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Inflammation Research
Erschienen in: Inflammation Research 12/2010

01.12.2010 | Original Research Paper

Central and peripheral anti-inflammatory effects of maprotiline on carrageenan-induced paw edema in rats

verfasst von: V. Hajhashemi, H. Sadeghi, M. Minaiyan, A. Movahedian, A. Talebi

Erschienen in: Inflammation Research | Ausgabe 12/2010

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Abstract

Objective

To explore the site of action of maprotiline, as an atypical antidepressant, on carrageenan-induced paw edema.

Subjects

Male Wistar rats were used.

Methods

Firstly, the anti-inflammatory effect of systemic maprotiline (12.5, 25 and 50 mg kg−1) was assessed using a paw edema model. Secondly, different doses of maprotiline were administrated intracerebroventricularly, intrathecally and locally before carrageenan challenge. Finally, we tried to reverse the anti-inflammatory effect of maprotiline by propranolol (10 mg kg−1), prazosin (4 mg kg−1), yohimbine (10 mg kg−1), naloxone (4 mg kg−1) and mifepristone (5 mg kg−1).

Results

Systemic, intracerebroventricular and subplantar application of maprotiline significantly inhibited peripheral edema, but intrathecal maprotiline did not alter the degree of paw swelling. The applied antagonists failed to change the anti-inflammatory activity of maprotiline.

Conclusion

These results demonstrate that maprotiline has a potent anti-inflammatory effect and this effect is linked to the peripheral and supraspinal actions of the drug.
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Metadaten
Titel
Central and peripheral anti-inflammatory effects of maprotiline on carrageenan-induced paw edema in rats
verfasst von
V. Hajhashemi
H. Sadeghi
M. Minaiyan
A. Movahedian
A. Talebi
Publikationsdatum
01.12.2010
Verlag
SP Birkhäuser Verlag Basel
Erschienen in
Inflammation Research / Ausgabe 12/2010
Print ISSN: 1023-3830
Elektronische ISSN: 1420-908X
DOI
https://doi.org/10.1007/s00011-010-0225-1

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