgensen, Ida E. Holm, Paul N. Valdmanis, Niels Wellner, Christian B. Vægter, Sarah J. Lincoln, Anders Nykjær, Nilüfer Ertekin-Taner, Jessica E. Young, Mette Nyegaard, Olav M. Andersen
Astrocytes respond to a neurotoxic Aβ fragment with state-dependent Ca2+ alteration and multiphasic transmitter release
Cuong Pham, Karine Hérault, Martin Oheim, Steeve Maldera, Vincent Vialou, Bruno Cauli, Dongdong Li
Nuclear lamina invaginations are not a pathological feature of C9orf72 ALS/FTD
Alyssa N. Coyne, Jeffrey D. Rothstein
Accumulation of alpha-synuclein within the liver, potential role in the clearance of brain pathology associated with Parkinson’s disease
Juan F. Reyes, Sara Ekmark-Léwen, Marina Perdiki, Therése Klingstedt, Alana Hoffmann, Emilia Wiechec, Per Nilsson, K. Peter R. Nilsson, Irina Alafuzoff, Martin Ingelsson, Martin Hallbeck
Cell specific quantitative iron mapping on brain slices by immuno-µPIXE in healthy elderly and Parkinson’s disease
I. Friedrich, K. Reimann, S. Jankuhn, E. Kirilina, J. Stieler, M. Sonntag, J. Meijer, N. Weiskopf, T. Reinert, T. Arendt, M. Morawski
Space-occupying brain lesions, trauma-related tau astrogliopathy, and ARTAG: a report of two cases and a literature review
Adam D. Bachstetter, Filip G. Garrett, Gregory A. Jicha, Peter T. Nelson
Coping with brain amyloid: genetic heterogeneity and cognitive resilience to Alzheimer’s pathophysiology
Vijay K. Ramanan, Timothy G. Lesnick, Scott A. Przybelski, Michael G. Heckman, David S. Knopman, Jonathan Graff-Radford, Val J. Lowe, Mary M. Machulda, Michelle M. Mielke, Clifford R. Jack Jr., Ronald C. Petersen, Owen A. Ross, Prashanthi Vemuri
Perspective of mesenchymal transformation in glioblastoma
Yona Kim, Frederick S. Varn, Sung-Hye Park, Byung Woo Yoon, Hye Ran Park, Charles Lee, Roel G. W. Verhaak, Sun Ha Paek
Early alterations of neurovascular unit in the retina in mouse models of tauopathy
Fan Xia, Yonju Ha, Shuizhen Shi, Yi Li, Shengguo Li, Jonathan Luisi, Rakez Kayed, Massoud Motamedi, Hua Liu, Wenbo Zhang
TDP-43 proteinopathy alters the ribosome association of multiple mRNAs including the glypican Dally-like protein (Dlp)/GPC6
Erik M. Lehmkuhl, Suvithanandhini Loganathan, Eric Alsop, Alexander D. Blythe, Tina Kovalik, Nicholas P. Mortimore, Dianne Barrameda, Chuol Kueth, Randall J. Eck, Bhavani B. Siddegowda, Archi Joardar, Hannah Ball, Maria E. Macias, Robert Bowser, Kendall Van Keuren-Jensen, Daniela C. Zarnescu
Chronically altered NMDAR signaling in epilepsy mediates comorbid depression
Mohammad Amin Sadeghi, Sara Hemmati, Sina Mohammadi, Hasan Yousefi-Manesh, Ali Vafaei, Meysam Zare, Ahmad Reza Dehpour
Macrophages and microglia: the cerberus of glioblastoma
Alice Buonfiglioli, Dolores Hambardzumyan
Two distinct conformers of PrPD type 1 of sporadic Creutzfeldt–Jakob disease with codon 129VV genotype faithfully propagate in vivo
Ignazio Cali, Juan Carlos Espinosa, Satish K. Nemani, Alba Marin-Moreno, Manuel V. Camacho, Rabail Aslam, Tetsuyuki Kitamoto, Brian S. Appleby, Juan Maria Torres, Pierluigi Gambetti
Amyloid pathology arrangements in Alzheimer’s disease brains modulate in vivo seeding capability
Claudia Duran-Aniotz, Ines Moreno-Gonzalez, Nazaret Gamez, Nelson Perez-Urrutia, Laura Vegas-Gomez,, Claudio Soto, Rodrigo Morales
Neuropathological and behavioral characterization of aged Grn R493X progranulin-deficient frontotemporal dementia knockin mice
Jonathan Frew, Haakon Berge Nygaard
Oral administration of repurposed drug targeting Cyp46A1 increases survival times of prion infected mice
Tahir Ali, Samia Hannaoui, Satish Nemani, Waqas Tahir, Irina Zemlyankina, Pearl Cherry, Su Yeon Shim, Valerie Sim, Hermann M. Schaetzl, Sabine Gilch
The expression of B7-H3 isoforms in newly diagnosed glioblastoma and recurrence and their functional role
Marina Digregorio, Natacha Coppieters, Arnaud Lombard, Paul Noel Lumapat, Felix Scholtes, Bernard Rogister
Repetitive mild traumatic brain injury in mice triggers a slowly developing cascade of long-term and persistent behavioral deficits and pathological changes
Xiaoyun Xu, Matthew Cowan, Flavio Beraldo, Amy Schranz, Patrick McCunn, Nicole Geremia, Zalman Brown, Maitray Patel, Karen L. Nygard, Reza Khazaee, Lihong Lu, Xingyu Liu, Michael J. Strong, Gregory A. Dekaban, Ravi Menon, Robert Bartha, Mark Daley, Haojie Mao, Vania Prado, Marco A. M. Prado, Lisa Saksida, Tim Bussey, Arthur Brown
Molecular classification of a complex structural rearrangement of the RB1 locus in an infant with sporadic, isolated, intracranial, sellar region retinoblastoma
Kathleen M. Schieffer, Alexander Z. Feldman, Esko A. Kautto, Sean McGrath, Anthony R. Miller, Maria Elena Hernandez-Gonzalez, Stephanie LaHaye, Katherine E. Miller, Daniel C. Koboldt, Patrick Brennan, Benjamin Kelly, Amy Wetzel, Vibhuti Agarwal, Margaret Shatara, Suzanne Conley, Diana P. Rodriguez, Rolla Abu-Arja, Ala Shaikhkhalil, Matija Snuderl, Brent A. Orr, Jonathan L. Finlay, Diana S. Osorio, Annie I. Drapeau, Jeffrey R. Leonard, Christopher R. Pierson, Peter White, Vincent Magrini, Elaine R. Mardis, Richard K. Wilson, Catherine E. Cottrell, Daniel R. Boué
Streamlined alpha-synuclein RT-QuIC assay for various biospecimens in Parkinson’s disease and dementia with Lewy bodies
Connor Bargar, Wen Wang, Steven A. Gunzler, Alexandra LeFevre, Zerui Wang, Alan J. Lerner, Neena Singh, Curtis Tatsuoka, Brian Appleby, Xiongwei Zhu, Rong Xu, Vahram Haroutunian, Wen-Quan Zou, Jiyan Ma, Shu G. Chen
SCF + G-CSF treatment in the chronic phase of severe TBI enhances axonal sprouting in the spinal cord and synaptic pruning in the hippocampus
Xuecheng Qiu, Suning Ping, Michele Kyle, Lawrence Chin, Li-Ru Zhao
Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion protein
Ivan Martinez-Valbuena, Rafael Valenti-Azcarate, Irene Amat-Villegas, Irene Marcilla, Gloria Marti-Andres, Maria-Cristina Caballero, Mario Riverol, María-Teresa Tuñon, Paul E. Fraser, María-Rosario Luquin
Hsp90 co-chaperones, FKBP52 and Aha1, promote tau pathogenesis in aged wild-type mice
Marangelie Criado-Marrero, Niat T. Gebru, Danielle M. Blazier, Lauren A. Gould, Jeremy D. Baker, David Beaulieu-Abdelahad, Laura J. Blair
Amyloid precursor protein elevates fusion of promyelocytic leukemia nuclear bodies in human hippocampal areas with high plaque load
David Marks, Natalie Heinen, Lisa Bachmann, Sophia Meermeyer, Michelle Werner, Lucia Gallego, Peter Hemmerich, Verian Bader, Konstanze F. Winklhofer, Elisabeth Schröder, Shirley K. Knauer, Thorsten Müller
TNFα secreted by glioma associated macrophages promotes endothelial activation and resistance against anti-angiogenic therapy
Qingxia Wei, Olivia Singh, Can Ekinci, Jaspreet Gill, Mira Li, Yasin Mamatjan, Shirin Karimi, Severa Bunda, Sheila Mansouri, Kenneth Aldape, Gelareh Zadeh
Human alpha-synuclein overexpressing MBP29 mice mimic functional and structural hallmarks of the cerebellar subtype of multiple system atrophy
Lisa Mészáros, Markus J. Riemenschneider, Heiko Gassner, Franz Marxreiter, Stephan von Hörsten, Alana Hoffmann, Jürgen Winkler
Novel targetable FGFR2 and FGFR3 alterations in glioblastoma associate with aggressive phenotype and distinct gene expression programs
Maria-Magdalena Georgescu, Mohammad Zahidul Islam, Yan Li, James Traylor, Anil Nanda
Correlative light and electron microscopy suggests that mutant huntingtin dysregulates the endolysosomal pathway in presymptomatic Huntington’s disease
Ya Zhou, Thomas R. Peskett, Christian Landles, John B. Warner, Kirupa Sathasivam, Edward J. Smith, Shu Chen, Ronald Wetzel, Hilal A. Lashuel, Gillian P. Bates, Helen R. Saibil
Brain insulin signaling and cerebrovascular disease in human postmortem brain
Zoe Arvanitakis, Ana W. Capuano, Hoau-Yan Wang, Julie A. Schneider, Alifiya Kapasi, David A. Bennett, Rexford S. Ahima, Steven E. Arnold
Complement mediates neuroinflammation and cognitive decline at extended chronic time points after traumatic brain injury
Khalil Mallah, Christine Couch, Mohammed Alshareef, Davis Borucki, Xiaofeng Yang, Ali Alawieh, Stephen Tomlinson
Enhanced detection of expanded repeat mRNA foci with hybridization chain reaction
M. Rebecca Glineburg, Yuan Zhang, Amy Krans, Elizabeth M. Tank, Sami J. Barmada, Peter K. Todd
Mild traumatic brain injury induces microvascular injury and accelerates Alzheimer-like pathogenesis in mice
Yingxi Wu, Haijian Wu, Jianxiong Zeng, Brock Pluimer, Shirley Dong, Xiaochun Xie, Xinying Guo, Tenghuan Ge, Xinyan Liang, Sudi Feng, Youzhen Yan, Jian-Fu Chen, Naomi Sta Maria, Qingyi Ma, Fernando Gomez-Pinilla, Zhen Zhao
Combined epigenetic/genetic study identified an ALS age of onset modifier
Ming Zhang, Zhengrui Xi, Sara Saez-Atienzar, Ruth Chia, Danielle Moreno, Christine Sato, Mahdi Montazer Haghighi, Bryan J. Traynor, Lorne Zinman, Ekaterina Rogaeva
In-depth characterization of a mouse model of post-traumatic epilepsy for biomarker and drug discovery
Rossella Di Sapia, Federico Moro, Marica Montanarella, Valentina Iori, Edoardo Micotti, Daniele Tolomeo, Kevin K. W. Wang, Annamaria Vezzani, Teresa Ravizza, Elisa R. Zanier
Sex-specific DNA methylation differences in Alzheimer’s disease pathology
Lanyu Zhang, Juan I. Young, Lissette Gomez, Tiago C. Silva, Michael A. Schmidt, Jesse Cai, Xi Chen, Eden R. Martin, Lily Wang
Blocking microglial activation of reactive astrocytes is neuroprotective in models of Alzheimer’s disease
Jong-Sung Park, Tae-In Kam, Saebom Lee, Hyejin Park, Yumin Oh, Seung-Hwan Kwon, Jae-Jin Song, Donghoon Kim, Hyunhee Kim, Aanishaa Jhaldiyal, Dong Hee Na, Kang Choon Lee, Eun Ji Park, Martin G. Pomper, Olga Pletnikova, Juan C. Troncoso, Han Seok Ko, Valina L. Dawson, Ted M. Dawson, Seulki Lee
Filamentous tangles with nemaline rods in MYH2 myopathy: a novel phenotype
Nicolas N. Madigan, Michael J. Polzin, Gaofeng Cui, Teerin Liewluck, Mohammad H. Alsharabati, Christopher J. Klein, Anthony J. Windebank, Georges Mer, Margherita Milone
Robust α-synuclein pathology in select brainstem neuronal populations is a potential instigator of multiple system atrophy
Ethan W. Hass, Zachary A. Sorrentino, Grace M. Lloyd, Nikolaus R. McFarland, Stefan Prokop, Benoit I. Giasson
Therapeutic targeting of Lyn kinase to treat chorea-acanthocytosis
Kevin Peikert, Enrica Federti, Alessandro Matte, Gabriela Constantin, Enrica Caterina Pietronigro, Paolo Francesco Fabene, Paola Defilippi, Emilia Turco, Federico Del Gallo, Pietro Pucci, Angela Amoresano, Anna Illiano, Flora Cozzolino, Maria Monti, Francesca Garello, Enzo Terreno, Seth Leo Alper, Hannes Glaß, Lisann Pelzl, Katja Akgün, Tjalf Ziemssen, Rainer Ordemann, Florian Lang, Anna Maria Brunati, Elena Tibaldi, Immacolata Andolfo, Achille Iolascon, Giuseppe Bertini, Mario Buffelli, Carlo Zancanaro, Erika Lorenzetto, Angela Siciliano, Massimiliano Bonifacio, Adrian Danek, Ruth Helen Walker, Andreas Hermann, Lucia De Franceschi
Early onset senescence and cognitive impairment in a murine model of repeated mTBI
Nicole Schwab, YoungJun Ju, Lili-Naz Hazrati
Aβ43 aggregates exhibit enhanced prion-like seeding activity in mice
Alejandro Ruiz-Riquelme, Alison Mao, Marim M. Barghash, Heather H. C. Lau, Erica Stuart, Gabor G. Kovacs, K. Peter R. Nilsson, Paul E. Fraser, Gerold Schmitt-Ulms, Joel C. Watts
Heparanase overexpression impedes perivascular clearance of amyloid-β from murine brain: relevance to Alzheimer’s disease
Xiao Zhang, Paul O’Callaghan, Honglian Li, Yingxia Tan, Ganlin Zhang, Uri Barash, Xiaomin Wang, Lars Lannfelt, Israel Vlodavsky, Ulf Lindahl, Jin-Ping Li
Correction to: Hsp90 co‑chaperones, FKBP52 and Aha1, promote tau pathogenesis in aged wild‑type mice
Marangelie Criado-Marrero, Niat T. Gebru, Danielle M. Blazier, Lauren A. Gould, Jeremy D. Baker, David Beaulieu-Abdelahad, Laura J. Blair
Tau isoforms are differentially expressed across the hippocampus in chronic traumatic encephalopathy and Alzheimer’s disease
Jonathan D. Cherry, Camille D. Esnault, Zachary H. Baucom, Yorghos Tripodis, Bertrand R. Huber, Victor E. Alvarez, Thor D. Stein, Dennis W. Dickson, Ann C. McKee
The degree of astrocyte activation is predictive of the incubation time to prion disease
Natallia Makarava, Olga Mychko, Jennifer Chen-Yu Chang, Kara Molesworth, Ilia V. Baskakov
Design considerations of an IL13Rα2 antibody–drug conjugate for diffuse intrinsic pontine glioma
Xiaolei Lian, Dina Kats, Samuel Rasmussen, Leah R. Martin, Anju Karki, Charles Keller, Noah E. Berlow
Genetic inactivation of SARM1 axon degeneration pathway improves outcome trajectory after experimental traumatic brain injury based on pathological, radiological, and functional measures
Donald V. Bradshaw Jr., Andrew K. Knutsen, Alexandru Korotcov, Genevieve M. Sullivan, Kryslaine L. Radomski, Bernard J. Dardzinski, Xiaomei Zi, Dennis P. McDaniel, Regina C. Armstrong
Cannabinoid receptor CB2 ablation protects against TAU induced neurodegeneration
M. Galán-Ganga, C. Rodríguez-Cueto, J. Merchán-Rubira, F. Hernández, J. Ávila, M. Posada-Ayala, J. L. Lanciego, E. Luengo, M. G. Lopez, A. Rábano, J. Fernández-Ruiz, I. Lastres-Becker
VISTA regulates microglia homeostasis and myelin phagocytosis, and is associated with MS lesion pathology
Malte Borggrewe, Susanne M. Kooistra, Evelyn M. Wesseling, Fenja L. Gierschek, Maaike L. Brummer, Elizabeth C. Nowak, Tiago Medeiros-Furquim, Tegan A. Otto, Sam W. Lee, Randolph J. Noelle, Bart J. L. Eggen, Jon D. Laman
Variation in the vulnerability of mice expressing human superoxide dismutase 1 to prion-like seeding: a study of the influence of primary amino acid sequence
Jacob I. Ayers, Guilian Xu, Kristy Dillon, Qing Lu, Zhijuan Chen, John Beckman, Alma K. Moreno-Romero, Diana L. Zamora, Ahmad Galaleldeen, David R. Borchelt
Genome-wide analysis identifies a novel LINC-PINT splice variant associated with vascular amyloid pathology in Alzheimer’s disease
Joseph S. Reddy, Mariet Allen, Charlotte C. G. Ho, Stephanie R. Oatman, Özkan İş, Zachary S. Quicksall, Xue Wang, Jiangli Jin, Tulsi A. Patel, Troy P. Carnwath, Thuy T. Nguyen, Kimberly G. Malphrus, Sarah J. Lincoln, Minerva M. Carrasquillo, Julia E. Crook, Takahisa Kanekiyo, Melissa E. Murray, Guojun Bu, Dennis W. Dickson, Nilüfer Ertekin-Taner
In vivo 5-ethynyluridine (EU) labelling detects reduced transcription in Purkinje cell degeneration mouse mutants, but can itself induce neurodegeneration
Lisanne J. van’t Sant, Joshua J. White, Jan H. J. Hoeijmakers, Wilbert P. Vermeij, Dick Jaarsma
Loss of H3K27 trimethylation is frequent in IDH1-R132H but not in non-canonical IDH1/2 mutated and 1p/19q codeleted oligodendroglioma: a Japanese cohort study
Umma Habiba, Hirokazu Sugino, Roumyana Yordanova, Koki Ise, Zen-ichi Tanei, Yusuke Ishida, Satoshi Tanikawa, Shunsuke Terasaka, Ken-ichi Sato, Yuuta Kamoshima, Masahiko Katoh, Motoo Nagane, Junji Shibahara, Masumi Tsuda, Shinya Tanaka
Identifying degenerative effects of repetitive head trauma with neuroimaging: a clinically-oriented review
Breton M. Asken, Gil D. Rabinovici
Zika virus induces neuronal and vascular degeneration in developing mouse retina
Yi Li, Shuizhen Shi, Fan Xia, Chao Shan, Yonju Ha, Jing Zou, Awadalkareem Adam, Ming Zhang, Tian Wang, Hua Liu, Pei-Yong Shi, Wenbo Zhang
An update on the neurological short tandem repeat expansion disorders and the emergence of long-read sequencing diagnostics
Sanjog R. Chintalaphani, Sandy S. Pineda, Ira W. Deveson, Kishore R. Kumar
Ultrasensitive tau biosensor cells detect no seeding in Alzheimer’s disease CSF
Brian D. Hitt, Jaime Vaquer-Alicea, Victor A. Manon, Joshua D. Beaver, Omar M. Kashmer, Jan N. Garcia, Marc I. Diamond
Publisher Correction to: C11orf95-RELA fusion drives aberrant gene expression through the unique epigenetic regulation for ependymoma formation
Tatsuya Ozawa, Syuzo Kaneko, Frank Szulzewsky, Zhiwei Qiao, Mutsumi Takadera, Yoshitaka Narita, Tadashi Kondo, Eric C. Holland, Ryuji Hamamoto, Koichi Ichimura
Altered lipid metabolism marks glioblastoma stem and non-stem cells in separate tumor niches
Sajina Shakya, Anthony D. Gromovsky, James S. Hale, Arnon M. Knudsen, Briana Prager, Lisa C. Wallace, Luiz O. F. Penalva, H. Alex Brown, Bjarne W. Kristensen, Jeremy N. Rich, Justin D. Lathia, J. Mark Brown, Christopher G. Hubert
Repetitive transcranial magnetic stimulation increases the brain’s drainage efficiency in a mouse model of Alzheimer’s disease
Yangyang Lin, Jian Jin, Rongke Lv, Yuan Luo, Weiping Dai, Wenchang Li, Yamei Tang, Yuling Wang, Xiaojing Ye, Wei-Jye Lin
Pathology of the neurovascular unit in leukodystrophies
Parand Zarekiani, Marjolein Breur, Nicole I. Wolf, Helga E. de Vries, Marjo S. van der Knaap, Marianna Bugiani
Neuropathological hallmarks of fetal hydrocephalus linked to CCDC88C pathogenic variants
Florent Marguet, Myriam Vezain, Pascale Marcorelles, Séverine Audebert-Bellanger, Kévin Cassinari, Nathalie Drouot, Pascal Chambon, Bruno J. Gonzalez, Arie Horowitz, Annie Laquerriere, Pascale Saugier-Veber
α-Synuclein pathology in Parkinson disease activates homeostatic NRF2 anti-oxidant response
Alberto Delaidelli, Mette Richner, Lixiang Jiang, Amelia van der Laan, Ida Bergholdt Jul Christiansen, Nelson Ferreira, Jens R. Nyengaard, Christian B. Vægter, Poul H. Jensen, Ian R. Mackenzie, Poul H. Sorensen, Asad Jan
A novel splicing variant of ANXA11 in a patient with amyotrophic lateral sclerosis: histologic and biochemical features
Makoto Sainouchi, Yuya Hatano, Mari Tada, Tomohiko Ishihara, Shoichiro Ando, Taisuke Kato, Jun Tokunaga, Gaku Ito, Hiroaki Miyahara, Yasuko Toyoshima, Akio Yokoseki, Tetsutaro Ozawa, Kohei Akazawa, Osamu Onodera, Akiyoshi Kakita
In Parkinson's patient-derived dopamine neurons, the triplication of α-synuclein locus induces distinctive firing pattern by impeding D2 receptor autoinhibition
Min Lin, Phillip M. Mackie, Fatima Shaerzadeh, Joyonna Gamble-George, Douglas R. Miller, Chris J. Martyniuk, Habibeh Khoshbouei
CSF1R inhibition rescues tau pathology and neurodegeneration in an A/T/N model with combined AD pathologies, while preserving plaque associated microglia
Chritica Lodder, Isabelle Scheyltjens, Ilie Cosmin Stancu, Pablo Botella Lucena, Manuel Gutiérrez de Ravé, Sarah Vanherle, Tim Vanmierlo, Niels Cremers, Hannah Vanrusselt, Bert Brône, Bernard Hanseeuw, Jean-Noël Octave, Astrid Bottelbergs, Kiavash Movahedi, Ilse Dewachter
Autophagy is affected in patients with hypokalemic periodic paralysis: an involvement in vacuolar myopathy?
Thomas O. Krag, Sonja Holm-Yildiz, Nanna Witting, John Vissing
Altered ribosomal function and protein synthesis caused by tau
Harrison Tudor Evans, Deonne Taylor, Andrew Kneynsberg, Liviu-Gabriel Bodea, Jürgen Götz
Equilibrative nucleoside transporter 1 inhibition rescues energy dysfunction and pathology in a model of tauopathy
Ching-Pang Chang, Ya-Gin Chang, Pei-Yun Chuang, Thi Ngoc Anh Nguyen, Kuo-Chen Wu, Fang-Yi Chou, Sin-Jhong Cheng, Hui-Mei Chen, Lee-Way Jin, Kevin Carvalho, Vincent Huin, Luc Buée, Yung-Feng Liao, Chun-Jung Lin, David Blum, Yijuang Chern
Peripheral administration of SOD1 aggregates does not transmit pathogenic aggregation to the CNS of SOD1 transgenic mice
Isil Keskin, Elaheh Ekhtiari Bidhendi, Matthew Marklund, Peter M. Andersen, Thomas Brännström, Stefan L. Marklund, Ulrika Nordström
Autopsy findings of previously described case of diffuse intrinsic pontine glioma-like tumor with EZHIP expression and molecular features of PFA ependymoma
Murad Alturkustani, Jennifer A. Cotter, Roshan Mahabir, Debra Hawes, Carl Koschmann, Sriram Venneti, Alexander R. Judkins, Linda J. Szymanski
Correction to: Design considerations of an IL13Rα2 antibody–drug conjugate for difuse intrinsic pontine glioma
Xiaolei Lian, Dina Kats, Samuel Rasmussen, Leah R. Martin, Anju Karki, Charles Keller, Noah E. Berlow
Correction to: A novel splicing variant of ANXA11 in a patient with amyotrophic lateral sclerosis: histologic and biochemical features
Makoto Sainouchi, Yuya Hatano, Mari Tada, Tomohiko Ishihara, Shoichiro Ando, Taisuke Kato, Jun Tokunaga, Gaku Ito, Hiroaki Miyahara, Yasuko Toyoshima, Akio Yokoseki, Tetsutaro Ozawa, Kohei Akazawa, Osamu Onodera, Akiyoshi Kakita
Age-related changes in brain phospholipids and bioactive lipids in the APP knock-in mouse model of Alzheimer’s disease
Ceren Emre, Khanh V. Do, Bokkyoo Jun, Erik Hjorth, Silvia Gómez Alcalde, Marie-Audrey I. Kautzmann, William C. Gordon, Per Nilsson, Nicolas G. Bazan, Marianne Schultzberg
Pathological tau drives ectopic nuclear speckle scaffold protein SRRM2 accumulation in neuron cytoplasm in Alzheimer’s disease
Pamela J. McMillan, Timothy J. Strovas, Misa Baum, Brooke K. Mitchell, Randall J. Eck, Nzinga Hendricks, Jeanna M. Wheeler, Caitlin S. Latimer, C. Dirk Keene, Brian C. Kraemer
Mouse closed head traumatic brain injury replicates the histological tau pathology pattern of human disease: characterization of a novel model and systematic review of the literature
Aydan Kahriman, James Bouley, Thomas W. Smith, Daryl A. Bosco, Amanda L. Woerman, Nils Henninger
Molecular diagnostics helps to identify distinct subgroups of spinal astrocytomas
Annamaria Biczok, Felix L. Strübing, Julia M. Eder, Rupert Egensperger, Oliver Schnell, Stefan Zausinger, Julia E. Neumann, Jochen Herms, Joerg-Christian Tonn, Mario M. Dorostkar
Spatial progression and molecular heterogeneity of IDH-mutant glioblastoma determined by DNA methylation-based mapping
James F. Lyon, Varshini Vasudevaraja, Kanish Mirchia, Jamie M. Walker, Robert J. Corona, Lawrence S. Chin, Ivy Tran, Matija Snuderl, Timothy E. Richardson, Mariano S. Viapiano
Inducing sterile pyramidal neuronal death in mice to model distinct aspects of gray matter encephalitis
Justus B. H. Wilke, Martin Hindermann, Amir Moussavi, Umer Javed Butt, Rakshit Dadarwal, Stefan A. Berghoff, Aref Kalantari Sarcheshmeh, Anja Ronnenberg, Svenja Zihsler, Sahab Arinrad, Rüdiger Hardeland, Jan Seidel, Fred Lühder, Klaus-Armin Nave, Susann Boretius, Hannelore Ehrenreich
Spinal Muscular Atrophy autophagy profile is tissue-dependent: differential regulation between muscle and motoneurons
Alba Sansa, Ivan Hidalgo, Maria P. Miralles, Sandra de la Fuente, M. Jose Perez-Garcia, Francina Munell, Rosa M. Soler, Ana Garcera
RBM5-AS1 promotes radioresistance in medulloblastoma through stabilization of SIRT6 protein
Chuanying Zhu, Keke Li, Mawei Jiang, Siyu Chen
Reappraisal of metabolic dysfunction in neurodegeneration: Focus on mitochondrial function and calcium signaling
Pooja Jadiya, Joanne F. Garbincius, John W. Elrod
IL-17F depletion accelerates chitosan conduit guided peripheral nerve regeneration
Feixiang Chen, Weihuang Liu, Qiang Zhang, Ping Wu, Ao Xiao, Yanan Zhao, Ying Zhou, Qiaona Wang, Yun Chen, Zan Tong
Chronic complement dysregulation drives neuroinflammation after traumatic brain injury: a transcriptomic study
Amer Toutonji, Mamatha Mandava, Silvia Guglietta, Stephen Tomlinson
The ESCRT-III protein VPS4, but not CHMP4B or CHMP2B, is pathologically increased in familial and sporadic ALS neuronal nuclei
Alyssa N. Coyne, Jeffrey D. Rothstein
Downstream effects of polypathology on neurodegeneration of medial temporal lobe subregions
L. E. M. Wisse, S. Ravikumar, R. Ittyerah, S. Lim, J. Lane, M. L. Bedard, L. Xie, S. R. Das, T. Schuck, M. Grossman, E. B. Lee, M. D. Tisdall, K. Prabhakaran, J. A. Detre, G. Mizsei, J. Q. Trojanowski, E. Artacho-Pérula, M. M. de Iñiguez de Onzono Martin, M. M. Arroyo-Jiménez, M. Muñoz Lopez, F. J. Molina Romero, M. P. Marcos Rabal, S. Cebada Sánchez, J. C. Delgado González, C. de la Rosa Prieto, M. Córcoles Parada, D. A. Wolk, D. J. Irwin, R. Insausti, P. A. Yushkevich
Protein farnesylation is upregulated in Alzheimer’s human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer’s model mice
Angela Jeong, Shaowu Cheng, Rui Zhong, David A. Bennett, Martin O. Bergö, Ling Li
Loss with ageing but preservation of frontal cortical capillary pericytes in post-stroke dementia, vascular dementia and Alzheimer’s disease
Ren Ding, Yoshiki Hase, Matthew Burke, Vincent Foster, William Stevenson, Tuomo Polvikoski, Raj N. Kalaria
Right temporal variant frontotemporal dementia is pathologically heterogeneous: a case-series and a systematic review
Hulya Ulugut, Anke A. Dijkstra, Marta Scarioni, Frederik Barkhof, Philip Scheltens, Annemieke J. M. Rozemuller, Yolande A. L. Pijnenburg
Single-cell multimodal analysis in a case with reduced penetrance of Progranulin-Frontotemporal Dementia
Karthick Natarajan, Jesper Eisfeldt, Maria Hammond, José Miguel Laffita-Mesa, Kalicharan Patra, Behzad Khoshnood, Linn Öijerstedt, Caroline Graff
Metabolic and transcriptomic profiles of glioblastoma invasion revealed by comparisons between patients and corresponding orthotopic xenografts in mice
Cristina Cudalbu, Pierre Bady, Marta Lai, Lijing Xin, Olga Gusyatiner, Marie-France Hamou, Mario Lepore, Jean-Philippe Brouland, Roy T. Daniel, Andreas F. Hottinger, Monika E. Hegi
Predictors of cognitive impairment in primary age-related tauopathy: an autopsy study
Megan A. Iida, Kurt Farrell, Jamie M. Walker, Timothy E. Richardson, Gabriel A. Marx, Clare H. Bryce, Dushyant Purohit, Gai Ayalon, Thomas G. Beach, Eileen H. Bigio, Etty P. Cortes, Marla Gearing, Vahram Haroutunian, Corey T. McMillan, Edward B. Lee, Dennis W. Dickson, Ann C. McKee, Thor D. Stein, John Q. Trojanowski, Randall L. Woltjer, Gabor G. Kovacs, Julia K. Kofler, Jeffrey Kaye, Charles L. White III, John F. Crary
Supratentorial non-RELA, ZFTA-fused ependymomas: a comprehensive phenotype genotype correlation highlighting the number of zinc fingers in ZFTA-NCOA1/2 fusions
Arnault Tauziède-Espariat, Aurore Siegfried, Yvan Nicaise, Thomas Kergrohen, Philipp Sievers, Alexandre Vasiljevic, Alexandre Roux, Edouard Dezamis, Chiara Benevello, Marie-Christine Machet, Sophie Michalak, Chloe Puiseux, Francisco Llamas-Gutierrez, Pierre Leblond, Franck Bourdeaut, Jacques Grill, Christelle Dufour, Léa Guerrini-Rousseau, Samuel Abbou, Volodia Dangouloff-Ros, Nathalie Boddaert, Raphaël Saffroy, Lauren Hasty, Ellen Wahler, Mélanie Pagès, Felipe Andreiuolo, Emmanuèle Lechapt, Fabrice Chrétien, Thomas Blauwblomme, Kévin Beccaria, Johan Pallud, Stéphanie Puget, Emmanuelle Uro-Coste, Pascale Varlet
The pathogenic role of c-Kit+ mast cells in the spinal motor neuron-vascular niche in ALS
Mariángeles Kovacs, Catalina Alamón, Cecilia Maciel, Valentina Varela, Sofía Ibarburu, Lucas Tarragó, Peter H. King, Ying Si, Yuri Kwon, Olivier Hermine, Luis Barbeito, Emiliano Trias
Forebrain Shh overexpression improves cognitive function and locomotor hyperactivity in an aneuploid mouse model of Down syndrome and its euploid littermates
Feng J. Gao, Donna Klinedinst, Fabian-Xosé Fernandez, Bei Cheng, Alena Savonenko, Benjamin Devenney, Yicong Li, Dan Wu, Martin G. Pomper, Roger H. Reeves
RIPK1 or RIPK3 deletion prevents progressive neuronal cell death and improves memory function after traumatic brain injury
Antonia Clarissa Wehn, Igor Khalin, Marco Duering, Farida Hellal, Carsten Culmsee, Peter Vandenabeele, Nikolaus Plesnila, Nicole Angela Terpolilli
Experimental colitis promotes sustained, sex-dependent, T-cell-associated neuroinflammation and parkinsonian neuropathology
Madelyn C. Houser, W. Michael Caudle, Jianjun Chang, George T. Kannarkat, Yuan Yang, Sean D. Kelly, Danielle Oliver, Valerie Joers, Kathleen M. Shannon, Ali Keshavarzian, Malú Gámez Tansey
Microglial transcriptome analysis in the rNLS8 mouse model of TDP-43 proteinopathy reveals discrete expression profiles associated with neurodegenerative progression and recovery
Mandana Hunter, Krista J. Spiller, Myrna A. Dominique, Hong Xu, Francis W. Hunter, Terry C. Fang, Rebecca G. Canter, Christopher J. Roberts, Richard M. Ransohoff, John Q. Trojanowski, Virginia M.-Y. Lee
Deep learning assisted quantitative assessment of histopathological markers of Alzheimer’s disease and cerebral amyloid angiopathy
Valentina Perosa, Ashley A. Scherlek, Mariel G. Kozberg, Lindsey Smith, Thomas Westerling-Bui, Corinne A. Auger, Serge Vasylechko, Steven M. Greenberg, Susanne J. van Veluw
Defining tumor-associated vascular heterogeneity in pediatric high-grade and diffuse midline gliomas
Xin Wei, Michaël H. Meel, Marjolein Breur, Marianna Bugiani, Esther Hulleman, Timothy N. Phoenix
Importance of extracellular vesicle secretion at the blood–cerebrospinal fluid interface in the pathogenesis of Alzheimer’s disease
Charysse Vandendriessche, Sriram Balusu, Caroline Van Cauwenberghe, Marjana Brkic, Marie Pauwels, Nele Plehiers, Arnout Bruggeman, Pieter Dujardin, Griet Van Imschoot, Elien Van Wonterghem, An Hendrix, Femke Baeke, Riet De Rycke, Kris Gevaert, Roosmarijn E. Vandenbroucke
Blood-spinal cord barrier leakage is independent of motor neuron pathology in ALS
Sarah Waters, Molly E. V. Swanson, Birger V. Dieriks, Yibin B. Zhang, Natasha L. Grimsey, Helen C. Murray, Clinton Turner, Henry J. Waldvogel, Richard L. M. Faull, Jiyan An, Robert Bowser, Maurice A. Curtis, Mike Dragunow, Emma Scotter
Prion strains associated with iatrogenic CJD in French and UK human growth hormone recipients
Jean-Yves Douet, Alvina Huor, Hervé Cassard, Séverine Lugan, Naïma Aron, Chloé Mesic, Didier Vilette, Tomás Barrio, Nathalie Streichenberger, Armand Perret-Liaudet, Marie-Bernadette Delisle, Patrice Péran, Jean-Philippe Deslys, Emmanuel Comoy, Jean-Luc Vilotte, Katayoun Goudarzi, Vincent Béringue, Marcelo A. Barria, Diane L. Ritchie, James W. Ironside, Olivier Andréoletti
Disease-, region- and cell type specific diversity of α-synuclein carboxy terminal truncations in synucleinopathies
Ethan W. Hass, Zachary A. Sorrentino, Yuxing Xia, Grace M. Lloyd, John Q. Trojanowski, Stefan Prokop, Benoit I. Giasson
Diffuse leptomeningeal glioneuronal tumour (DLGNT) in children: the emerging role of genomic analysis
Neevika Manoharan, Pamela Ajuyah, Akanksha Senapati, Marie Wong, Anna Mullins, Michael Rodriguez, Helen Doyle, Geoff McCowage, Loretta M. S. Lau, Paul G. Ekert, David S. Ziegler
Immune cell deconvolution of bulk DNA methylation data reveals an association with methylation class, key somatic alterations, and cell state in glial/glioneuronal tumors
Omkar Singh, Drew Pratt, Kenneth Aldape
Synaptic tau: A pathological or physiological phenomenon?
Miranda Robbins, Emma Clayton, Gabriele S. Kaminski Schierle
Effects of microglial depletion and TREM2 deficiency on Aβ plaque burden and neuritic plaque tau pathology in 5XFAD mice
Argyro Thalia Delizannis, Annelies Nonneman, Wangchen Tsering, An De Bondt, Ilse Van den Wyngaert, Bin Zhang, Emily Meymand, Modupe F. Olufemi, Pyry Koivula, Shaniya Maimaiti, John Q. Trojanowski, Virginia M.-Y. Lee, Kurt R. Brunden
Exogenous Aβ seeds induce Aβ depositions in the blood vessels rather than the brain parenchyma, independently of Aβ strain-specific information
Tsuyoshi Hamaguchi, Jee Hee Kim, Akane Hasegawa, Ritsuko Goto, Kenji Sakai, Kenjiro Ono, Yoshinori Itoh, Masahito Yamada
Analysis of genes (TMEM106B, GRN, ABCC9, KCNMB2, and APOE) implicated in risk for LATE-NC and hippocampal sclerosis provides pathogenetic insights: a retrospective genetic association study
Adam J. Dugan, Peter T. Nelson, Yuriko Katsumata, Lincoln M. P. Shade, Kevin L. Boehme, Merilee A. Teylan, Matthew D. Cykowski, Shubhabrata Mukherjee, John S. K. Kauwe, Timothy J. Hohman, Julie A. Schneider, David W. Fardo
The intracellular milieu of Parkinson’s disease patient brain cells modulates alpha-synuclein protein aggregation
Nadja Gustavsson, Ekaterina Savchenko, Oxana Klementieva, Laurent Roybon
MFG-E8 (LACTADHERIN): a novel marker associated with cerebral amyloid angiopathy
Paula Marazuela, Montse Solé, Anna Bonaterra-Pastra, Jesús Pizarro, Jessica Camacho, Elena Martínez-Sáez, H. Bea Kuiperij, Marcel M. Verbeek, Anna M. de Kort, Floris H. B. M. Schreuder, Catharina J. M. Klijn, Laura Castillo-Ribelles, Olalla Pancorbo, David Rodríguez-Luna, Francesc Pujadas, Pilar Delgado, Mar Hernández-Guillamon
A recurrent RYR1 mutation associated with early-onset hypotonia and benign disease course
Valérie Biancalana, John Rendu, Annabelle Chaussenot, Helen Mecili, Eric Bieth, Mélanie Fradin, Sandra Mercier, Maud Michaud, Marie-Christine Nougues, Laurent Pasquier, Sabrina Sacconi, Norma B. Romero, Pascale Marcorelles, François Jérôme Authier, Antoinette Gelot Bernabe, Emmanuelle Uro-Coste, Claude Cances, Bertrand Isidor, Armelle Magot, Marie-Christine Minot-Myhie, Yann Péréon, Julie Perrier-Boeswillwald, Gilles Bretaudeau, Nicolas Dondaine, Alison Bouzenard, Mégane Pizzimenti, Bruno Eymard, Ana Ferreiro, Jocelyn Laporte, Julien Fauré, Johann Böhm
The association of Lewy bodies with limbic-predominant age-related TDP-43 encephalopathy neuropathologic changes and their role in cognition and Alzheimer’s dementia in older persons
Sonal Agrawal, Lei Yu, Sukriti Nag, Konstantinos Arfanakis, Lisa L. Barnes, David A. Bennett, Julie A. Schneider
Absence of Apolipoprotein E is associated with exacerbation of prion pathology and promotes microglial neurodegenerative phenotype
Joanna E. Pankiewicz, Anita M. Lizińczyk, Leor A. Franco, Jenny R. Diaz, Mitchell Martá-Ariza, Martin J. Sadowski
Generation of human chronic wasting disease in transgenic mice
Zerui Wang, Kefeng Qin, Manuel V. Camacho, Ignazio Cali, Jue Yuan, Pingping Shen, Justin Greenlee, Qingzhong Kong, James A. Mastrianni, Wen-Quan Zou
Synchronous supratentorial and infratentorial oligodendrogliomas with incongruous IDH1 mutations, a case report
Alexander H. C. W. Agopyan-Miu, Matei A. Banu, Michael L. Miller, Christopher Troy, Gunnar Hargus, Peter Canoll, Tony J. C. Wang, Neil Feldstein, Aya Haggiagi, Guy M. McKhann II
Correction to: The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson’s disease
David I. Finkelstein, Jessica L. Billings, Paul A. Adlard, Scott Ayton, Amelia Sedjahtera, Colin L. Masters, Simon Wilkins, David M. Shackleford, Susan A. Charman, Wojciech Bal, Izabela A. Zawisza, Ewa Kurowska, Andrew L. Gundlach, Sheri Ma, Ashley I. Bush, Dominic J. Hare, Philip A. Doble, Simon Crawford, Elisabeth C. L. Gautier, Jack Parsons, Penny Huggins, Kevin J. Barnham, Robert A. Cherny
Loss of presenilin function enhances tau phosphorylation and aggregation in mice
Carlos M. Soto-Faguás, Paula Sanchez-Molina, Carlos A. Saura
Low-grade peripheral inflammation affects brain pathology in the AppNL-G-Fmouse model of Alzheimer’s disease
Junhua Xie, Nina Gorlé, Charysse Vandendriessche, Griet Van Imschoot, Elien Van Wonterghem, Caroline Van Cauwenberghe, Eef Parthoens, Evelien Van Hamme, Saskia Lippens, Lien Van Hoecke, Roosmarijn E. Vandenbroucke
TNF-mediated neuroinflammation is linked to neuronal necroptosis in Alzheimer's disease hippocampus
Anusha Jayaraman, Thein Than Htike, Rachel James, Carmen Picon, Richard Reynolds
Anatomic survey of seeding in Alzheimer’s disease brains reveals unexpected patterns
Barbara E. Stopschinski, Kelly Del Tredici, Sandi-Jo Estill-Terpack, Estifanos Ghebremdehin, Fang F. Yu, Heiko Braak, Marc I. Diamond
Transmission of amyloid-beta and tau pathologies is associated with cognitive impairments in a primate
Suzanne Lam, Fanny Petit, Anne-Sophie Hérard, Susana Boluda, Sabiha Eddarkaoui, Martine Guillermier, Franck Letournel, Marie-Laure Martin-Négrier, Maxime Faisant, Catherine Godfraind, Jean Boutonnat, Claude-Alain Maurage, Vincent Deramecourt, Mathilde Duchesne, David Meyronet, Tanguy Fenouil, André Mauès de Paula, Valérie Rigau, Fanny Vandenbos-Burel, Danielle Seilhean, Charles Duyckaerts, Susana Boluda, Isabelle Plu, Dan Christian Chiforeanu, Annie Laquerrière, Florent Marguet, Béatrice Lannes, Benoît Lhermitte, Luc Buée, Charles Duyckaerts, Stéphane Haïk, Jean-Luc Picq, Marc Dhenain
White matter injury but not germinal matrix hemorrhage induces elevated osteopontin expression in human preterm brains
Gisela Nilsson, Ana A. Baburamani, Mary A. Rutherford, Changlian Zhu, Carina Mallard, Henrik Hagberg, Regina Vontell, Xiaoyang Wang
Low-level blast exposure induces chronic vascular remodeling, perivascular astrocytic degeneration and vascular-associated neuroinflammation
Miguel A. Gama Sosa, Rita De Gasperi, Dylan Pryor, Georgina S. Perez Garcia, Gissel M. Perez, Rania Abutarboush, Usmah Kawoos, Seth Hogg, Benjamin Ache, William G. Janssen, Allison Sowa, Timothy Tetreault, David G. Cook, Susan J. Tappan, Sam Gandy, Patrick R. Hof, Stephen T. Ahlers, Gregory A. Elder
TREM2 modulates differential deposition of modified and non-modified Aβ species in extracellular plaques and intraneuronal deposits
Pranav Joshi, Florian Riffel, Sathish Kumar, Nàdia Villacampa, Sandra Theil, Samira Parhizkar, Christian Haass, Marco Colonna, Michael T. Heneka, Thomas Arzberger, Jochen Herms, Jochen Walter
Inefficient quality control of ribosome stalling during APP synthesis generates CAT-tailed species that precipitate hallmarks of Alzheimer’s disease
Suman Rimal, Yu Li, Rasika Vartak, Ji Geng, Ishaq Tantray, Shuangxi Li, Sungun Huh, Hannes Vogel, Charles Glabe, Lea T. Grinberg, Salvatore Spina, William W. Seeley, Su Guo, Bingwei Lu
Deep learning reveals disease-specific signatures of white matter pathology in tauopathies
Anthony R. Vega, Rati Chkheidze, Vipul Jarmale, Ping Shang, Chan Foong, Marc I. Diamond, Charles L. White III, Satwik Rajaram
The α-dystrobrevins play a key role in maintaining the structure and function of the extracellular matrix–significance for protein elimination failure arteriopathies
Matthew MacGregor Sharp, Jordan Cassidy, Thomas Thornton, James Lyles, Abby Keable, Maureen Gatherer, Masato Yasui, Yoichiro Abe, Shinsuke Shibata, Roy O. Weller, Dariusz C. Górecki, Roxana O. Carare
Neuropathology of SCA34 showing widespread oligodendroglial pathology with vacuolar white matter degeneration: a case study
Kokoro Ozaki, Takashi Irioka, Toshiki Uchihara, Akane Yamada, Ayako Nakamura, Takamasa Majima, Susumu Igarashi, Hiroshi Shintaku, Mayumi Yakeishi, Yukio Tsuura, Yasushi Okazaki, Kinya Ishikawa, Takanori Yokota
Ex vivo MRI atlas of the human medial temporal lobe: characterizing neurodegeneration due to tau pathology
Sadhana Ravikumar, Laura E. M. Wisse, Sydney Lim, Ranjit Ittyerah, Long Xie, Madigan L. Bedard, Sandhitsu R. Das, Edward B. Lee, M. Dylan Tisdall, Karthik Prabhakaran, Jacqueline Lane, John A. Detre, Gabor Mizsei, John Q. Trojanowski, John L. Robinson, Theresa Schuck, Murray Grossman, Emilio Artacho-Pérula, Maria Mercedes Iñiguez de Onzoño Martin, María del Mar Arroyo Jiménez, Monica Muñoz, Francisco Javier Molina Romero, Maria del Pilar Marcos Rabal, Sandra Cebada Sánchez, José Carlos Delgado González, Carlos de la Rosa Prieto, Marta Córcoles Parada, David J. Irwin, David A. Wolk, Ricardo Insausti, Paul A. Yushkevich
A novel SMARCA2-CREM fusion: expanding the molecular spectrum of intracranial mesenchymal tumors beyond the FET genes
Arnault Tauziède-Espariat, Gaëlle Pierron, Delphine Guillemot, Philipp Sievers, Dominique Cazals-Hatem, Thierry Faillot, Alexandre Roux, Joseph Benzakoun, Sophie Bockel, Nicolas Weinbreck, Lauren Hasty, Emmanuèle Lechapt, Fabrice Chrétien, Pascale Varlet
Association between CSF alpha-synuclein seeding activity and genetic status in Parkinson’s disease and dementia with Lewy bodies
Kathrin Brockmann, Corinne Quadalti, Stefanie Lerche, Marcello Rossi, Isabel Wurster, Simone Baiardi, Benjamin Roeben, Angela Mammana, Milan Zimmermann, Ann-Kathrin Hauser, Christian Deuschle, Claudia Schulte, Katharina Waniek, Ingolf Lachmann, Simon Sjödin, Ann Brinkmalm, Kaj Blennow, Henrik Zetterberg, Thomas Gasser, Piero Parchi
CNS tumors with YWHAE:NUTM2 and KDM2B-fusions present molecular similarities to extra-CNS tumors having BCOR internal tandem duplication or alternative fusions
Arnault Tauziède-Espariat, Gaëlle Pierron, Delphine Guillemot, Dorian Bochaton, Sarah Watson, Julien Masliah-Planchon, Alexandre Vasiljevic, Alexandra Meurgey, Guillaume Chotard, Lauren Hasty, Ellen Wahler, Emmanuèle Lechapt, Fabrice Chrétien, Jacques Grill, Franck Bourdeaut, Yassine Bouchoucha, Stéphanie Puget, Céline Icher-de-Bouyn, Vincent Jecko, Liesbeth Cardoen, Volodia Dangouloff-Ros, Nathalie Boddaert, Pascale Varlet
P62 accumulates through neuroanatomical circuits in response to tauopathy propagation
François-Xavier Blaudin de Thé, Benjamin Lassus, Ari W. Schaler, Stephanie L. Fowler, Chris N. Goulbourne, Ross Jeggo, Clotilde Mannoury la Cour, Mark J. Millan, Karen E. Duff
TP53 wild-type/PPM1D mutant diffuse intrinsic pontine gliomas are sensitive to a MDM2 antagonist
Cheng Xu, Heng Liu, Christopher J. Pirozzi, Lee H. Chen, Paula K. Greer, Bill H. Diplas, Liwei Zhang, Matthew S. Waitkus, Yiping He, Hai Yan
High diagnostic performance of independent alpha-synuclein seed amplification assays for detection of early Parkinson’s disease
Marco J. Russo, Christina D. Orru, Luis Concha-Marambio, Simone Giaisi, Bradley R. Groveman, Carly M. Farris, Bret Holguin, Andrew G. Hughson, David-Erick LaFontant, Chelsea Caspell-Garcia, Christopher S. Coffey, Jennifer Mollon, Samantha J. Hutten, Kalpana Merchant, Roland G. Heym, Claudio Soto, Byron Caughey, Un Jung Kang
Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein
Charlotte F. Brzozowski, Baraa A. Hijaz, Vijay Singh, Nolwazi Z. Gcwensa, Kaela Kelly, Edward S. Boyden, Andrew B. West, Deblina Sarkar, Laura A. Volpicelli-Daley
Annotation of pituitary neuroendocrine tumors with genome-wide expression analysis
Abdellah Tebani, Jelena Jotanovic, Neda Hekmati, Åsa Sivertsson, Olafur Gudjonsson, Britt Edén Engström, Johan Wikström, Mathias Uhlèn, Olivera Casar-Borota, Fredrik Pontén
Tyrosine 136 phosphorylation of α-synuclein aggregates in the Lewy body dementia brain: involvement of serine 129 phosphorylation by casein kinase 2
Kazunori Sano, Yasushi Iwasaki, Yuta Yamashita, Keiichi Irie, Masato Hosokawa, Katsuya Satoh, Kenichi Mishima
Chemogenetic modulation of sensory neurons reveals their regulating role in melanoma progression
Pedro A. C. Costa, Walison N. Silva, Pedro H. D. M. Prazeres, Caroline C. Picoli, Gabriela D. A. Guardia, Alinne C. Costa, Mariana A. Oliveira, Pedro P. G. Guimarães, Ricardo Gonçalves, Mauro C. X. Pinto, Jaime H. Amorim, Vasco A. C. Azevedo, Rodrigo R. Resende, Remo C. Russo, Thiago M. Cunha, Pedro A. F. Galante, Akiva Mintz, Alexander Birbrair
Retina tissue validation of optical coherence tomography determined outer nuclear layer loss in FTLD-tau
Benjamin J. Kim, Vivian Lee, Edward B. Lee, Adrienne Saludades, John Q. Trojanowski, Joshua L. Dunaief, Murray Grossman, David J. Irwin
Overexpression of Lin28A in neural progenitor cells in vivo does not lead to brain tumor formation but results in reduced spine density
Maximilian Middelkamp, Lisa Ruck, Christoph Krisp, Piotr Sumisławski, Behnam Mohammadi, Matthias Dottermusch, Valerie Meister, Lukas Küster, Hartmut Schlüter, Sabine Windhorst, Julia E. Neumann
RyR1-related myopathy mutations in ATP and calcium binding sites impair channel regulation
Qi Yuan, Haikel Dridi, Oliver B. Clarke, Steven Reiken, Zephan Melville, Anetta Wronska, Alexander Kushnir, Ran Zalk, Leah Sittenfeld, Andrew R. Marks
Prion type 2 selection in sporadic Creutzfeldt–Jakob disease affecting peripheral ganglia
Anna Hofmann, Arne Wrede, Wiebke M. Jürgens-Wemheuer, Walter J. Schulz-Schaeffer
Alpha-synuclein from patient Lewy bodies exhibits distinct pathological activity that can be propagated in vitro
Nicholas P. Marotta, Jahan Ara, Norihito Uemura, Marshall G. Lougee, Emily S. Meymand, Bin Zhang, E. James Petersson, John Q. Trojanowski, Virginia M.-Y. Lee
Assembly of α-synuclein and neurodegeneration in the central nervous system of heterozygous M83 mice following the peripheral administration of α-synuclein seeds
Jennifer A. Macdonald, John L. Chen, Masami Masuda-Suzukake, Manuel Schweighauser, Zane Jaunmuktane, Thomas Warner, Janice L. Holton, Annabelle Grossman, Richard Berks, Isabelle Lavenir, Michel Goedert
Correction to: High diagnostic performance of independent alpha-synuclein seed amplification assays for detection of early Parkinson’s disease
Marco J. Russo, Christina D. Orru, Luis Concha-Marambio, Simone Giaisi, Bradley R. Groveman, Carly M. Farris, Bret Holguin, Andrew G. Hughson, David-Erick LaFontant, Chelsea Caspell-Garcia, Christopher S. Cofey, Jennifer Mollon, Samantha J. Hutten, Kalpana Merchant, Roland G. Heym, Claudio Soto, Byron Caughey, Un Jung Kang
Machine learning modeling of genome-wide copy number alteration signatures reliably predicts IDH mutational status in adult diffuse glioma
Nicholas Nuechterlein, Linda G. Shapiro, Eric C. Holland, Patrick J. Cimino
Clinically aggressive pediatric spinal ependymoma with novel MYC amplification demonstrates molecular and histopathologic similarity to newly described MYCN-amplified spinal ependymomas
Margaret Shatara, Kathleen M. Schieffer, Darren Klawinski, Diana L. Thomas, Christopher R. Pierson, Eric A. Sribnick, Jeremy Jones, Diana P. Rodriguez, Carol Deeg, Elizabeth Hamelberg, Stephanie LaHaye, Katherine E. Miller, James Fitch, Benjamin Kelly, Kristen Leraas, Ruthann Pfau, Peter White, Vincent Magrini, Richard K. Wilson, Elaine R. Mardis, Mohamed S. Abdelbaki, Jonathan L. Finlay, Daniel R. Boué, Catherine E. Cottrell, David R. Ghasemi, Kristian W. Pajtler, Diana S. Osorio
STAT3 inhibitor mitigates cerebral amyloid angiopathy and parenchymal amyloid plaques while improving cognitive functions and brain networks
Jogender Mehla, Itender Singh, Deepti Diwan, James W. Nelson, Molly Lawrence, Eunjae Lee, Adam Q. Bauer, David M. Holtzman, Gregory J. Zipfel
De novo pathogenic variant in SETX causes a rapidly progressive neurodegenerative disorder of early childhood-onset with severe axonal polyneuropathy
Aristides Hadjinicolaou, Kathie J. Ngo, Daniel Y. Conway, John P. Provias, Steven K. Baker, Lauren I. Brady, Craig L. Bennett, Albert R. La Spada, Brent L. Fogel, Grace Yoon
MiR-212-3p functions as a tumor suppressor gene in group 3 medulloblastoma via targeting nuclear factor I/B (NFIB)
Naveenkumar Perumal, Ranjana K. Kanchan, David Doss, Noah Bastola, Pranita Atri, Ramakanth Chirravuri-Venkata, Ishwor Thapa, Raghupathy Vengoji, Shailendra K. Maurya, David Klinkebiel, Geoffrey A. Talmon, Mohd W. Nasser, Surinder K. Batra, Sidharth Mahapatra
Impaired SorLA maturation and trafficking as a new mechanism for SORL1 missense variants in Alzheimer disease
Anne Rovelet-Lecrux, Sebastien Feuillette, Laetitia Miguel, Catherine Schramm, Ségolène Pernet, Olivier Quenez, Isabelle Ségalas-Milazzo, Laure Guilhaudis, Stéphane Rousseau, Gaëtan Riou, Thierry Frébourg, Dominique Campion, Gaël Nicolas, Magalie Lecourtois
Temporal patterns of microglial activation in white matter following experimental mild traumatic brain injury: a systematic literature review
Prashanth S. Velayudhan, Nicole Schwab, Lili-Naz Hazrati, Anne L. Wheeler
Neurodegenerative brain changes are associated with area deprivation in the United Kingdom: findings from the Brains for Dementia Research study
Calum A. Hamilton, Fiona E. Matthews, Daniel Erskine, Johannes Attems, Alan J. Thomas
APOE ε4 associates with increased risk of severe COVID-19, cerebral microhaemorrhages and post-COVID mental fatigue: a Finnish biobank, autopsy and clinical study
Samu N. Kurki, Jonas Kantonen, Karri Kaivola, Laura Hokkanen, Mikko I. Mäyränpää, Henri Puttonen, Juha Martola, Minna Pöyhönen, Mia Kero, Jarno Tuimala, Olli Carpén, Anu Kantele, Olli Vapalahti, Marjaana Tiainen, Pentti J. Tienari, Kai Kaila, Johanna Hästbacka, Liisa Myllykangas
IDH-wild type glioblastomas featuring at least 30% giant cells are characterized by frequent RB1 and NF1 alterations and hypermutation
Valeria Barresi, Michele Simbolo, Andrea Mafficini, Maurizio Martini, Martina Calicchia, Maria Liliana Piredda, Chiara Ciaparrone, Giada Bonizzato, Serena Ammendola, Maria Caffo, Giampietro Pinna, Francesco Sala, Rita Teresa Lawlor, Claudio Ghimenton, Aldo Scarpa
Emergence of distinct and heterogeneous strains of amyloid beta with advanced Alzheimer’s disease pathology in Down syndrome
Alison M. Maxwell, Peng Yuan, Brianna M. Rivera, Wilder Schaaf, Mihovil Mladinov, Vee P. Prasher, Andrew C. Robinson, William F. DeGrado, Carlo Condello