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Inflammation Research

Erschienen in:

06.03.2023 | Original Research Paper

Amnion-derived serum amyloid A1 participates in sterile inflammation of fetal membranes at parturition

verfasst von: Yi-kai Lin, Fan Zhang, Wen-jia Lei, Xiao-wen Gan, Meng-die Li, Fan Pan, Wang-sheng Wang, Kang Sun

Erschienen in: Inflammation Research | Ausgabe 4/2023

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Abstract

Objectives

Sterile inflammation of fetal membranes is an indispensable event of normal parturition. However, triggers of sterile inflammation are not fully resolved. Serum amyloid A1 (SAA1) is an acute phase protein produced primarily by the liver. Fetal membranes can also synthesize SAA1 but its functions are not well defined. Given the role of SAA1 in the acute phase response to inflammation, we postulated that SAA1 synthesized in the fetal membranes may be a trigger of local inflammation at parturition.

Methods

The changes of SAA1 abundance in parturition were studied in the amnion of human fetal membranes. The role of SAA1 in chemokine expression and leukocyte chemotaxis was examined in cultured human amnion tissue explants as well as primary human amnion fibroblasts. The effects of SAA1 on monocytes, macrophages and dendritic cells were investigated in cells derived from a human leukemia monocytic cell line (THP-1).

Results

SAA1 synthesis increased significantly in human amnion at parturition. SAA1 evoked multiple chemotaxis pathways in human amnion fibroblasts along with upregulation of a series of chemokines via both toll-like receptor 4 (TLR4) and formyl peptide receptor 2 (FPR2). Moreover, SAA1-conditioned medium of cultured amnion fibroblasts was capable of chemoattracting virtually all types of mononuclear leukocytes, particularly monocytes and dendritic cells, which reconciled with the chemotactic activity of conditioned medium of cultured amnion tissue explants collected from spontaneous labor. Furthermore, SAA1 could induce the expression of genes associated with inflammation and extracellular matrix remodeling in monocytes, macrophages and dendritic cells derived from THP-1.

Conclusions

SAA1 is a trigger of sterile inflammation of the fetal membranes at parturition.

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Titel: Amnion-derived serum amyloid A1 participates in sterile inflammation of fetal membranes at parturition
verfasst von: Yi-kai Lin
Fan Zhang
Wen-jia Lei
Xiao-wen Gan
Meng-die Li
Fan Pan
Wang-sheng Wang
Kang Sun
Publikationsdatum: 06.03.2023
Verlag: Springer International Publishing
Erschienen in: Inflammation Research / Ausgabe 4/2023
Print ISSN: 1023-3830
Elektronische ISSN: 1420-908X
DOI: https://doi.org/10.1007/s00011-023-01713-3

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