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Acta Diabetologica

Erschienen in:

24.06.2020 | COVID-19 | Review Article Zur Zeit gratis

Diabetes increases the mortality of patients with COVID-19: a meta-analysis

verfasst von: Zeng-hong Wu, Yun Tang, Qing Cheng

Erschienen in: Acta Diabetologica | Ausgabe 2/2021

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Abstract

Aims

Nowadays, the ongoing pandemic of COVID-19 caused by the novel coronavirus Syndrome-Coronavirus-2 (SARS-CoV-2) is an emerging, rapidly evolving situation. Complications such as hypertension, diabetes, COPD, cardiovascular disease, and cerebrovascular disease are major risk factors for patients with COVID-19.

Methods

No meta-analysis has explored if or not diabetes related to mortality of patients with COVID-19. Therefore, this meta-analysis first aims to explore the possible clinical mortality between diabetes and COVID-19, analyze if diabetes patients infected with SARS-CoV-2 are exposed to the worst clinical prognostic risk, and to evaluate the reliability of the evidence.

Results

Our results showed a close relationship between diabetes and mortality of COVID-19, with a pooled OR of 1.75 (95% CI 1.31–2.36; P = 0.0002). The pooled data were calculated with the fixed effects model (FEM) as no heterogeneity appeared in the studies. Sensitivity analysis showed that after omitting any single study or converting a random effect model to FEM, the main results still held.

Conclusions

Our meta-analysis showed that diabetes increases the mortality of patients with COVID-19. These results indicated the disturbance of blood glucose in the COVID-19 patients. More importantly, this meta-analysis grades the reliability of evidence for further basic and clinical research into the diabetes dysfunction in COVID-19 patients.

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Titel: Diabetes increases the mortality of patients with COVID-19: a meta-analysis
verfasst von: Zeng-hong Wu
Yun Tang
Qing Cheng
Publikationsdatum: 24.06.2020
Verlag: Springer Milan
Schlagwort: COVID-19
Erschienen in: Acta Diabetologica / Ausgabe 2/2021
Print ISSN: 0940-5429
Elektronische ISSN: 1432-5233
DOI: https://doi.org/10.1007/s00592-020-01546-0

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Diabetes increases the mortality of patients with COVID-19: a meta-analysis

Abstract