Human adenovirus (HAdV) is a highly contagious pathogen that can cause a wide variety of clinical symptoms, including respiratory tract disease, conjunctivitis, gastroenteritis, and urinary tract infection [
1‐
4]. This infection is generally self-limiting; however, in immunocompromised patients, it can lead to severe damage to multiple organs, such as the liver, heart, meninges, and brain [
5]. HAdV belongs to the family
Adenoviridae within the genus
mastadenovirus, with a nonenveloped, icosahedral viral particle. HAdV contains a double-stranded DNA genome, ranging from 26 to 45 kb in length [
6]. To date, HAdVs can be divided into seven species (A-G), with at least 113 types (
http://www.hadvwg.gmu.edu). Most novel HAdVs originate from intertypic recombination, which could result in changes in viral fitness, tissue tropism, and virulence, such as HAdV-55 and HAdV-56 [
7‐
9]. As of April 2022, the World Health Organization has reported severe acute hepatitis outbreaks among children from 11 countries across Europe and America, which have induced great public concern. Of the 169 reported hepatitis cases, HAdV was detected in at least 74 cases (43.8%), and 18 were identified as HAdV-41 belonging to the F species. Accordingly, HAdV is currently presumed to be a possible etiology of this outbreak [
10]. Therefore, the aim of this review was to summarize the epidemiological and genetic characteristics of HAdV circulating in China, as well as the relationship between severe liver function impairment and HAdV infections.