Erschienen in:
08.08.2022 | COVID-19 | Review
Fenofibrate for COVID-19 and related complications as an approach to improve treatment outcomes: the missed key for Holy Grail
verfasst von:
Shadi Salem Alkhayyat, Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Maisra M. El-Bouseary, Amal M. AboKamer, Gaber El-Saber Batiha, Jesus Simal-Gandara
Erschienen in:
Inflammation Research
|
Ausgabe 10-11/2022
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Abstract
Introduction
Fenofibrate is an agonist of peroxisome proliferator activated receptor alpha (PPAR-α), that possesses anti-inflammatory, antioxidant, and anti-thrombotic properties. Fenofibrate is effective against a variety of viral infections and different inflammatory disorders. Therefore, the aim of critical review was to overview the potential role of fenofibrate in the pathogenesis of SARS-CoV-2 and related complications.
Results
By destabilizing SARS-CoV-2 spike protein and preventing it from binding angiotensin-converting enzyme 2 (ACE2), a receptor for SARS-CoV-2 entry, fenofibrate can reduce SARS-CoV-2 entry in human cells Fenofibrate also suppresses inflammatory signaling pathways, which decreases SARS-CoV-2 infection-related inflammatory alterations. In conclusion, fenofibrate anti-inflammatory, antioxidant, and antithrombotic capabilities may help to minimize the inflammatory and thrombotic consequences associated with SARSCoV-2 infection. Through attenuating the interaction between SARS-CoV-2 and ACE2, fenofibrate can directly reduce the risk of SARS-CoV-2 infection.
Conclusions
As a result, fenofibrate could be a potential treatment approach for COVID-19 control.