Skip to main content
Erschienen in: Journal of Public Health 11/2022

23.02.2021 | COVID-19 | Review Article Zur Zeit gratis

Incubation period for COVID-19: a systematic review and meta-analysis

verfasst von: Balram Rai, Anandi Shukla, Laxmi Kant Dwivedi

Erschienen in: Journal of Public Health | Ausgabe 11/2022

Einloggen, um Zugang zu erhalten

Abstract

Aim

This study aims to conduct a review of the existing literature about incubation period for COVID-19, which can provide insights to the transmission dynamics of the disease.

Methods

A systematic review followed by meta-analysis was performed for the studies providing estimates for the incubation period of COVID-19. The heterogeneity and bias in the included studies were tested by various statistical measures, including I2 statistic, Cochran’s Q test, Begg’s test and Egger’s test.

Results

Fifteen studies with 16 estimates of the incubation period were selected after implementing the inclusion and exclusion criteria. The pooled estimate of the incubation period is 5.74 (5.18, 6.30) from the random effects model. The heterogeneity in the selected studies was found to be 95.2% from the I2 statistic. There is no potential bias in the included studies for meta-analysis.

Conclusion

This review provides sufficient evidence for the incubation period of COVID-19 through various studies, which can be helpful in planning preventive and control measures for the disease. The pooled estimate from the meta-analysis is a valid and reliable estimate of the incubation period for COVID-19.
Literatur
Zurück zum Zitat Ahrens W, Pigeot I (eds) (2014) Handbook of epidemiology, vol 451. Springer, New York Ahrens W, Pigeot I (eds) (2014) Handbook of epidemiology, vol 451. Springer, New York
Zurück zum Zitat Backer JA, Klinkenberg D, Wallinga J (2020) Incubation period of 2019 novel coronavirus (2019-nCoV) infections among travellers from Wuhan, China, 20–28 January 2020. Eurosurveillance 25(5):2000062CrossRef Backer JA, Klinkenberg D, Wallinga J (2020) Incubation period of 2019 novel coronavirus (2019-nCoV) infections among travellers from Wuhan, China, 20–28 January 2020. Eurosurveillance 25(5):2000062CrossRef
Zurück zum Zitat Brookmeyer R (1998) Incubation period of infectious diseases. Encyclopedia of biostatistics, vol 3. Wiley, New York, pp 2011–2016 Brookmeyer R (1998) Incubation period of infectious diseases. Encyclopedia of biostatistics, vol 3. Wiley, New York, pp 2011–2016
Zurück zum Zitat Fraser C, Riley S, Anderson RM, Ferguson NM (2004) Factors that make an infectious disease outbreak controllable. Proc Natl Acad Sci 101(16):6146–6151CrossRef Fraser C, Riley S, Anderson RM, Ferguson NM (2004) Factors that make an infectious disease outbreak controllable. Proc Natl Acad Sci 101(16):6146–6151CrossRef
Zurück zum Zitat Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, et al (2020) Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med 382(18):1708–1720 Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, et al (2020) Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med 382(18):1708–1720
Zurück zum Zitat Hozo SP, Djulbegovic B, Hozo I (2005) Estimating the mean and variance from the median, range, and the size of a sample. BMC Med Res Methodol 5(1):13CrossRef Hozo SP, Djulbegovic B, Hozo I (2005) Estimating the mean and variance from the median, range, and the size of a sample. BMC Med Res Methodol 5(1):13CrossRef
Zurück zum Zitat Hu Z, Song C, Xu C, Jin G, Chen Y, Xu X, Ma H, Chen W, Lin Y, Zheng Y, Wang J (2020) Clinical characteristics of 24 asymptomatic infections with COVID-19 screened among close contacts in Nanjing, China. Science China Life Sciences 63(5):706–711CrossRef Hu Z, Song C, Xu C, Jin G, Chen Y, Xu X, Ma H, Chen W, Lin Y, Zheng Y, Wang J (2020) Clinical characteristics of 24 asymptomatic infections with COVID-19 screened among close contacts in Nanjing, China. Science China Life Sciences 63(5):706–711CrossRef
Zurück zum Zitat Lauer SA, Grantz KH, Bi Q, Jones FK, Zheng Q, Meredith HR, et al (2020) The incubation period of coronavirus disease 2019 (COVID-19) from publicly reported confirmed cases: estimation and application. Ann Intern Med 172(9): 577–582 Lauer SA, Grantz KH, Bi Q, Jones FK, Zheng Q, Meredith HR, et al (2020) The incubation period of coronavirus disease 2019 (COVID-19) from publicly reported confirmed cases: estimation and application. Ann Intern Med 172(9): 577–582
Zurück zum Zitat Lessler J, Reich NG, Brookmeyer R, Perl TM, Nelson KE, Cummings DA (2009) Incubation periods of acute respiratory viral infections: a systematic review. Lancet Infect Dis 9(5):291–300CrossRef Lessler J, Reich NG, Brookmeyer R, Perl TM, Nelson KE, Cummings DA (2009) Incubation periods of acute respiratory viral infections: a systematic review. Lancet Infect Dis 9(5):291–300CrossRef
Zurück zum Zitat Li LQ, Huang T, Wang YQ, Wang ZP, Liang Y, Huang TB, Zhang HY, Sun W, Wang Y (2020a) COVID-19 patients’ clinical characteristics, discharge rate, and fatality rate of meta-analysis. J Med Virol 92(6):577–583CrossRef Li LQ, Huang T, Wang YQ, Wang ZP, Liang Y, Huang TB, Zhang HY, Sun W, Wang Y (2020a) COVID-19 patients’ clinical characteristics, discharge rate, and fatality rate of meta-analysis. J Med Virol 92(6):577–583CrossRef
Zurück zum Zitat Linton NM, Kobayashi T, Yang Y, Hayashi K, Akhmetzhanov AR, Jung SM, et al (2020) Incubation period and other epidemiological characteristics of 2019 novel coronavirus infections with right truncation: a statistical analysis of publicly available case data. J Clin Med 9(2):538 Linton NM, Kobayashi T, Yang Y, Hayashi K, Akhmetzhanov AR, Jung SM, et al (2020) Incubation period and other epidemiological characteristics of 2019 novel coronavirus infections with right truncation: a statistical analysis of publicly available case data. J Clin Med 9(2):538
Zurück zum Zitat Nussbaumer-Streit B, Mayr V, Dobrescu AI, Chapman A, Persad E, Klerings I, ... Gartlehner G (2020) Quarantine alone or in combination with other public health measures to control COVID-19: a rapid review. Cochrane Database Syst Rev 4(4):CD013574 Nussbaumer-Streit B, Mayr V, Dobrescu AI, Chapman A, Persad E, Klerings I, ... Gartlehner G (2020) Quarantine alone or in combination with other public health measures to control COVID-19: a rapid review. Cochrane Database Syst Rev 4(4):CD013574
Zurück zum Zitat Pollán M, Pérez-Gómez B, Pastor-Barriuso R, Oteo J, Hernán MA, Pérez-Olmeda M, et al (2020) Prevalence of SARS-CoV-2 in Spain (ENE-COVID): a nationwide, population-based seroepidemiological study. The Lancet 396(10250):535–544 Pollán M, Pérez-Gómez B, Pastor-Barriuso R, Oteo J, Hernán MA, Pérez-Olmeda M, et al (2020) Prevalence of SARS-CoV-2 in Spain (ENE-COVID): a nationwide, population-based seroepidemiological study. The Lancet 396(10250):535–544
Zurück zum Zitat Sterne JA, Harbord RM (2004) Funnel plots in meta-analysis. Stata J 4(2):127–141CrossRef Sterne JA, Harbord RM (2004) Funnel plots in meta-analysis. Stata J 4(2):127–141CrossRef
Zurück zum Zitat Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, Moher D, Becker BJ, Sipe TA, Thacker SB (2000) Meta-analysis of observational studies in epidemiology: a proposal for reporting. JAMA 283(15):2008–2012CrossRef Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, Moher D, Becker BJ, Sipe TA, Thacker SB (2000) Meta-analysis of observational studies in epidemiology: a proposal for reporting. JAMA 283(15):2008–2012CrossRef
Zurück zum Zitat Twu SJ, Chen TJ, Chen CJ et al (2003) Control measures for severe acute respiratory syndrome (SARS) in Taiwan. Emerg Infect Dis 9:718–720CrossRef Twu SJ, Chen TJ, Chen CJ et al (2003) Control measures for severe acute respiratory syndrome (SARS) in Taiwan. Emerg Infect Dis 9:718–720CrossRef
Zurück zum Zitat van Enst WA, Ochodo E, Scholten RJ, Hooft L, Leeflang MM (2014) Investigation of publication bias in meta-analyses of diagnostic test accuracy: a meta-epidemiological study. BMC Med Res Methodol 14(1):70CrossRef van Enst WA, Ochodo E, Scholten RJ, Hooft L, Leeflang MM (2014) Investigation of publication bias in meta-analyses of diagnostic test accuracy: a meta-epidemiological study. BMC Med Res Methodol 14(1):70CrossRef
Zurück zum Zitat Varia M, Wilson S, Sarwal S, McGeer A, Gournis E, Galanis E (2003) Investigation of a nosocomial outbreak of severe acute respiratory syndrome (SARS) in Toronto, Canada. CMAJ 169(4):285–292PubMedPubMedCentral Varia M, Wilson S, Sarwal S, McGeer A, Gournis E, Galanis E (2003) Investigation of a nosocomial outbreak of severe acute respiratory syndrome (SARS) in Toronto, Canada. CMAJ 169(4):285–292PubMedPubMedCentral
Zurück zum Zitat Virlogeux V, Fang VJ, Wu JT, Ho LM, Peiris JM, Leung GM, Cowling BJ (2015) Incubation period duration and severity of clinical disease following severe acute respiratory syndrome coronavirus infection. Epidemiology 26(5):666CrossRef Virlogeux V, Fang VJ, Wu JT, Ho LM, Peiris JM, Leung GM, Cowling BJ (2015) Incubation period duration and severity of clinical disease following severe acute respiratory syndrome coronavirus infection. Epidemiology 26(5):666CrossRef
Zurück zum Zitat Virlogeux V, Fang VJ, Park M, Wu JT, Cowling BJ (2016) Comparison of incubation period distribution of human infections with MERS-CoV in South Korea and Saudi Arabia. Sci Rep 6:35839CrossRef Virlogeux V, Fang VJ, Park M, Wu JT, Cowling BJ (2016) Comparison of incubation period distribution of human infections with MERS-CoV in South Korea and Saudi Arabia. Sci Rep 6:35839CrossRef
Zurück zum Zitat Wan X, Wang W, Liu J, Tong T (2014) Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range. BMC Med Res Methodol 14(1):135CrossRef Wan X, Wang W, Liu J, Tong T (2014) Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range. BMC Med Res Methodol 14(1):135CrossRef
Zurück zum Zitat Xiao Z, Xie X, Guo W, Luo Z, Liao J, Wen F, Zhou Q, Han L, Zheng T (2020) Examining the incubation period distributions of COVID-19 on Chinese patients with different travel histories. J Infect Dev Ctries 14(4):323–327CrossRef Xiao Z, Xie X, Guo W, Luo Z, Liao J, Wen F, Zhou Q, Han L, Zheng T (2020) Examining the incubation period distributions of COVID-19 on Chinese patients with different travel histories. J Infect Dev Ctries 14(4):323–327CrossRef
Zurück zum Zitat Yan Y, Shin WI, Pang YX, Meng Y, Lai J, You C, et al (2020) The first 75 days of novel coronavirus (SARS-CoV-2) outbreak: recent advances, prevention, and treatment. Int J Environ Res Public Health 17(7):2323 Yan Y, Shin WI, Pang YX, Meng Y, Lai J, You C, et al (2020) The first 75 days of novel coronavirus (SARS-CoV-2) outbreak: recent advances, prevention, and treatment. Int J Environ Res Public Health 17(7):2323
Metadaten
Titel
Incubation period for COVID-19: a systematic review and meta-analysis
verfasst von
Balram Rai
Anandi Shukla
Laxmi Kant Dwivedi
Publikationsdatum
23.02.2021
Verlag
Springer Berlin Heidelberg
Erschienen in
Journal of Public Health / Ausgabe 11/2022
Print ISSN: 2198-1833
Elektronische ISSN: 1613-2238
DOI
https://doi.org/10.1007/s10389-021-01478-1

Weitere Artikel der Ausgabe 11/2022

Journal of Public Health 11/2022 Zur Ausgabe

Passend zum Thema

ANZEIGE

IPD-Fallzahlen & Pneumokokken-Impfung bei Kindern in Deutschland

Das Niveau der postpandemischen Fallzahlen für invasive Pneumokokken-Erkrankungen (IPD) ist aus Sicht des Referenz-Zentrums für Streptokokken in Aachen alarmierend [1]. Wie sich die monatlichen IPD-Fallzahlen bei Kindern und Jugendlichen von Juli 2015 bis März 2023 entwickelt haben, lesen Sie hier.

ANZEIGE

HPV-Impfung: Auch für junge Erwachsene sinnvoll und wichtig

Auch nach dem 18. Lebensjahr kann eine HPV-Impfung sinnvoll und wichtig sein. Viele gesetzliche Krankenkassen übernehmen die Kosten auch zu einem späteren Zeitpunkt noch.

ANZEIGE

Impfstoffe – Krankheiten vorbeugen, bevor sie entstehen

Seit mehr als 130 Jahren entwickelt und produziert MSD Impfstoffe für alle Altersgruppen. Hier finden Sie nützliche Informationen und Praxismaterialien rund um das Thema Impfen.

MSD Sharp & Dohme GmbH