nach oben

Social Psychiatry and Psychiatric Epidemiology

Erschienen in:

18.09.2022 | Original Paper

Association between parental bipolar disorder and increased risk of exposure to prescription opioids for their offspring

verfasst von: Dian-Jeng Li, Mu-Hong Chen, Ya-Mei Bai, Shih-Jen Tsai, Chih-Ming Cheng, Tung-Ping Su, Tzeng-Ji Chen, Ta-Chuan Yeh, Chih-Sung Liang

Erschienen in: Social Psychiatry and Psychiatric Epidemiology | Ausgabe 2/2023

Einloggen, um Zugang zu erhalten

Abstract

Purpose

Individuals with bipolar disorder (BD) may have an increased risk of exposure to prescription opioids. However, it is still unknown whether such risk also occurs in their offspring. This study aimed to investigate the risk of exposure to prescription opioid use and related medical conditions in the offspring of parents with BD.

Methods

This study used the Taiwan National Health Research Database and included offspring who had any parent with a diagnosis of BD. The matched-control cohort was randomly identified from the offspring of parents without any major psychiatric disorders (MPD). We identified data pertaining to opioid prescription and related medical conditions, namely pain disorder, malignancy, autoimmune disease, and arthropathy. The Poisson regression was used to estimate odds ratios and 95% confidence intervals.

Results

In total, 11,935 offspring of parents with BD and 119,350 offspring of parents without any MPD were included. After controlling for demographics and mental disorders, offspring of parents with BD demonstrated higher rates of prescription opioid use than those of parents without MPD, especially the intravenous/intramuscular form of opioids and prescription in hospital settings. In addition, offspring of parents with BD had a higher odds of pain disorders than those of parents without MPD.

Conclusion

Our study identifies a higher odd for developing pain disorders and exposure to prescription opioids among children of parents with BD.

Nur mit Berechtigung zugänglich

Grande I, Berk M, Birmaher B, Vieta E (2016) Bipolar disorder. Lancet 9(387):1561–1572CrossRef

Murray CJL, Lopez AD, Harvard School of Public Health., World Health Organization., World Bank (1996) The global burden of disease: a comprehensive assessment of mortality and disability from diseases, injuries, and risk factors in 1990 and projected to 2020. Published by the Harvard School of Public Health on behalf of the World Health Organization and the World Bank Harvard University Press, Cambridge

Novick DM, Swartz HA, Frank E (2010) Suicide attempts in bipolar I and bipolar II disorder: a review and meta-analysis of the evidence. Bipolar Disord 12:1–9CrossRefPubMedPubMedCentral

Nourse R, Reade C, Stoltzfus J, Mittal V (2014) Demographics, clinical characteristics, and treatment of aggressive patients admitted to the acute behavioral unit of a community general hospital: a prospective observational study. Prim Care Companion CNS Disord. https://doi.org/10.4088/PCC.13m01589CrossRefPubMedPubMedCentral

Rosa AR, Reinares M, Michalak EE et al (2010) Functional impairment and disability across mood states in bipolar disorder. Value Health 13:984–988CrossRefPubMed

Woods SW (2000) The economic burden of bipolar disease. J clin psychiatry 61(Supp 13):38–41PubMed

Ketter TA (2015) Advances in treatment of bipolar disorders, 1st edn. American Psychiatric Pub, Washington, DC

Franklin GM, American Academy of N (2014) Opioids for chronic noncancer pain: a position paper of the American Academy of Neurology. Neurology 83:1277–1284CrossRefPubMed

Spivak S, Cullen B, Eaton W et al (2018) Prescription opioid use among individuals with serious mental illness. Psychiatry Res 267:85–87CrossRefPubMed

10.

Martins SS, Keyes KM, Storr CL, Zhu H, Chilcoat HD (2009) Pathways between nonmedical opioid use/dependence and psychiatric disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions. Drug Alcohol Depend 1(103):16–24CrossRef

11.

Merrill JO, Von Korff M, Banta-Green CJ et al (2012) Prescribed opioid difficulties, depression and opioid dose among chronic opioid therapy patients. Gen Hosp Psychiatry 34:581–587CrossRefPubMedPubMedCentral

12.

Owen-Smith A, Stewart C, Sesay MM et al (2020) Chronic pain diagnoses and opioid dispensings among insured individuals with serious mental illness. BMC Psychiatry 20:40CrossRefPubMedPubMedCentral

13.

Vadivelu N, Kai AM, Kodumudi G, Babayan K, Fontes M, Burg MM (2017) Pain and psychology-A reciprocal relationship. Ochsner J 17:173–180PubMedPubMedCentral

14.

Craddock N, Sklar P (2013) Genetics of bipolar disorder. Lancet 11(381):1654–1662CrossRef

15.

Kerner B (2014) Genetics of bipolar disorder. Appl Clin Genet 7:33–42CrossRefPubMedPubMedCentral

16.

Huang JS, Yang FC, Chien WC et al (2021) Risk of Substance use disorder and its associations with comorbidities and psychotropic agents in patients with autism. JAMA Pediatr 1(175):e205371CrossRef

17.

Liang CS, Bai YM, Hsu JW et al (2020) The risk of sexually transmitted infections following first-episode schizophrenia among adolescents and young adults: a Cohort Study of 220 545 subjects. Schizophr Bull 8(46):795–803CrossRef

18.

Chen MH, Hsu JW, Huang KL et al (2018) Sexually transmitted infection among adolescents and young adults with attention-deficit/hyperactivity disorder: a Nationwide Longitudinal Study. J Am Acad Child Adolesc Psychiatry 57:48–53CrossRefPubMed

19.

Chen MH, Hsu JW, Huang KL et al (2018) Risk and coaggregation of major psychiatric disorders among first-degree relatives of patients with bipolar disorder: a nationwide population-based study. Psychol Med 12:1–8

20.

Chen MH, Lan WH, Hsu JW et al (2016) Risk of developing type 2 diabetes in adolescents and young adults with autism spectrum disorder: a Nationwide Longitudinal Study. Diabetes Care 39:788–793CrossRefPubMed

21.

Zhang B, Wang HE, Bai YM et al (2021) Inflammatory bowel disease is associated with higher dementia risk: a nationwide longitudinal study. Gut 70:85–91CrossRefPubMed

22.

Charlson ME, Pompei P, Ales KL, Mackenzie CR (1987) A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40:373–383CrossRefPubMed

23.

Arias F, Szerman N, Vega P, Mesias B, Basurte I, Rentero D (2017) Bipolar disorder and substance use disorders. Madrid study on the prevalence of dual disorders/pathology. Adicciones 29:186–194CrossRefPubMed

24.

Martins SS, Fenton MC, Keyes KM, Blanco C, Zhu H, Storr CL (2012) Mood and anxiety disorders and their association with non-medical prescription opioid use and prescription opioid-use disorder: longitudinal evidence from the National Epidemiologic Study on Alcohol and Related Conditions. Psychol Med 42:1261–1272CrossRefPubMed

25.

Huang B, Dawson DA, Stinson FS et al (2006) Prevalence, correlates, and comorbidity of nonmedical prescription drug use and drug use disorders in the United States: results of the national epidemiologic survey on alcohol and related conditions. J clin psychiatry 67:1062–1073CrossRefPubMed

26.

Edlund MJ, Martin BC, Fan MY, Devries A, Braden JB, Sullivan MD (2010) Risks for opioid abuse and dependence among recipients of chronic opioid therapy: results from the TROUP study. Drug Alcohol Depend 1(112):90–98CrossRef

27.

Park TW, Lin LA, Hosanagar A, Kogowski A, Paige K, Bohnert AS (2016) Understanding risk factors for opioid overdose in clinical populations to inform treatment and policy. J Addict Med 10:369–381CrossRefPubMed

28.

Albanese MJ, Clodfelter JR, Pardo RC, Ghaemi TB, Nassir S (2006) Underdiagnosis of bipolar disorder in men with substance use disorder. J Psychiatr Pract 12:124–127CrossRefPubMed

29.

Raouna A, Osam CS, Macbeth A (2018) Clinical staging model in offspring of parents with bipolar disorder: a systematic review. Bipolar Disord 20:313–333CrossRefPubMed

30.

Smith VC, Wilson CR, Committee on substance use, prevention (2016) Families affected by parental substance use. Pediatrics. https://doi.org/10.1542/peds.2016-1575CrossRefPubMedPubMedCentral

31.

Straussner SLA, Fewell CH (2018) A review of recent literature on the impact of parental substance use disorders on children and the provision of effective services. Curr Opin Psychiatry 31:363–367CrossRefPubMed

32.

McHugh RK, Votaw VR, Sugarman DE, Greenfield SF (2018) Sex and gender differences in substance use disorders. Clin Psychol Rev 66:12–23CrossRefPubMed

33.

Lalli M, Brouillette K, Kapczinski F, De Azevedo CT (2021) Substance use as a risk factor for bipolar disorder: a systematic review. J Psychiatr Res 144:285–295CrossRefPubMed

34.

Stubbs B, Eggermont L, Mitchell AJ et al (2015) The prevalence of pain in bipolar disorder: a systematic review and large-scale meta-analysis. Acta Psychiatr Scand 131:75–88CrossRefPubMed

35.

Borsbo B, Peolsson M, Gerdle B (2009) The complex interplay between pain intensity, depression, anxiety and catastrophising with respect to quality of life and disability. Disabil Rehabil 31:1605–1613CrossRefPubMed

36.

Goesling J, Henry MJ, Moser SE et al (2015) Symptoms of depression are associated with opioid use regardless of pain severity and physical functioning among treatment-seeking patients with chronic pain. J Pain 16:844–851CrossRefPubMed

37.

Katon W, Lin EH, Kroenke K (2007) The association of depression and anxiety with medical symptom burden in patients with chronic medical illness. Gen Hosp Psychiatry 29:147–155CrossRefPubMed

38.

Stahl S, Briley M (2004) Understanding pain in depression. Hum Psychopharmacol 19(Suppl 1):S9–S13CrossRefPubMed

39.

Strigo IA, Simmons AN, Matthews SC, Craig AD, Paulus MP (2008) Association of major depressive disorder with altered functional brain response during anticipation and processing of heat pain. Arch Gen Psychiatry 65:1275–1284CrossRefPubMedPubMedCentral

40.

Scherrer JF, Svrakic DM, Freedland KE et al (2014) Prescription opioid analgesics increase the risk of depression. J Gen Intern Med 29:491–499CrossRefPubMed

41.

Chen M, Jiang Q, Zhang L (2021) The prevalence of bipolar disorder in autoimmune disease: a systematic review and meta-analysis. Ann Palliat Med 10:350–361CrossRefPubMed

42.

Mariani SM (2004) Genes and autoimmune diseases - a complex inheritance. Med Gen Med 6:18

43.

Jeanty C, Derderian SC, Mackenzie TC (2014) Maternal-fetal cellular trafficking: clinical implications and consequences. Curr Opin Pediatr 26:377–382CrossRefPubMedPubMedCentral

44.

Busse JW, Craigie S, Juurlink DN et al (2017) Guideline for opioid therapy and chronic noncancer pain. CMAJ 8(189):E659–E666CrossRef

45.

Davis MA, Lin LA, Liu H, Sites BD (2017) Prescription opioid use among adults with mental health disorders in the United States. J Am Board Fam Med 30:407–417CrossRefPubMed

Titel: Association between parental bipolar disorder and increased risk of exposure to prescription opioids for their offspring
verfasst von: Dian-Jeng Li
Mu-Hong Chen
Ya-Mei Bai
Shih-Jen Tsai
Chih-Ming Cheng
Tung-Ping Su
Tzeng-Ji Chen
Ta-Chuan Yeh
Chih-Sung Liang
Publikationsdatum: 18.09.2022
Verlag: Springer Berlin Heidelberg
Erschienen in: Social Psychiatry and Psychiatric Epidemiology / Ausgabe 2/2023
Print ISSN: 0933-7954
Elektronische ISSN: 1433-9285
DOI: https://doi.org/10.1007/s00127-022-02360-5

Update Psychiatrie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Association between parental bipolar disorder and increased risk of exposure to prescription opioids for their offspring