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14.10.2020 | Original Article

Adaptative mechanism of the equilibrative nucleoside transporter 1 (ENT-1) and blood adenosine levels in elite freedivers

verfasst von: M. Marlinge, D. Vairo, A. Bertaud, C. Vernet, M. Chefrour, L. Bruzzese, M. C. Chaptal, G. Mottola, A. Boussuges, J. J. Risso, M. Blot-Chabaud, M. Coulange, R. Guieu, F. Joulia

Erschienen in: European Journal of Applied Physiology | Ausgabe 1/2021

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Abstract

Purpose

Long static or intense dynamic apnoea-like high-altitude exposure is inducing hypoxia. Adenosine is known to participate to the adaptive response to hypoxia leading to the control of heart rate, blood pressure and vasodilation. Extracellular adenosine level is controlled through the equilibrative nucleoside transporter 1 (ENT-1) and the enzyme adenosine deaminase (ADA). The aim of this study was to determine the control of adenosine blood level (ABL) via ENT-1 and ADA during apnoea-induced hypoxia in elite freedivers was similar to high-altitude adaptation.

Methods

Ten freediver champions and ten controls were studied. Biological (e.g. ENT-1, ADA, ABL, PaO₂, PaCO₂ and pH) and cardiovascular (e.g. heart rate, arterial pressure) parameters were measured at rest and after a submaximal dry static apnoea.

Results

In freedivers, ABL was higher than in control participants in basal condition and increased more in response to apnoea. Also, freedivers showed an ADA increased in response to apnoea. Finally, ENT-1 level and function were reduced for the free divers.

Conclusion

Our results suggest in freedivers the presence of an adaptive mechanism similar to the one observed in human exposed to chronic hypoxia induced by high-altitude environment.

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Titel: Adaptative mechanism of the equilibrative nucleoside transporter 1 (ENT-1) and blood adenosine levels in elite freedivers
verfasst von: M. Marlinge
D. Vairo
A. Bertaud
C. Vernet
M. Chefrour
L. Bruzzese
M. C. Chaptal
G. Mottola
A. Boussuges
J. J. Risso
M. Blot-Chabaud
M. Coulange
R. Guieu
F. Joulia
Publikationsdatum: 14.10.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Applied Physiology / Ausgabe 1/2021
Print ISSN: 1439-6319
Elektronische ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-020-04523-1

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Abstract

Purpose

Methods

Results

Conclusion

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