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European Journal of Applied Physiology

Erschienen in:

01.05.2011 | Original Article

Aging effects on exercise-induced alternations in plasma acylated ghrelin and leptin in male rats

verfasst von: Ya-Wen Hsu, Yi-Ju Pan, Yu-Min Cho, Tsan-Hon Liou, Pesus Chou, Paulus S. Wang

Erschienen in: European Journal of Applied Physiology | Ausgabe 5/2011

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Abstract

Ghrelin and exercise have been known to stimulate the release of growth hormone which is related to the glucose metabolism. However, the age effects of exercise on ghrelin in energy consumption remain unclear. Young (3 month old) and middle-aged (12 month old) Sprague–Dawley male rats were overnight fasted, and then randomly partitioned into exercise and control groups. Exercise groups swam for 20 min in 25°C water. Rats immersed in 25°C water for 20 min were used as control animals. All blood samples were collected before and 10, 20, 30, and 60 min after initiation of exercise via the right jugular vein. Our results indicated that the swimming regimen decreased the secretion of acylated ghrelin and insulin, but increased the secretion of leptin, lactate, and glucose. In addition, exercise significantly amplified the inverse correlation between leptin and acylated ghrelin (r < −0.6) in middle-age group. Both the above findings were not emphasized in related articles before. Moreover, the time courses of these changes were slightly different in young and middle-aged rats. In basal metabolic characteristics, body weight and the plasma lactate, glucose, insulin, and leptin are higher in middle-age group than that in young group. In conclusion, compared with young rats, middle-aged rats have higher basal body weight, plasma glucose, insulin, and leptin, but age had no effect on the level of plasma acylated ghrelin. A 20-min exercise regimen decreased acylated ghrelin and increased leptin with inverse correlation between them which was strengthened during exercise, but were not influenced by age.

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Titel: Aging effects on exercise-induced alternations in plasma acylated ghrelin and leptin in male rats
verfasst von: Ya-Wen Hsu
Yi-Ju Pan
Yu-Min Cho
Tsan-Hon Liou
Pesus Chou
Paulus S. Wang
Publikationsdatum: 01.05.2011
Verlag: Springer-Verlag
Erschienen in: European Journal of Applied Physiology / Ausgabe 5/2011
Print ISSN: 1439-6319
Elektronische ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-010-1704-3

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