Skip to main content
Erschienen in: Pädiatrie 5/2023

18.10.2023 | Allergie und Atopie in der Pädiatrie | Zertifizierte Fortbildung

Allergen-Immuntherapie - Update 2023

Aufklärung und richtige Therapiewahl bei allergischen Erkrankungen

verfasst von: Dr. med. Franziska Sattler, Dr. med. Ludwig Schmid, Dr. med. Philipp Utz, Dr. med. Armin Grübl

Erschienen in: Pädiatrie | Ausgabe 5/2023

zum CME-Kurs Einloggen, um Zugang zu erhalten

Auszug

Die Allergen-Immuntherapie hat sich als kausale Therapieoption in der Kinder- und Jugendmedizin etabliert. Sie stellt bei Beachtung von Kontraindikationen und Vorgaben der jeweiligen Fachinformation eine bewährte und sichere Behandlung dar. Dieser Beitrag bringt Sie zu den Therapieoptionen und deren praktischer Anwendung auf den neuesten Stand. …
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
Zurück zum Zitat Thamm R, Poethko-Müller C, Hüther A, Thamm M (2018) Allergische Erkrankungen bei Kindern und Jugendlichen in Deutschland - Querschnittergebnisse aus KiGGS Welle 2 und Trends. Journal of Health Monitoring. 2018; 3(3): 3-18. DOI 10.17886/RKIGBE2018075 Thamm R, Poethko-Müller C, Hüther A, Thamm M (2018) Allergische Erkrankungen bei Kindern und Jugendlichen in Deutschland - Querschnittergebnisse aus KiGGS Welle 2 und Trends. Journal of Health Monitoring. 2018; 3(3): 3-18. DOI 10.17886/RKIGBE2018075
2.
Zurück zum Zitat Noon L, Cantar B Prophylactic Inoculation against Hay Fever. Lancet. 1911;177:1572-3 Noon L, Cantar B Prophylactic Inoculation against Hay Fever. Lancet. 1911;177:1572-3
3.
Zurück zum Zitat Pfaar O, Ankermann T, Augustin M et al. Commenting participation and process support: Kaul S, Mahler V, Schwalfenberg A. Guideline on allergen immunotherapy in IgE-mediated allergic diseases: S2K Guideline of the German Society of Allergology and Clinical Immunology (DGAKI), Society of Pediatric Allergology and Environmental Medicine (GPA), Medical Association of German Allergologists (AeDA), Austrian Society of Allergology and Immunology (ÖGAI), Swiss Society for Allergology and Immunology (SSAI), German Dermatological Society (DDG), German Society of Oto-Rhino-Laryngology, Head and Neck Surgery (DGHNO-KHC), German Society of Pediatrics and Adolescent Medicine (DGKJ), Society of Pediatric Pulmonology (GPP), German Respiratory Society (DGP), German Professional Association of Otolaryngologists (BVHNO), German Association of Paediatric and Adolescent Care Specialists (BVKJ), Federal Association of Pneumologists, Sleep and Respiratory Physicians (BdP), Professional Association of German Dermatologists (BVDD). Allergol Select. 2022 Sep 6;6:167-232. doi: 10.5414/ALX02331E. PMID: 36178453; PMCID: PMC9513845. Pfaar O, Ankermann T, Augustin M et al. Commenting participation and process support: Kaul S, Mahler V, Schwalfenberg A. Guideline on allergen immunotherapy in IgE-mediated allergic diseases: S2K Guideline of the German Society of Allergology and Clinical Immunology (DGAKI), Society of Pediatric Allergology and Environmental Medicine (GPA), Medical Association of German Allergologists (AeDA), Austrian Society of Allergology and Immunology (ÖGAI), Swiss Society for Allergology and Immunology (SSAI), German Dermatological Society (DDG), German Society of Oto-Rhino-Laryngology, Head and Neck Surgery (DGHNO-KHC), German Society of Pediatrics and Adolescent Medicine (DGKJ), Society of Pediatric Pulmonology (GPP), German Respiratory Society (DGP), German Professional Association of Otolaryngologists (BVHNO), German Association of Paediatric and Adolescent Care Specialists (BVKJ), Federal Association of Pneumologists, Sleep and Respiratory Physicians (BdP), Professional Association of German Dermatologists (BVDD). Allergol Select. 2022 Sep 6;6:167-232. doi: 10.5414/ALX02331E. PMID: 36178453; PMCID: PMC9513845.
4.
Zurück zum Zitat PALISADE Group of Clinical Investigators; Vickery BP, Vereda A, Casale TB, Beyer K, du Toit G, Hourihane JO, Jones SM, Shreffler WG, Marcantonio A, Zawadzki R, Sher L, Carr WW, Fineman S, Greos L, Rachid R, Ibáñez MD, Tilles S, Assa'ad AH, Nilsson C, Rupp N, Welch MJ, Sussman G, Chinthrajah S, Blumchen K, Sher E, Spergel JM, Leickly FE, Zielen S, Wang J, Sanders GM, Wood RA, Cheema A, Bindslev-Jensen C, Leonard S, Kachru R, Johnston DT, Hampel FC Jr, Kim EH, Anagnostou A, Pongracic JA, Ben-Shoshan M, Sharma HP, Stillerman A, Windom HH, Yang WH, Muraro A, Zubeldia JM, Sharma V, Dorsey MJ, Chong HJ, Ohayon J, Bird JA, Carr TF, Siri D, Fernández-Rivas M, Jeong DK, Fleischer DM, Lieberman JA, Dubois AEJ, Tsoumani M, Ciaccio CE, Portnoy JM, Mansfield LE, Fritz SB, Lanser BJ, Matz J, Oude Elberink HNG, Varshney P, Dilly SG, Adelman DC, Burks AW. AR101 Oral Immunotherapy for Peanut Allergy. N Engl J Med. 2018;379(21):1991-2001. doi: 10.1056/NEJMoa1812856. Epub 2018 Nov 18. PMID: 30449234. PALISADE Group of Clinical Investigators; Vickery BP, Vereda A, Casale TB, Beyer K, du Toit G, Hourihane JO, Jones SM, Shreffler WG, Marcantonio A, Zawadzki R, Sher L, Carr WW, Fineman S, Greos L, Rachid R, Ibáñez MD, Tilles S, Assa'ad AH, Nilsson C, Rupp N, Welch MJ, Sussman G, Chinthrajah S, Blumchen K, Sher E, Spergel JM, Leickly FE, Zielen S, Wang J, Sanders GM, Wood RA, Cheema A, Bindslev-Jensen C, Leonard S, Kachru R, Johnston DT, Hampel FC Jr, Kim EH, Anagnostou A, Pongracic JA, Ben-Shoshan M, Sharma HP, Stillerman A, Windom HH, Yang WH, Muraro A, Zubeldia JM, Sharma V, Dorsey MJ, Chong HJ, Ohayon J, Bird JA, Carr TF, Siri D, Fernández-Rivas M, Jeong DK, Fleischer DM, Lieberman JA, Dubois AEJ, Tsoumani M, Ciaccio CE, Portnoy JM, Mansfield LE, Fritz SB, Lanser BJ, Matz J, Oude Elberink HNG, Varshney P, Dilly SG, Adelman DC, Burks AW. AR101 Oral Immunotherapy for Peanut Allergy. N Engl J Med. 2018;379(21):1991-2001. doi: 10.1056/NEJMoa1812856. Epub 2018 Nov 18. PMID: 30449234.
5.
Zurück zum Zitat Greenhawt M, Sindher SB, Wang J et al. Phase 3 Trial of Epicutaneous Immunotherapy in Toddlers with Peanut Allergy. N Engl J Med. 2023;388(19):1755-66. doi: 10.1056/NEJMoa2212895. PMID: 37163622. Greenhawt M, Sindher SB, Wang J et al. Phase 3 Trial of Epicutaneous Immunotherapy in Toddlers with Peanut Allergy. N Engl J Med. 2023;388(19):1755-66. doi: 10.1056/NEJMoa2212895. PMID: 37163622.
6.
Zurück zum Zitat Thoms F, Jennings GT, Maudrich M et al. Immunization of cats to induce neutralizing antibodies against Fel d 1, the major feline allergen in human subjects. J Allergy Clin Immunol. 2019;144(1):193-203. doi: 10.1016/j.jaci.2019.01.050. Epub 2019 May 2. PMID: 31056187 Thoms F, Jennings GT, Maudrich M et al. Immunization of cats to induce neutralizing antibodies against Fel d 1, the major feline allergen in human subjects. J Allergy Clin Immunol. 2019;144(1):193-203. doi: 10.1016/j.jaci.2019.01.050. Epub 2019 May 2. PMID: 31056187
7.
Zurück zum Zitat Dorofeeva Y, Shilovskiy I, Tulaeva I et al. Past, present, and future of allergen immunotherapy vaccines. Allergy. 2021;76(1):131-149. doi: 10.1111/all.14300. Epub 2020 Apr 29. PMID: 32249442; PMCID: PMC7818275 Dorofeeva Y, Shilovskiy I, Tulaeva I et al. Past, present, and future of allergen immunotherapy vaccines. Allergy. 2021;76(1):131-149. doi: 10.1111/all.14300. Epub 2020 Apr 29. PMID: 32249442; PMCID: PMC7818275
9.
Zurück zum Zitat Roberts G, Pfaar O, Akdis CA et al. EAACI Guidelines on Allergen Immunotherapy: Allergic rhinoconjunctivitis. Allergy. 2018;73(4):765-798. doi: 10.1111/all.13317. Epub 2017 Oct 30. PMID: 28940458 Roberts G, Pfaar O, Akdis CA et al. EAACI Guidelines on Allergen Immunotherapy: Allergic rhinoconjunctivitis. Allergy. 2018;73(4):765-798. doi: 10.1111/all.13317. Epub 2017 Oct 30. PMID: 28940458
10.
Zurück zum Zitat Senti G, Freiburghaus AU, Larenas-Linnemann D et al. Intralymphatic Immunotherapy: Update and Unmet Needs. Int Arch Allergy Immunol. 2019;178(2):141-149. doi: 10.1159/000493647. Epub 2018 Nov 2. PMID: 30391954 Senti G, Freiburghaus AU, Larenas-Linnemann D et al. Intralymphatic Immunotherapy: Update and Unmet Needs. Int Arch Allergy Immunol. 2019;178(2):141-149. doi: 10.1159/000493647. Epub 2018 Nov 2. PMID: 30391954
11.
Zurück zum Zitat Sturm GJ, Varga EM, Roberts G et al. EAACI guidelines on allergen immunotherapy: Hymenoptera venom allergy. Allergy. 2018;73(4):744-764. doi: 10.1111/all.13262. Epub 2017 Dec 5. PMID: 28748641 Sturm GJ, Varga EM, Roberts G et al. EAACI guidelines on allergen immunotherapy: Hymenoptera venom allergy. Allergy. 2018;73(4):744-764. doi: 10.1111/all.13262. Epub 2017 Dec 5. PMID: 28748641
12.
Zurück zum Zitat Hedlin G, Wille S, Browaldh L et al. Immunotherapy in children with allergic asthma: effect on bronchial hyperreactivity and pharmacotherapy. J Allergy Clin Immunol. 1999; 103: 609-14 Hedlin G, Wille S, Browaldh L et al. Immunotherapy in children with allergic asthma: effect on bronchial hyperreactivity and pharmacotherapy. J Allergy Clin Immunol. 1999; 103: 609-14
13.
Zurück zum Zitat Przybilla B. Diagnose und Therapie der Bienen- und Wespengiftallergie. Allergo J 2011; 20: 318-9 Przybilla B. Diagnose und Therapie der Bienen- und Wespengiftallergie. Allergo J 2011; 20: 318-9
14.
Zurück zum Zitat Murray CS, Foden P, Sumner H et al. Preventing Severe Asthma Exacerbations in Children. A Randomized Trial of Mite-Impermeable Bedcovers. Am J Respir Crit Care Med. 2017; 196: 150-8 Murray CS, Foden P, Sumner H et al. Preventing Severe Asthma Exacerbations in Children. A Randomized Trial of Mite-Impermeable Bedcovers. Am J Respir Crit Care Med. 2017; 196: 150-8
15.
Zurück zum Zitat Kopp MV, Ott H, Lange L. Kinderallergologie in Klinik und Praxis. Springer, Heidelberg. 2014 Kopp MV, Ott H, Lange L. Kinderallergologie in Klinik und Praxis. Springer, Heidelberg. 2014
16.
Zurück zum Zitat Schmid-Grendelmeier P. [Recombinant allergens. For routine use or still only science?]. Hautarzt. 2010, 61(11): 946-53 Schmid-Grendelmeier P. [Recombinant allergens. For routine use or still only science?]. Hautarzt. 2010, 61(11): 946-53
17.
Zurück zum Zitat Bousquet J, V. C. Aria Workshop Group; World Health Organization. Allergic rhinitis and its impact on asthma. J Allergy Clin Immunol. 2001; 108 (Suppl): S147-S334 Bousquet J, V. C. Aria Workshop Group; World Health Organization. Allergic rhinitis and its impact on asthma. J Allergy Clin Immunol. 2001; 108 (Suppl): S147-S334
19.
Zurück zum Zitat Tates K et al. 'I've come for his throat': roles and identities in doctor-parent-child communication. Child Care Health Dev. 2002;28(1):109-16 Tates K et al. 'I've come for his throat': roles and identities in doctor-parent-child communication. Child Care Health Dev. 2002;28(1):109-16
20.
Zurück zum Zitat Cox L, Calderón M, Pfaar O. Subcutaneous allergen immunotherapy for allergic disease: examining efficacy, safety and cost-effectiveness of current and novel formulations. Immunotherapy. 2012; 4: 601-16 Cox L, Calderón M, Pfaar O. Subcutaneous allergen immunotherapy for allergic disease: examining efficacy, safety and cost-effectiveness of current and novel formulations. Immunotherapy. 2012; 4: 601-16
21.
Zurück zum Zitat Kelso JM. The rate of systemic reactions to immunotherapy injections is the same whether or not the dose is reduced after a local reaction. Ann Allergy Asthma Immunol. 2004; 92: 225-7 Kelso JM. The rate of systemic reactions to immunotherapy injections is the same whether or not the dose is reduced after a local reaction. Ann Allergy Asthma Immunol. 2004; 92: 225-7
22.
Zurück zum Zitat Kramer MF, Heath MD. Aluminium in allergen- specific subcutaneous immunotherapy - a German perspective. Vaccine. 2014; 32: 4140-8 Kramer MF, Heath MD. Aluminium in allergen- specific subcutaneous immunotherapy - a German perspective. Vaccine. 2014; 32: 4140-8
23.
Zurück zum Zitat Frost L, Johansen P, Pedersen S et al. Persistent subcutaneous nodules in children hyposensitized with aluminium-containing allergen extracts. Allergy. 1985; 40: 368-72 Frost L, Johansen P, Pedersen S et al. Persistent subcutaneous nodules in children hyposensitized with aluminium-containing allergen extracts. Allergy. 1985; 40: 368-72
24.
Zurück zum Zitat Lopez S, Pelaez A, Navarro LA et al. Aluminium allergy in patients hyposensitized with aluminiumprecipitated antigen extracts. Contact Dermat. 1994; 31: 37-40 Lopez S, Pelaez A, Navarro LA et al. Aluminium allergy in patients hyposensitized with aluminiumprecipitated antigen extracts. Contact Dermat. 1994; 31: 37-40
26.
Zurück zum Zitat Rutishauser C. Adhärenzförderung bei Jugendlichen mit chronischen Krankheiten - ein adoleszentenspezifischer Ansatz, Schweizer Zeitschrift für Psychiatrie und Neurologie, 2019 Nummer 5, 43-6 Rutishauser C. Adhärenzförderung bei Jugendlichen mit chronischen Krankheiten - ein adoleszentenspezifischer Ansatz, Schweizer Zeitschrift für Psychiatrie und Neurologie, 2019 Nummer 5, 43-6
27.
Zurück zum Zitat Milgrom H, Bender B, Ackerson L et al.: Noncompliance and treatment failure in children with asthma. J Allergy Clin Immunol. 1996; 98(6 Pt 1): 1051-7 Milgrom H, Bender B, Ackerson L et al.: Noncompliance and treatment failure in children with asthma. J Allergy Clin Immunol. 1996; 98(6 Pt 1): 1051-7
28.
Zurück zum Zitat Spindler T, Schauerte G. Irgendwie klappt es nicht: Adhärenz und Compliance bei Jugendlichen, InFo Pneumologie & Allergologie 2021;3(2): 2-7 Spindler T, Schauerte G. Irgendwie klappt es nicht: Adhärenz und Compliance bei Jugendlichen, InFo Pneumologie & Allergologie 2021;3(2): 2-7
29.
Zurück zum Zitat Fischer PJ, Friedrichs F. Praktische Durchführung der Hyposensibilisierung. Monatsschr Kinderheilkd 2013; 161: 608-15 Fischer PJ, Friedrichs F. Praktische Durchführung der Hyposensibilisierung. Monatsschr Kinderheilkd 2013; 161: 608-15
30.
Zurück zum Zitat Ring J, Beyer K, Biedermann T et al. Guideline (S2) on acute therapy and management of anaphylaxis: 2021 update. S2-Guideline of the German Society for Allergology and Clinical Immunology (DGAKI), the Medical Association of German Allergologists (AeDA), the Society of Pediatric Allergy and Environmental Medicine (GPA), the German Academy of Allergology and Environmental Medicine (DAAU), the German Professional Association of Pediatricians (BVKJ), the Society for Neonatology and Paediatric Intensive Care (GNPI), the German Society of Dermatology (DDG), the Austrian Society for Allergology and Immunology (ÖGAI), the Swiss Society for Allergy and Immunology (SGAI), the German Society of Anaesthesiology and Intensive Care Medicine (DGAI), the German Society of Pharmacology (DGP), the German Respiratory Society (DGP), the patient organization German Allergy and Asthma Association (DAAB), the German Working Group of Anaphylaxis Training and Education (AGATE). Allergo J Int. 2021;30(1):1-25 Ring J, Beyer K, Biedermann T et al. Guideline (S2) on acute therapy and management of anaphylaxis: 2021 update. S2-Guideline of the German Society for Allergology and Clinical Immunology (DGAKI), the Medical Association of German Allergologists (AeDA), the Society of Pediatric Allergy and Environmental Medicine (GPA), the German Academy of Allergology and Environmental Medicine (DAAU), the German Professional Association of Pediatricians (BVKJ), the Society for Neonatology and Paediatric Intensive Care (GNPI), the German Society of Dermatology (DDG), the Austrian Society for Allergology and Immunology (ÖGAI), the Swiss Society for Allergy and Immunology (SGAI), the German Society of Anaesthesiology and Intensive Care Medicine (DGAI), the German Society of Pharmacology (DGP), the German Respiratory Society (DGP), the patient organization German Allergy and Asthma Association (DAAB), the German Working Group of Anaphylaxis Training and Education (AGATE). Allergo J Int. 2021;30(1):1-25
Metadaten
Titel
Allergen-Immuntherapie - Update 2023
Aufklärung und richtige Therapiewahl bei allergischen Erkrankungen
verfasst von
Dr. med. Franziska Sattler
Dr. med. Ludwig Schmid
Dr. med. Philipp Utz
Dr. med. Armin Grübl
Publikationsdatum
18.10.2023
Verlag
Springer Medizin
Erschienen in
Pädiatrie / Ausgabe 5/2023
Print ISSN: 1867-2132
Elektronische ISSN: 2196-6443
DOI
https://doi.org/10.1007/s15014-023-4982-z

Weitere Artikel der Ausgabe 5/2023

Pädiatrie 5/2023 Zur Ausgabe