Purpose
To investigate the correlation of the serum leptin, NPY, amylin in the childhood obesity.
Methods
The body mass index (BMI), waist and hip circumference, blood pressure (systolic/diastolic), lipid profile, fasting glucose, insulin, leptin, neuropeptide Y(NPY), amylin were measured in 56 children (24 obese children and 32 non-obese controls). We calculated HOMA-IR and evaluated the relationship between each anthropometric data, metabolic bio-marker and diet regulating factor (leptin, NPY, amylin).
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Results
Insulin and total cholesterol, triglyceride, LDL-cholesterol levels of the obese group were significantly higher than those of the non-obese group (p<0.05). leptin, NPY, leptin/NPY ratio, amylin levels of the obese group were significantly higher than those of the non-obese group (p<0.05). leptin showed significant correlation with BMI (r= 0.379, p= 0.043), NPY (r= 0.377, p= 0.044), L/N ratio (r= 0.754, p= 0.000) in the obese group. amylin showed significant correlation with insulin (r= 0.400, p= 0.048), HOMA-IR (r= 0.459, p= 0.028) in the obese group.
Conclusion
There is abnormality in central diet regulatory system caused by leptin and neuropeptide Y resistance in the obese group. And amylin showed significant correlation with insulin resistance
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