nach oben

Current Allergy and Asthma Reports

Erschienen in:

01.09.2020 | Autoimmunity (T Tarrant, Section Editor)

Cogan’s Syndrome: Clinical Presentations and Update on Treatment

verfasst von: Gabriela Mabel Espinoza, Joseph Wheeler, Katherine K. Temprano, Angela Prost Keller

Erschienen in: Current Allergy and Asthma Reports | Ausgabe 9/2020

Einloggen, um Zugang zu erhalten

Abstract

Purpose of Review

Cogan’s syndrome (CS) is a rare systemic vasculitis that can severely affect vision and hearing, which may also have significant systemic effects. Early recognition of this autoimmune disorder and intervention can minimize disabling and irreversible damage.

Recent Findings

This article will review the varying clinical presentations of CS and emerging information of systemic disease associated with CS. We will also review recently published promising treatment outcomes using immune modulating medications.

Summary

As our framework for recognizing the markers of CS and the associated systemic disorders expands, more effective guidelines and treatment options may emerge.

Haynes BF, Kaiser-Kupfer MI, Mason P, Fauci AS. Cogan syndrome: studies in thirteen patients, long-term follow-up, and a review of the literature. Medicine. 1980;59:426–41.CrossRef

Vollertsen RS, McDonald TJ, Younge BR, et al. Cogan’s syndrome: 18 cases and a review of the literature. Mayo Clin Proc. 1986;61:344–61. https://doi.org/10.1016/s0025-6196(12)61951-x.CrossRefPubMed

Gluth MB, Baratz KH, Matteson EL, Driscoll CL. Cogan syndrome: a retrospective review of 60 patients throughout a half century. Mayo Clin Proc. 2006;81:483–8. https://doi.org/10.4065/81.4.483.CrossRefPubMed

4••.

Mora P, Calzetti G, Ghirardini S, et al. Cogan’s syndrome: state of the art of systemic immunosuppressive treatment in adult and pediatric patients. Autoimmun Rev. 2017;16:385–90. https://doi.org/10.1016/j.autrev.2017.02.009Systematic review of combination therapy for Cogan’s syndrome. CrossRefPubMed

5••.

Durtette C, Hachulla E, Resche-Rigon M, et al. Cogan syndrome: characteristics, outcome and treatment in a French nationwide retrospective study and literature review. Autoimmun Rev. 2017;16:1219–23. https://doi.org/10.1016/j.autrev.2017.10.005Most recent large (62 patients) retrospective review of Cogan’s syndrome with comparison data regarding therapeutic agents. CrossRefPubMed

Morgan RF, Baumgartner CJ. Meniere’s disease complicated by recurrent interstitial keratitis: excellent result following cervical ganglionectomy. West J Surg. 1934;42:628.

Cogan DG. Syndrome of non-syphilitic interstitial keratitis and vestibuloauditory symptoms. Arch Ophthalmol. 1945;33:144–9.CrossRef

Greco A, Gallo A, Fusconi M, Magliulo G, Turchetta R, Marinelli C, et al. Cogan’s syndrome: an autoimmune inner ear disease. Autoimmun Rev. 2013;12:396–400. https://doi.org/10.1016/j.autrev.2012.07.012.CrossRefPubMed

Kessel A, Vadasz Z, Toubi E. Cogan syndrome – pathogenesis, clinical variants and treatment approaches. Autoimmun Rev. 2014;13:351–4. https://doi.org/10.1016/j.autrev.2014.01.002.CrossRefPubMed

10.

Lunardi C, Bason C, Leandri M, Navone R, Lestani M, Millo E, et al. Autoantibodies to inner ear and endothelial antigens in Cogan’s syndrome. Lancet. 2002;360:915–21. https://doi.org/10.1016/S0140-6736(02)11028-2.CrossRefPubMed

11.

Jung DH, Nadol JB Jr, Folkerth RD, Merola JF. Histopathology of the inner ear in a case with recent onset of Cogan’s syndrome: evidence for vasculitis. Ann Otol Rhinol Laryngol. 2016;125:20–4. https://doi.org/10.1177/0003489415595426.CrossRefPubMed

12.

Grasland A, Pouchot J, Hachulla E, Blétry O, Papo T, Vinceneux P, et al. Typical and atypical Cogan’s syndrome: 32 cases and review of the literature. Rheumatology. 2004;43:1007–15. https://doi.org/10.1093/rheumatology/keh228.CrossRefPubMed

13.

Espinoza GM, Prost A. Cogan’s syndrome and other ocular vasculitides. Curr Rheumatol Rep. 2015;17:24. https://doi.org/10.1007/s11926-015-0499-y.CrossRefPubMed

14.

Shahid FL, Mukherjee R, Knapp C. Cogan’s syndrome associated with orbital inflammation. Orbit. 2013;32:206–7. https://doi.org/10.3109/01676830.2013.764324.CrossRefPubMed

15.

Singer JR, Reddy RK. Serous neurosensory retinal detachment associated with atypical Cogan syndrome: a case report. Retin Cases Brief Rep. 2015;9:315–9. https://doi.org/10.1097/ICB.0000000000000201.CrossRefPubMed

16••.

Colodetti R, Spina G, Leal T, et al. Cogan’s syndrome – a rare aortitis, difficult to diagnose but with therapeutic potential. Rev Assoc Med Bras (1992). 2017;63:1028–31. https://doi.org/10.1590/1806-9282.63.12.1028Important description of the most common systemic vascular complication of Cogan’s syndrome. CrossRef

17.

Shamriz O, Tal Y, Gross M. Autoimmune inner ear disease: immune biomarkers, audiovestibular aspects, and therapeutic modalities of Cogan’s syndrome. J Immunol Res. 2018;2018:1498640–8. https://doi.org/10.1155/2018/1498640.CrossRefPubMedPubMedCentral

18.

Vavricka SR, Greuter T, Scharl M, Mantzaris G, Shitrit AB, Filip R, et al. Cogan’s syndrome in patients with inflammatory bowel disease – a case series. J Crohns Colitis. 2015;9:886–90. https://doi.org/10.1093/ecco-jcc/jjv128.CrossRefPubMed

19.

Scharl M, Frei P, Fried M, Rogler G, Vavricka SR. Association between Cogan’s syndrome and inflammatory bowel disease: a case series. J Crohns Colitis. 2011;5:64–8. https://doi.org/10.1016/j.crohns.2010.09.003.CrossRefPubMed

20.

Branislava I, Marijana T, Nemanja D, Dragan S, Maja Z. Atypical Cogan’s syndrome associated with coronary disease. Chin Med J. 2011;124:3192–4.PubMed

21.

Gaubitz M, Lubben B, Seidel M, et al. Cogan’s syndrome: organ-specific autoimmune disease or systemic vasculitis? A report of two cases and review of the literature. Clin Exp Rheumatol. 2001;19:463–9.PubMed

22.

Gasparovic H, Djuric Z, Bosnic D, Petricevic M, Brida M, Dotlic S, et al. Aortic root vasculitis associated with Cogan’s syndrome. Ann Thorac Surg. 2011;92:340–1. https://doi.org/10.1016/j.athoracsur.2010.12.068.CrossRefPubMed

23.

Hautefort C, Loundon N, Montchilova M, Marlin S, Garabedian EN, Ulinski T. Mycophenolate mofetil as a treatment of steroid dependent Cogan’s syndrome in childhood. Int J Pediatr Otorhinolaryngol. 2009;73:1477–9. https://doi.org/10.1016/j.ijporl.2009.06.025.CrossRefPubMed

24.

Pagnini I, Zannin ME, Vittadello F, Sari M, Simonini G, Cimaz R, et al. Clinical features and outcome of Cogan syndrome. J Pediatr. 2012;160:303–7. https://doi.org/10.1016/jpeds.2011.07.051.CrossRefPubMed

25••.

Sakano H, Harris JP. Emerging options in immune-mediated hearing loss. Laryngoscope Investig Otolaryngol. 2018;4:102–8. https://doi.org/10.1002/lio2.205Nicely delineated treatment options for autoimmune inflammation of the inner ear that is a hallmark of Cogan’s syndrome. CrossRefPubMedPubMedCentral

26••.

Padoan R, Cazzador D, Pendolino AL, et al. Cogan’s syndrome: new therapeutic approaches in the biological era. Expert Opin Biol Ther. 2019;19:781–8. https://doi.org/10.1080/14712598.2019.1611779Comprehensive review of rising role of biologic agents in the treatment of Cogan’s syndrome. CrossRefPubMed

27.

Matteson EL, Choi HK, Poe DS, Wise C, Lowe VJ, Mcdonald TJ, et al. Etanercept therapy for immune-mediated cochleovestibular disorders: a multi-center, open-label, pilot study. Arthritis Rheum. 2005;53:337–42. https://doi.org/10.1002/art.21179.CrossRefPubMed

28.

Shibuya M, Fujio K, Morita K, Harada H, Kanda H, Yamamoto K. Successful treatment with tocilizumab in a case of Cogan’s syndrome complicated with aortitis. Mod Rheumatol. 2013;23:577–81. https://doi.org/10.1007/s10165-012-0691-0.CrossRefPubMed

29.

Vollersten R. Vasculitis and Cogan’s syndrome. Rheum Dis Clin N Am. 1990;16:433–8.

Titel: Cogan’s Syndrome: Clinical Presentations and Update on Treatment
verfasst von: Gabriela Mabel Espinoza
Joseph Wheeler
Katherine K. Temprano
Angela Prost Keller
Publikationsdatum: 01.09.2020
Verlag: Springer US
Erschienen in: Current Allergy and Asthma Reports / Ausgabe 9/2020
Print ISSN: 1529-7322
Elektronische ISSN: 1534-6315
DOI: https://doi.org/10.1007/s11882-020-00945-1

Update HNO

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.

Newsletter bestellen

Springer Medizin

Cogan’s Syndrome: Clinical Presentations and Update on Treatment