Skip to main content
Erschienen in: BMC Pediatrics 1/2021

Open Access 01.12.2021 | Research article

Bidirectional association of neurodevelopment with growth: a prospective cohort study

verfasst von: Xiaotong Wei, Jiajin Hu, Liu Yang, Ming Gao, Lin Li, Ning Ding, Yanan Ma, Deliang Wen

Erschienen in: BMC Pediatrics | Ausgabe 1/2021

Abstract

Background

The study aims to use the cross-lagged model and utilize data from the Born in Shenyang Cohort Study to characterize the bidirectional associations of the term-born infants’ neurodevelopment in five domains and physical growth in early life.

Method

This study consists of 688 mother-child dyads from the Born in Shenyang Cohort Study. Infants’ anthropometric (weight and length) and development in neurological outcomes (Gesell Development Scale) were measured at the age of 6 and 12 months. Cross-lagged analyses and multiple linear regression analyses were used to explore the longitudinal relationships in both directions.

Results

In terms of longitudinal studies, the inverse associations between infants’ two skills (gross motor and social behavior) at the age of 6 months with BMI Z -scores at the age of 12 months (gross motor: aβ = − 0.20, 95% CI: − 0.31 to- 0.09; social behavior: aβ = − 0.23, 95% CI: − 0.33 to- 0.13) were found. Conversely, a higher infant Z -scored BMI at the age of 6 months predicted a lower gross motor at the age of 12 months (aβ = − 0.08, 95% CI: − 0.12 to- 0.04). In cross-lagged analyses, an adverse association in both directions between gross motor and Z -scored BMI was observed.

Conclusion

We found bidirectional relationships between infants’ neurodevelopment of gross motor with physical growth and suggested the term-born infants, who are on the edge of the developmental danger, should not be overlooked.
Hinweise

Supplementary Information

The online version contains supplementary material available at https://​doi.​org/​10.​1186/​s12887-021-02655-7.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Abkürzungen
ALSPAC
Avon Longitudinal Study of Parents and Children
SEED
The study to explore early development
BISCS
Born in Shenyang Cohort Study
BMI
Body Mass Index
WFA
Weight for age
WHO
World Health Organization
GDS
Gesell Development Scale
DQ
Developmental quotient
GWG
Gestational weight gain
Wt
Weight

Background

The relationships between physical growth and neurodevelopment are found; however, the literature for infants, especially within term-born, is relatively few [1, 2]. As far as we know, the outstanding cohort study, which named Avon Longitudinal Study of Parents and Children (ALSPAC), has paid attention to this relationship. They found that physical growth in adults and children were not associated with neurodevelopment, suggesting that physical development in early life may be a critical period of later neural development [3]. Between birth and 1 year, body weight has triples, body length increases by more than 50%, and brain volumes increase to 75% of an adult’s size [4].
Besides, although recent studies have found that bidirectional effects between physical growth and neurodevelopment, that is, physical growth may be both influencing and responding to infants, few studies have the analysis of these relationships. On the one hand, physical growth may be a sign of disruption of the critical steps during brain development. The brain and nervous system growing at its fastest rate during this time, such as weight status and weight gain during this process, can have long-term impacts on the brain’s developing structure and function [58]. Moreover, research addressing children’s physical growth on neurodevelopment has shown controversial findings. Some studies found that weight status has been negatively associated with neurodevelopment, especially in motor development and cognitive development. However, longitudinal studies confirmed no temporal associations in the population [912]. On the other hand, the state of neurodevelopment in young children might also affect physical development [13, 14]. However, few epidemiologic studies that focus on the effects and have shown controversial findings [15]. Although a comprehensive systematic review study showed infants with better development in psychiatric and neurological demonstrated a greater gain in height and weight gain between 4 and 12 months, the study to explore early development (SEED) showed infants with intellectual disability and neurodevelopmental impairments, in particular, would be at greater risk for rapid weight gain or obesity during infancy [16].
The bidirectional relationships between early life neurodevelopment with physical growth can be affected by numerous confounding factors. As these factors are often complex and interdependent, using independent regression models is cumbersome. In this paper, the study needs to explore the relationships between physical growth and neurodevelopment during infancy, and investigate causal pathways beginning in early life. The cross-lagged analysis should be used to overcome these problems, which is a powerful statistical approach to address methodological problems.
In this study, we considered to use the cross-lagged models and utilize data from the Born in Shenyang Cohort Study (BISCS) to characterize the bidirectional associations of term-born infants’ neurodevelopment in five domains (adaptive behavior, gross motor, fine motor, language, and social behavior) and physical growth (Body Mass Index (BMI) Z -score and weight gain velocity) in the early life.

Methods

Population and study design

The BISCS was a representative, prospective cohort study conducted by China Medical University between 2017 and 2020. We enrolled pregnant women from 54 hospitals and community health care centers, which were all perinatal care institutes that provide antenatal and maternity care in the urban areas of Shenyang, located in northeast China [17]. In-person visits were conducted with mothers between 13 and 27 weeks and 28–36 weeks of gestation to record maternal demographic information and collect biological samples. The visits were conducted again at the age of 1, 3, 6 and 12 months postpartum to record maternal postnatal data and infant information, and use the Gesell Developmental Scale to assess the infant neurodevelopmental levels at the age of 6 and 12 months. Children born to mothers before 36 weeks gestation, with severe complications during pregnancy, diseases in the nervous system around birth, as part of a multiple pregnancies (e.g., twins, triplets), or without complete baseline and follow-up data were excluded. As Fig. 1, a final cohort of 688 women was completed at delivery, at the age of 6 months postpartum (n = 459), and at the age of 12 months postpartum (n = 449). There was no difference found in maternal and infant demographic information between attrite participants and those with complete information (see Table S1).

Measures

Anthropometric outcomes

The weight and length at birth of the infants were recorded from the medical records, and at the age of 6 months (mean: 6.87 ± 1.27) and at the age of 12 months postpartum (mean: 11.67 ± 1.41) by BISCS staff, according to a standard protocol. The weight and length were measured with a digital scale and a stadiometer while children were wearing no shoes and light clothes (Seca 416 and 376 +; Seca Corporation, Hamburg, Germany). Birth Z -score, Z-scored BMI for age, sex-specific weight for age (WFA) and weight-for-length (WFL) were calculated based on the World Health Organization (WHO) child growth reference [18]. Weight gain velocity was calculated as the change in WFA Z -score from birth to 6 months and 6 months to 12 months [19].

Infants’ neurodevelopment

Participants in this birth cohort were administered the Gesell Development Scale (GDS), which has been used extensively after being translated and standardized [20]. The Gesell Development Scale is used to evaluate the function of the central nervous system and identify defects in the neuromuscular or sensory system, which consists of five domains, including the adaptive domain (coordination, imitation, object recovery, discrimination and perception), gross motor domain (changes in posture, head balance and behavioral observations of standing, sitting and walking) and fine motor domain (ability to hold objects with fingers), language domain (vocabulary comprehension and dialogue skills), and social domain (social habits, reactions to persons, autonomy and independence). Developmental quotient (DQ) is defined as the quotient between developmental age and actual age, and the DQ of each child was calculated for each specific domain. Higher developmental quotient (DQ) scores mean higher cognitive levels [21]. Two well-trained pediatricians from the Shengjing Hospital of China Medical University assessed all participants to maximize reliability. They assessed all children in their assigned domain to avoid interexaminer variability.

Covariates

Based on previous research [2225], other variables were used to describe maternal and infants’ demographic characteristics and control for confounding variables. These variables were collected from hospital records (maternal age, maternal pre-pregnancy BMI [26], gestational weight gain (GWG), delivery mode, parity, child sex, gestational weeks, and birth weight) and questionnaires (maternal education, annual family income, primary caregiver, mode of infant feeding, the introduction of solid foods at the age of 6 months and micronutrients supplementation (Iron, Vitamin B12 and Zinc) at the age of 6 months). Only 0.85% of women smoked and 1.15% of women were drinking during pregnancy, so this variable was not included. We calculated the GWG rate (kg/week) as the total GWG divided by the number of gestational weeks at delivery. Based on the IOM, above optimal weight gains are above 16 kg for mothers with normal weight and more than 11.5 kg for overweight mothers, respectively [27, 28]. We categorized the mode of infant feeding as: formula feeding only, mixed breast and formula, and breast milk feeding only. Micronutrient supplementation (Iron, Vitamin B12 and Zinc) was treated as a dichotomized variable (yes/no). To ensure data integrity, the wholly conditional specification multiple imputation (m = 20) was used to impute missing data.

Statistical analyses

Longitudinal analyses

Multiple linear regression analyses were fitted to assess the association of infants’ BMI Z -score and weight gain velocity with neurodevelopmental status at the age of 6 and 12 months. The analyses used repeated measured weight status and neurodevelopmental variables at two-time points. The analyses were adjusted for all the above confounding factors. Furthermore, the associations between neurodevelopmental status at the age of 6 months and weight status at the age of 12 months were additionally adjusted for weight status at baseline (6 months) to study whether neurodevelopmental status predicted the change in infants’ Z -scored BMI or weight gain velocity, and vice versa. The above analyses were also carried out in the relationships between Z -scored WFL and neurodevelopmental status. Linear regression analyses were run using SPSS version 20.0 (SPSS 20.0, [2011], IBM).

Cross-lagged analyses

This cross-lagged analysis included confounders, stability effects, cross-sectional associations, longitudinal associations, and cross-lagged associations. Firstly, we examined the stability model, which only included the cross-sectional analysis, with confounding factors regressed at two baselines. Then, based on the first step, we entered the lagged association between infant BMI Z -score and weight gain velocity at the age of 6 months with neurodevelopmental status at the age of 12 months, and the lagged association between neurodevelopmental status at the age of 6 months with infant BMI Z -score and weight gain velocity at the age of 12 months. Finally, the above two lag associations entered the whole model at the same time. The above relationships were adjusted for all the above confounding factors. Besides, the cross-lagged associations were adjusted for weight status at baseline (the age of 6 months) or neurodevelopmental status at baseline (the age of 6 months). The cross-lagged analyses were conducted with Mplus, version 7.11.

Results

Participants characteristics

Characteristics at follow-up at the age of 6 and 12 months were shown (Table S1, see Supplemental materials). Among eligible mother-offspring pairs, the mean (SD) age of the recruited mothers was 30.4 ± 3.9 years, and about a quarter of mothers were overweight. Four hundred and fifty-nine infants (234 [51.1%] were boys, 225 [48.9%]) were girls who assessed at the age of 6 months. At the age of 6 and 12 months, the mean infants’ BMI Z- score were 0.16 ± 0.97 and 0.23 ± 1.05, respectively. Nearly one-fourth of infants went through rapid weight gain, and at the age of 6 months and at the age of 12 months, 47 (10.2%) and 51 (11.4%) were overweight, respectively. The infant average DQ scores in domains of adaptive behavior, gross motor, fine motor, language, and social behavior were 97.9, 100.3, 94.1, 85.9, and 93.2 at the age of 6 months, respectively. Furthermore, the mean scores were 103.3, 101.2, 104.8, 94.9, and 112.7 at the age of 12 months, respectively.

Longitudinal analyses

As shown in Tables 1 and S2 (see Supplemental materials), the linear regression analysis evaluated the associations between neurodevelopmental status at the age of 6 months and Z -scored BMI at the age of 12 months. Results found that an additional unit of infants’ two skills (gross motor and social behavior) at the age of 6 months could be decompensated by 0.2 SD decrease (0.23 SD decrease) in BMI at the age of 12 months (gross motor: aβ = − 0.20, 95% CI: − 0.31 to- 0.09, P = 0.002; social behavior: aβ = − 0.23, 95% CI: − 0.33 to- 0.13, P = 0.005). No effect of the other three neurodevelopment skills was observed. Similar associations had been found between the DQ scores at the age of 6 months and the risk of rapid weight gain or Z -scored WFL at the age of 12 months in Tables S2 and S4 (see Supplemental materials).
Table 1
Longitudinal associations between neurodevelopment and BMI z-scores at 6 and 12 months of agea
Outcomes at 12 months
Predictors at 6 months
 
β (95% CI)
Infant Z-scored BMI
Adaptive behavior
Model 1
−0.06(− 0.20,0.08)
Model 2
−0.04(− 0.18,0.10)
Model 3
−0.03(− 0.19,0.13)
Gross motor
Model 1
−0.54(− 0.67,-0.41)*
Model 2
−0.44(− 0.58,-0.30)*
Model 3
−0.20(− 0.31,-0.09)*
Fine motor
Model 1
−0.03(− 0.15,0.09)
Model 2
−0.03(− 0.16,0.11)
Model 3
−0.01(− 0.05,0.04)
Language
Model 1
−0.03(− 0.13,0.07)
Model 2
−0.03(− 0.12,0.07)
Model 3
−0.02(− 0.10,0.06)
Social behavior
Model 1
−0.35(− 0.48,-0.23)*
Model 2
−0.31(− 0.41,-0.21)*
Model 3
−0.23(− 0.33,-0.13)*
Model 1: adjusted for basic information; Model 2: model 1+ maternal pre-pregnancy BMI, gestational weight gain, delivery mode, gestational weeks, birth weight z score, mode of infant feeding, introduction of solid foods and micronutrients supplementation; Model 3: model 2+ Infant Z-scored BMI at 6 months in the neurodevelopment- BMI relationships, or neurodevelopment scores at 6 months in the BMI – neurodevelopment relationships
*Statistically significant
aN = 449. N varied from 1.7 to 2.8% in each regression because the complete data for each subscale of the Gesell Development Scale were varied
As shown in Table 2, the linear regression analysis assessed the associations between Z -scored BMI at the age of 6 months and neurodevelopmental status at the age of 12 months (Table 2). Each SD increase in infant Z -scored BMI at the age of 6 months was associated with 0.08 unit reduction in the gross motor domain at the age of 12 months (aβ = − 0.08, 95% CI: − 0.12 to- 0.04, P = 0.03). However, Z -scored BMI at the age of 6 months showed a negative correlation with social behavior skills at the age of 12 months, which tends to disappear when considering social behavior skills at the age of 6 months as a confounding variable (model 2: aβ = − 0.08, 95% CI: − 0.11 to- 0.05, P = 0.03; model 3: aβ = − 0.05, 95% CI: − 0.08 to 0.00, P = 0.06). Like Z-scored BMI results, the relationships between weight gain velocity or Z -scored WFL and at the age of 6 months with neurodevelopmental status at the age of 12 months were performed in Tables S3 and S5 (see Supplemental materials).
Table 2
Longitudinal associations between BMI z-scores and neurodevelopment at 6 and 12 months of agea
Outcomes at 12 months
Predictors at 6 months
 
β (95% CI)
Adaptive behavior
Infant Z-scored BMI
Model 1
−0.01(− 0.03,0.01)
Model 2
−0.01(− 0.02,0.01)
Model 3
−0.01(− 0.02,0.01)
Gross motor
Model 1
−0.29(− 0.36,-0.22)*
Model 2
−0.19(− 0.29,-0.09)*
Model 3
−0.08(− 0.12,− 0.04)*
Fine motor
Model 1
-0.04(−0.11,0.03)
Model 2
−0.02(− 0.06,0.03)
Model 3
−0.02(− 0.04,0.01)
Language
Model 1
−0.02(− 0.04,0.01)
Model 2
−0.02(− 0.04,0.01)
Model 3
−0.02(− 0.03,0.01)
Social behavior
Model 1
−0.09(− 0.12,− 0.08)*
Model 2
-0.08(−0.11,− 0.05)*
Model 3
-0.05(−0.08,0.00)
Model 1: adjusted for basic information; Model 2: model 1+ maternal pre-pregnancy BMI, gestational weight gain, delivery mode, gestational weeks, birth weight z score, mode of infant feeding, introduction of solid foods and micronutrients supplementation; Model 3: model 2+ Infant Z-scored BMI at 6 months in the neurodevelopment- BMI relationships, or neurodevelopment scores at 6 months in the BMI – neurodevelopment relationships
*Statistically significant
aN = 449. N varied from 1.7 to 2.8% in each regression because the complete data for each subscale of the Gesell Development Scale were varied

Cross-lagged analyses

The cross-lagged models of bidirectional associations between infant neurological development levels and Z -scored BMI at 6 and 12 months were shown in Fig. 2. All cross-lagged analyses demonstrated SRMR and RMSEA were close to zero, and TLI and CFI were above 0.9, which means the degrees of fitting were good. An adverse association in both directions between gross motor and Z -scored BMI was observed. The negative relationship of social behavior at the age of 6 months of age with BMI Z -score at the age of 12 months was found, but there was not differed statistically in the opposite direction. Similar to Z-scored BMI results, of bidirectional associations between weight gain velocity with neurodevelopmental status were performed in Fig. 3.

Discussion

To the best of our knowledge, the current study is one of the few to explore the bidirectional associations between neurodevelopment, as assessed by the Gesell Development Scale, and physical growth among term-born infants. Our birth cohort study suggests the negative associations between gross motor and social behavior at the age of 6 months with weight status at the age of 12 months. Regarding the opposite direction of relationship, a higher infant Z -scored BMI at the age of 6 months predicted a lower neurological development level in the gross motor at the age of 12 months. Gross motor performed a bidirectional relationship, although neurological development level had a more significant effect on infants’ BMI Z -score than the opposite. Similar associations had been found in weight gain velocity.
In motor abilities, our findings are consistent with previous studies demonstrating that gross motor skills were negatively associated with infant physical growth in both directions [29]. Our results indicate a bidirectional causal temporal relationship between gross motor skills and infant physical growth, which means that an increase in physical index or in gross motor capacity can cause each other to decline. In clinical practice, more attention should be paid to physical development or neural development, which is beneficial to strengthen the predictive function of each other. However, Schmidt et al. found minimal correlations between motor development and weight status, suggesting that weight status and motor milestones are mostly independent of one another [30]. There are several possible reasons for these differences. First, the samples were analyzed in different age groups. Most recent studies concentrate on exploring relationships in preschool children or school-aged children, whereas the participants in our study were infants, especially within term-born infants. Second, differences may have arisen due to the fact that different tools measured the participants. The current study evaluated motor skills using the GDS, which were in line with motor milestones and dependent on the age interval of the infants. However, this scale is still heterogeneous with other measurement tools. Potential mechanisms for these effects include the possibility that infants with poor gross motor performance are frequently associated with biomechanical problems and morphological constraints on tasks involving changes in overweight/obese status and fat mass [31]. However, Gentier and colleagues suggested that a deficit in childhood motor skills should be examined in a broader sense, rather than a mechanical interpretation. For example, it is plausible that the reduced physical activity and the lack of decision-making, planning, and control functions in infants with poor motor ability are causal factors in obese status, suggesting that impaired motor development is also related to children with obesity [12]. Therefore, additional exploratory analyses to determine the bidirectional associations between motor domains and weight status should be conducted.
Consistent with our results, previous studies observed the relationships between social skills and infant’s physical development [32]. According to the Infant Research framework [33], infant social communication abilities develop in dynamic functional interactions between mothers and infants. Ostensibly, it should be recognized that the relationship between mother and infant is bidirectional and may influence infant clues’ accuracy. As infants grow, they use communicate abilities to express wants or dislike certain foods [34]. Suppose infants have poor social skills, such as infrequent laughter, reduced focus, shared attention, and/or unclear signals to articulate their needs (including the cues of full or hungry). In that case, it may preclude their potential development of caregivers’ feeding responsiveness [35]. Scholars propose that maternal responsiveness to their children’s expressions, such as appetite, hunger, and satiety is essential when developing a healthy diet and could play an essential role in offspring weight status [32]. Besides, it is generally known that language and social competence can be simultaneously discussed as previous studies have demonstrated that children’s social and language development are synchronized mainly [36]; however, no relationship between language ability and body weight was found in our study. Additional research is needed to investigate further the potential contribution of children’s social communication skills and language ability to maternal factors.
Our prospective study provided a unique opportunity to explore the bidirectional relationships between infants’ neurodevelopment and physical growth and had attempted to analyze the associations of mutual prediction, which have been of little attention to date. In our study, the bidirectional relationships between term-born infants’ neurodevelopment of gross motor with physical growth are found. However, there are also several limitations. First, our study is limited in sample size and follow-up time, then might weakly predict later attainment. Nevertheless, physical and neurological development in early life is irreversible 3. Based on this study, long-term follow-up data will be used to verify our research results further. Second, Confounding factors, such as feeding style (responding style, authoritative feeding, etc.), breastfeeding (bottle or exclusive breastfeeding) were not fully adjusted.

Conclusion

Our works suggest that the development within term-born infants should not be overlooked, but only concerned children with developmental disabilities are incomplete. Strengthen knowledge education for caregivers and improve the physical examination system for infants and young children could avoid becoming a hidden danger in developmental delays.

Acknowledgements

We thank all the participants who took part in our study, and interviewers, nurses, computer and laboratory technicians, clerical workers, research scientists, volunteers, managers, and receptionists of the BISCS study for their supports and dedications. The study was supported by China Postdoctoral Science Foundation (2019 M661179).

Code availability

Not applicable.

Declarations

All procedures were approved by the medical ethics committee of China Medical University (application number: 71774173). The mothers were informed of the project aims and requirements. We obtained written informed consent from the mothers prior to enrollment.
Not applicable.

Competing interests

The authors declare no potential conflicts of interest.
Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://​creativecommons.​org/​licenses/​by/​4.​0/​. The Creative Commons Public Domain Dedication waiver (http://​creativecommons.​org/​publicdomain/​zero/​1.​0/​) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Literatur
1.
Zurück zum Zitat Richards M, Hardy R, Kuh D, Wadsworth ME. Birth weight and cognitive function in the British 1946 birth cohort: longitudinal population based study. BMJ. 2001;322:199–203.CrossRefPubMedPubMedCentral Richards M, Hardy R, Kuh D, Wadsworth ME. Birth weight and cognitive function in the British 1946 birth cohort: longitudinal population based study. BMJ. 2001;322:199–203.CrossRefPubMedPubMedCentral
5.
Zurück zum Zitat Adelantado-Renau M, Esteban-Cornejo I, Rodriguez-Ayllon M, Cadenas-Sanchez C, Gil-Cosano JJ, Mora-Gonzalez J, et al. Inflammatory biomarkers and brain health indicators in children with overweight and obesity: the activebrains project. Brain Behav Immun. 2019;81:588–97 10.1016/j.bbi.2019.07.020. Adelantado-Renau M, Esteban-Cornejo I, Rodriguez-Ayllon M, Cadenas-Sanchez C, Gil-Cosano JJ, Mora-Gonzalez J, et al. Inflammatory biomarkers and brain health indicators in children with overweight and obesity: the activebrains project. Brain Behav Immun. 2019;81:588–97 10.1016/j.bbi.2019.07.020.
6.
Zurück zum Zitat Liping L, et al. Fat mass and obesity-associated (FTO) protein regulates adult neurogenesis. Hum Mol Genet. 2017;26(13):2398–411 10.1093/hmg/ddx128.CrossRef Liping L, et al. Fat mass and obesity-associated (FTO) protein regulates adult neurogenesis. Hum Mol Genet. 2017;26(13):2398–411 10.1093/hmg/ddx128.CrossRef
7.
Zurück zum Zitat Grantham-McGregor S, et al. Developmental potential in the first 5 years for children in developing countries. Lancet. 2007;369:60–70 10.1016/S0140-6736(07)60032-4.CrossRefPubMedPubMedCentral Grantham-McGregor S, et al. Developmental potential in the first 5 years for children in developing countries. Lancet. 2007;369:60–70 10.1016/S0140-6736(07)60032-4.CrossRefPubMedPubMedCentral
8.
Zurück zum Zitat Thompson RA, Nelson CA. Developmental science and the media: early brain development. Am Psychol. 2001;56:5–15.CrossRefPubMed Thompson RA, Nelson CA. Developmental science and the media: early brain development. Am Psychol. 2001;56:5–15.CrossRefPubMed
17.
Zurück zum Zitat Hu J, Aris I, Oken E, Ma Y, Ding N, Gao M, et al. Association of total and trimester-specific gestational weight gain rate with early infancy weight status: a prospective birth cohort study in China. Nutrients. 2019;11(2):280. https://doi.org/10.3390/nu11020280. Hu J, Aris I, Oken E, Ma Y, Ding N, Gao M, et al. Association of total and trimester-specific gestational weight gain rate with early infancy weight status: a prospective birth cohort study in China. Nutrients. 2019;11(2):280. https://​doi.​org/​10.​3390/​nu11020280.
21.
Zurück zum Zitat Perera F, Li TY, Zhou ZJ, Yuan T, Chen YH, Qu L, et al. Benefits of reducing prenatal exposure to coal-burning pollutants to children’s neurodevelopment in China. Environ Health Perspect. 2008;116(10):1396–400. https://doi.org/10.1289/ehp.11480. Perera F, Li TY, Zhou ZJ, Yuan T, Chen YH, Qu L, et al. Benefits of reducing prenatal exposure to coal-burning pollutants to children’s neurodevelopment in China. Environ Health Perspect. 2008;116(10):1396–400. https://​doi.​org/​10.​1289/​ehp.​11480.
22.
Zurück zum Zitat Tian Y, et al. Influencing factors of the neurodevelopment of high-risk infants. Gen Psychiatry. 2018;31:e100034 https://doi.org/CNKI:SUN:JSYI.0.2018-06-005.CrossRef Tian Y, et al. Influencing factors of the neurodevelopment of high-risk infants. Gen Psychiatry. 2018;31:e100034 https://​doi.​org/​CNKI:SUN:JSYI.0.2018-06-005.CrossRef
32.
Zurück zum Zitat Shloim N, Shafiq I, Blundell-Birtill P, Hetherington MM. Infant hunger and satiety cues during the first two years of life: developmental changes of within meal signalling. Appetite. 2018;128:303–10.CrossRefPubMed Shloim N, Shafiq I, Blundell-Birtill P, Hetherington MM. Infant hunger and satiety cues during the first two years of life: developmental changes of within meal signalling. Appetite. 2018;128:303–10.CrossRefPubMed
35.
Zurück zum Zitat Gartstein MA, Crawford J, Robertson CD. Early markers of language and attention: mutual contributions and the impact of parent–infant interactions. Child Psychiatry Hum Dev. 2007;39:9–26.CrossRefPubMed Gartstein MA, Crawford J, Robertson CD. Early markers of language and attention: mutual contributions and the impact of parent–infant interactions. Child Psychiatry Hum Dev. 2007;39:9–26.CrossRefPubMed
Metadaten
Titel
Bidirectional association of neurodevelopment with growth: a prospective cohort study
verfasst von
Xiaotong Wei
Jiajin Hu
Liu Yang
Ming Gao
Lin Li
Ning Ding
Yanan Ma
Deliang Wen
Publikationsdatum
01.12.2021
Verlag
BioMed Central
Erschienen in
BMC Pediatrics / Ausgabe 1/2021
Elektronische ISSN: 1471-2431
DOI
https://doi.org/10.1186/s12887-021-02655-7

Weitere Artikel der Ausgabe 1/2021

BMC Pediatrics 1/2021 Zur Ausgabe

Neuer Typ-1-Diabetes bei Kindern am Wochenende eher übersehen

23.04.2024 Typ-1-Diabetes Nachrichten

Wenn Kinder an Werktagen zum Arzt gehen, werden neu auftretender Typ-1-Diabetes und diabetische Ketoazidosen häufiger erkannt als bei Arztbesuchen an Wochenenden oder Feiertagen.

Neue Studienergebnisse zur Myopiekontrolle mit Atropin

22.04.2024 Fehlsichtigkeit Nachrichten

Augentropfen mit niedrig dosiertem Atropin können helfen, das Fortschreiten einer Kurzsichtigkeit bei Kindern zumindest zu verlangsamen, wie die Ergebnisse einer aktuellen Studie mit verschiedenen Dosierungen zeigen.

Spinale Muskelatrophie: Neugeborenen-Screening lohnt sich

18.04.2024 Spinale Muskelatrophien Nachrichten

Seit 2021 ist die Untersuchung auf spinale Muskelatrophie Teil des Neugeborenen-Screenings in Deutschland. Eine Studie liefert weitere Evidenz für den Nutzen der Maßnahme.

Fünf Dinge, die im Kindernotfall besser zu unterlassen sind

18.04.2024 Pädiatrische Notfallmedizin Nachrichten

Im Choosing-Wisely-Programm, das für die deutsche Initiative „Klug entscheiden“ Pate gestanden hat, sind erstmals Empfehlungen zum Umgang mit Notfällen von Kindern erschienen. Fünf Dinge gilt es demnach zu vermeiden.

Update Pädiatrie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.